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1. 发明授权

US06900200B2 Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists 失效
标题翻译：三环羟基甲酰胺及其衍生物tocolytic催产素受体拮抗剂
公开(公告)号：US06900200B2
公开(公告)日：2005-05-31
申请号：US10120100
申请日：2002-04-10
申请人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph P. Sabatucci , Eugene John Trybulski , Kevin Anthony Memoli , William Jennings Sanders
发明人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph P. Sabatucci , Eugene John Trybulski , Kevin Anthony Memoli , William Jennings Sanders
IPC分类号： A61K31/5517 , A61P1/16 , A61P7/02 , A61P9/04 , A61P9/12 , A61P15/00 , A61P15/06 , A61P15/18 , A61P25/18 , A61P25/22 , A61P27/06 , A61P27/10 , A61P27/16 , A61P43/00 , C07D471/14 , C07D487/04 , A61P15/16
CPC分类号： C07D471/14 , C07D487/04
摘要： This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
摘要翻译：本发明提供了作为催产素受体竞争性拮抗剂的新型取代的三环甲酰胺，以及其制备方法，其用于治疗，抑制，抑制或预防早产，痛经和子宫内膜炎的药物组合物和方法，在剖宫产分娩之前，促进产前运送到医疗机构。这些化合物也可用于提高生育率，提高农场动物的生存率和发情同步; 并且可用于预防和治疗包括强迫症（OCD）和神经精神障碍在内的催产素系统在中枢神经系统中的功能障碍。

2. 发明授权

US07064120B2 Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists 失效
标题翻译：三环吡啶甲酰胺及其衍生物tocolytic催产素受体拮抗剂
公开(公告)号：US07064120B2
公开(公告)日：2006-06-20
申请号：US10120025
申请日：2002-04-10
申请人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph Peter Sabatucci , Kevin Anthony Memoli , Eugene John Trybulski
发明人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph Peter Sabatucci , Kevin Anthony Memoli , Eugene John Trybulski
IPC分类号： A61P15/00 , A61K31/55 , C07D487/12
CPC分类号： C07D471/14 , C07D487/04
摘要： This invention provides novel substituted tricyclic pyridyl carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea, endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
摘要翻译：本发明提供了作为催产素受体竞争性拮抗剂的新型取代的三环吡啶甲酰胺及其制备方法，其用于治疗，抑制，抑制或预防早产，痛经，子宫内膜炎，抑制劳动的药物组合物和方法在剖宫产分娩之前，促进产前运输到医疗机构。这些化合物也可用于提高生育率，提高农场动物的生存率和发情同步; 并且可用于预防和治疗包括强迫症（OCD）和神经精神障碍在内的催产素系统在中枢神经系统中的功能障碍。

3. 发明授权

US07109193B2 Tricyclic diazepines tocolytic oxytocin receptor antagonists 失效
标题翻译：三环二氮嗪类溶瘤性催产素受体拮抗剂
公开(公告)号：US07109193B2
公开(公告)日：2006-09-19
申请号：US10119971
申请日：2002-04-10
申请人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph Peter Sabatucci , Kevin Anthony Memoli , Eugene John Trybulski
发明人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , Joseph Peter Sabatucci , Kevin Anthony Memoli , Eugene John Trybulski
IPC分类号： A61P15/00 , A61K31/55 , C07D487/12
CPC分类号： C07D487/04 , C07D487/14
摘要： This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including treatment of preterm labor, dysmenorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
摘要翻译：本发明提供新的三环二氮杂类化合物以及利用这些化合物治疗和/或预防和/或抑制可由催产素拮抗剂活性治疗或减轻的疾病的方法和药物组合物，包括治疗早产，痛经，子宫内膜炎，并在剖宫产分娩前抑制劳动。这些化合物也可用于提高生育率，提高农场动物的生存率和发情同步; 并且可用于预防和治疗包括强迫症（OCD）和神经精神障碍在内的催产素系统在中枢神经系统中的功能障碍。

4. 发明授权

US07053083B2 Cyclohexylphenyl vasopressin agonists 失效
标题翻译：环己基苯基加压素激动剂
公开(公告)号：US07053083B2
公开(公告)日：2006-05-30
申请号：US10120917
申请日：2002-04-11
申请人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , John P. Dusza , Kevin A. Memoli
发明人： Amedeo Arturo Failli , Jay Scott Shumsky , Thomas Joseph Caggiano , John P. Dusza , Kevin A. Memoli
IPC分类号： A61P7/00 , A61K31/55 , C07D243/00
CPC分类号： C07D471/04 , C07D243/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl “Z” represents optionally substituted phenyl or a 6-membered aromatic ring having one nitrogen atom; “W” represents a optionally substituted phenyl or 5-membered aromatic ring having one nitrogen atom; “X” represents an optionally substituted 5-membered aromatic ring having one sulfur atom; as well as methods and pharmaceutical compositions utilizing these compounds for the inducing temporary delay of urination or treatment of disorders remedied by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders.
摘要翻译：本发明提供下列通式的化合物：其中Y是NR或 - （CH 2 CH 2）n。 R为H或烷基“Z”表示任选取代的苯基或具有一个氮原子的6-元芳环; “W”表示具有一个氮原子的任选取代的苯基或5元芳环; “X”表示具有一个硫原子的任选取代的5元芳环; 以及利用这些化合物诱导临时延迟排尿或治疗由加压素激动剂活性（包括尿崩症，夜间遗尿症，夜尿症，尿失禁或出血和凝血障碍）补救的病症的方法和药物组合物。

5. 发明授权

US07223752B2 Biphenyl vasopressin agonists 失效
公开(公告)号：US07223752B2
公开(公告)日：2007-05-29
申请号：US10980939
申请日：2004-11-04
申请人： Amedeo Arturo Failli , John P. Dusza , Thomas Joseph Caggiano , Jay Scott Shumsky , Kevin A. Memoli , Eugene J. Trybulski
发明人： Amedeo Arturo Failli , John P. Dusza , Thomas Joseph Caggiano , Jay Scott Shumsky , Kevin A. Memoli , Eugene J. Trybulski
IPC分类号： C07D403/12 , C07D243/38 , A61K31/551
CPC分类号： C07D243/10 , C07D243/38 , C07D401/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04
摘要： A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1–C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, halogen or (C1–C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, or (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, (C1–C6) lower alkoxy, or halogen; or (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, halogen, or (C1–C6) lower alkoxy; represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C1–C6) lower alkyl, halogen, or (C1–C6) lower alkoxy; R1 is a moiety of the formula and R2, R3, R7, R8 and R9 are, independently, selected from a group consisting of hydrogen, (C1–C3) lower alkyl, OCH3, halogen, CF3, —SCH3, OCF3, SCF3, or CN; or a pharmaceutically acceptable salt, or pro-drug form thereof.

6. 发明申请

US20100016639A1 PRODUCTION OF CHIRALLY PURE AMINO ALCOHOL INTERMEDIATES, DERIVATIVES THEREOF, AND USES THEREOF 失效
标题翻译：生产纯氨基醇的中间体，其衍生物及其用途
公开(公告)号：US20100016639A1
公开(公告)日：2010-01-21
申请号：US12546121
申请日：2009-08-24
申请人： John Sellstedt , Gloria Cheal , Razzak Noureldin , Anita Wai-Yin Chan , Panolil Raveendranath , Thomas Joseph Caggiano
发明人： John Sellstedt , Gloria Cheal , Razzak Noureldin , Anita Wai-Yin Chan , Panolil Raveendranath , Thomas Joseph Caggiano
IPC分类号： C07C209/00
CPC分类号： C07C213/02 , C07B2200/07 , C07C215/08 , C07D333/34
摘要： A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
摘要翻译：描述了选择性制备可用于制备用烷基，取代的芳基或取代的杂芳基磺化或酰化的酰胺的手性2S-氨基醇的方法。该方法包括使二噻唑-1,2-二羧酸二叔丁酯与（4S）-4-苄基-3 - [（S） - 三氟甲基 - 烷基取代的烷酰基] -1,3-恶唑烷-2-酮得到1-（1S，2S） - （[（4S）-4-苄基-2-氧代-1,3-恶唑烷-3-基] - 羰基} - 三氟甲基 - 烷基取代的烷基的二 - 叔丁基）肼-1,2-二羧酸。然后将该二羧酸酯还原，得到1-（1S，2S） - [三氟甲基 - 烷基取代的烷基]肼-1-（羟甲基）-1,2-二羧酸二叔丁酯。所得产物用酸解封，得到（2S，3S） - 三氟 - 肼基 - 甲基烷-1-醇的酸加成盐。（2S，3S） - 三氟-2-肼基 - 甲基烷-1-醇的酸加成盐在合适的金属催化剂存在下氢化，得到氨基醇（2S，3S）-2-氨基 - 三氟 - 甲基链烷-1-醇HCl。

7. 发明申请

US20080249150A1 HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE 失效
标题翻译：含有氨基酸的淀粉酶生产的杂环磺酰胺抑制剂
公开(公告)号：US20080249150A1
公开(公告)日：2008-10-09
申请号：US12142306
申请日：2008-06-19
申请人： Lynn Resnick , Donna M. Huryn , Joan E. Sabalski , Joshua D. Berkowitz , Anthony Frank Kreft , Dennis Martin Kubrak , Thomas Joseph Caggiano , Koi Michele Morris
发明人： Lynn Resnick , Donna M. Huryn , Joan E. Sabalski , Joshua D. Berkowitz , Anthony Frank Kreft , Dennis Martin Kubrak , Thomas Joseph Caggiano , Koi Michele Morris
IPC分类号： A61K31/4196 , C07D409/02 , A61K31/415 , A61P25/28 , C07D231/12
CPC分类号： A61K31/416 , C07D231/12 , C07D409/12
摘要： Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.
摘要翻译：提供了可用于降低β淀粉样蛋白水平的化合物。化合物具有式Ia的结构：其中R 1是低级烷基，取代的低级烷基，苯基，取代的苯基，苄基，取代的苄基，苄氧基，取代的苄氧基或SO 2， / 5> 5

8. 发明申请

US20070249869A1 Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof 失效
标题翻译：手性纯氨基醇中间体，其衍生物及其用途的生产
公开(公告)号：US20070249869A1
公开(公告)日：2007-10-25
申请号：US11787962
申请日：2007-04-18
申请人： John Sellstedt , Gloria Cheal , Razzak Noureldin , Anita Wai-Yin Chan , Panolil Raveendranath , Thomas Joseph Caggiano
发明人： John Sellstedt , Gloria Cheal , Razzak Noureldin , Anita Wai-Yin Chan , Panolil Raveendranath , Thomas Joseph Caggiano
IPC分类号： C07C215/02
CPC分类号： C07C213/02 , C07B2200/07 , C07C215/08 , C07D333/34
摘要： A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
摘要翻译：描述了选择性制备用于制备用烷基，取代的芳基或取代的杂芳基磺化或酰化的酰胺的手性2S-氨基醇的方法。该方法包括使二噻唑-1,2-二羧酸二叔丁酯与（4S）-4-苄基-3 - [（S） - 三氟甲基 - 烷基取代的烷酰基] -1,3-恶唑烷-2-酮得到1-（1S，2S） - （[（4S）-4-苄基-2-氧代-1,3-恶唑烷-3-基] - 羰基} - 三氟甲基 - 烷基取代的烷基的二 - 叔丁基）肼-1,2-二羧酸。然后将该二羧酸酯还原，得到1-（1S，2S） - [三氟甲基 - 烷基取代的烷基]肼-1-（羟甲基）-1,2-二羧酸二叔丁酯。所得产物用酸解封，得到（2S，3S） - 三氟 - 肼基 - 甲基烷-1-醇的酸加成盐。（2S，3S） - 三氟-2-肼基 - 甲基烷-1-醇的酸加成盐在合适的金属催化剂存在下氢化，得到氨基醇（2S，3S）-2-氨基 - 三氟 - 甲基链烷-1-醇HCl。

9. 发明授权

US07425580B2 (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands 失效
标题翻译：（二芳基甲基） - 丙二腈及其作为雌激素受体配体的用途
公开(公告)号：US07425580B2
公开(公告)日：2008-09-16
申请号：US11124808
申请日：2005-05-09
申请人： Thomas Joseph Caggiano , Antony Aldo Brazzale
发明人： Thomas Joseph Caggiano , Antony Aldo Brazzale
IPC分类号： A61K31/135 , C07C255/32
CPC分类号： C07C255/35 , C07C255/37
摘要： The present invention concerns compounds of formula: where R1, R2, R3 and R4 are defined in the specification.
摘要翻译：本发明涉及下式的化合物：其中R 1，R 2，R 3和R 4定义在规范中。

10. 发明授权

US5922730A Alkylated rapamycin derivatives 失效
公开(公告)号：US5922730A
公开(公告)日：1999-07-13
申请号：US103445
申请日：1998-06-24
申请人： David Cheng Hu , Alexander Aleksey Greenfield , Thomas Joseph Caggiano , Craig Eugene Caufield
发明人： David Cheng Hu , Alexander Aleksey Greenfield , Thomas Joseph Caggiano , Craig Eugene Caufield
IPC分类号： C07D498/18 , A61K31/445 , A61K31/435 , C07D471/04
CPC分类号： C07D498/18
摘要： This invention relates to compounds which possess immunosuppressive and/or anti tumor and/or antinflammatory activity in vivo and/or inhibit thymocyte proliferation in vitro. These compounds are therefore useful in the treaiment of transplantation rejection, autoimmune diseases such as lupus, rheumatoid ardiritis, diabetes mellitus, multiple sclerosis and in the treatment of Candida albicans infections and also in treatment of diseases of inflammation. These compounds are represented by the formula below ##STR1## wherein W and Y are OR.sup.1 and X and Z together form a bond or W and X are OR.sup.2 and Y and Z together form a bond, wherein:R.sup.1 is selected from --(CH.sub.2).sub.n --Ar with a proviso that Ar is not phenyl,--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.3 with a proviso that n is greater than one,--CH.sub.2 CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m --CH.sub.3,--(CH.sub.2).sub.n --CH.sub.2 CH(OR.sup.3)CH.sub.2 OR.sup.4 where R.sup.3 and R.sup.4 are H, C.sub.1 -C.sub.10 alkyl, or R.sup.3 and R.sup.4 together are ethylene, methylene or dimethylmethylene;--CH.sub.2 (CH.sub.2).sub.n --OR.sup.3 with a proviso that R.sup.3 is not H, C.sub.1 -C.sub.10 alkyl, or C(O)C.sub.1 -C.sub.10 alkyl;and --CH.sub.2 (CH.sub.2).sub.n --X where X is F, Cl, Br or I;R.sup.2 is selected from H, C.sub.1 -C.sub.10 alkyl, Ar(CH.sub.2).sub.n --, C.sub.3 -C.sub.10 alkenyl, --(CH.sub.2 (CH.sub.2 O).sub.n CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m --CH.sub.3, --CH.sub.2 (CH.sub.2).sub.n --OR.sup.3, --CH.sub.2 (CH.sub.2).sub.n --Xwhere X is F, Cl, Br or I;and --(CH.sub.2).sub.n --CH.sub.2 CH(OR.sup.5)CH.sub.2 OR.sup.6 where R.sup.5 and R.sup.6 are selected independently from H, C.sub.1 -C.sub.10 alkyl, --(CH.sub.2).sub.n --Ar, --CONH(CH.sub.2).sub.n --Ar or COC(CH.sub.3).sub.2 --(CH.sub.2).sub.n --Ar, --COR.sup.7 and --CO.sub.2 R.sup.7, where R.sup.7 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or Ar; or R.sup.5 and R.sup.6 together are methylene, ethylene, or dimethylmethylene;R.sup.3 and R.sup.4 indepently are H, methyl, --(CH.sub.2).sub.n CH.sub.3, --(CH.sub.2).sub.n Ar, --(CH.sub.2).sub.n CH.dbd.CH.sub.2, --C(O)R.sup.7, --CO.sub.2 R.sup.7, --CONH(CH.sub.2).sub.n Ar or --C(O)C(CH.sub.3).sub.2 --(CH.sub.2).sub.n Ar;Ar is selected independently from phenyl, pyridinyl, quinolinyl, indolyl, furanyl, 1, 2, 3-triazolyl and tetrazolyl;n=1-10 independently; andm=1-5 independently,or a pharmaceutically acceptable acid addition salt where one can be formed.

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