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1. 发明申请

US20070069120A1 Method and apparatus for high-order differential mobility separations 有权
标题翻译：用于高阶差分迁移率分离的方法和装置
公开(公告)号：US20070069120A1
公开(公告)日：2007-03-29
申请号：US11237523
申请日：2005-09-28
申请人： Alexandre Shvartsburg , Richard Smith , Gordon Anderson
发明人： Alexandre Shvartsburg , Richard Smith , Gordon Anderson
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： The present invention relates generally to separation of ions based on their transport properties. More particularly, the invention relates to separation of ionic mixtures and characterization of ions in gases using higher-order differential ion mobility spectrometry (HODIMS) enabled by asymmetric waveforms of fundamentally new types. The invention discloses a method and apparatus for separation of ionic mixtures and characterization, identification, or quantification of ions in a gas based substantially on the terms of third or higher order in a series expansion of ion mobility as a function of electric field intensity. This is achieved using a periodic, time-dependent electric field with novel waveform profiles that cancel or substantially reduce the contributions to time-averaged ion motion of the leading n (where n≧2) terms of that expansion, thereby achieving ion separations based substantially on the (n+1)th term. Separations using HODIMS with different n are expected to be highly orthogonal, enabling multidimensional separations employing HODIMS analyzers of different orders. The expected high orthogonality between HODIMS and mass spectrometry or ion mobility spectrometry would make HODIMS/MS and HODIMS/IMS combinations powerful analytical tools of broad utility.
摘要翻译：本发明一般涉及基于它们的运输特性分离离子。更具体地，本发明涉及离子混合物的分离和使用通过基本上新型的不对称波形实现的高阶差分离子迁移谱（HODIMS）的气体中的离子表征。本发明公开了一种用于分离离子混合物的方法和装置，并且基于离子迁移率的串联扩展作为电场强度的函数，基本上以三阶或更高阶的项为基础来表征，鉴定或定量气体中的离子。这是使用具有新颖波形分布的周期性，时间依赖性电场来实现的，其消除或基本上减少对该扩展的前导n（其中n≥2）项的时间平均离子运动的贡献，由此实现基于离子分离基本上在第（n + 1）项。使用具有不同n的HODIMS的分离预计将具有高度正交性，可以使用具有不同阶数的HODIMS分析仪进行多维分离。 HODIMS和质谱法或离子迁移光谱法之间预期的高正交性将使HODIMS / MS和HODIMS / IMS组合成为强大的广泛应用的分析工具。

2. 发明申请

US20060219889A1 Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD) 有权
标题翻译：用于偶极方向对准的离子迁移光谱法的方法和装置（IMS-ADD）
公开(公告)号：US20060219889A1
公开(公告)日：2006-10-05
申请号：US11097855
申请日：2005-03-31
申请人： Alexandre Shvartsburg , Keqi Tang , Richard Smith
发明人： Alexandre Shvartsburg , Keqi Tang , Richard Smith
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/004 , H01J49/40
摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that “locks” the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ˜3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.
摘要翻译：描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。通过以特定的角度对漂移场施加更强的交变电场来实现对准，所述交变电场通过超过一定值的力矩“锁定”离子偶极子。该值取决于缓冲气体组成，压力和温度，但在某些条件下可能低至〜3德拜。目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。

3. 发明申请

US20070200059A1 Interface and process for enhanced transmission of non-circular ion beams between stages at unequal pressure 有权
标题翻译：用于在不同压力的阶段之间增强非圆形离子束传输的界面和过程
公开(公告)号：US20070200059A1
公开(公告)日：2007-08-30
申请号：US11361264
申请日：2006-02-24
申请人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
发明人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
IPC分类号： H01J49/06
CPC分类号： H01J49/067
摘要： The invention discloses a new interface with non-circular conductance limit aperture(s) useful for effective transmission of non-circular ion beams between stages with different gas pressure. In particular, the invention provides an improved coupling of field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of planar or side-to-side geometry to downstream stages such as mass spectrometry or ion mobility spectrometry. In this case, the non-circular aperture is rectangular; other geometries may be optimum in other applications. In the preferred embodiment, the non-circular aperture interface is followed by an electrodynamic ion funnel that may focus wide ion beams of any shape into tight circular beams with virtually no losses. The jet disrupter element of the funnel may also have a non-circular geometry, matching the shape of arriving ion beam. The improved sensitivity of planar FAIMS/MS has been demonstrated in experiments using a non-contiguous elongated aperture but other embodiments (e.g., with a contiguous slit aperture) may be preferable, especially in conjunction with an ion funnel operated at high pressures.
摘要翻译：本发明公开了一种具有非圆形电导限制孔径的新界面，其可用于在具有不同气体压力的级之间有效地传输非圆形离子束。特别地，本发明提供了平面或侧对面几何的场非对称波形离子淌度光谱（FAIMS）分析仪与诸如质谱或离子淌度光谱法的下游阶段的改进的耦合。在这种情况下，非圆形孔是矩形的; 其他几何形状在其他应用中可能是最佳的。在优选实施例中，非圆形孔径界面之后是电动离子漏斗，其可将任何形状的宽离子束聚焦成紧密的圆形梁，实际上没有损失。漏斗的喷射破坏器元件也可以具有与到达的离子束的形状匹配的非圆形几何形状。已经在使用不连续的细长孔的实验中证明了平面FAIMS / MS的改进的灵敏度，但是其它实施例（例如，具有连续的狭缝孔）可能是优选的，特别是与在高压下操作的离子漏斗相结合。

4. 发明申请

US20060226353A1 DEVICE FOR TWO-DIMENSIONAL GAS-PHASE SEPARATION AND CHARACTERIZATION OF ION MIXTURES 有权
标题翻译：用于二维气相分离和离子混合特征的装置
公开(公告)号：US20060226353A1
公开(公告)日：2006-10-12
申请号：US11103984
申请日：2005-04-11
申请人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
发明人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译：本发明涉及气相离子的分离和表征装置。该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

5. 发明申请

US20050092918A1 High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel 有权
公开(公告)号：US20050092918A1
公开(公告)日：2005-05-05
申请号：US10933661
申请日：2004-09-02
申请人： Richard Smith , Keqi Tang , Alexandre Shvartsburg
发明人： Richard Smith , Keqi Tang , Alexandre Shvartsburg
IPC分类号： G01N27/64 , H01J49/02 , H01J49/04 , H01J49/06 , H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/066 , G01N27/622 , H01J49/40
摘要： A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.

6. 发明申请

US20050061967A1 Pattern recognition of whole cell mass spectra 有权
标题翻译：全细胞质谱的模式识别
公开(公告)号：US20050061967A1
公开(公告)日：2005-03-24
申请号：US10863745
申请日：2004-06-07
申请人： Alexandre Shvartsburg , Jon Wilkes , Paul Chiarelli , Ricky Holland , Dan Buzatu , Michael Beaudoin
发明人： Alexandre Shvartsburg , Jon Wilkes , Paul Chiarelli , Ricky Holland , Dan Buzatu , Michael Beaudoin
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/04
摘要： A method for reproducibly analyzing mass spectra from different sample sources is provided. The method deconvolutes the complex spectra by collapsing multiple peaks of different molecular mass that originate from the same molecular fragment into a single peak. The differences in molecular mass are apparent differences caused by different charge states of the fragment and/or different metal ion adducts and/or reactant products of one or more of the charge states. The deconvoluted spectrum is compared to a library of mass spectra acquired from samples of known identity to unambiguously determine the identity of one or more components of the sample undergoing analysis.
摘要翻译：提供了一种可重复分析来自不同样品源的质谱的方法。该方法通过将起源于相同分子片段的不同分子量的多个峰折叠成单个峰来解卷积复谱。分子质量的差异是由片段和/或不同金属离子加合物和/或一种或多种电荷状态的反应物产物的不同电荷状态引起的明显差异。将解卷积光谱与从已知身份的样品获得的质谱图库进行比较，以明确地确定正在进行分析的样品的一个或多个组分的身份。

7. 发明授权

US07684934B2 Pattern recognition of whole cell mass spectra 有权
标题翻译：全细胞质谱的模式识别
公开(公告)号：US07684934B2
公开(公告)日：2010-03-23
申请号：US10863745
申请日：2004-06-07
申请人： Alexandre Shvartsburg , Jon G. Wilkes , Paul Chiarelli , Ricky D. Holland , Dan A. Buzatu , Michael A. Beaudoin
发明人： Alexandre Shvartsburg , Jon G. Wilkes , Paul Chiarelli , Ricky D. Holland , Dan A. Buzatu , Michael A. Beaudoin
IPC分类号： G06F19/00
CPC分类号： H01J49/04
摘要： A method for reproducibly analyzing mass spectra from different sample sources is provided. The method deconvolutes the complex spectra by collapsing multiple peaks of different molecular mass that originate from the same molecular fragment into a single peak. The differences in molecular mass are apparent differences caused by different charge states of the fragment and/or different metal ion adducts and/or reactant products of one or more of the charge states. The deconvoluted spectrum is compared to a library of mass spectra acquired from samples of known identity to unambiguously determine the identity of one or more components of the sample undergoing analysis.
摘要翻译：提供了一种可重复分析来自不同样品源的质谱的方法。该方法通过将起源于相同分子片段的不同分子量的多个峰折叠成单个峰来解卷积复谱。分子质量的差异是由片段和/或不同金属离子加合物和/或一种或多种电荷状态的反应物产物的不同电荷状态引起的明显差异。将解卷积光谱与从已知身份的样品获得的质谱图库进行比较，以明确地确定正在进行分析的样品的一个或多个组分的身份。

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