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1. 发明授权

US09492525B2 Human respiratory syncytial virus vaccine 有权
标题翻译：人呼吸道合胞病毒疫苗
公开(公告)号：US09492525B2
公开(公告)日：2016-11-15
申请号：US13543493
申请日：2012-07-06
申请人： Ali I. Fattom , Nicolas Lukacs , James R. Baker, Jr. , Vira Bitko , Tarek Hamouda
发明人： Ali I. Fattom , Nicolas Lukacs , James R. Baker, Jr. , Vira Bitko , Tarek Hamouda
IPC分类号： A61K9/107 , A61P37/04 , A61K39/155 , A61K39/12 , C07K16/10 , C12N7/00 , A61K9/00 , A61K9/06 , A61K9/127 , A61K9/51 , A61K31/716 , A61K31/722 , A61K39/00
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K9/1271 , A61K9/5115 , A61K31/716 , A61K31/722 , A61K47/26 , A61K47/38 , A61K47/44 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55566 , A61K2039/55583 , C07K16/1027 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18534 , A61K2300/00
摘要： The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.
摘要翻译：本发明涉及用于在受试者中诱导对RSV的免疫应答的RSV疫苗和方法，包括施用RSV疫苗。

2. 发明授权

US10206996B2 Herpes simplex virus nanoemulsion vaccine 有权
公开(公告)号：US10206996B2
公开(公告)日：2019-02-19
申请号：US13591775
申请日：2012-08-22
申请人： Ali I. Fattom , Jakub Simon , James R. Baker, Jr. , Tarek Hamouda , Vira Bitko
发明人： Ali I. Fattom , Jakub Simon , James R. Baker, Jr. , Tarek Hamouda , Vira Bitko
IPC分类号： A61K39/00 , A61K39/245 , A61K39/39 , A61K9/107 , A61K39/12
摘要： The present application relates to the field of human immunology, in particular, a herpes simplex virus (HSV) vaccine. The subunit vaccine composition comprises isolated surface glycoproteins from herpes simplex viruses, fusion proteins or fragments thereof mixed in varied combination with a nanoemulsion, which is a potent immune enhancer.

3. 发明授权

US09561271B2 Nanoemulsion respiratory syncytial virus (RSV) subunit vaccine 有权
标题翻译：纳米乳液呼吸道合胞病毒（RSV）亚单位疫苗
公开(公告)号：US09561271B2
公开(公告)日：2017-02-07
申请号：US13608317
申请日：2012-09-10
申请人： Ali I. Fattom , Tarek Hamouda , Vira Bitko , James R. Baker, Jr.
发明人： Ali I. Fattom , Tarek Hamouda , Vira Bitko , James R. Baker, Jr.
IPC分类号： A61K39/155 , A61K9/107 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/44 , A61K39/12 , A61K39/00
CPC分类号： A61K39/155 , A61K9/1075 , A61K39/12 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/44 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55566 , C12N2760/18034
摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.
摘要翻译：本申请涉及免疫学领域，特别是呼吸道合胞病毒（RSV）表面蛋白，融合（F）和糖蛋白（G）蛋白亚基疫苗的疫苗组合物优先与免疫细胞靶向和增强子混合，纳米乳剂诱导保护性免疫应答，并避免疫苗诱导疾病增强。

4. 发明授权

US09144606B2 Nanoemulsion influenza vaccine 有权
标题翻译：纳米乳液流感疫苗
公开(公告)号：US09144606B2
公开(公告)日：2015-09-29
申请号：US12427517
申请日：2009-04-21
申请人： James R. Baker, Jr. , Tarek Hamouda , Joyce A. Sutcliffe
发明人： James R. Baker, Jr. , Tarek Hamouda , Joyce A. Sutcliffe
IPC分类号： A61K39/145 , C07K14/005 , C12N7/00 , A61K9/107 , A61K39/00 , A61K39/12
CPC分类号： A61K39/145 , A61K9/0014 , A61K9/0043 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55566 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , C12N2760/16271
摘要： The present invention relates to methods for inducing an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.
摘要翻译：本发明涉及在受试者中诱导针对流感的免疫应答的方法，包括施用包含流感免疫原或蛋白质的纳米乳剂疫苗组合物。

5. 发明授权

US08236335B2 Antimicrobial nanoemulsion compositions and methods 有权
标题翻译：抗微生物纳米乳剂组合物及方法
公开(公告)号：US08236335B2
公开(公告)日：2012-08-07
申请号：US11928447
申请日：2007-10-30
申请人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
发明人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
IPC分类号： A01N25/00 , A01N33/12 , A61K9/00
CPC分类号： A61K31/522 , A61K8/062 , A61K8/068 , A61K9/1075 , A61K31/14 , A61K45/06 , A61K2800/413 , A61Q17/005 , B82Y5/00 , Y02A50/393 , Y02A50/402 , Y02A50/463 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/937 , Y10S514/938 , A61K2300/00
摘要： The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.
摘要翻译：本发明涉及用于降低与各种致病生物体和病毒有关的感染性，发病率和死亡率的组合物和方法。本发明还涉及用于对由致病菌和病毒定殖或以其它方式感染的区域进行净化的方法和组合物。此外，本发明涉及用于降低食品中病原生物体的感染性的方法和组合物。

6. 发明授权

US06635676B2 Non-toxic antimicrobial compositions and methods of use 有权
公开(公告)号：US06635676B2
公开(公告)日：2003-10-21
申请号：US09965447
申请日：2001-09-27
申请人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
发明人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
IPC分类号： A61K3114
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/062 , A61K9/1075 , A61K31/14 , A61K45/06 , A61K2800/21 , A61K2800/413 , A61Q17/005 , B82Y5/00 , Y10S514/937 , Y10S514/938 , A61K2300/00
摘要： The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.

7. 发明授权

US06506803B1 Methods of preventing and treating microbial infections 有权
标题翻译：预防和治疗微生物感染的方法
公开(公告)号：US06506803B1
公开(公告)日：2003-01-14
申请号：US09561111
申请日：2000-04-28
申请人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
发明人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
IPC分类号： A01N2500
CPC分类号： A61K9/1075 , A61K45/06 , Y02A50/475 , Y02A50/481 , Y10S514/938
摘要： The present invention provides methods and compositions for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of microorganisms including bacteria, bacterial spores, fungi, fungal spores and enveloped viruses.
摘要翻译：本发明提供了使用水包油乳液灭活包括细菌孢子在内的细菌的方法和组合物。水包油乳液包含油，表面活性剂和有机磷酸盐基溶剂。这些方法可用于灭活多种微生物，包括细菌，细菌孢子，真菌，真菌孢子和包膜病毒。

8. 发明授权

US08962026B2 Nanoemulsion therapeutic compositions and methods of using the same 有权
标题翻译：纳米乳剂治疗组合物及其使用方法
公开(公告)号：US08962026B2
公开(公告)日：2015-02-24
申请号：US12567571
申请日：2009-09-25
申请人： James R. Baker, Jr. , Mark R. Hemmila , Stewart C. Wang , Tarek Hamouda , John J. LiPuma , Jessica A. Knowlton , Paul E. Makidon , Luz P. Blanco , Jeffery V. Groom, II , Anna U. Bielinska
发明人： James R. Baker, Jr. , Mark R. Hemmila , Stewart C. Wang , Tarek Hamouda , John J. LiPuma , Jessica A. Knowlton , Paul E. Makidon , Luz P. Blanco , Jeffery V. Groom, II , Anna U. Bielinska
IPC分类号： A61K9/107
CPC分类号： A61K31/198 , A61K9/1075 , A61K31/045 , A61K31/047 , A61K31/14 , A61K31/341 , A61K31/4425 , A61K45/06
摘要： The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
摘要翻译：本发明涉及治疗性纳米乳剂组合物及其利用方法。特别地，本文描述了用于治疗和/或预防感染（例如，呼吸道感染（例如，与囊性纤维化相关）），烧伤伤口管理和免疫原性组合物（例如，包含伯克霍尔德氏菌（Burkholderia））的纳米乳剂组合物抗原），其在施用免疫原性组合物的受试者中产生有效的免疫应答（例如，针对伯克霍尔德氏菌属的细菌物种）。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物），工业和研究应用。

9. 发明授权

US08771731B2 Antimicrobial nanoemulsion compositions and methods 有权
标题翻译：抗微生物纳米乳剂组合物及方法
公开(公告)号：US08771731B2
公开(公告)日：2014-07-08
申请号：US11506442
申请日：2006-08-18
申请人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
发明人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
IPC分类号： A61K9/66 , A61K9/18 , A61K31/14
CPC分类号： A61K9/1075 , A61K8/062 , A61K31/14 , A61K31/522 , A61K45/06 , A61K2800/21 , A61K2800/413 , A61Q17/005 , A61Q19/00 , B82Y5/00 , A61K2300/00
摘要： The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.
摘要翻译：本发明涉及用于降低与各种致病生物体和病毒有关的感染性，发病率和死亡率的组合物和方法。本发明还涉及用于对由致病菌和病毒定殖或以其它方式感染的区域进行净化的方法和组合物。此外，本发明涉及用于降低食品中病原生物体的感染性的方法和组合物。

10. 发明授权

US07767216B2 Antimicrobial compositions and methods of use 有权
标题翻译：抗微生物组合物和使用方法
公开(公告)号：US07767216B2
公开(公告)日：2010-08-03
申请号：US09751059
申请日：2000-12-29
申请人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
发明人： James R. Baker, Jr. , Tarek Hamouda , Amy Shih , Andrzej Myc
IPC分类号： A01N25/00 , A01N33/12 , A61K9/00
CPC分类号： A61K9/1075 , A61K45/06
摘要： The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs. In particular, decreased pathogenic organism infectivity, morbidity, and mortality is accomplished by contacting the pathogenic organism with an oil-in-water nanoemulsion comprising an oil, an organic solvent, and a surfactant dispersed in an aqueous phase.
摘要翻译：本发明涉及用于降低与各种致病生物体和病毒有关的感染性，发病率和死亡率的组合物和方法。本发明还涉及用于对由致病菌和病毒定殖或以其它方式感染的区域进行净化的方法和组合物。此外，本发明涉及用于降低食品中病原生物体的感染性的方法和组合物。特别地，通过使致病生物与包含分散在水相中的油，有机溶剂和表面活性剂的水包油纳米乳液接触来实现降低的致病生物体的感染性，发病率和死亡率。

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