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    • 2. 发明申请
    • Systems and methods for the biometric analysis of index founder populations
    • 指数创始人人口生物特征分析的系统和方法
    • US20070111247A1
    • 2007-05-17
    • US11601471
    • 2006-11-17
    • Joel StephensJoseph Flicek
    • Joel StephensJoseph Flicek
    • C12Q1/68G06F19/00
    • C12Q1/6827C12Q1/6883C12Q1/6888C12Q2600/156C12Q2600/158G16B20/00G16B40/00G16H50/70
    • Systems, methods and apparatus for associating a clinical parameter with one or more candidate chromosomal regions in the human genome are provided. An index founder population is identified in a test population based upon the genotype X of each member of the test population such that the posterior probability Pr(K|X) for the index founder population is greater for K=1 than any other integer K, where K is the number of subpopulations in the index founder population. The clinical parameter is measured for each respective member of the index founder population. Then a quantitative phenotypic analysis is performed between (i) the genotype X of each respective member of the index founder population and (ii) the clinical parameter thereby identifying one or more candidate chromosomal regions in the human genome that associate with the clinical parameter.
    • 提供了将临床参数与人类基因组中的一个或多个候选染色体区域相关联的系统,方法和装置。 基于测试群体的每个成员的基因型X在测试群体中鉴定指数创始人群体,使得指数创始人群体的后验概率Pr(K | X)对于K = 1比任何其他整数K更大, 其中K是指数创始人群中的亚群人数。 针对指数创始人群体的每个成员测量临床参数。 然后在(i)指数创始人群体的每个成员的基因型X和(ii)临床参数之间进行定量表型分析,从而鉴定与临床参数相关联的人类基因组中的一个或多个候选染色体区域。