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1. 发明申请

US20140378663A1 FC VARIANTS WITH REDUCED EFFECTOR FUNCTIONS 审中-公开
标题翻译：具有降低效应函数的FC变量
公开(公告)号：US20140378663A1
公开(公告)日：2014-12-25
申请号：US14128828
申请日：2012-06-25
申请人： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
发明人： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
IPC分类号： C07K16/28 , C07K16/40
CPC分类号： C07K16/28 , C07K16/2887 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/71 , C07K2317/76
摘要： A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide.
摘要翻译：用于产生包含Fc区的亲本多肽的变体的方法，所述变体与亲本多肽相比显示出降低的与蛋白质C1q的结合和至少一种受体FcγγR的结合。

2. 发明申请

US20130122546A1 NOVEL SIGNAL PEPTIDE, AND USE THEREOF FOR PRODUCING RECOMBINANT PROTEINS 有权
标题翻译：新型信号肽及其生产重组蛋白的用途
公开(公告)号：US20130122546A1
公开(公告)日：2013-05-16
申请号：US13583337
申请日：2011-03-17
申请人： Alexandre Fontayne
发明人： Alexandre Fontayne
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , C07K2319/02 , C12N15/62
摘要： A use of a signal peptide for producing a recombinant polypeptide of interest in an expression system, the signal peptide includes at least 12 amino acids of formula (I): (X1)iX2X3X4SX5X6X7, wherein: X1 is a peptide containing from 3 to 6 amino acids, i equal to 0 or 1, X2 is a peptide containing from 3 to 9 hydrophobic amino acids, X3 is a peptide containing from 3 to 5 amino acids, the peptide including at least 3 contiguous or non-contiguous leucines X4 is a peptide containing from 2 to 5 amino acids chosen from Ala, Thr, Ser, Gln, Ile, Met, X5 is Ala or Val, X6 is Gln, Asn or His, X7 is Ala or Cys, provided that when the signal peptide originates from a natural precursor of a specific protein, the polypeptide of interest is different from the protein.
摘要翻译：信号肽在表达系统中用于产生感兴趣的重组多肽的信号肽，所述信号肽包含至少12个式（I）的氨基酸：（X1）iX2X3X4SX5X6X7，其中：X1是含有3至6个氨基的肽酸，I等于0或1，X2是含有3至9个疏水性氨基酸的肽，X3是含有3至5个氨基酸的肽，包括至少3个连续或不连续的亮氨酸X4的肽是肽含有选自Ala，Thr，Ser，Gln，Ile，Met，X5的2至5个氨基酸是Ala或Val，X 6是Gln，Asn或His，X 7是Ala或Cys，条件是当信号肽起源于特定蛋白质的天然前体，目的多肽与蛋白质不同。

3. 发明授权

US08535668B2 Chimeric anti-ricin antibody 失效
标题翻译：嵌合抗蓖麻毒蛋白抗体
公开(公告)号：US08535668B2
公开(公告)日：2013-09-17
申请号：US13508108
申请日：2010-11-04
申请人： Philippe Thullier , Alexandre Fontayne
发明人： Philippe Thullier , Alexandre Fontayne
IPC分类号： A61K39/395 , C07K16/16 , C07K16/40
CPC分类号： C07K16/40 , C07K16/16 , C07K2317/21 , C07K2317/24 , G01N33/573
摘要： A chimeric monoclonal antibody targeted at ricin, in which the light chain and heavy chain are such that: the constant region of the light chain and the constant region of the heavy chain are essentially made up respectively of the constant region of the light chain and the constant region of the heavy chain of human immunoglobulin, the variable region of the light chain and the variable region of the heavy chain include respectively the variable region of the light chain and the variable region of the heavy chain of macaque immunoglobulin, the monoclonal antibody not substantially inducing an immune response against chimeric antibodies.
摘要翻译：靶向蓖麻毒素的嵌合单克隆抗体，其中轻链和重链是：轻链的恒定区和重链的恒定区基本上分别由轻链的恒定区和人免疫球蛋白重链的恒定区，轻链的可变区和重链的可变区分别包括轻链的可变区和猕猴免疫球蛋白重链的可变区，单克隆抗体不是基本上诱导针对嵌合抗体的免疫应答。

4. 发明授权

US09512230B2 Transcription units and the use thereof in expression vectors 有权
标题翻译：转录单位及其在表达载体中的用途
公开(公告)号：US09512230B2
公开(公告)日：2016-12-06
申请号：US14375503
申请日：2013-02-08
申请人： Alexandre Fontayne , Francois Coutard
发明人： Alexandre Fontayne , Francois Coutard
IPC分类号： C07K16/28 , C07K16/34 , C12N15/85
CPC分类号： C07K16/2887 , C07K16/34 , C12N15/85 , C12N2830/007 , C12N2830/15 , C12N2830/42 , C12N2830/60 , C12N2830/85
摘要： Novel transcription units that may be used in expression vectors. The transcription unit allow antibodies to be produced whose gain in productivity is not linked to a particular antigenic target antibody and therefore by extrapolation to a given recombinant protein, nor linked to the culture medium.
摘要翻译：可用于表达载体的新型转录单位。转录单元允许产生其生产力增益不与特定抗原靶抗体相关的抗体，因此通过外推到给定的重组蛋白质，也不与培养基连接。

5. 发明申请

US20150072368A1 TRANSCRIPTION UNITS AND THE USE THEREOF IN EXPRESSION VECTORS 有权
标题翻译：转录单位及其在表达载体中的用途
公开(公告)号：US20150072368A1
公开(公告)日：2015-03-12
申请号：US14375503
申请日：2013-02-08
申请人： Alexandre Fontayne , François Coutard
发明人： Alexandre Fontayne , François Coutard
IPC分类号： C07K16/28 , C12N15/85 , C07K16/34
CPC分类号： C07K16/2887 , C07K16/34 , C12N15/85 , C12N2830/007 , C12N2830/15 , C12N2830/42 , C12N2830/60 , C12N2830/85
摘要： Novel transcription units that may be used in expression vectors. The transcription unit allow antibodies to be produced whose gain in productivity is not linked to a particular antigenic target antibody and therefore by extrapolation to a given recombinant protein, nor linked to the culture medium.
摘要翻译：可用于表达载体的新型转录单位。转录单元允许产生其生产力增益不与特定抗原靶抗体相关的抗体，因此通过外推到给定的重组蛋白质，也不与培养基连接。

6. 发明授权

US08883450B2 Signal peptide, and use thereof for producing recombinant proteins 有权
标题翻译：信号肽及其在制备重组蛋白质中的应用
公开(公告)号：US08883450B2
公开(公告)日：2014-11-11
申请号：US13583337
申请日：2011-03-17
申请人： Alexandre Fontayne
发明人： Alexandre Fontayne
IPC分类号： C12P21/04 , C12N15/00 , A61K38/00 , C07H21/02 , C12N15/62 , C07K7/08
CPC分类号： C07K7/08 , C07K2319/02 , C12N15/62
摘要： A use of a signal peptide for producing a recombinant polypeptide of interest in an expression system, the signal peptide includes at least 12 amino acids of formula (I): (X1)iX2X3X4SX5X6X7, wherein: X1 is a peptide containing from 3 to 6 amino acids, i equal to 0 or 1, X2 is a peptide containing from 3 to 9 hydrophobic amino acids, X3 is a peptide containing from 3 to 5 amino acids, the peptide including at least 3 contiguous or non-contiguous leucines X4 is a peptide containing from 2 to 5 amino acids chosen from Ala, Thr, Ser, Gln, Ile, Met, X5 is Ala or Val, X6 is Gln, Asn or His, X7 is Ala or Cys, provided that when the signal peptide originates from a natural precursor of a specific protein, the polypeptide of interest is different from the protein.
摘要翻译：信号肽在表达系统中用于产生感兴趣的重组多肽的信号肽，所述信号肽包含至少12个式（I）的氨基酸：（X1）iX2X3X4SX5X6X7，其中：X1是含有3至6个氨基的肽酸，I等于0或1，X2是含有3至9个疏水性氨基酸的肽，X3是含有3至5个氨基酸的肽，包括至少3个连续或不连续的亮氨酸X4的肽是肽含有选自Ala，Thr，Ser，Gln，Ile，Met，X5的2至5个氨基酸是Ala或Val，X 6是Gln，Asn或His，X 7是Ala或Cys，条件是当信号肽来源于特定蛋白质的天然前体，目的多肽与蛋白质不同。

7. 发明申请

US20120258100A1 CHIMERIC ANTI-RICIN ANTIBODY 失效
标题翻译： CHIMERIC抗体抗体
公开(公告)号：US20120258100A1
公开(公告)日：2012-10-11
申请号：US13508108
申请日：2010-11-04
申请人： Philippe Thullier , Alexandre Fontayne
发明人： Philippe Thullier , Alexandre Fontayne
IPC分类号： C07K16/16 , A61K39/395 , A61L2/16 , A61K35/00 , C12N15/85 , G01N33/577 , C12N15/13 , A61K31/711
CPC分类号： C07K16/40 , C07K16/16 , C07K2317/21 , C07K2317/24 , G01N33/573
摘要： A chimeric monoclonal antibody targeted at ricin, in which the light chain and heavy chain are such that: the constant region of the light chain and the constant region of the heavy chain are essentially made up respectively of the constant region of the light chain and the constant region of the heavy chain of human immunoglobulin, the variable region of the light chain and the variable region of the heavy chain include respectively the variable region of the light chain and the variable region of the heavy chain of macaque immunoglobulin, the monoclonal antibody not substantially inducing an immune response against chimeric antibodies.
摘要翻译：靶向蓖麻毒素的嵌合单克隆抗体，其中轻链和重链是：轻链的恒定区和重链的恒定区基本上分别由轻链的恒定区和人免疫球蛋白重链的恒定区，轻链的可变区和重链的可变区分别包括轻链的可变区和猕猴免疫球蛋白重链的可变区，单克隆抗体不是基本上诱导针对嵌合抗体的免疫应答。

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