专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130331369A1 3-Spirocyclic Piperidine Derivatives as Ghrelin Receptor Agonists 审中-公开
公开(公告)号：US20130331369A1
公开(公告)日：2013-12-12
申请号：US13962689
申请日：2013-08-08
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： C07D471/10 , A61K31/55 , C07D487/10 , A61K31/407 , A61K31/435 , A61K45/06
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译：本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。

2. 发明授权

US08546416B2 3-spirocyclic piperidine derivatives as ghrelin receptor agonists 有权
标题翻译： 3-螺环哌啶衍生物作为生长素释放肽受体激动剂
公开(公告)号：US08546416B2
公开(公告)日：2013-10-01
申请号：US13479596
申请日：2012-05-24
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： C07D211/00 , C07D213/00 , C07D215/00 , C07D219/00 , C07D221/00 , C07D217/00
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译：本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。

3. 发明申请

US20120302540A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS 有权
标题翻译：作为GHRELIN受体激动剂的3-螺环哌啶衍生物
公开(公告)号：US20120302540A1
公开(公告)日：2012-11-29
申请号：US13479596
申请日：2012-05-24
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： A61K31/438 , A61P1/00 , A61K31/407 , A61K31/55 , C07D471/10 , C07D487/10
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译：本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。

4. 发明申请

US20160184318A1 AUTOTAXIN INHIBITORS 有权
标题翻译：维生素抑制剂
公开(公告)号：US20160184318A1
公开(公告)日：2016-06-30
申请号：US14906161
申请日：2014-07-16
申请人： David BEATTIE , Urs BAETTIG , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , Ddavid Andrew SANDHAM , Oliver Ross STEWARD , Christopher Thomson
发明人： David BEATTIE , Urs BAETTIG , Darren Mark LEGRAND , Andrew Stuart LISTER , Jeffrey MCKENNA , David William PEARCE , Ddavid Andrew SANDHAM , Oliver Ross STEWARD , Christopher Thomson
IPC分类号： A61K31/551 , A61K31/454 , C07D401/10 , A61K31/4245 , C07D401/14 , A61K31/5377 , A61K31/4545 , C07D403/12 , A61K31/506 , C07D403/10 , A61K31/41 , C07D405/12 , A61K31/496 , C07D413/10 , C07D417/10 , A61K31/427 , C07D471/08 , A61K31/439 , C07D417/14 , C07D413/14
CPC分类号： A61K31/551 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/504 , A61K31/506 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/08 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
摘要翻译：本发明涉及自体吸收素抑制剂的新型化合物，其制备方法，药物组合物和含有它们的药物及其在自体吸收素介导的疾病和病症中的用途。

5. 发明申请

US20130185924A1 CHAMFERING OF LAMINATE LAYERS 有权
标题翻译：层压板的切割
公开(公告)号：US20130185924A1
公开(公告)日：2013-07-25
申请号：US13641636
申请日：2011-07-19
申请人： Yohann Bellanger , Christopher Thomson
发明人： Yohann Bellanger , Christopher Thomson
IPC分类号： B23Q11/10 , F04D29/38 , B29C70/54
CPC分类号： B23Q11/10 , B23Q11/1053 , B24B9/20 , B24B41/068 , B24B55/02 , B29C70/54 , B29C70/545 , B29C2035/165 , F04D29/38 , Y10T29/49995 , Y10T29/54
摘要： A method of machining a fibrous sheet for a composite structure is described. The sheet comprises a resin matrix having a glass transition temperature, wherein the method comprises cooling the sheet substantially to maintain the temperature of the matrix below its glass transition temperature during machining.
摘要翻译：描述了用于复合结构的纤维片材的加工方法。片材包括具有玻璃化转变温度的树脂基质，其中所述方法包括在加工过程中基本上冷却片材的温度低于其玻璃化转变温度。

6. 发明申请

US20170037030A1 AUTOTAXIN INHIBITORS 审中-公开
标题翻译：维生素抑制剂
公开(公告)号：US20170037030A1
公开(公告)日：2017-02-09
申请号：US15305602
申请日：2015-04-21
申请人： Vikki FURMINGER , Owen HUGHES , Darren LEGRAND , Emily STANLEY , Christopher THOMSON , Gareth WILLIAMS
发明人： Vikki Furminger , Owen Rhys Hughes , Darren Mark Legrand , Emily Stanley , Christopher Thomson , Gareth Williams
IPC分类号： C07D401/12 , A61K31/454
CPC分类号： C07D401/12 , A61K31/454 , A61K45/06 , C07D211/26 , C07D211/34 , C07D211/58 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.
摘要翻译：本发明涉及自体吸收素抑制剂的新化合物，其制备方法，药物组合物和含有它们的药物及其在治疗ATX依赖性或ATX介导的疾病或病症中的用途。

7. 发明申请

US20130237519A1 BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
公开(公告)号：US20130237519A1
公开(公告)日：2013-09-12
申请号：US13599267
申请日：2012-08-30
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

8. 发明申请

US20060132320A1 Mechanical self-cleaning probe via a jiggler 有权
标题翻译：机械自清洁探头通过跳汰机
公开(公告)号：US20060132320A1
公开(公告)日：2006-06-22
申请号：US11004660
申请日：2004-12-02
申请人： John Branzell , Christopher Thomson
发明人： John Branzell , Christopher Thomson
IPC分类号： G08B21/00
CPC分类号： G01F23/00 , F24H9/2007 , G01F23/241 , G01F23/265 , G01F23/268 , Y10T137/7306 , Y10T137/8342
摘要： A device, having a container for holding a fluid moving therein and a conductance probe installed therein for providing a conductance signal indicating whether it is in contact with the fluid, features a jiggler arrangement having a jiggler arranged on the conductance probe so as to form a mechanical self-cleaning conductance probe, which responds to movement of the fluid, for wiping the conductance probe to keep deposits from building up on the conductance probe. The jiggler arrangement may include one or more grooves thereon so that the jiggler can be loosely fitted on the tip between one or more retaining rings arranged in the one or more grooves. The jiggler arrangement may include one or more retaining rings snap-fit on the tip for loosely arranging and retaining the jiggler on the tip.
摘要翻译：一种具有用于保持流体移动的容器和安装在其中的用于提供与流体接触的电导信号的电导探针的装置，其特征在于，具有布置在电导探针上的摆动器，以形成机械自清洁电导探针，其响应流体的运动，用于擦拭电导探针以保持沉积物不会积聚在电导探针上。摆轮装置可以包括一个或多个凹槽，使得摆轮可以松动地装配在布置在一个或多个凹槽中的一个或多个保持环之间的尖端上。摆轮装置可以包括一个或多个卡扣配合在尖端上，用于松动地布置并将夹具保持在尖端上。

9. 发明授权

US09630945B2 Autotaxin inhibitors 有权
公开(公告)号：US09630945B2
公开(公告)日：2017-04-25
申请号：US14653649
申请日：2013-12-17
申请人： Vikki Furminger , Owen Rhys Hughes , Darren Mark Le Grand , Emily Stanley , Christopher Thomson
发明人： Vikki Furminger , Owen Rhys Hughes , Darren Mark Le Grand , Emily Stanley , Christopher Thomson
IPC分类号： C07D401/12 , A61K31/454 , C07D451/04 , A61K31/4192 , A61K31/445 , A61K31/46 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D211/32 , C07D211/60 , C07D249/04 , C07D265/30 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D401/06 , C07D263/38 , C07D211/26 , C07D211/34 , C07D211/58
CPC分类号： C07D401/12 , A61K31/4192 , A61K31/445 , A61K31/454 , A61K31/46 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/58 , C07D211/60 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04
摘要： The present invention relates to novel compounds of formula (I) (I) that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.

10. 发明申请

US20170007614A1 Autotaxin inhibitors 审中-公开
标题翻译：自体贴剂抑制剂
公开(公告)号：US20170007614A1
公开(公告)日：2017-01-12
申请号：US15210560
申请日：2016-07-14
申请人： Darren Mark Legrand , Vikki Furminger , Christopher Thomson , Owen Rhys Hughes , Emily Stanley
发明人： Darren Mark Legrand , Vikki Furminger , Christopher Thomson , Owen Rhys Hughes , Emily Stanley
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/4468 , A61K31/4192 , A61K31/496 , A61K31/439 , A61K31/55 , A61K31/454 , A61K31/5375
CPC分类号： A61K31/5377 , A61K31/337 , A61K31/4174 , A61K31/4192 , A61K31/4245 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/4468 , A61K31/454 , A61K31/496 , A61K31/5375 , A61K31/55 , C07D211/34 , C07D249/08 , C07D295/185 , C07D401/12 , C07D403/12 , C07D413/12 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
摘要翻译：本发明涉及自体吸收素抑制剂的新型化合物，其制备方法，药物组合物和含有它们的药物及其在自体吸收素介导的疾病和病症中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式