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1. 发明授权

US6127578A Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination 失效
标题翻译：改变神经鞘脂代谢和检测伏马菌素摄入和污染的方法
公开(公告)号：US6127578A
公开(公告)日：2000-10-03
申请号：US627499
申请日：1996-04-04
申请人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
发明人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
IPC分类号： A61K31/13 , A61K31/22 , A61K31/225 , C07C215/10 , C07C215/00
CPC分类号： A61K31/225 , A61K31/13 , A61K31/22 , C07C215/10 , Y10S436/815
摘要： This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
摘要翻译：本发明提供了改变细胞中鞘脂代谢的方法，包括使细胞与伏马毒素或其类似物接触。本发明还提供一种检测受试者中伏马菌素或伏马菌素类似物的消耗的方法，包括（A）在受试者的样品中检测鞘脂代谢途径的状态和（B）比较代谢途径与正常受试者的代谢途径，代谢途径状态的变化表明伏马菌素或伏马菌素类似物的消耗。还提供了检测来自食物或饲料的样品中伏马毒素或伏马菌素类似物污染物的存在的方法，包括检测鞘脂代谢途径的反应，表明存在伏马菌素或伏马菌素类似物污染的反应。此外，提供了包含伏马毒素和伏马菌素类似物的新型伏马菌素类似物和组合物。

2. 发明授权

US06720184B1 Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination 失效
标题翻译：改变神经鞘脂代谢和检测伏马菌素摄入和污染的方法
公开(公告)号：US06720184B1
公开(公告)日：2004-04-13
申请号：US09676835
申请日：2000-10-02
申请人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
发明人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
IPC分类号： G01N3302
CPC分类号： C07C215/10 , A61K31/13 , A61K31/22 , A61K31/225 , Y10S436/815
摘要： This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
摘要翻译：本发明提供了改变细胞中鞘脂代谢的方法，包括使细胞与伏马毒素或其类似物接触。本发明还提供一种检测受试者中伏马菌素或伏马菌素类似物的消耗的方法，包括（A）在受试者的样品中检测鞘脂代谢途径的状态和（B）比较代谢途径与正常受试者的代谢途径，代谢途径状态的变化表明伏马菌素或伏马菌素类似物的消耗。还提供了检测来自食物或饲料的样品中伏马毒素或伏马菌素类似物污染物的存在的方法，包括检测鞘脂代谢途径的反应，表明存在伏马菌素或伏马菌素类似物污染的反应。此外，提供了包含伏马毒素和伏马菌素类似物的新型伏马菌素类似物和组合物。

3. 发明授权

US5232837A Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination 失效
标题翻译：改变脂质代谢和检测霉菌素摄入和污染的方法
公开(公告)号：US5232837A
公开(公告)日：1993-08-03
申请号：US740426
申请日：1991-08-05
申请人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
发明人： Alfred H. Merrill, Jr. , Elaine W. Wang , Dennis C. Liotta , Ronald T. Riley
IPC分类号： A61K31/13 , A61K31/22 , A61K31/225 , C07C215/10
CPC分类号： A61K31/225 , A61K31/13 , A61K31/22 , C07C215/10 , Y10S436/815
摘要： This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
摘要翻译：本发明提供了改变细胞中鞘脂代谢的方法，包括使细胞与伏马毒素或其类似物接触。本发明还提供一种检测受试者中伏马菌素或伏马菌素类似物的消耗的方法，包括（A）在受试者的样品中检测鞘脂代谢途径的状态和（B）比较代谢途径与正常受试者的代谢途径，代谢途径状态的变化表明伏马菌素或伏马菌素类似物的消耗。还提供了检测来自食物或饲料的样品中伏马毒素或伏马菌素类似物污染物的存在的方法，包括检测鞘脂代谢途径的反应，表明存在伏马菌素或伏马菌素类似物污染的反应。此外，提供了包含伏马毒素和伏马菌素类似物的新型伏马菌素类似物和组合物。

4. 发明授权

US5518879A Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination 失效
公开(公告)号：US5518879A
公开(公告)日：1996-05-21
申请号：US42147
申请日：1993-04-02
申请人： Alfred H. Merrill, Jr. , Elaine W. Wang , Ronald T. Riley
发明人： Alfred H. Merrill, Jr. , Elaine W. Wang , Ronald T. Riley
IPC分类号： A61K31/13 , A61K31/22 , A61K31/225 , C07C215/10 , C12Q1/00 , C07C69/34 , C07C69/52 , G01N33/02
CPC分类号： A61K31/225 , A61K31/13 , A61K31/22 , C07C215/10 , Y10S436/815
摘要： This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.

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