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1. 发明授权

US09291621B2 AGER-peptides and use thereof 有权
标题翻译： AGER-肽及其用途
公开(公告)号：US09291621B2
公开(公告)日：2016-03-22
申请号：US11795282
申请日：2006-01-18
申请人： Alfred Hahn , Ralf Loebbert , Nicole Teusch , Achim Möller , Ulrich Ebert , Martin Schmidt
发明人： Alfred Hahn , Ralf Loebbert , Nicole Teusch , Achim Möller , Ulrich Ebert , Martin Schmidt
IPC分类号： A61K39/00 , G01N33/564 , C07K16/28
CPC分类号： C07K16/2803 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K7/08 , C07K2317/24 , C12N15/85 , C12P21/005 , C12P21/02 , G01N33/564 , G01N33/566 , G01N2333/70503 , G01N2500/00
摘要： The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor multimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.
摘要翻译：本发明涉及来自高级糖化终产物（AGER）的受体的N末端的结构域的鉴定，功能和用途。称为受体多聚表位（RME）的这些结构域在所有AGER蛋白质序列中都是高度保守的。它们代表AGER与其他蛋白质自身结合和异源化的介质。本发明同样涉及衍生自AGER（AGER-CDP）的C结构域的肽的鉴定，功能和用途。本发明的AGER RME和AGER-CDP适用于鉴定调节天然配体相互作用的AGER配体的靶标; 作为用于个体的主动或被动免疫的免疫原，作为用于鉴定免疫原性反应的诊断手段，以及用于调节涉及AGER的蛋白质 - 蛋白质相互作用的肽配体。

2. 发明申请

US20100226915A1 AGER-Peptides and Use Thereof 有权
标题翻译： AGER-肽及其用途
公开(公告)号：US20100226915A1
公开(公告)日：2010-09-09
申请号：US11795282
申请日：2006-01-18
申请人： Alfred Hahn , Ralph Loebbert , Nicole Teusch , Achim Möller
发明人： Alfred Hahn , Ralph Loebbert , Nicole Teusch , Achim Möller
IPC分类号： A61K39/395 , C07K16/18 , G01N33/566 , A61K39/00 , A61K31/7088 , A61K38/43 , C12N15/63 , C12N1/00 , C12N5/16 , C12P21/06 , C07K14/00
CPC分类号： C07K16/2803 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K7/08 , C07K2317/24 , C12N15/85 , C12P21/005 , C12P21/02 , G01N33/564 , G01N33/566 , G01N2333/70503 , G01N2500/00
摘要： The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor mulitimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.
摘要翻译：本发明涉及来自高级糖化终产物（AGER）的受体的N末端的结构域的鉴定，功能和用途。称为受体多聚表位（RME）的这些结构域在所有AGER蛋白质序列中都是高度保守的。它们代表AGER与其他蛋白质自身结合和异源化的介质。本发明同样涉及衍生自AGER（AGER-CDP）的C结构域的肽的鉴定，功能和用途。本发明的AGER RME和AGER-CDP适用于鉴定调节天然配体相互作用的AGER配体的靶标; 作为用于个体的主动或被动免疫的免疫原，作为用于鉴定免疫原性反应的诊断手段，以及用于调节涉及AGER的蛋白质 - 蛋白质相互作用的肽配体。

3. 发明授权

US09296697B2 Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors 有权
标题翻译：杂芳基取代的胍化合物及其作为5-HT 5受体的结合伴侣的用途
公开(公告)号：US09296697B2
公开(公告)日：2016-03-29
申请号：US11990937
申请日：2006-08-23
申请人： Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
发明人： Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
IPC分类号： C07D213/75 , C07D213/84 , C07D213/85 , C07D215/38 , C07D217/22 , C07D239/42 , C07D409/04 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： C07D213/75 , A61K31/44 , A61K31/47 , A61K31/505 , C07D213/84 , C07D213/85 , C07D215/38 , C07D217/22 , C07D239/42 , C07D409/04
摘要： The invention relates to the hetaryl-substituted guanidine compounds of general formula (I), enantiomeres, diastereomeres and/or tautomeres thereof, in addition to the pharmaceutically acceptable salts thereof and the prodrugs of the known compounds. The invention also relates to the use of said hetaryl-substituted guanidine compounds as binding partners for 5-HT5-receptors for treating and/or for the prophylaxis of illnesses which are modulated by a 5-HT5-receptor activity, in particular, for treating and/or for the prophylaxis of neurodegenerative and neuropsychiatric disorders, and signs, symptoms and dysfunctions associated with said disorders.
摘要翻译：本发明涉及通式（I）的杂芳基取代的胍化合物，其对映异构体，非对映体和/或其互变异构体，以及其药学上可接受的盐和已知化合物的前药。本发明还涉及所述杂芳基取代的胍化合物作为5-HT 5受体的结合伴侣用于治疗和/或预防由5-HT5受体活性调节的疾病的用途，特别是用于治疗和/或用于预防与所述疾病相关的神经变性和神经精神障碍以及体征，症状和功能障碍。

4. 发明申请

US20110009380A1 QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR 有权
标题翻译：适用于治疗依托莫司汀5-HT6受体调节的病症的喹啉化合物
公开(公告)号：US20110009380A1
公开(公告)日：2011-01-13
申请号：US12532407
申请日：2008-03-23
申请人： Sean Colm Turner , Andreas Haupt , Wilfried Braje , Udo Lange , Karla Drescher , Karsten Wicke , Liliane Unger , Mario Mezler , Wolfgang Wernet , Alfred Hahn , Matthias Mayrer
发明人： Sean Colm Turner , Andreas Haupt , Wilfried Braje , Udo Lange , Karla Drescher , Karsten Wicke , Liliane Unger , Mario Mezler , Wolfgang Wernet , Alfred Hahn , Matthias Mayrer
IPC分类号： A61K31/4709 , C07D401/02 , A61K31/4725 , C07D401/14 , A61P25/00 , A61P25/28 , A61P25/18
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel quinoline compounds. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein R is a moiety of the formula wherein A, R1 to R4 are as defined in the claims and the specification, n is 0, 1 or 2; m is 0, 1, 2 or 3; Ra, Rb are independently selected from the group consisting of halogen, CN, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C(O)Raa, C(O)NRccRbb and NRccRbb; X is CH2, C(O), S, S(O) or S(O)2; which is located in the 3- or 4-position of the quinoline ring; Ar is a radical Ar1, Ar2—Ar3 or Ar2—O—Ar3, wherein Ar1, Ar2 and Ar3 are each independently selected from the group consisting of aryl or hetaryl wherein aryl or hetaryl moieties may be unsubstituted or may carry 1, 2, 3 substituents Rx, wherein and physiologically tolerated acid addition salts and the N-oxides thereof.
摘要翻译：本发明涉及新颖的喹啉化合物。该化合物具有有价值的治疗特性，特别适用于治疗对血清素5-HT 6受体调节作出反应的疾病。其中R是下式的部分，其中A，R 1至R 4如权利要求和说明书中所定义，n为0,1或2; m为0,1,2或3; R a，R b独立地选自卤素，CN，C 1 -C 4 - 烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C 1 -C 4卤代烷氧基，C（O）R aa，C（O）NR c R b b 和NRccRbb; X是CH 2，C（O），S，S（O）或S（O）2; 其位于喹啉环的3-或4-位; Ar是Ar1，Ar2-Ar3或Ar2-O-Ar3基团，其中Ar1，Ar2和Ar3各自独立地选自芳基或杂芳基，其中芳基或杂芳基部分可以是未取代的或可以携带1,2,3 取代基Rx，其中和生理上耐受的酸加成盐及其N-氧化物。

5. 发明申请

US20110207788A1 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors 有权
标题翻译： 5环杂芳族化合物及其作为5-ht5受体的结合伴侣的用途
公开(公告)号：US20110207788A1
公开(公告)日：2011-08-25
申请号：US11990731
申请日：2006-08-21
申请人： Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Andreas Haupt , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
发明人： Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Andreas Haupt , Francisco Javier Garcia-Ladona , Wolfgang Wernet , Alfred Hahn
IPC分类号： A61K31/42 , C07D233/00 , C07D249/14 , C07D261/06 , A61K31/415 , A61K31/4196 , A61P25/28
CPC分类号： C07D417/04 , C07D231/38 , C07D233/70 , C07D233/88 , C07D249/14 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The invention relates to 5-ring heteroaromatic compounds of general formula (I), their use for the treatment and/or prevention of diseases, and medicaments containing same.
摘要翻译：本发明涉及通式（I）的5-环杂芳族化合物，其用于治疗和/或预防疾病的用途，以及含有它们的药物。

6. 发明授权

US5361436A Patient support apparatus for medical examinations 失效
标题翻译：用于体格检查的患者支持装置
公开(公告)号：US5361436A
公开(公告)日：1994-11-08
申请号：US107057
申请日：1993-08-17
申请人： Alfred Hahn
发明人： Alfred Hahn
IPC分类号： A61B6/04 , A61G13/02 , A61G7/00 , A61G13/00
CPC分类号： A61G13/02 , A61B6/04
摘要： A support apparatus for supporting and positioning a patient during a medical examination includes a patient support plate and a combination of elements for lifting and pivoting the support plate which operate to pivot the support plate around a stationary, virtual (i.e., non-load bearing) axis disposed at an end region of the support plate.
摘要翻译：用于在医学检查期间支撑和定位患者的支撑装置包括患者支撑板和用于提升和枢转支撑板的元件的组合，所述支撑板用于使支撑板绕静止的虚拟（即，非负载）轴设置在支撑板的端部区域。

7. 发明授权

US4655220A Apparatus for contactless fragmentation of concrements in vivo 失效
标题翻译：用于体内不规则碎片化的装置
公开(公告)号：US4655220A
公开(公告)日：1987-04-07
申请号：US694578
申请日：1985-01-24
申请人： Alfred Hahn , George Vogel
发明人： Alfred Hahn , George Vogel
IPC分类号： A61B17/22 , G10K9/12
CPC分类号： G10K9/12
摘要： The invention relates to an apparatus for the contactless fragmentation of a concrement present in the body of a living being. A shock wave generator is aimed at a target region in the body and includes a coil having the form of a spherical segment. In front of the coil is arranged a mating radiator element, which closes off a liquid filled space and generates therein a shock wave focused on the centers of curvature of the coil and element upon brief connection of the coil to a high voltage. The concrement to be fragmented is positioned to lie at these centers of curvature.
摘要翻译：本发明涉及一种用于存在于生物体内的混凝土的非接触碎裂的装置。冲击波发生器瞄准身体中的目标区域，并且包括具有球形段形式的线圈。在线圈的前面设置有配合的散热器元件，其将液体填充的空间封闭，并且在将线圈短暂连接到高电压时在其中产生聚焦在线圈和元件的曲率中心上的冲击波。要分段的混凝土位于这些曲率中心。

8. 发明授权

US4641335A Primary-beam collimator for stereo radiographic x-ray diagnostic apparatus 失效
标题翻译：用于立体放射X光诊断仪的一次射束准直仪
公开(公告)号：US4641335A
公开(公告)日：1987-02-03
申请号：US720321
申请日：1985-04-05
申请人： Alfred Hahn
发明人： Alfred Hahn
IPC分类号： G21K1/04 , A61B6/02 , A61B6/06 , A61B6/08 , G21K1/02
CPC分类号： A61B6/022 , A61B6/06 , A61B6/08 , G21K1/02
摘要： A primary-beam collimator for a stereo radiographic x-ray diagnostic installation has an x-ray tube with dual focal points (F1, F2) arranged at a distance from each other. Shutter leaves (1a, 1b, 2a, 2b, 3a, 3b, 4a, 4b) are provided, and adjustable so that two beam pyramids (I from focal point F1, and II from focal point F2) can be individually controlled. Two internal shutter leaves (4a, 4b) are provided for restricting the beam in planes perpendicular to the stereo base F1-F2. These are adjustable between two external shutter leaves--each in the direction of its corresponding external shutter leaf. The internal shutter leaves (4a, 4b) are constructed so that, when adjusted to their external positions, they permit the emission of a central beam-pyramid from a central focal point (FN) and, together with the external shutter leaves (2a, 2b), they close the external shutter openings.
摘要翻译：用于立体放射X射线诊断装置的一次束准直仪具有配置为彼此距离的双焦点（F1，F2）的X射线管。提供了快门叶片（1a，1b，2a，2b，3a，3b，4a，4b），并且可调节，使得可以单独地控制两个横梁金字塔（来自焦点F1的I和来自焦点F2的II）。提供两个内部快门叶片（4a，4b），用于在垂直于立体基座F1-F2的平面中限制光束。这些可以在两个外部快门叶片之间调节，每个叶片沿相应的外部快门叶片的方向。内部快门叶片（4a，4b）被构造成使得当调节到其外部位置时，它们允许从中心焦点（FN）发射中心束 - 金字塔，并且与外部快门叶片（2a， 2b），它们关闭外部闸门开口。

9. 发明授权

US4582310A Patient support table 失效
标题翻译：病人支持表
公开(公告)号：US4582310A
公开(公告)日：1986-04-15
申请号：US670048
申请日：1984-11-09
申请人： Alfred Hahn
发明人： Alfred Hahn
IPC分类号： A61G13/06 , B66F7/06 , A61G13/00
CPC分类号： B66F7/065 , A61G13/06 , A61G2210/50
摘要： An x-ray examination table having a trestle on which a patient support platform is height-adjustably mounted, characterized by the trestle having a liftable member on which the table is mounted being connected to a base by a double-jointed support arrangement and being movable to the base by a lifting arrangement. The double-jointed support arrangement includes a pair of brackets pivotally connected together and having one of the pair being pivotally connected to the liftable member and the other being pivotally connected to the base. The pivotal connections are shafts which extend parallel to each other for each linkage arrangement and perpendicular to the shafts of the adjacent linkage arrangement so that the double-jointed supports guide the liftable member as it is moved between the upper and lowermost positions.
摘要翻译：一种具有托架的X射线检查台，患者支撑平台可高度可调节地安装在该支架上，其特征在于，所述支架具有其上安装有所述工作台的可升降构件，其通过双重接合的支撑装置连接到基座并且可移动通过提升安排到基地。双接头支撑装置包括一对托架，其枢转地连接在一起，并且一对托架枢转地连接到可升降构件，另一个枢转地连接到基座。枢转连接是针对每个联动装置彼此平行地延伸并且垂直于相邻联动装置的轴的轴，使得双重接合的支承件在可升降构件在上下位置之间移动时引导可升降构件。

10. 发明授权

US09109026B2 Dual variable domain immunoglobulins and uses thereof 有权
公开(公告)号：US09109026B2
公开(公告)日：2015-08-18
申请号：US12477668
申请日：2009-06-03
申请人： Tariq Ghayur , Alfred Hahn , Bernhard Mueller
发明人： Tariq Ghayur , Alfred Hahn , Bernhard Mueller
IPC分类号： C07K16/00 , C12P21/08 , C07H21/04 , C12P21/04 , C12N5/16 , C12N1/20 , C12N15/00 , A61K39/395 , A61K39/40 , C07K16/22 , C07K16/18 , C07K16/24 , C07K16/28 , C07K1/00
CPC分类号： C07K16/2869 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K47/6845 , A61K47/6849 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/248 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/525 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

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