专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06169072A Cyclic adhesion inhibitors 有权
标题翻译：环状粘连抑制剂
公开(公告)号：US06169072A
公开(公告)日：2001-01-02
申请号：US09164585
申请日：1998-10-01
申请人： Alfred Jonczyk , G{umlaut over (u)}nter Hölzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Beate Diefenbach , Horst Kessler , Roland Haubner , Jochen Wermuth
发明人： Alfred Jonczyk , G{umlaut over (u)}nter Hölzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Beate Diefenbach , Horst Kessler , Roland Haubner , Jochen Wermuth
IPC分类号： A61K3800
CPC分类号： C07K14/75 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-B-Asp-D-E) I in which B, D, and E have the meanings defined herein, and their salts. These compounds act as interin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
摘要翻译：本发明涉及式Iin的新型环肽，其中B，D和E具有本文定义的含义及其盐。这些化合物用作中间体抑制剂，特别可用于预防和治疗循环障碍和肿瘤治疗。

2. 发明授权

US5849692A Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors 失效
标题翻译：含有Arg-Gly-Asp及其衍生物的环状肽作为粘合抑制剂
公开(公告)号：US5849692A
公开(公告)日：1998-12-15
申请号：US616770
申请日：1996-03-15
申请人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Beate Diefenbach , Horst Kessler , Roland Haubner , Jochen Wermuth
发明人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Beate Diefenbach , Horst Kessler , Roland Haubner , Jochen Wermuth
IPC分类号： A61K38/00 , A61K38/08 , A61K38/12 , A61P9/00 , A61P19/00 , A61P35/00 , C07K1/113 , C07K1/22 , C07K7/52 , C07K7/64 , C07K14/75 , C07K14/78 , C07K17/08
CPC分类号： C07K14/75 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-B-Asp-D-E) I in which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
摘要翻译：本发明涉及式I环 - （Arg-B-Asp-D-E）Iin的新型环肽，其中B，D和E具有本文定义的含义及其盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍和肿瘤治疗。

3. 发明授权

US5705481A Cyclopeptides 失效
标题翻译：环肽
公开(公告)号：US5705481A
公开(公告)日：1998-01-06
申请号：US436601
申请日：1995-05-08
申请人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Guido Melzer , Beate Diefenbach
发明人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Friedrich Rippmann , Guido Melzer , Beate Diefenbach
IPC分类号： A61K38/00 , C07K7/64 , C07K14/75 , A61K38/08 , A61K38/12
CPC分类号： C07K14/75 , C07K7/64 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula I cyclo-(A-B-C-D-Arg) I in which A and B are each independently of one another Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val; C is Asp or Asp(O--C.sub.1-4 -alkyl); and D is Gly or Ala; at least two of the amino acid radicals stated being present in the D-form;and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
摘要翻译：本发明涉及式I环 - （ABCD-Arg）Iin的新型环肽，其中A和B各自独立地为Ala，Asn，Asp，Arg，Cys，Gln，Glu，Gly，His，Ile，Leu，Lys ，Met，Phe，Pro，Ser，Thr，Trp，Tyr或Val; C是Asp或Asp（O-C 1-4 - 烷基）; D为Gly或Ala; 所述至少两个所述氨基酸基团以D-形式存在; 和它们的盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍和肿瘤治疗。

4. 发明授权

US5747457A Linear adhesion inhibitors 失效
标题翻译：线粘附抑制剂
公开(公告)号：US5747457A
公开(公告)日：1998-05-05
申请号：US329820
申请日：1994-10-27
申请人： Alfred Jonczyk , Brunhilde Felding-Habermann , Beate Diefenbach , Friedrich Rippmann
发明人： Alfred Jonczyk , Brunhilde Felding-Habermann , Beate Diefenbach , Friedrich Rippmann
IPC分类号： A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07K1/113 , C07K1/22 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/093 , C07K5/103 , C07K5/113 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/46 , C07K14/75 , C07K17/02 , A61K38/04 , C07K5/00 , C07K16/00
CPC分类号： C07K14/46 , C07K14/75 , A61K38/00
摘要： Linear peptides of the formula I X-A-Cys(R.sup.1)-B-Z I, in which A, B, R.sup.1, X and Z are as defined, are highly active inhibitors of the binding of the blood platelet integrin GP IIbIIIa (a.sub.IIb .beta..sub.3) to natural ligands and are suitable, inter alia, for the prophylaxis and for the treatment of circulatory disorders, thrombosis, myocardial infarction, coronary heart disease, arteriosclerosis, atherosclerosis, tumors and osteolytic diseases, and have a supporting effect in wound healing processes.
摘要翻译：式I XA-Cys（R1）-BZ I（其中A，B，R1，X和Z如上所定义）的线性肽是血小板整合素GP IIbIIIa（aIIbβ3）结合的高度活性抑制剂，适用于预防和治疗循环障碍，血栓形成，心肌梗死，冠心病，动脉硬化，动脉粥样硬化，肿瘤和溶骨性疾病，并且在伤口愈合过程中具有支持作用。

5. 发明授权

US5866540A Cyclic adhesion inhibitors 失效
标题翻译：环状粘连抑制剂
公开(公告)号：US5866540A
公开(公告)日：1999-02-02
申请号：US368760
申请日：1995-01-04
申请人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Guido Melzer , Beate Diefenbach , David A. Cheresh , Horst Kessler , Marion Gurrath , Gerhard Muller
发明人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Guido Melzer , Beate Diefenbach , David A. Cheresh , Horst Kessler , Marion Gurrath , Gerhard Muller
IPC分类号： A61K38/00 , A61K38/12 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/64 , C07K14/75 , C07K14/78 , C07K7/54
CPC分类号： C07K14/75 , C07K14/78 , A61K38/00
摘要： The present invention relates to pharmaceutical compositions which contain at least one cyclopeptide of formula I (a)-(r):(a) cyclo(-Arg-Gly-Asp-D-Phe-Val-Ala);(b) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Ala);(c) cyclo(-Arg-Gly-Asp-Phe-Val-D-Ala);(d) cyclo(-Arg-Gly-Asp-Phe-Leu-D-Ala);(e) cyclo(-Arg-Gly-Asp-D-Phe-Val-Gly);(f) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Gly);(g) cyclo(-D-Arg-Gly-Asp-Phe-Val-Ala);(h) cyclo(-D-Arg-Gly-Asp-Phe-Val-Gly);(i) cyclo(-Arg-Gly-Asp-Phe-Pro-Gly);(j) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Gly);(k) cyclo(-Arg-Gly-Asp-Phe-Pro-Ala);(l) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Ala);(m) cyclo(-D-Arg-Gly-Asp-Phe-Val);(n) cyclo(-Arg-D-Ala-Asp-Phe-Val);(o) cyclo(-Arg-Gly-Asp-D-Phe-Val);(p) cyclo(-Arg-Ala-Asp-D-Phe-Val);(q) cyclo(-Arg-Gly-Asp-Phe-D-Val);(r) cyclo(-Arg-Gly-D-Asp-Phe-Val);or a salt thereof. The pharmaceutical compositions can be used as cell adhesion inhibitors, e.g., in the treatment of thrombosis, myocardial infarct, apoplexy, arteriosclerosis, inflammations, angina pectoris, and/or tumors.
摘要翻译：本发明涉及含有至少一种式I（a） - （r）的环肽的药物组合物：（a）环（-Arg-Gly-Asp-D-Phe-Val-Ala）; （b）环（-Arg-Gly-Asp-D-Phe-Leu-Ala）; （c）环（-Arg-Gly-Asp-Phe-Val-D-Ala）; （d）环（-Arg-Gly-Asp-Phe-Leu-D-Ala）; （e）环（-Arg-Gly-Asp-D-Phe-Val-Gly）; （f）环（-Arg-Gly-Asp-D-Phe-Leu-Gly）; （g）环（-D-Arg-Gly-Asp-Phe-Val-Ala）; （h）环（-D-Arg-Gly-Asp-Phe-Val-Gly）; （i）环（-Arg-Gly-Asp-Phe-Pro-Gly）; （j）环（-Arg-Gly-Asp-Phe-D-Pro-Gly）; （k）环（-Arg-Gly-Asp-Phe-Pro-Ala）; （1）环（-Arg-Gly-Asp-Phe-D-Pro-Ala）; （m）环（-D-Arg-Gly-Asp-Phe-Val）; （n）环（-Arg-D-Ala-Asp-Phe-Val）; （o）环（-Arg-Gly-Asp-D-Phe-Val）; （p）环（-Arg-Ala-Asp-D-Phe-Val）; （q）环（-Arg-Gly-Asp-Phe-D-Val）; （r）环（-Arg-Gly-D-Asp-Phe-Val）; 或其盐。药物组合物可用作细胞粘附抑制剂，例如用于治疗血栓形成，心肌梗塞，中风，动脉硬化，炎症，心绞痛和/或肿瘤。

6. 发明授权

US5693612A Cyclopeptides of the formula I 失效
标题翻译：式I的环肽
公开(公告)号：US5693612A
公开(公告)日：1997-12-02
申请号：US430238
申请日：1995-04-28
申请人： Alfred Jonczyk , Gunter Holzemann , Simon Goodman , Horst Kessler , Roland Haubner , Jochen Wermuth
发明人： Alfred Jonczyk , Gunter Holzemann , Simon Goodman , Horst Kessler , Roland Haubner , Jochen Wermuth
IPC分类号： A61K38/00 , A61K38/08 , A61K38/12 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P19/10 , A61P31/00 , A61P35/00 , A61P43/00 , C07K1/22 , C07K5/02 , C07K5/10 , C07K5/12 , C07K7/52 , C07K7/64 , C07K14/75
CPC分类号： C07K14/75 , C07K5/1019 , C07K7/52 , A61K38/00 , Y10S930/27
摘要： The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-A-Asp-R.sup.1 -R.sup.2) I in which A, R.sup.1 and R.sup.2 have the meaning given in claim 1, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, bones and in tumour therapy, and as antimicrobial and antiviral active compounds.
摘要翻译：本发明涉及式I环 - （Arg-A-Asp-R1-R2）Iin的新型环肽，其中A，R 1和R 2具有权利要求1中给出的含义及其盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍，骨骼和肿瘤治疗以及抗微生物和抗病毒活性化合物。

7. 发明授权

US6001961A Cyclic adhesion inhibitors 失效
标题翻译：环状粘连抑制剂
公开(公告)号：US6001961A
公开(公告)日：1999-12-14
申请号：US694387
申请日：1996-09-16
申请人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
发明人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
IPC分类号： A61K38/00 , A61K38/04 , A61K38/12 , A61P9/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P39/00 , A61P43/00 , C07K1/113 , C07K7/64 , C07K7/00
CPC分类号： C07K7/64 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula Icyclo-(nArg-nGly-nAsp-nD-nE) I,in whichD and E in each case independently of one another are Gly, Ala, .beta.-Ala, Asn, Asp, Asp(OR), Arg, Cha, Cys, Gln, Glu, His, Ile, Leu, Lys, Lys(Ac), Lys(AcNH.sub.2), Lys(AcSH), Met, Nal, Nle, Orn, Phe, 4-Hal-Phe, homo-Phe, Phg, Pro, Pya, Ser, Thr, Tia, Tic, Trp, Tyr or Val, which amino acid residues can also be derivatized,R is alkyl having 1-18 carbon atoms,Hal is F, Cl, Br, I,Ac is alkanoyl having 1-10 carbon atoms, aroyl having 7-11 carbon atoms or aralkanoyl having 8-12 carbon atoms,n denotes no substituent or an alkyl radical R, benzyl or an aralkyl radical having 7-18 carbon atoms on the alpha-amino function of the relevant amino acid residue,with the proviso that at least one amino acid residue has a substituent n and that, where residues of optically active amino acids and amino acid derivatives are involved, both the D and the L forms are included, and also their physiologically acceptable salts.These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, angiogenic disorders, microbial infections and in tumor therapy.
摘要翻译：本发明涉及式I环 - （nArg-nGly-nAsp-nD-nE）I的新型环肽，其中D和E各自独立地为Gly，Ala，β-Ala，Asn，Asp，Asp （OR），Arg，Cha，Cys，Gln，Glu，His，Ile，Leu，Lys，Lys（Ac），Lys（AcNH 2），Lys（AcSH），Met，Nal，Nle，Orn， -Phe，Phe-Phe，Phg，Pro，Pya，Ser，Thr，Tia，Tic，Trp，Tyr或Val，该氨基酸残基也可被衍生化，R是具有1-18个碳原子的烷基，Hal是F， Cl，Br，I，Ac是具有1-10个碳原子的烷酰基，具有7-11个碳原子的芳酰基或具有8-12个碳原子的芳烷酰基，n表示没有取代基或烷基R，苄基或具有7- 相关氨基酸残基的α-氨基官能团上的18个碳原子，条件是至少一个氨基酸残基具有取代基n，并且当涉及光学活性氨基酸和氨基酸衍生物的残基时，D 并且包括L形式，也包括它们的生理学可接受的盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍，血管生成障碍，微生物感染和肿瘤治疗。

8. 发明授权

US06127335A Cyclic adhesion inhibitors 有权
标题翻译：环状粘连抑制剂
公开(公告)号：US06127335A
公开(公告)日：2000-10-03
申请号：US155721
申请日：1999-04-08
申请人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Horst Kessler , Marcus Koppitz
发明人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Horst Kessler , Marcus Koppitz
IPC分类号： A61K38/00 , A61K31/00 , A61K38/12 , A61P7/02 , A61P31/00 , A61P31/04 , A61P35/00 , B01D15/08 , B01J20/281 , C07K1/22 , C07K7/64 , C07K14/75 , C07K14/78 , G01N30/88 , C07K5/12
CPC分类号： C07K7/64 , C07K14/75 , A61K38/00
摘要： The invention concerns cyclopeptides of formula (I): Cyclo-(Arg-Gly-Asp-X-Y) in which X is Cha, Nal, Phe, 2-R.sup.1 -Phe, 3-R.sup.1 -Phe, 4-R.sup.1 -Phe, homo-Phe, Phg, Thi, Trp, Tyr or derivatives of Tyr, whereby the OH group can be etherified by alkyl groups containing 1-18 C-atoms and the amino-acid groups given can also be derivatives, R.sup.1 is NH.sub.2, NO.sub.2, I Br, Cl, F, alkyl with 1-18 C-atoms, Ar, Ar--O or.sup.3 H, Y is Gly in which the .alpha. N-atom may be substituted by R.sup.2 and/or the .alpha. C-atom may be substituted by R.sup.3 and/or R.sup.4, with the provision that Gly has at least one of the substituents specified, Ar is phenyl which may be substituted by one or two of groups NH.sub.2, NO.sub.2, I, Br, Cl, F, alkyl with 1-6 C-atoms or .sup.3 H, R.sup.2, R.sup.3 or R.sup.4, independently of each other, are alkyl with 1-18 C-atoms or R.sup.2 and R.sup.3 or R.sup.3 and R.sup.4 together in each case are a branched or unbranched alklyene chain with 3 to 18 C-atoms so that either the .alpha. N-atom or the .alpha. C-atom together with the alkylene chain, or the .alpha. C-atom alone, forms a ring with alkylene chain, whereby, when optically active amino-acid or amino-acid-derivative groups are involved, both the D- and the L-form are included, plus derivatives, in particular the .beta.-ester of aspartic acid or N-guanidine acyl derivatives of arginine or prodrug as well as their physiologically acceptable salts. These compounds act as integrin inhibitors and may be used particularly for the prophylaxis and treatment of circulatory and angiogenic conditions and microbial infections as well as in tumor therapy.
摘要翻译： PCT No.PCT / EP97 / 01657 Sec。 371日期1999年4月8日 102（e）1999年4月8日PCT PCT 1997年4月2日PCT公布。公开号WO97 / 38009 日期：1997年10月16日本发明涉及式（I）的环肽：其中X为Cha，Nal，Phe，2-R1-Phe，3-R1-Phe，4- R1-Phe，hom-Phe，Phg，Thi，Trp，Tyr或Tyr的衍生物，其中OH基团可以被含有1-18个C原子的烷基醚化，并且所给出的氨基酸基团也可以是衍生物，R1 是NH 2，NO 2，I Br，Cl，F，具有1-18个C原子的烷基，Ar，Ar-O或3 H，Y是其中αN原子可以被R 2和/或αC- 原子可以被R 3和/或R 4取代，条件是Gly具有至少一个指定的取代基，Ar是可被一个或两个NH 2，NO 2，I，Br，Cl，F，具有1-6个C原子的烷基或3H，R 2，R 3或R 4彼此独立地是具有1-18个碳原子的烷基或者R 2，R 3或R 3和R 4在每种情况下一起是支链或非支链烷基链具有3至18个C原子，使得αN原子或αC原子与亚烷基链一起，或者单独的αC原子形成具有亚烷基链的环，由此当涉及光学活性氨基酸或氨基酸衍生物基团时，包括D-和L-形式，加上衍生物，特别是β 的天冬氨酸或精氨酸或前药的N-胍酰基衍生物及其生理上可接受的盐。这些化合物作为整合素抑制剂起作用，可用于预防和治疗循环和血管生成病症和微生物感染以及肿瘤治疗。

9. 发明授权

US06566491B2 Cyclopeptide derivatives 有权
标题翻译：环肽衍生物
公开(公告)号：US06566491B2
公开(公告)日：2003-05-20
申请号：US09051603
申请日：1998-08-18
申请人： Alfred Jonczyk , Simon Lawrence Goodman , Beate Diefenbach , Arne Sutter , Horst Kessler
发明人： Alfred Jonczyk , Simon Lawrence Goodman , Beate Diefenbach , Arne Sutter , Horst Kessler
IPC分类号： A61K3812
CPC分类号： C07K7/64 , A61K38/00 , C07K14/75 , Y02P20/55
摘要： The invention relates to compounds of the formula (I) R1—Q1—X—Q2—R2, in which: Q1, Q2, each independent of one another, are missing or are —NH—(CH2)n—CO—; R1, R2, each independent of one another, are missing or are cyclo-(Arg-Gly-Asp-Z), wherein Z is missing in side chain of Q1 or Q2 of if Q1 and/or Q2 missing, is bound to X, at least one of the groups R1 or R2 always having to be included; X is —CO—R18—CO—, and if R1—Q1— or R2—Q2— are missing is R10, R13, Het-CO or a flourescent pigment residue linked through a —CONH—, —COO—, NH—C(═S)—N—, —NH—C(═O)—NH—, —SO2 NH—or —NHCO— bond; and Z, R10, R13, R16, R18, Het and n have the meaning given in claim 1. The invention also relates to the salts of said compounds. These compounds and their salts can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, angiogenic diseases and in tumor therapy.
摘要翻译：本发明涉及式（I）的化合物：R1-Q1-X-Q2-R2，其中：Q1，Q2彼此独立地缺失或是-NH-（CH2）n-CO-; R1，R2各自独立，缺失或是环 - （Arg-Gly-Asp-Z），其中如果Q1和/或Q2缺失，则Q1或Q2侧链中缺失Z，与X 总是必须包括R1或R2组中的至少一个; X是-CO-R18-CO-，如果R1-Q1-或R2-Q2-缺失，则是R10，R13，Het-CO或通过-CONH-，-COO-，NH-C连接的荧光色素残基（= S）-N-，-NH-C（= O）-NH-，-SO 2 NH-或-NHCO-键; Z，R10，R13，R16，R18，Het和n具有权利要求1中给出的含义。本发明还涉及所述化合物的盐。这些化合物及其盐可用作整联蛋白抑制剂，特别是用于预防和治疗循环系统疾病，血栓形成，心脏梗塞，冠心病，动脉硬化，血管发生疾病和肿瘤治疗。

10. 发明授权

US06534478B1 Cyclic azapeptides with angiogenic effect 失效
标题翻译：具有血管生成作用的环状氮杂肽
公开(公告)号：US06534478B1
公开(公告)日：2003-03-18
申请号：US09446974
申请日：2000-03-23
申请人： Alfred Jonczyk , Simon Goodman , Horst Kessler , Jochen Wermuth , Jörg Schmitt
发明人： Alfred Jonczyk , Simon Goodman , Horst Kessler , Jochen Wermuth , Jörg Schmitt
IPC分类号： A61K3800
CPC分类号： C07K7/56 , A61K38/00
摘要： Compounds of the formula I cyclo-(aArg-aGly-aAsp-aX-aY) I in which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prophylaxis and treatment of diseases of the circulation, in thrombosis, cardiac infarct, coronary heart diseases, arteriosclerosis, in pathological processes which are supported or propagated by angiogenesis and in tumour therapy.
摘要翻译： aArg，aGly，aAsp，aX和aY具有权利要求1所述含义的式Ⅰin化合物及其盐可用作整联蛋白抑制剂，特别是用于预防和治疗血栓形成疾病，心肌梗死，冠心病，动脉硬化，血管生成和肿瘤治疗支持或传播的病理过程。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式