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1. 发明申请

US20060025460A1 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权
公开(公告)号：US20060025460A1
公开(公告)日：2006-02-02
申请号：US11156364
申请日：2005-06-17
申请人： Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
发明人： Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

2. 发明申请

US20150038184A1 WIRELESS COMMUNICATION METHOD AND APPARATUS 审中-公开
标题翻译：无线通信方法和设备
公开(公告)号：US20150038184A1
公开(公告)日：2015-02-05
申请号：US14114450
申请日：2012-04-27
申请人： Andrew Donald Macafee , Steve Byrom , Konrad Gooding , David Mann
发明人： Andrew Donald Macafee , Steve Byrom , Konrad Gooding , David Mann
IPC分类号： H04W76/02 , H04B7/26
CPC分类号： H04B7/26 , H04W76/10 , H04W76/14 , H04W84/08 , H04W88/04 , H04W88/06
摘要： A TETRA communications system, comprising a first TETRA communication device, connected to a first communication means by means of a first data link to transport TETRA message data and control information between said first communication means and said first TETRA communication device, a second TETRA communication device connected to a second communication means by means of a second data link to transport TETRA message data and control information between said second communication means and said second TETRA communication device, wherein said first communication means and said second communication means are further operable to establish a communications link with each other over a communications network to allow said message data and control information to be transported between said first and second TETRA communication device via said first communication means and said second communication means.
摘要翻译：一种TETRA通信系统，包括第一TETRA通信设备，通过第一数据链路连接到第一通信装置，以在所述第一通信装置和所述第一TETRA通信设备之间传输TETRA消息数据和控制信息;第二TETRA通信设备通过第二数据链路连接到第二通信装置，以在所述第二通信装置和所述第二TETRA通信装置之间传送TETRA消息数据和控制信息，其中所述第一通信装置和所述第二通信装置还可操作以建立通信通过通信网络彼此链接，以允许所述消息数据和控制信息经由所述第一通信装置和所述第二通信装置在所述第一和第二TETRA通信设备之间传送。

3. 发明授权

US07848487B2 Methods for sterilizing biological materials containing non-aqueous solvents 失效
标题翻译：消毒含有非水溶剂的生物材料的方法
公开(公告)号：US07848487B2
公开(公告)日：2010-12-07
申请号：US12264106
申请日：2008-11-03
申请人： Shirley Miekka , Martin J. Macphee , William N. Drohan , David Mann , Wilson Burgess
发明人： Shirley Miekka , Martin J. Macphee , William N. Drohan , David Mann , Wilson Burgess
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译：公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母，对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。

4. 发明申请

US20070156478A1 High performance business framework and associated analysis and diagnostic tools and processes 审中-公开
标题翻译：高性能业务框架及相关分析与诊断工具和流程
公开(公告)号：US20070156478A1
公开(公告)日：2007-07-05
申请号：US11524511
申请日：2006-09-21
申请人： Richard Breene , Paul Nunes , Walter Shill , Robert Thomas , David Mann , Susan Cantrell , Anita Thompson , Narendra Mulani
发明人： Richard Breene , Paul Nunes , Walter Shill , Robert Thomas , David Mann , Susan Cantrell , Anita Thompson , Narendra Mulani
IPC分类号： G06F9/44
CPC分类号： G06F8/10 , G06Q10/0631 , G06Q10/0637 , G06Q10/06375 , G06Q10/06393 , G06Q30/0201 , G06Q90/00
摘要： Disclosed is a high performance business framework and related tools and processes for describing how known high performance businesses derive performance contributions from three building blocks. The present invention provides methods and tools for researching, measuring and quantifying these three building blocks to enable assessments to be made of various companies in various industries and methods and tools for enabling these various companies to identify and adopt solutions that enable them to model themselves after high performers.
摘要翻译：披露了一个高性能业务框架以及相关的工具和流程，用于描述众所周知的高性能业务从三个构建块获得绩效贡献。本发明提供了用于研究，测量和量化这三个构建块的方法和工具，以使得能够对各行业的各种公司进行评估以及使这些公司能够识别并采用能使他们自己建模的方法和工具的方法和工具高绩效者

5. 发明授权

US07214905B2 Cover for a welding-type power source 失效
标题翻译：焊接式电源盖
公开(公告)号：US07214905B2
公开(公告)日：2007-05-08
申请号：US10251390
申请日：2002-09-20
申请人： James Brook , David Radtke , David Mann
发明人： James Brook , David Radtke , David Mann
IPC分类号： B23K9/10
CPC分类号： B23K9/32
摘要： A welding system comprising a welding-type power source and a protective cover for the welding-type power source. The protective cover may be comprised of a synthetic fabric and a polymeric fluid barrier. The protective cover may have a member secured to the synthetic fabric to enable a user to grip the member to lift the cover from the welding-type power source. The protective cover may have a plurality of eyelets to enable the cover to be drawn against the welding-type power source. The protective cover may comprise a portion adapted to receive an exhaust pipe of the welding-type power source. The portion of the cover adapted to receive the exhaust pipe may comprise a heat-resistant synthetic fabric.
摘要翻译：一种焊接系统，包括焊接型电源和用于焊接型电源的保护盖。保护罩可以由合成织物和聚合物流体屏障组成。保护罩可以具有固定到合成织物上的构件，以使使用者能够握住构件以从焊接型电源提升盖。保护盖可以具有多个孔眼，以使覆盖物能够抵靠焊接型电源被拉伸。保护盖可以包括适于接收焊接型电源的排气管的部分。适于接收排气管的盖的部分可以包括耐热合成织物。

6. 发明申请

US20050145394A1 Extended coverage ordinary hazard sprinkler system 审中-公开
公开(公告)号：US20050145394A1
公开(公告)日：2005-07-07
申请号：US11056510
申请日：2005-02-11
申请人： Thomas Wancho , David Mann
发明人： Thomas Wancho , David Mann
IPC分类号： A62C31/02 , B05B1/26 , A62C37/08
CPC分类号： B05B1/265 , A62C31/02 , A62C37/14
摘要： A sprinkler discharges a column of water downwardly onto a deflector that has a plurality of peripheral tines with a respective non-radial tapered notch separating each adjacent pair of tines. Opposed cutouts with tabs in the central portion of the deflector combine with the notches and with depressed peripheral tabs to produce a predetermined spray pattern.

7. 发明申请

US20050047958A1 Methods for sterilizing preparations of digestive enzymes 审中-公开
标题翻译：消化酶制剂灭菌方法
公开(公告)号：US20050047958A1
公开(公告)日：2005-03-03
申请号：US10840425
申请日：2004-05-07
申请人： David Mann , Wilson Burgess , William Drohan , Yuri Griko , Martin MacPhee
发明人： David Mann , Wilson Burgess , William Drohan , Yuri Griko , Martin MacPhee
IPC分类号： A61L2/08 , A61K9/08 , A61K9/19 , A61K38/46 , A61K38/48 , A61K41/00 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/36 , A61K47/42 , A61L2/00 , A61L2/10 , A61L2/12 , A61P1/06 , A61P1/12 , A61P1/14 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/08 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/16 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P27/16 , A61P43/00 , C12N13/00
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0082 , C12N13/00
摘要： Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, α-galactosidase and iduronate-2-sulfatase, with irradiation.
摘要翻译：公开了用于对消化酶的制备物进行消毒以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素酶，纳米细菌，衣原体，立克次体），对TSE和/或单细胞或多细胞寄生虫单独或组合负责的酵母，霉菌，真菌，朊病毒或类似物质。这些方法包括消化酶的消毒，如胰蛋白酶，α-半乳糖苷酶和艾杜糖醛酸-2-硫酸酯酶的照射。

8. 发明授权

US08252405B2 Single-walled carbon nanotubes and methods of preparation thereof 有权
标题翻译：单壁碳纳米管及其制备方法
公开(公告)号：US08252405B2
公开(公告)日：2012-08-28
申请号：US11588873
申请日：2006-10-26
申请人： Hongjie Dai , David Mann , Guangyu Zhang
发明人： Hongjie Dai , David Mann , Guangyu Zhang
IPC分类号： B23B7/00 , B44C1/165 , D01F9/12
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/162 , C01B2202/02 , Y10T428/24 , Y10T428/24174 , Y10T428/30
摘要： The present invention provides single-walled carbon nanotubes and systems and methods for their preparation.
摘要翻译：本发明提供单壁碳纳米管及其制备方法和制备方法。

9. 发明申请

US20080107585A1 MAXIMUM REACTION RATE CONVERTER PROCESS FOR EXOTHERMIC REACTIONS 有权
标题翻译：用于异常反应的最大反应速率转换过程
公开(公告)号：US20080107585A1
公开(公告)日：2008-05-08
申请号：US11932019
申请日：2007-10-31
申请人： SHASHI SINGH , David Mann , Anant Pisut
发明人： SHASHI SINGH , David Mann , Anant Pisut
IPC分类号： C01C1/04
CPC分类号： C01C1/0423 , B01J8/008 , B01J8/067 , B01J23/462 , B01J2208/00212 , B01J2208/00221 , B01J2208/00513 , B01J2208/00548 , B01J2219/00238 , C01C1/0441 , C01C1/0482 , Y02E60/364 , Y02P20/52
摘要： An ammonia converter and method are disclosed. The reactor can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The reactor 100 can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109. The catalyst tubes 109 comprise reactive zones 122 having catalyst and reaction limited zones 124 that can comprise inert devices that function to both separate the reactive zones, increase heat transfer area, and reduce the temperature of the reaction mixture as the effluent passes through the catalyst tube 109
摘要翻译：公开了氨转化器和方法。反应器可以通过控制沿着反应器长度的放热反应的反应温度来平行所需产物的平衡曲线来改变氨的转化率。反应器100可以包括壳体101和内部催化剂管109。进料气流进入反应器，流过壳体101，并通过与催化剂管109的间接热交换加热。催化剂管109包括具有催化剂和反应限制区124的反应区122，其可以包含用于分离反应区的惰性装置，增加传热面积，并且当流出物通过催化剂管时降低反应混合物的温度 109

10. 发明申请

US20060099131A1 MAXIMUM REACTION RATE CONVERTER SYSTEM FOR EXOTHERMIC REACTIONS 有权
标题翻译：用于异常反应的最大反应速率转换器系统
公开(公告)号：US20060099131A1
公开(公告)日：2006-05-11
申请号：US10904315
申请日：2004-11-03
申请人： Shashi Singh , David Mann , Anant Pisut
发明人： Shashi Singh , David Mann , Anant Pisut
IPC分类号： C01C1/04
CPC分类号： C01C1/0423 , B01J8/008 , B01J8/067 , B01J23/462 , B01J2208/00212 , B01J2208/00221 , B01J2208/00513 , B01J2208/00548 , B01J2219/00238 , C01C1/0441 , C01C1/0482 , Y02E60/364 , Y02P20/52
摘要： An ammonia converter system and method are disclosed. The reactor can alter the conversion of ammonia by controlling the reaction temperature of the exothermic reaction along the length of the reactor to parallel the equilibrium curve for the desired product. The reactor 100 can comprise a shell 101 and internal catalyst tubes 109. The feed gas stream enters the reactor, flows through the shell 101, and is heated by indirect heat exchange with the catalyst tubes 109. The catalyst tubes 109 comprise reactive zones 122 having catalyst and reaction limited zones 124 that can comprise inert devices that function to both separate the reactive zones, increase heat transfer area, and reduce the temperature of the reaction mixture as the effluent passes through the catalyst tube 109.
摘要翻译：公开了一种氨转化器系统和方法。反应器可以通过控制沿着反应器长度的放热反应的反应温度来平行所需产物的平衡曲线来改变氨的转化率。反应器100可以包括壳体101和内部催化剂管109.进料气体流进入反应器，流过壳体101，并通过与催化剂管109的间接热交换而被加热。催化剂管109包括反应区域122，反应区域122具有催化剂和反应限制区124，其可以包括用于分离反应区的惰性装置，增加传热面积，并且当流出物通过催化剂管109时降低反应混合物的温度。

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