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    • 1. 发明授权
    • Analgesic and immunomodulatory cannabinoids
    • 止痛和免疫调节大麻素
    • US06939977B2
    • 2005-09-06
    • US10309686
    • 2002-12-04
    • Alexandros MakriyannisDai LuAtmaram Khanolkar
    • Alexandros MakriyannisDai LuAtmaram Khanolkar
    • C07D311/80C07D407/04C07D409/04C07D311/02C07D311/78C07D31/80
    • C07D407/04C07D311/80C07D409/04
    • Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. X is a covalent bond, —CH2— or —CHR1—, wherein R1 a C1 to C3 substituted or unsubstituted alkyl group. Y is a heterocyclic ring, a substituted heterocyclic ring, a carbocyclic ring, a substituted carbocyclic ring, a fused bicyclic ring system, a substituted fused bicyclic ring system, a bridged bicyclic ring system, a substituted bridged bicyclic ring system, a bridged tricyclic ring system or a substituted bridged tricyclic ring system. Also disclosed is a method of stimulating a CB1 and/or CB2 receptor in a subject. The method comprises administering to the subject a therapeutically effective amount of R-X-Y.
    • 公开了由以下结构式表示的新化合物:<?in-line-formula description =“In-line formula”end =“lead”?> RXY; <?in-line-formula description =“In-line Formulas” 末端=“尾”→其生理学上可接受的盐。 R是大麻素或取代大麻素的三环核心。 X是共价键,-CH 2 - 或-CHR 1 - ,其中R 1,C 1至C 3取代或未取代的烷基。 Y是杂环,取代的杂环,碳环,取代的碳环,稠合双环系统,取代的稠合双环体系,桥连双环体系,取代的桥连双环体系,桥连三环 系统或取代的桥接三环系统。 还公开了刺激受试者中的CB1和/或CB2受体的方法。 该方法包括向受试者施用治疗有效量的R-X-Y。