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1. 发明授权

US06576658B2 Compositions and uses of dictyostatin compounds 失效
标题翻译：丝氨酸蛋白酶抑制剂化合物的组成和用途
公开(公告)号：US06576658B2
公开(公告)日：2003-06-10
申请号：US09793323
申请日：2001-02-26
申请人： Amy E. Wright , Jennifer L. Cummins , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
发明人： Amy E. Wright , Jennifer L. Cummins , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
IPC分类号： A61K31335
CPC分类号： A61K31/366 , A61K31/365 , C07K14/43595
摘要： Dictyostatin-1 has been found to stabilize microtubules and prohibit their depolymerization to free tubulin. Because of these activities, the dictyostatin compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.
摘要翻译：已经发现丝氨酸蛋白酶抑制素-1可以稳定微管，并禁止其解聚游离微管蛋白。由于这些活性，丝氨酸蛋白酶抑制素化合物可用于治疗许多发生异常细胞增殖的疾病，例如药物敏感和耐药性癌症，自身免疫性疾病和炎性疾病。

2. 发明授权

US06677370B2 Compositions and uses of dictyostatin compounds 有权
标题翻译：丝氨酸蛋白酶抑制剂化合物的组成和用途
公开(公告)号：US06677370B2
公开(公告)日：2004-01-13
申请号：US10360200
申请日：2003-02-06
申请人： Amy E. Wright , Jennifer L. Cummins , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
发明人： Amy E. Wright , Jennifer L. Cummins , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
IPC分类号： A61K31335
CPC分类号： A61K31/366 , A61K31/365 , C07K14/43595
摘要： Dictyostatin-1 has been found to stabilize microtubules and prohibit their depolymerization to free tubulin. Because of these activities, the dictyostatin compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.
摘要翻译：已经发现丝氨酸蛋白酶抑制素-1可以稳定微管，并禁止其解聚游离微管蛋白。由于这些活性，丝氨酸蛋白酶抑制素化合物可用于治疗许多发生异常细胞增殖的疾病，例如药物敏感和耐药性癌症，自身免疫性疾病和炎性疾病。

3. 发明授权

US06384187B1 Antiproliferative activity of microsclerodermins 有权
标题翻译：微生物的抗增殖活性
公开(公告)号：US06384187B1
公开(公告)日：2002-05-07
申请号：US09568692
申请日：2000-05-11
申请人： Amy E. Wright , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
发明人： Amy E. Wright , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
IPC分类号： C07K750
CPC分类号： C07K7/56 , A61K38/00
摘要： The subject invention pertains to a series of cyclic peptides known as the microsclerodermins, which possess unusual amino acids, and which have been observed to inhibit the proliferation of tumor cell lines. The subject invention also pertains to methods useful in inhibiting pathological cellular proliferation in animals, including humans and other mammals. In accordance with the teachings of the subject invention, microsclerodermin compounds can be used to inhibit cellular proliferation including that which is responsible for tumors and other cancers. In a specific embodiment, the novel compositions and methods of use of the subject invention can advantageously be useful in the treatment of a patient hosting cancer cells, for example, inhibiting the growth of tumor cells in a mammalian host.
摘要翻译：本发明涉及一系列已知为具有不寻常氨基酸的微小霉菌的环状肽，其已被观察到抑制肿瘤细胞系的增殖。本发明还涉及可用于抑制动物（包括人类和其他哺乳动物）的病理性细胞增殖的方法。根据本发明的教导，可以使用微细胞毒素化合物来抑制细胞增殖，包括负责肿瘤和其它癌症的细胞增殖。在一个具体实施方案中，本发明的新颖组合物和使用方法可以有利地用于治疗宿主癌细胞的患者，例如抑制哺乳动物宿主中肿瘤细胞的生长。

4. 发明授权

US06495594B2 Biologically active analogs of discodermolide 失效
标题翻译： discodermolide的生物活性类似物
公开(公告)号：US06495594B2
公开(公告)日：2002-12-17
申请号：US09796175
申请日：2001-02-28
申请人： Sarath P. Gunasekera , Ross E. Longley , Richard A. Isbrucker , Gopal K. Paul , Shirley A. Pomponi , Amy E. Wright
发明人： Sarath P. Gunasekera , Ross E. Longley , Richard A. Isbrucker , Gopal K. Paul , Shirley A. Pomponi , Amy E. Wright
IPC分类号： A61K3135
CPC分类号： C07D309/32 , A61K31/365 , C07B2200/07 , C07C271/22 , C07D309/30
摘要： The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.
摘要翻译：本发明提供了可以有利地用于免疫调节和/或治疗癌症的生物活性的抗真菌化合物的新组合物。本发明的化合物可用于治疗癌症，作为微管蛋白聚合器和微管稳定剂。本发明还涉及鉴定说使用discodermolide分子的区域，这些区域负责氯仿化合物的生物活性的某些方面。

5. 发明授权

US07521474B2 Biologically active lasonolide compounds 失效
标题翻译：生物活性季铵化合物
公开(公告)号：US07521474B2
公开(公告)日：2009-04-21
申请号：US11494229
申请日：2006-07-27
申请人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
发明人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
IPC分类号： A61K31/335 , C07D325/04 , C07D493/12
CPC分类号： C07D493/18
摘要： The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.
摘要翻译：本发明提供生物活性大环内酯化合物的新组合物，其可有利地用于阻断细胞增殖，治疗癌症，治疗真菌感染和控制食品，化妆品和其它消费品的腐败。

6. 发明授权

US07115756B2 Biologically active lasonolide compounds 失效
公开(公告)号：US07115756B2
公开(公告)日：2006-10-03
申请号：US10875670
申请日：2004-06-23
申请人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
发明人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
IPC分类号： C07D325/04 , C07D493/12
CPC分类号： C07D493/18
摘要： The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

7. 发明授权

US06835736B1 Discorhabdin compounds and methods of use 失效
标题翻译： Discorhabdin化合物和使用方法
公开(公告)号：US06835736B1
公开(公告)日：2004-12-28
申请号：US10376118
申请日：2003-02-28
申请人： Sarath P. Gunasekera , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
发明人： Sarath P. Gunasekera , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
IPC分类号： A61K3144
CPC分类号： C07D471/10 , A61K31/44
摘要： The subject invention provides novel compositions of biologically active discorhabdin compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.
摘要翻译：本发明提供了可以有利地用于抑制病理性细胞增殖的生物活性的discorhabdin化合物的新组合物。本发明的化合物可用于治疗包括肿瘤在内的癌症。

8. 发明授权

US6057333A Discorhabdin compounds and methods of use 失效
标题翻译： Discorhabdin化合物和使用方法
公开(公告)号：US6057333A
公开(公告)日：2000-05-02
申请号：US122572
申请日：1998-07-24
申请人： Sarath P. Gunaskera , Peter J. McCarthy , Shirley A. Pomponi , Amy E. Wright , Ross E. Longley
发明人： Sarath P. Gunaskera , Peter J. McCarthy , Shirley A. Pomponi , Amy E. Wright , Ross E. Longley
IPC分类号： C07D471/20 , A61K31/44 , C07D401/14
CPC分类号： C07D471/20
摘要： Discorhabdin compounds are derived from marine sponges of the genus Batzella or prepared by synthetic methods. These compounds, and pharmaceutical compositions containing them as active ingredients, are useful as immunomodulatory, antitumor agents, and/or caspase inhibitors.
摘要翻译： Discorhabdin化合物衍生自Batzella属的海绵或通过合成方法制备。这些化合物和含有它们作为活性成分的药物组合物可用作免疫调节剂，抗肿瘤剂和/或胱天蛋白酶抑制剂。

9. 发明授权

US07094803B2 Biologically active raspailamide compounds 失效
标题翻译：生物活性raspailamide化合物
公开(公告)号：US07094803B2
公开(公告)日：2006-08-22
申请号：US10889925
申请日：2004-07-12
申请人： K. Brian Killday , Amy E. Wright , Shirley A. Pomponi , Ross E. Longley
发明人： K. Brian Killday , Amy E. Wright , Shirley A. Pomponi , Ross E. Longley
IPC分类号： A61K31/35
CPC分类号： C07D407/06 , C07D309/10
摘要： The subject invention provides novel compositions of biologically active polyketide compounds that can advantageously be used in blocking cellular proliferation and treatment of cancer.
摘要翻译：本发明提供了可有利地用于阻断细胞增殖和治疗癌症的生物活性聚酮化合物的新组合物。

10. 发明授权

US06218419B1 Aminoiminoquinone and aminoquinone alkaloid compounds and methods of use 有权
标题翻译：氨基亚氨基醌和氨基醌生物碱化合物及其使用方法
公开(公告)号：US06218419B1
公开(公告)日：2001-04-17
申请号：US09349070
申请日：1999-07-08
申请人： Sarath P. Gunasekera , Peter J. McCarthy , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
发明人： Sarath P. Gunasekera , Peter J. McCarthy , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
IPC分类号： A61K31404
CPC分类号： C07D209/12
摘要： The subject application concerns novel compounds with useful biological properties. For example, these compounds can be used as antinflammatory, anti-proliferative, immunomodulatory, and/or neuroprotective agents. Specific examples of the compounds of the subject invention include Secobatzelline A and Secobatzelline B, which can be isolated from marine sponges.
摘要翻译：本申请涉及具有有用生物学性质的新化合物。例如，这些化合物可以用作抗炎，抗增殖，免疫调节和/或神经保护剂。本发明化合物的具体实例包括Secobatzelline A和Secobatzelline B，其可以从海绵中分离出来。

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