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1. 发明申请

US20050267481A1 Systems, devices and apparatuses for bony fixation and disk repair and replacement and methods related thereto 审中-公开
标题翻译：用于骨固定和椎间盘修复和置换的系统，装置和装置及其相关方法
公开(公告)号：US20050267481A1
公开(公告)日：2005-12-01
申请号：US10968867
申请日：2004-10-18
申请人： Allen Carl , Josef Winkler , Robert Beisel , Spanky Raymond , Daniel Savage , Jason Gromek , Carl Nilsson
发明人： Allen Carl , Josef Winkler , Robert Beisel , Spanky Raymond , Daniel Savage , Jason Gromek , Carl Nilsson
IPC分类号： A61B20060101 , A61B17/00 , A61B17/16 , A61B17/17 , A61B17/32 , A61B17/58 , A61B17/88 , A61F2/44
CPC分类号： A61F2/4455 , A61B17/1631 , A61B17/1642 , A61B17/1671 , A61B17/1757 , A61B17/32002 , A61B17/8875
摘要： The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize a new apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member, which also preferably is arcuate, and avoids the associated problems with prior cage or straight rod and screw systems. Also featured are systems, apparatuses and methods for repairing, replacing or augmenting the nucleus and/or annulus of a disc.
摘要翻译：本发明的特征在于用于固定相邻骨段，骨结构的段和脊椎的相邻脊椎动物的新方法，装置和装置。所述方法，装置和装置利用新的装置，用于在骨骼或骨骼结构部分或相邻椎骨或浸没在骨骼或骨骼结构部分或相邻椎骨内的通道的表面中形成通道。在更具体的实施例中，这种装置和方法包括形成弧形通道，并且哪个通道可以在其中容纳弯曲的杆或植入构件，其也优选地是弧形的，并且避免了与现有的笼或直杆和螺杆系统相关联的问题。还特征在于用于修复，替换或增加盘的核和/或环的系统，装置和方法。

2. 发明授权

US09549772B2 Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy 有权
标题翻译：选择性地将低温能量递送到椎间盘组织和相关的椎间盘内低温治疗方法
公开(公告)号：US09549772B2
公开(公告)日：2017-01-24
申请号：US14316051
申请日：2014-06-26
申请人： Allen Carl
发明人： Allen Carl
IPC分类号： A61B18/02 , A61B18/00 , A61B17/00
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00261 , A61B2018/0022 , A61B2018/00339 , A61B2018/00642 , A61B2018/00714 , A61B2018/00791 , A61B2018/00821 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293 , A61B2090/374 , A61B2090/378
摘要： The present invention relates to devices and methods for altering the tissue in and around an intervertebral disc through localized hypothermia therapy to restore function of the disc and reduce pain. Hypothermia therapy is defined as the reduction of tissue temperature to below that of the equilibrium temperature. Target therapeutic temperatures and times are varied according to the desired treatment effect. Intended effects of hypothermia of the intervertebral disc include cellular disruption leading to cell death and or structural and chemical denaturation within the anulus fibrosus, nucleus pulposus, or nerve fibers, temporary or permanent deadening of the nerves within or surrounding the disc, induction of a healing response, angiogenesis, or accelerated degeneration and/or drying of the nucleus pulposus and/or anulus fibrosus. Various effects can be achieved by reaching different temperatures for differing periods of time or by the proximity of the hypothermia therapy device to the treatment target. Accordingly, it is an object of one or more the embodiments of the invention to provide hypothermic therapy to selected locations within an intervertebral disc utilizing a flexible and guidable cryogenic device.
摘要翻译：本发明涉及用于通过局部低温治疗来改变椎间盘内和周围的组织以恢复椎间盘功能并减轻疼痛的装置和方法。低温治疗定义为组织温度降低到平衡温度以下。目标治疗温度和时间根据所需的治疗效果而变化。椎间盘低温的预期作用包括导致细胞死亡的细胞破坏和在纤维环，髓核或神经纤维内的结构和化学变性，椎间盘内或周围的神经的暂时或永久性衰弱，诱导愈合响应，血管生成或加速的髓核和/或纤维环的变性和/或干燥。通过在不同的时间段内达到不同的温度或通过低温治疗装置接近治疗目标可以实现各种效果。因此，本发明的一个或多个实施方案的目的是利用柔性和可引导的低温装置向椎间盘内的选定位置提供低温治疗。

3. 发明申请

US20100268237A1 Systems, Devices and Apparatuses For Bony Fixation and Disk Repair and Replacement Methods Related Thereto 有权
标题翻译：用于骨固定和磁盘修复及相关替代方法的系统，设备和装置
公开(公告)号：US20100268237A1
公开(公告)日：2010-10-21
申请号：US12087912
申请日：2007-01-17
申请人： Allen Carl , Josef K. Winkler , Robert Floyd Beisel , Spanky Allen Raymond , Daniel Stephen Savage , Jason John Gromek , Carl Michael Nilsson , Nathan Jeffrey Pierce
发明人： Allen Carl , Josef K. Winkler , Robert Floyd Beisel , Spanky Allen Raymond , Daniel Stephen Savage , Jason John Gromek , Carl Michael Nilsson , Nathan Jeffrey Pierce
IPC分类号： A61B17/56
CPC分类号： A61B17/1757 , A61B17/1631 , A61B17/1633 , A61B17/1642 , A61B17/1671 , A61B17/70 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/4611 , A61F2002/30481 , A61F2002/30576 , A61F2002/30841 , A61F2002/30878 , A61F2002/4628 , A61F2220/0025
摘要： The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members.
摘要翻译：本发明的特征在于用于固定相邻骨段，骨结构的段和脊椎的相邻脊椎动物的新方法，装置和装置。所述方法，装置和装置利用一种用于在骨骼或骨骼结构部分或邻近椎骨表面形成通道的装置或浸没在骨骼或骨结构部分或相邻椎骨内的通道。在更具体的实施例中，这种装置和方法包括形成弓形通道，并且哪个通道可以在其中容纳弯曲的杆或植入构件。还特征的是用于在形成这种通道的同时将间隔件可移除地悬挂在椎间空间中的系统，装置和方法以及用于动态植入构件的系统，装置和方法。

4. 发明申请

US20060058790A1 Spinous process reinforcement device and method 有权
公开(公告)号：US20060058790A1
公开(公告)日：2006-03-16
申请号：US11197573
申请日：2005-08-03
申请人： Allen Carl , Dan Sachs
发明人： Allen Carl , Dan Sachs
IPC分类号： A61B17/70
CPC分类号： A61F2/4405 , A61B17/70 , A61B17/7004 , A61B17/7064 , A61B17/7067 , A61B2017/0256 , A61B2090/064 , A61F2002/30079 , A61F2002/30242 , A61F2002/30563 , A61F2002/30579 , A61F2002/30642 , A61F2002/30841 , A61F2210/009 , A61F2230/0071 , B33Y80/00
摘要： A method and device for reinforcing a spinous process is provided. Also provided are devices and method for attaching devices thereto.

5. 发明申请

US20050149007A1 Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy 有权
标题翻译：选择性地将低温能量递送到椎间盘组织和相关的椎间盘内低温治疗方法
公开(公告)号：US20050149007A1
公开(公告)日：2005-07-07
申请号：US10653692
申请日：2003-09-02
申请人： Allen Carl
发明人： Allen Carl
IPC分类号： A61B17/00 , A61B18/02 , A61B19/00
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00261 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293 , A61B2090/378
摘要： The present invention relates to devices and methods for altering the tissue in and around an intervertebral disc through localized hypothermia therapy to restore function of the disc and reduce pain. Hypothermia therapy is defined as the reduction of tissue temperature to below that of the equilibrium temperature. Target therapeutic temperatures and times are varied according to the desired treatment effect. Intended effects of hypothermia of the intervertebral disc include cellular disruption leading to cell death and or structural and chemical denaturation within the anulus fibrosus, nucleus pulposus, or nerve fibers, temporary or permanent deadening of the nerves within or surrounding the disc, induction of a healing response, angiogenesis, or accelerated degeneration and/or drying of the nucleus pulposus and/or anulus fibrosus. Various effects can be achieved by reaching different temperatures for differing periods of time or by the proximity of the hypothermia therapy device to the treatment target. Accordingly, it is an object of one or more the embodiments of the invention to provide hypothermic therapy to selected locations within an intervertebral disc utilizing a flexible and guidable cryogenic device.
摘要翻译：本发明涉及用于通过局部低温治疗来改变椎间盘内和周围的组织以恢复椎间盘功能并减轻疼痛的装置和方法。低温治疗定义为组织温度降低到平衡温度以下。目标治疗温度和时间根据所需的治疗效果而变化。椎间盘低温的预期作用包括导致细胞死亡的细胞破坏和在纤维环，髓核或神经纤维内的结构和化学变性，椎间盘内或周围的神经的暂时或永久性衰弱，诱导愈合响应，血管生成或加速的髓核和/或纤维环的变性和/或干燥。通过在不同的时间段内达到不同的温度或通过低温治疗装置接近治疗目标可以实现各种效果。因此，本发明的一个或多个实施方案的目的是利用柔性和可引导的低温装置向椎间盘内的选定位置提供低温治疗。

6. 发明授权

US06607530B1 Systems and methods for spinal fixation 有权
标题翻译：脊柱固定的系统和方法
公开(公告)号：US06607530B1
公开(公告)日：2003-08-19
申请号：US09536732
申请日：2000-03-28
申请人： Allen Carl , Ricky D. Hart , Josef K. Winkler
发明人： Allen Carl , Ricky D. Hart , Josef K. Winkler
IPC分类号： A61B1770
CPC分类号： A61B17/15 , A61B17/1604 , A61B17/1642 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/70 , A61B17/7011 , A61B17/7083 , A61B17/92 , A61B2017/00004 , A61B2017/0256 , A61B2090/08021 , A61F2/4455 , A61F2/4611 , A61F2002/4627 , A61F2002/4687 , A61F2310/00365
摘要： Featured are a method and apparatus for fixing adjacent vertebrate of a spine that avoids the need and associated problems with prior cage or straight rod and screw systems. Methods and apparatus of the invention utilize a new implant member, which preferably is arcuate. Preferred methods of the invention for stabilizing adjacent vertebrae of the spine, include steps of providing a positioning apparatus including two guide sleeves, each guide sleeve having a long axis and locating the two guide sleeves with respect to the adjacent vertebrae such that a vertex formed by the long axis of each guide sleeve is located in the intervertebral space for the adjacent vertebrae. The method further includes forming an aperture in each of the adjacent vertebrae using the guide sleeves and inserting an implant into the apertures formed in each of the adjacent vertebrae so that the implant extends between the adjacent vertebrae and through the intervertebral space. In an alternative method a cutting fixture including a pivot arm is secured to the adjacent vertebrae and a cutting device is secured to the pivot arm. The pivot arm and cutting device are configured and arranged so that rotation of the pivot arm about a particularly located pivot point allows the cutting device to form the aperture in each of the adjacent vertebrae.
摘要翻译：特别是用于固定脊椎的相邻脊椎动物的方法和装置，其避免了现有的笼或直杆和螺杆系统的需要和相关问题。本发明的方法和装置利用新的植入物构件，其优选是弧形的。用于稳定脊椎相邻椎骨的本发明的优选方法包括提供包括两个导向套筒的定位装置的步骤，每个导向套筒具有长轴线并使两个导向套筒相对于相邻的椎骨定位，使得顶点由每个引导套筒的长轴位于相邻椎骨的椎间空间中。该方法还包括使用引导套管在每个相邻的椎骨中形成孔，并将植入物插入形成在每个相邻椎骨中的孔中，使得植入物在相邻的椎骨之间延伸并穿过椎间空间。在替代方法中，包括枢转臂的切割夹具固定到相邻的椎骨，并且切割装置固定到枢转臂。枢转臂和切割装置被构造和布置成使得枢转臂围绕特别定位的枢转点的旋转允许切割装置在每个相邻椎骨中形成孔。

7. 发明授权

US08721647B2 Systems, devices and apparatuses for bony fixation and disk repair and replacement methods related thereto 有权
标题翻译：用于骨固定和椎间盘修复及替换方法的系统，装置和装置
公开(公告)号：US08721647B2
公开(公告)日：2014-05-13
申请号：US13351644
申请日：2012-01-17
申请人： Allen Carl , Josef K. Winkler , Robert Floyd Beisel , Spanky Allen Raymond , Daniel Stephen Savage , Jason John Gromek , Carl Michael Nilsson
发明人： Allen Carl , Josef K. Winkler , Robert Floyd Beisel , Spanky Allen Raymond , Daniel Stephen Savage , Jason John Gromek , Carl Michael Nilsson
IPC分类号： A61B17/16 , A61B17/17
CPC分类号： A61F2/4455 , A61B17/1631 , A61B17/1642 , A61B17/1671 , A61B17/1757 , A61B17/32002 , A61B17/8875
摘要： The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize a new apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member, which also preferably is arcuate, and avoids the associated problems with prior cage or straight rod and screw systems. Also featured are systems, apparatuses and methods for repairing, replacing or augmenting the nucleus and/or annulus of a disc.
摘要翻译：本发明的特征在于用于固定相邻骨段，骨结构的段和脊椎的相邻脊椎动物的新方法，装置和装置。所述方法，装置和装置利用新的装置，用于在骨骼或骨骼结构部分或相邻椎骨或浸没在骨骼或骨骼结构部分或相邻椎骨内的通道的表面中形成通道。在更具体的实施例中，这种装置和方法包括形成弧形通道，并且哪个通道可以在其中容纳弯曲的杆或植入构件，其也优选地是弧形的，并且避免了与现有的笼或直杆和螺杆系统相关联的问题。还特征在于用于修复，替换或增加盘的核和/或环的系统，装置和方法。

8. 发明申请

US20130211392A1 SELECTIVE DELIVERY OF CRYOGENIC ENERGY TO INTERVERTEBRAL DISC TISSUE AND RELATED METHODS OF INTRADISCAL HYPOTHERMIA THERAPY 审中-公开
标题翻译：选择性递送轻度能量到椎间盘突出组织和相关方法的侵袭性神经痛治疗
公开(公告)号：US20130211392A1
公开(公告)日：2013-08-15
申请号：US13601234
申请日：2012-08-31
申请人： Allen Carl
发明人： Allen Carl
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00261 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293 , A61B2090/378
摘要： A method of delivering cryogenic energy within a vertebral body comprising forming a hole within the vertebral body; inserting a cryoprobe into said body, wherein said cryoprobe has a distal tip and a thermally transmissive region located proximate to said tip; activating said thermally transmissive region; and delivering cryogenic energy for one or more time periods in the range of 1 minute to 60 minutes.
摘要翻译：一种在椎体内递送低温能量的方法，包括在椎体内形成孔; 将冷冻探针插入所述体内，其中所述冷冻探针具有位于所述尖端附近的远侧末端和热传导区域; 激活所述热传导区域; 并在1分钟至60分钟的范围内提供一个或多个时间段的低温能量。

9. 发明授权

US07144394B2 Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy 有权
公开(公告)号：US07144394B2
公开(公告)日：2006-12-05
申请号：US10653692
申请日：2003-09-02
申请人： Allen Carl
发明人： Allen Carl
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00261 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293 , A61B2090/378
摘要： The present invention relates to devices and methods for altering the tissue in and around an intervertebral disc through localized hypothermia therapy to restore function of the disc and reduce pain. Hypothermia therapy is defined as the reduction of tissue temperature to below that of the equilibrium temperature. Target therapeutic temperatures and times are varied according to the desired treatment effect. Intended effects of hypothermia of the intervertebral disc include cellular disruption leading to cell death and or structural and chemical denaturation within the anulus fibrosus, nucleus pulposus, or nerve fibers, temporary or permanent deadening of the nerves within or surrounding the disc, induction of a healing response, angiogenesis, or accelerated degeneration and/or drying of the nucleus pulposus and/or anulus fibrosus. Various effects can be achieved by reaching different temperatures for differing periods of time or by the proximity of the hypothermia therapy device to the treatment target. Accordingly, it is an object of one or more the embodiments of the invention to provide hypothermic therapy to selected locations within an intervertebral disc utilizing a flexible and guidable cryogenic device.

10. 发明申请

US20060036256A1 Spine stabilization device and method 有权
标题翻译：脊柱稳定装置及方法
公开(公告)号：US20060036256A1
公开(公告)日：2006-02-16
申请号：US11197041
申请日：2005-08-03
申请人： Allen Carl , Dan Sachs
发明人： Allen Carl , Dan Sachs
IPC分类号： A61F5/00
CPC分类号： A61B17/7067 , A61B17/7004 , A61B17/7053 , A61B17/7064 , A61B17/707 , A61B2017/0256 , A61B2017/564 , A61B2017/681 , A61B2090/064 , B33Y80/00
摘要： A spine stabilization device is provided including an elongate member coupled to a spinous proces. One aspect includes a dynamic stabilizer in a stabilization device.
摘要翻译：提供了一种脊柱稳定装置，其包括联接到棘突的细长构件。一个方面包括稳定装置中的动态稳定器。

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