专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110250139A1 Modified Pyrazine Derivatives and Uses Thereof 有权
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US20110250139A1
公开(公告)日：2011-10-13
申请号：US13140082
申请日：2009-12-17
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00 , A61P13/12 , A61P13/10 , C07D241/20 , A61K31/4965
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein are excretable by the renal system of a subject or patient and are useful for visualizing the renal system of a subject or patient. Upon excitation by electromagnetic radiation, a number of the compounds disclosed herein exhibit luminescence and are externally detectable when present in the body fluid of a patient or subject. Also provided herein are methods for visualizing the renal system of a subject or patient.
摘要翻译：本文提供了包含具有多个含（乙二醇）取代基的吡嗪衍生物的化合物，制剂和制剂。本文公开的许多化合物可由受试者或患者的肾系统排泄，并且可用于使受试者或患者的肾脏系统可视化。当通过电磁辐射激发时，本文公开的许多化合物表现出发光，并且当存在于患者或受试者的体液中时可外部检测。本文还提供了用于使受试者或患者的肾系统可视化的方法。

2. 发明申请

US20140170071A1 Modified Pyrazine Derivatives and Uses Thereof 审中-公开
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US20140170071A1
公开(公告)日：2014-06-19
申请号：US14187530
申请日：2014-02-24
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： In some embodiments, the invention provides modified pyrazine derivatives containing a central pyrazine ring with two secondary amine groups attached directly to the central pyrazine ring and two amino carbonyl groups attached directly to the central pyrazine ring. The secondary amine groups are terminated by alkyl groups containing from 1 to 6 carbons. The amino carbonyl groups can be terminated by a wide range of substituents including, but not limited to, alkyl and alkylene groups, polyether groups, including poly(ethylene glycol) groups, secondary and tertiary amine groups, polyhydroxylated alkyl groups, amino carbonyl groups, amino thioketone groups, and combinations thereof. In some embodiments, the invention provides modified pyrazine derivatives useful as optical agents in a wide variety of biomedical imaging procedures, including diagnostic and imaging procedures. In an embodiment, for example, modified pyrazine derivatives are provided which are useful in monitoring organ and system functioning, for example in monitoring renal system functioning.
摘要翻译：在一些实施方案中，本发明提供了含有中间吡嗪环的改性吡嗪衍生物，其具有直接连接至中央吡嗪环的两个仲胺基团和直接连接至中央吡嗪环的两个氨基羰基基团。仲胺基团被含有1至6个碳原子的烷基封端。氨基羰基可以通过宽范围的取代基来终止，包括但不限于烷基和亚烷基，聚醚基团，包括聚（乙二醇）基团，仲和叔胺基团，多羟基化烷基基团，氨基羰基基团，氨基硫酮基团及其组合。在一些实施方案中，本发明提供了在多种生物医学成像方法中用作光学剂的改性吡嗪衍生物，包括诊断和成像程序。在一个实施方案中，例如，提供了可用于监测器官和系统功能的修饰的吡嗪衍生物，例如在监测肾系统功能。

3. 发明授权

US08703100B2 Modified pyrazine derivatives and uses thereof 有权
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US08703100B2
公开(公告)日：2014-04-22
申请号：US13140082
申请日：2009-12-17
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00 , A61P13/12 , A61P13/10 , C07D241/20 , A61K31/4965
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein are excretable by the renal system of a subject or patient and are useful for visualizing the renal system of a subject or patient. Upon excitation by electromagnetic radiation, a number of the compounds disclosed herein exhibit luminescence and are externally detectable when present in the body fluid of a patient or subject. Also provided herein are methods for visualizing the renal system of a subject or patient.
摘要翻译：本文提供了包含具有多个含（乙二醇）取代基的吡嗪衍生物的化合物，制剂和制剂。本文公开的许多化合物可由受试者或患者的肾系统排泄，并且可用于使受试者或患者的肾脏系统可视化。当通过电磁辐射激发时，本文公开的许多化合物表现出发光，并且当存在于患者或受试者的体液中时可外部检测。本文还提供了用于使受试者或患者的肾系统可视化的方法。

4. 发明申请

US20140186267A1 Modified Pyrazine Derivatives and Uses Thereof 有权
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US20140186267A1
公开(公告)日：2014-07-03
申请号：US14196188
申请日：2014-03-04
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein are excretable by the renal system of a subject or patient and are useful for visualizing the renal system of a subject or patient. Upon excitation by electromagnetic radiation, a number of the compounds disclosed herein exhibit luminescence and are externally detectable when present in the body fluid of a patient or subject. Also provided herein are methods for visualizing the renal system of a subject or patient.
摘要翻译：本文提供了包含具有多个含（乙二醇）取代基的吡嗪衍生物的化合物，制剂和制剂。本文公开的许多化合物可由受试者或患者的肾系统排泄，并且可用于使受试者或患者的肾脏系统可视化。当通过电磁辐射激发时，本文公开的许多化合物表现出发光，并且当存在于患者或受试者的体液中时可外部检测。本文还提供了用于使受试者或患者的肾系统可视化的方法。

5. 发明授权

US08697033B2 Modified pyrazine derivatives and uses thereof 有权
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US08697033B2
公开(公告)日：2014-04-15
申请号：US13140107
申请日：2009-12-17
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00 , A61P13/12 , A61P13/10 , C07D241/20 , A61K31/4965
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： In some embodiments, the invention provides modified pyrazine derivatives containing a central pyrazine ring with two secondary amine groups attached directly to the central pyrazine ring and two amino carbonyl groups attached directly to the central pyrazine ring. The secondary amine groups are terminated by alkyl groups containing from 1 to 6 carbons. The amino carbonyl groups can be terminated by a wide range of substituents including, but not limited to, alkyl and alkylene groups, polyether groups, including poly(ethylene glycol) groups, secondary and tertiary amine groups, polyhydroxylated alkyl groups, amino carbonyl groups, amino thioketone groups, and combinations thereof. In some embodiments, the invention provides modified pyrazine derivatives useful as optical agents in a wide variety of biomedical imaging procedures, including diagnostic and imaging procedures. In an embodiment, for example, modified pyrazine derivatives are provided which are useful in monitoring organ and system functioning, for example in monitoring renal system functioning.
摘要翻译：在一些实施方案中，本发明提供了含有中间吡嗪环的改性吡嗪衍生物，其具有直接连接至中央吡嗪环的两个仲胺基团和直接连接至中央吡嗪环的两个氨基羰基基团。仲胺基团被含有1至6个碳原子的烷基封端。氨基羰基可以通过宽范围的取代基来终止，包括但不限于烷基和亚烷基，聚醚基团，包括聚（乙二醇）基团，仲和叔胺基团，多羟基化烷基基团，氨基羰基基团，氨基硫酮基团及其组合。在一些实施方案中，本发明提供了在多种生物医学成像方法中用作光学剂的改性吡嗪衍生物，包括诊断和成像程序。在一个实施方案中，例如，提供了可用于监测器官和系统功能的修饰的吡嗪衍生物，例如在监测肾系统功能。

6. 发明申请

US20110177007A1 Dithienopyrrole Dyes for Imaging and Therapy 审中-公开
标题翻译：二噻吩并吡咯染料用于成像和治疗
公开(公告)号：US20110177007A1
公开(公告)日：2011-07-21
申请号：US13121250
申请日：2009-09-29
申请人： Raghavan Rajagopalan , William L. Neumann , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
发明人： Raghavan Rajagopalan , William L. Neumann , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
IPC分类号： A61K49/00 , C07D495/14 , C07H21/00 , C12N9/00 , C07K16/00 , C07H3/00 , C07K14/575 , C07K9/00 , C07D487/22 , C07D279/18 , C09B56/00 , C07D217/00 , C07D409/14 , C07D209/02 , C07D401/14 , C07D473/00 , C07K2/00 , C07K14/00 , A61P35/00 , A61M37/00
CPC分类号： C09B57/00 , A61K41/0057 , A61K49/0021 , G01N2458/00
摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienopyrrole core. In some embodiments, dyes of the present invention are dithienopyrrole dyes having a dithienopyrrole core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties.
摘要翻译：本发明提供光学剂，包括组合物，制剂和制剂，以及使用和制造光学剂的方法。本发明的光学剂包括具有二噻吩并吡咯核的稠环骨架结构的染料及其衍生物。在一些实施方案中，本发明的染料是具有任选被官能化以提供有用的光学，生物学，药代动力学和/或物理性质的二噻吩并吡咯核心的二噻吩并吡咯染料。

7. 发明申请

US20110250140A1 Modified Pyrazine Derivatives and Uses Thereof 有权
标题翻译：改性吡嗪衍生物及其用途
公开(公告)号：US20110250140A1
公开(公告)日：2011-10-13
申请号：US13140107
申请日：2009-12-17
申请人： Amruta Poreddy , William L. Neumann
发明人： Amruta Poreddy , William L. Neumann
IPC分类号： A61K49/00 , C07D241/26
CPC分类号： A61K49/00 , A61K49/0013 , C07D241/26
摘要： In some embodiments, the invention provides modified pyrazine derivatives containing a central pyrazine ring with two secondary amine groups attached directly to the central pyrazine ring and two amino carbonyl groups attached directly to the central pyrazine ring. The secondary amine groups are terminated by alkyl groups containing from 1 to 6 carbons. The amino carbonyl groups can be terminated by a wide range of substituents including, but not limited to, alkyl and alkylene groups, polyether groups, including poly(ethylene glycol) groups, secondary and tertiary amine groups, polyhydroxylated alkyl groups, amino carbonyl groups, amino thioketone groups, and combinations thereof. In some embodiments, the invention provides modified pyrazine derivatives useful as optical agents in a wide variety of biomedical imaging procedures, including diagnostic and imaging procedures. In an embodiment, for example, modified pyrazine derivatives are provided which are useful in monitoring organ and system functioning, for example in monitoring renal system functioning.
摘要翻译：在一些实施方案中，本发明提供了含有中间吡嗪环的改性吡嗪衍生物，其具有直接连接至中央吡嗪环的两个仲胺基团和直接连接至中央吡嗪环的两个氨基羰基基团。仲胺基团被含有1至6个碳原子的烷基封端。氨基羰基可以通过宽范围的取代基来终止，包括但不限于烷基和亚烷基，聚醚基团，包括聚（乙二醇）基团，仲和叔胺基团，多羟基化烷基基团，氨基羰基基团，氨基硫酮基团及其组合。在一些实施方案中，本发明提供了在多种生物医学成像方法中用作光学剂的改性吡嗪衍生物，包括诊断和成像程序。在一个实施方案中，例如，提供了可用于监测器官和系统功能的修饰的吡嗪衍生物，例如在监测肾系统功能。

8. 发明申请

US20110177006A1 Dithienofuran Dyes for Imaging and Therapy 审中-公开
标题翻译： Dithienofuran染料成像和治疗
公开(公告)号：US20110177006A1
公开(公告)日：2011-07-21
申请号：US13121210
申请日：2009-09-29
申请人： Raghavan Rajagopalan , William L. Neumann , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
发明人： Raghavan Rajagopalan , William L. Neumann , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
IPC分类号： A61K49/00 , C07D409/14 , C07D217/00 , C07D209/02 , C07D401/14 , C07D473/00 , C07K14/00 , C07K2/00 , C07H21/00 , C12N9/00 , C07K16/00 , C07H3/00 , C07K14/575 , C07K9/00 , C07D487/22 , C07D279/18 , C09B56/00 , A61P35/00 , A61M37/00
CPC分类号： C07D497/14 , A61K41/0057 , A61K49/0021 , A61K49/005 , A61K49/0054 , A61K49/0056 , C09B57/00
摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienofuran core. In some embodiments, dyes of the present invention are dithienofuran dyes having a dithienofuran core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties.
摘要翻译：本发明提供光学剂，包括组合物，制剂和制剂，以及使用和制造光学剂的方法。本发明的光学剂包括具有二噻吩并呋喃核心的稠环骨架结构的染料及其衍生物。在一些实施方案中，本发明的染料是具有任选官能化以提供有用的光学，生物学，药代动力学和/或物理性质的二噻吩并呋喃核心的二噻吩并呋喃染料。

9. 发明申请

US20110196231A1 Fused Ring Thiophene Dyes for Imaging and Therapy 审中-公开
标题翻译：熔融环噻吩染料用于成像和治疗
公开(公告)号：US20110196231A1
公开(公告)日：2011-08-11
申请号：US13121205
申请日：2009-09-29
申请人： Raghavan Rajagopalan , William L. Neuman , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
发明人： Raghavan Rajagopalan , William L. Neuman , Amruta Poreddy , John N. Freskos , Richard B. Dorshow
IPC分类号： A61B6/00 , C07D495/14 , A61M37/00
CPC分类号： A61K31/381 , A61K41/0057 , A61K49/0021 , A61K49/005 , A61K49/0054 , A61K49/0056 , C07D495/14
摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include oligomer dyes, and derivatives thereof, having a fused ring backbone structure having an oligothiophene core. In some embodiments, oligomer dyes of the present invention are fused ring thiophene dyes having an oligothiophene core comprising a plurality of fused thiophene, thiophene-oxide, and/or thiophene-dioxide rings, optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. The compounds are dithieno[3,2-b;2′,3′-d]thiophene derivatives.
摘要翻译：本发明提供光学剂，包括组合物，制剂和制剂，以及使用和制造光学剂的方法。本发明的光学剂包括具有低聚噻吩核的稠环骨架结构的低聚物染料及其衍生物。在一些实施方案中，本发明的低聚物染料是具有包含多个稠合噻吩，噻吩氧化物和/或噻吩二氧化物环的低聚噻吩核心的稠环噻吩染料，其任选被官能化以提供有用的光学，生物学，药代动力学和/ 或物理性质。化合物是二噻吩并[3,2-b; 2'，3'-d]噻吩衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式