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1. 发明授权

US08945626B2 Preparation of pharmaceutical compositions 有权
标题翻译：药物组合物的制备
公开(公告)号：US08945626B2
公开(公告)日：2015-02-03
申请号：US12309344
申请日：2007-07-13
申请人： Andrew James Elphick , John Staniforth , Dong Wang , David John Duncalf , Steven Paul Rannard , James Long , Alison Jayne Foster
发明人： Andrew James Elphick , John Staniforth , Dong Wang , David John Duncalf , Steven Paul Rannard , James Long , Alison Jayne Foster
IPC分类号： A61K9/14 , A61K8/81 , A61K31/167 , A61K9/16 , A01N25/04 , A61K9/10 , A61K9/19
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
摘要翻译：一种制备包含水不溶性对乙酰氨基酚或NSAID的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性对乙酰氨基酚或NSAID，ii）水溶性载体，和iii）溶剂，并且b）喷雾干燥该混合物以除去该溶剂或每种溶剂，并获得载体中对乙酰氨基酚或NSAID的基本上无溶剂的纳米分散体。

2. 发明授权

US09718036B2 Method of preparing carrier liquids 有权
公开(公告)号：US09718036B2
公开(公告)日：2017-08-01
申请号：US14241965
申请日：2012-08-20
申请人： Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： B01F3/20 , A61K9/14 , A61Q15/00 , A01N31/12 , A01N47/38 , A01N53/00 , A61Q19/00 , A61K8/04 , A61K9/19 , A01N25/04 , A61K9/10 , A23L27/00 , A23L27/30 , B82Y40/00
CPC分类号： B01F3/2064 , A01N25/04 , A01N31/12 , A01N47/38 , A01N53/00 , A23L27/30 , A23L27/82 , A61K8/04 , A61K9/10 , A61K9/145 , A61K9/146 , A61K9/19 , A61K2800/10 , A61K2800/412 , A61K2800/413 , A61K2800/84 , A61Q19/00 , B82Y40/00 , A01N2300/00
摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapor form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.

3. 发明授权

US09060937B2 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US09060937B2
公开(公告)日：2015-06-23
申请号：US12309292
申请日：2007-06-29
申请人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K9/50 , A61K9/16 , A61K31/167 , A01N25/04 , A61K9/10 , A61K9/19
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译：一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的沙坦，ii）水溶性载体，iii）沙坦和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。

4. 发明授权

US08821932B2 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US08821932B2
公开(公告)日：2014-09-02
申请号：US12309294
申请日：2007-06-29
申请人： David John Duncalf , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K9/10 , A61K31/351 , A61K8/04 , A61K9/16
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.
摘要翻译：一种制备包含水不溶性他汀类的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的他汀类，ii）水溶性载体，iii）每种他汀类的溶剂和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中他汀类药物基本上无溶剂的纳米分散体。

5. 发明申请

US20130196852A1 PROCESSES FOR PREPARING IMPROVED COMPOSITIONS 审中-公开
标题翻译：制备改进成分的方法
公开(公告)号：US20130196852A1
公开(公告)日：2013-08-01
申请号：US13877864
申请日：2011-10-04
申请人： Steven Paul Rannard , David Duncalf , Alison Jayne Foster , James Long , Dong Wang
发明人： Steven Paul Rannard , David Duncalf , Alison Jayne Foster , James Long , Dong Wang
IPC分类号： A01N25/04
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
摘要翻译：本发明提供一种制备包含至少一种活性剂和至少一种固体载体材料的改进组合物的方法，其中活性剂以纳米分散形式分散在载体材料中，该方法包括以下步骤：（a）形成包含活性剂，载体材料，稳定剂，活性剂和稳定剂的第一溶剂和用于载体材料的第二溶剂的液体混合物，和（b）干燥所述液体混合物以除去第一和第二溶剂，以在载体材料中获得活性剂与稳定剂的基本上无溶剂的纳米分散体，其中所述稳定剂能够在干燥期间稳定液体混合物中的活性剂，并且在所得的液体纳米 - 改进组合物的分散。

6. 发明申请

US20170112125A1 PROCESSES FOR PREPARING IMPROVED COMPOSITIONS 审中-公开
公开(公告)号：US20170112125A1
公开(公告)日：2017-04-27
申请号：US15282938
申请日：2016-09-30
申请人： Steven Paul Rannard , David Duncalf , Alison Jayne Foster , James Long , Dong Wang
发明人： Steven Paul Rannard , David Duncalf , Alison Jayne Foster , James Long , Dong Wang
IPC分类号： A01N25/04 , A01N25/22 , A01N43/90 , A01N43/653 , A23K20/10 , A01N47/38 , A01N43/40 , A01N43/54 , A01N25/30 , A23L33/10 , A01N53/00 , A01N47/02
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.

7. 发明申请

US20100015233A1 anti-parasitic compositions 审中-公开
标题翻译：抗寄生物组合物
公开(公告)号：US20100015233A1
公开(公告)日：2010-01-21
申请号：US12309295
申请日：2007-06-29
申请人： David John Duncalf , Asha Hassan Essa , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Asha Hassan Essa , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K9/14
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The present invention relates to nanodisperse antiparasitics and provides a composition comprising at least one water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the water-insoluble anti-parasitic drug (preferably an Artemisinin-type drug or a quinine type drug) is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm. The invention further provides an aqueous dispersion of a water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the anti-parasitic drug is in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm, the invention further subsists in a process for preparing an anti-parasitic composition comprising a water insoluble anti-parasitic agent and a water-soluble carrier, which comprises the steps of either: a) providing an emulsion comprising a solution of the anti-parasitic agent in a water-immiscible solvent for the same, and an aqueous solution of the carrier, or providing a mixture comprising at least one non-aqueous solvent optional water a water-soluble carrier material soluble in the mixture and a water-insoluble anti-parasitic agent soluble in the mixture, and, b) drying the emulsion (preferably by spray drying) to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the anti-parasitic agent in the carrier.
摘要翻译：本发明涉及纳米分散抗寄生虫药，并且提供包含至少一种水不溶性抗寄生虫药物和水溶性载体材料的组合物，其中所述水不溶性抗寄生虫药物（优选青蒿素型药物或奎宁型药物）以纳米分散形式的峰值直径低于1000nm的纳米分散形式分散在载体材料中。本发明还提供了水不溶性抗寄生虫药物和水溶性载体材料的水性分散体，其中所述抗寄生虫药物为纳米分散形式，其纳米分散体形式的峰值直径低于1000nm，本发明进一步存在于制备包含水不溶性抗寄生虫剂和水溶性载体的抗寄生物组合物的方法中，其包括以下步骤：a）提供包含抗寄生虫剂溶液的乳液或与提供包含至少一种非水溶剂任选的水的混合物，可溶于该混合物的水溶性载体材料和水不溶性抗寄生剂可溶于该混合物，和b）干燥乳液（优选通过喷雾干燥）以除去水和与水不混溶的溶剂，以获得基本上无溶剂的防虫剂纳米分散体 tic代理在承运人。

8. 发明申请

US20100015229A1 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US20100015229A1
公开(公告)日：2010-01-21
申请号：US12309294
申请日：2007-06-29
申请人： David John Duncalf , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K9/10 , A61K31/351 , A61P9/00 , A61P25/00 , A61P35/00 , A61P27/12
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.
摘要翻译：一种制备包含水不溶性他汀类的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的他汀类，ii）水溶性载体，iii）每种他汀类的溶剂和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中他汀类药物基本上无溶剂的纳米分散体。

9. 发明申请

US20090304806A1 Pharmaceutical Compositions 有权
标题翻译：药物组合物
公开(公告)号：US20090304806A1
公开(公告)日：2009-12-10
申请号：US12309292
申请日：2007-06-29
申请人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K31/41 , A61K9/14
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译：一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包含：i）不溶于水的沙坦，ii）水溶性载体，iii）沙坦和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。

10. 发明申请

US20140212466A1 METHOD OF PREPARING CARRIER LIQUIDS 有权
标题翻译：制备载体液体的方法
公开(公告)号：US20140212466A1
公开(公告)日：2014-07-31
申请号：US14241965
申请日：2012-08-20
申请人： Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： B01F3/20 , A23L1/236 , A23L1/22 , A61K9/10 , A01N25/04
CPC分类号： B01F3/2064 , A01N25/04 , A01N31/12 , A01N47/38 , A01N53/00 , A23L27/30 , A23L27/82 , A61K8/04 , A61K9/10 , A61K9/145 , A61K9/146 , A61K9/19 , A61K2800/10 , A61K2800/412 , A61K2800/413 , A61K2800/84 , A61Q19/00 , B82Y40/00 , A01N2300/00
摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapour form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.
摘要翻译：本发明提供了一种制备载体液体的方法，其包括以下步骤：（I）制备单相溶液，其包含：（a）溶剂或可混溶溶剂的混合物，（b）液体载体材料，溶于溶剂（a），和（c）也可溶于溶剂（a）的掺杂剂材料; （II）将步骤（I）中制备的单相溶液冷却（优选冷冻）至至少溶剂（a）和载体材料（b）两者变为固体的温度; 和（III）从蒸气形式的冷却（冷冻）单相溶液中除去固体溶剂（a），使得剩余的冷冻（冷冻）载体材料（b）和掺杂剂材料（c）返回到环境温度，从而提供具有分散在其中的掺杂剂材料（c）的液体载体材料（b）的产物。

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