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    • 10. 发明授权
    • Synthesis and applications of amino carboxylates
    • 氨基羧酸盐的合成与应用
    • US08501988B2
    • 2013-08-06
    • US12401715
    • 2009-03-11
    • Altony J. MirallesCarter M. Silvernail
    • Altony J. MirallesCarter M. Silvernail
    • C07C229/04
    • C07C227/08C07C319/12C07C323/52C07C229/16C07C229/24
    • A method of synthesizing carboxylated amines is disclosed. The method comprises reacting a mixture of a potassium salt of either a primary or secondary amine with a potassium salt of a halogenated carboxylic acid wherein the halogenated carboxylic acid is selected from the group consisting of brominated, chlorinated, or iodinated carboxylic acid in the presence of potassium hydroxide, and optionally in heating the reacting mixture; precipitating the potassium salt by optionally chilling the mixture and discarding the precipitate; purifying the carboxylate amine potassium salt from the liquid phase using water soluble alcohol and optionally adding formic acid to obtain the free aminocarboxylic acid and potassium formate. In a preferred embodiment, the halogenated carboxylic acid is chloroacetic acid.
    • 公开了一种合成羧化胺的方法。 该方法包括将伯胺或仲胺的钾盐与卤代羧酸的钾盐的混合物反应,其中卤代羧酸选自溴化,氯化或碘化的羧酸,在 氢氧化钾,任选地加热反应混合物; 通过任选地冷却混合物并抛弃沉淀物沉淀钾盐; 使用水溶性醇从液相中纯化羧酸胺钾盐,并任选加入甲酸得到游离氨基羧酸和甲酸钾。 在优选的实施方案中,卤代羧酸是氯乙酸。