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1. 发明授权

US08740891B2 Flexible multi-tubular cryoprobe 有权
标题翻译：灵活多管式冷冻探针
公开(公告)号：US08740891B2
公开(公告)日：2014-06-03
申请号：US12744001
申请日：2008-11-19
申请人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
摘要翻译：一种柔性多管式冷冻探针，包括用于接收来自流体源的近临界低温流体的入口流并用于排出低温流体出口流的壳体。多个流体输送管被牢固地附接到壳体。这包括一组入口流体输送管，用于从壳体接收入口流; 以及用于将出口流排放到壳体的一组出口流体输送管。每个流体输送管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。每个流体输送管的内径在约0.10mm至1.0mm之间的范围内，壁厚在约0.01mm至0.30mm的范围内。端盖定位在多个流体输送管的端部，以提供从入口流体输送管到出口流体输送管的流体转移。

2. 发明申请

US20110040297A1 FLEXIBLE MULTI-TUBULAR CRYOPROBE 有权
标题翻译：柔性多管型CRYOPROBE
公开(公告)号：US20110040297A1
公开(公告)日：2011-02-17
申请号：US12744001
申请日：2008-11-19
申请人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
摘要翻译：一种柔性多管式冷冻探针，包括用于接收来自流体源的近临界低温流体的入口流并用于排出低温流体出口流的壳体。多个流体输送管被牢固地附接到壳体。这包括一组入口流体输送管，用于从壳体接收入口流; 以及用于将出口流排放到壳体的一组出口流体输送管。每个流体输送管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。每个流体输送管的内径在约0.10mm至1.0mm之间的范围内，壁厚在约0.01mm至0.30mm的范围内。端盖定位在多个流体输送管的端部，以提供从入口流体输送管到出口流体输送管的流体转移。

3. 发明授权

US09345527B2 Method and system for cryoablation treatment 有权
标题翻译：冷冻消融治疗方法与系统
公开(公告)号：US09345527B2
公开(公告)日：2016-05-24
申请号：US13292967
申请日：2011-11-09
申请人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
IPC分类号： A61B18/18 , A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0262
摘要： A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.
摘要翻译：提供一种系统及其使用方法，用于冷却探针远端处的冷冻液用于冷冻手术。特别地，冷冻液被液体制冷剂冷却至低温，以便对生物组织进行冷冻手术。该系统是闭环的，并且在液体制冷剂通过整个系统的过程中，液体制冷剂总是在相对较低的压力下保持液态。

4. 发明申请

US20120053575A1 Method and System for Cryoablation Treatment 有权
标题翻译：冷冻消融治疗方法与系统
公开(公告)号：US20120053575A1
公开(公告)日：2012-03-01
申请号：US13292967
申请日：2011-11-09
申请人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0262
摘要： A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.
摘要翻译：提供一种系统及其使用方法，用于冷却探针远端处的冷冻液用于冷冻手术。特别地，冷冻液被液体制冷剂冷却至低温，以便对生物组织进行冷冻手术。该系统是闭环的，并且在液体制冷剂通过整个系统的过程中，液体制冷剂总是在相对低的压力下保持在液态。

5. 发明申请

US20090270851A1 Method and System for Cryoablation Treatment 有权
标题翻译：冷冻消融治疗方法与系统
公开(公告)号：US20090270851A1
公开(公告)日：2009-10-29
申请号：US12425938
申请日：2009-04-17
申请人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0262
摘要： A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.
摘要翻译：提供一种系统及其使用方法，用于冷却探针远端处的冷冻液用于冷冻手术。特别地，冷冻液被液体制冷剂冷却至低温，以便对生物组织进行冷冻手术。该系统是闭环的，并且在液体制冷剂通过整个系统的过程中，液体制冷剂总是在相对低的压力下保持在液态。

6. 发明授权

US08814850B2 Method and system for cryoablation treatment 有权
标题翻译：冷冻消融治疗方法与系统
公开(公告)号：US08814850B2
公开(公告)日：2014-08-26
申请号：US12425938
申请日：2009-04-17
申请人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , William J. Nydam
IPC分类号： A61B18/18 , A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/0262
摘要： A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.
摘要翻译：提供一种系统及其使用方法，用于冷却探针远端处的冷冻液用于冷冻手术。特别地，冷冻液被液体制冷剂冷却至低温，以便对生物组织进行冷冻手术。该系统是闭环的，并且在液体制冷剂通过整个系统的过程中，液体制冷剂总是在相对低的压力下保持在液态。

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