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1. 发明授权

US4690931A Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives 失效
标题翻译：治疗上有用的1-苯基-2-哌啶子基链烷醇衍生物
公开(公告)号：US4690931A
公开(公告)日：1987-09-01
申请号：US773926
申请日：1985-09-09
申请人： Alexander Wick , Jonathan Frost , Bernard Gaudilliere , Jean Bertin , Regis Dupont , Jean Rousseau
发明人： Alexander Wick , Jonathan Frost , Bernard Gaudilliere , Jean Bertin , Regis Dupont , Jean Rousseau
IPC分类号： C07D211/12 , A61K31/445 , A61K31/451 , A61P9/08 , A61P25/24 , A61P25/26 , A61P25/28 , C07C45/00 , C07C45/45 , C07C45/54 , C07C45/63 , C07C45/71 , C07C49/76 , C07C49/80 , C07C49/825 , C07C49/84 , C07C63/70 , C07C67/00 , C07C69/76 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/62 , C07D213/50 , C07D213/78 , C07D317/18 , C07D317/30
CPC分类号： C07D211/22 , C07C45/004 , C07C45/45 , C07C45/54 , C07C45/63 , C07C45/71 , C07C49/80 , C07C49/825 , C07C49/84 , C07D211/14 , C07D211/18
摘要： Compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R.sub.2 is hydroxyl or methoxy in the 4-position and R.sub.3 is hydrogen, R.sub.1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl,R.sub.2 is hydrogen, halogen, alkyl, hydroxyl, or alkoxy,R.sub.3 is hydrogen or alkyl,R.sub.4 is alkyl (in which case the compounds are (.+-.)-erythro) or when R.sub.3 represents hydrogen, R.sub.4 may also be hydrogen, and R.sub.5 is hydrogen, halogen, alkyl, alkoxy, or three methoxy groups in the 3-, 4- and 5-positions and pharmaceutically acceptable acid addition salts thereof, with the exclusion of compounds wherein:(a) one of R.sub.1 and R.sub.2 is in the 4-position and is hydroxyl, alkoxy or benzyloxy, the other is in the 3-position and is hydrogen, hydroxyl, alkoxy or benzyloxy, and R.sub.3 and R.sub.5 are hydrogen and wherein:(b) R.sub.1 is in the 4-position and is halogen, R.sub.4 is methyl and R.sub.2, R.sub.3 and R.sub.5 are hydrogen, are useful as medicaments.
摘要翻译：下式的化合物：其中R 1为氢，卤素，三氟甲基，烷基，羟基，烷氧基，苄氧基，烷酰氧基或苯甲酰氧基，或当R 4为4-位的羟基或甲氧基且R 3为氢时， R1还可以表示羟甲基氨基甲酰基或烷氧基羰基，R2是氢，卤素，烷基，羟基或烷氧基，R3是氢或烷基，R4是烷基（在这种情况下，化合物是（+/-） - 赤式）氢，R 4也可以是氢，R 5是氢，卤素，烷基，烷氧基或三个甲氧基的3-，4-和5-位及其药学上可接受的酸加成盐，其中：（ a）R1和R2中的一个是4-位，羟基，烷氧基或苄氧基，另一个是3-位，是氢，羟基，烷氧基或苄氧基，R3和R5是氢，其中：（b ）R1为4-位且为卤素，R4为甲基，R2，R3和R5为氢，可用作药物。

2. 发明授权

US5023266A Method of treatment of psychotic disorders 失效
标题翻译：治疗精神病的方法
公开(公告)号：US5023266A
公开(公告)日：1991-06-11
申请号：US469783
申请日：1990-01-24
申请人： Salomon Z. Langer , Jonathan R. Frost , Johannes Schoemaker , Bernard Gaudilliere , Jean Bertin , Jean Rousseau , Regis Dupont , Alexander E. Wick
发明人： Salomon Z. Langer , Jonathan R. Frost , Johannes Schoemaker , Bernard Gaudilliere , Jean Bertin , Jean Rousseau , Regis Dupont , Alexander E. Wick
IPC分类号： C07D211/14 , A61K31/445 , A61K31/451 , A61P25/18 , C07D211/18
CPC分类号： A61K31/445
摘要： Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.
摘要翻译： Ifenprodil及其类似物可用于治疗精神病如精神分裂症。

3. 发明授权

US4661498A Furo 3,2-c pyridine derivatives and their use in treating depression and cerebral ischemia 失效
标题翻译： Furo 3,2-c吡啶衍生物及其在治疗抑郁症和脑缺血中的应用
公开(公告)号：US4661498A
公开(公告)日：1987-04-28
申请号：US780453
申请日：1985-09-26
申请人： Alexander Wick , Jonathan Frost , Jean Bertin
发明人： Alexander Wick , Jonathan Frost , Jean Bertin
IPC分类号： A61K31/435 , A61P25/24 , A61P25/26 , C07D211/72 , C07D211/74 , C07D491/04 , C07D491/048 , A61K31/44
CPC分类号： C07D491/04 , C07D211/72 , C07D211/74
摘要： Compounds of general formula (I) ##STR1## wherein R1 represents a phenyl, halophenyl, methylphenyl, ethylphenyl, methoxyphenyl, trifluoromethylphenyl or naphthyl group, R2 represents hydrogen or a methyl or phenyl group, and R3 represents hydrogen or a benzyl group, except compounds in which R1 is a phenyl or 4-fluorophenyl group, R2 is hydrogen and R3 is hydrogen or a benzyl group, and their pharmaceutically acceptable acid addition salts have useful anti-depressant and anti-ischaemic properties.
摘要翻译：通式（I）的化合物其中R 1表示苯基，卤代苯基，甲基苯基，乙基苯基，甲氧基苯基，三氟甲基苯基或萘基，R 2表示氢或甲基或苯基，R 3表示氢或苄基除了R1是苯基或4-氟苯基，R2是氢和R3是氢或苄基的化合物以外，其药学上可接受的酸加成盐具有有用的抗抑郁和抗缺血性质。

4. 发明授权

US5034401A Derivatives of (1-hydroxy-2-piperidylalkyl-indol-2-ones, 2-quinolinones, 2-benzo(B)azapinones, benzimidazol-2-ones, and quinazolin-2-ones, their preparation and their application in therapeutics 失效
标题翻译：（1-羟基-2-哌啶基烷基 - 吲哚-2-酮，2-喹啉酮，2-苯并（B）吖庚因酮，苯并咪唑-2-酮和喹唑啉-2-酮的衍生物，其制备及其在治疗中的应用
公开(公告)号：US5034401A
公开(公告)日：1991-07-23
申请号：US378094
申请日：1989-07-11
申请人： Jonathan Frost , Patrick Lardenois , Jean Bertin , Alfred Saarmets , Corinne Rousselle
发明人： Jonathan Frost , Patrick Lardenois , Jean Bertin , Alfred Saarmets , Corinne Rousselle
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/445 , A61P25/00 , A61P25/28 , A61P35/00 , C07D401/06 , C07D401/14 , C07D405/14 , C07D491/107
CPC分类号： C07D401/06 , C07D401/14
摘要： A compound, in the form of a pure optical isomer or a mixture thereof, of formula (I): ##STR1## in which: Z represents a group of formula --CH.sub.2 --, --C(CH.sub.3).sub.2 --, --CH.dbd.CH--, --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --NH-- or --N(CH.sub.3)CH.sub.2 --, in which the nitrogen is bonded to the carbonyl group;R1 represents hydrogen or a C.sub.1 -C.sub.4 alkyl group;R2 represents hydrogen or a methyl group; andR3 represents:a phenoxy group which is unsubstituted or substituted by a halogen or a methyl group,a naphthyloxy group,a phenylmethyl group substituted by a halogen or a methyl group,an unsubstituted phenylmethyl group when Z does not representa group of formula --CH.dbd.CH-- or --(CH.sub.2).sub.2 --,a bis (4-fluorophenyl)-methyl group,a phenylmethoxy group which is unsubstituted or substituted by a halogen or a methyl group,a (2-naphthyl)methoxy group,a phenoxymethyl group which is unsubstituted or substituted by a halogen or a methyl group, ora pyridinyloxy group, andR4 represents hydrogen; orR3 and R4 form, together and with the piperidine ring to which they are attached, a spiro (2,3-dihydrobenzofuran-2,4'-piperid-1-yl) group; or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：式（I）的纯旋光异构体或其混合物形式的化合物：其中：Z表示式-CH 2 - ， - C（CH 3）2 - ， - CH = CH - ， - （CH 2）2 - ， - （CH 2）3 - ， - NH-或-N（CH 3）CH 2 - ，其中氮键合到羰基上; R1表示氢或C1-C4烷基; R2表示氢或甲基; R3表示：未被取代或被卤素或甲基取代的苯氧基，萘氧基，被卤素或甲基取代的苯基甲基，当Z不表示式 - CH = CH-或 - （CH 2）2 - ，双（4-氟苯基） - 甲基，未被取代或被卤素或甲基取代的苯基甲氧基，（2-萘基）甲氧基，苯氧基甲基未取代或被卤素或甲基取代的基团，或吡啶氧基，R4表示氢; 或者R 3和R 4与它们所连接的哌啶环一起形成螺（2,3-二氢苯并呋喃-2,4'-哌啶-1-基）基团; 或其药理学上可接受的酸加成盐。

5. 发明申请

US20050247785A1 Appliance with an ic card reader and overload protection 有权
标题翻译：家用IC卡读卡器和过载保护
公开(公告)号：US20050247785A1
公开(公告)日：2005-11-10
申请号：US10525056
申请日：2003-08-08
申请人： Jean Bertin
发明人： Jean Bertin
IPC分类号： G06K7/00 , G06K7/06
CPC分类号： G06K7/0086 , G06K7/0013
摘要： The appliance comprises an IC card reader for an operation with an IC card and a power supply for providing a supply voltage, in particular for the IC card. The appliance comprises further an overload protection circuit, which simulates an IC card extraction in case of an overload of the supply voltage. The power supply is then immediately switched off to avoid any damage for the power supply. In a preferred embodiment, the IC card reader is equipped with a card presence switch for indicating to a micro-controller of the appliance, that an IC card has been inserted into the card reader. The micro-controller provides then a control signal for switching on the power supply for the operation with the IC card. The protection circuit is coupled between the supply voltage for the IC card and the signal line of the card presence switch and provides a detection of a short circuit. The protection circuit may comprise a diode, a comparator or a transistor, which switches off the power supply via a logic circuit.
摘要翻译：该器具包括用于操作IC卡的IC卡读取器和用于提供电源电压的电源，特别是用于IC卡。该器具还包括过载保护电路，其在电源电压过载的情况下模拟IC卡提取。电源立即关闭，以避免电源损坏。在优选实施例中，IC卡读卡器配备有卡存在开关，用于向设备的微控制器指示IC卡已插入读卡器。微控制器提供用于接通用于IC卡操作的电源的控制信号。保护电路耦合在IC卡的电源电压和卡存在开关的信号线之间，并提供短路检测。保护电路可以包括二极管，比较器或晶体管，其经由逻辑电路断开电源。

6. 发明授权

US4503058A Therapeutically useful 3,7a-diazacyclohepta[j,k]fluorene derivatives 失效
标题翻译：治疗上有用的3,7a-二氮杂环庚烯[j，k]芴衍生物
公开(公告)号：US4503058A
公开(公告)日：1985-03-05
申请号：US446368
申请日：1982-12-02
申请人： Jean Bertin , Jonathan R. Frost
发明人： Jean Bertin , Jonathan R. Frost
IPC分类号： A61K31/55 , A61P9/00 , A61P25/28 , C07D471/16
CPC分类号： C07D471/16
摘要： Compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen, chlorine or methoxy, R.sub.2 represents hydrogen, methyl or benzyl, and R.sub.3 and R.sub.4 represent hydrogen, or R.sub.3 represents methyl and R.sub.4 represents hydrogen or R.sub.3 represents hydrogen and R.sub.4 represents methyl, are new compounds useful in therapy as they possess an antianoxic activity.
摘要翻译：下式的化合物，其中R1代表氢，氯或甲氧基，R2代表氢，甲基或苄基，R3和R4代表氢，或R3代表甲基，R4代表氢或R3代表氢，R4代表甲基。用于治疗的新化合物，因为它们具有抗疟药活性。

7. 发明授权

US08795611B2 Method for purifying the uranium from a natural uranium concentrate 有权
标题翻译：从天然铀浓缩物中净化铀的方法
公开(公告)号：US08795611B2
公开(公告)日：2014-08-05
申请号：US13515499
申请日：2010-12-20
申请人： Manuel Miguirditchian , Pascal Baron , Isabelle Bisel , Binh Dinh , Christian Sorel , Jean Bertin
发明人： Manuel Miguirditchian , Pascal Baron , Isabelle Bisel , Binh Dinh , Christian Sorel , Jean Bertin
IPC分类号： C01G43/00
CPC分类号： C22B3/0024 , C22B60/0239 , C22B60/026 , G21C19/46 , Y02P10/234 , Y02W30/883
摘要： A method with which uranium from a natural uranium concentrate may be purified, including a) extracting the uranium present as uranyl nitrate in an aqueous phase A1 resulting from the dissolution of the natural uranium concentrate in nitric acid, by means of an organic phase which contains an extractant in an organic diluent; b) washing the organic phase obtained at the end of step a), with an aqueous phase A2; and c) stripping the uranyl nitrate of the organic phase obtained at the end of step b), by circulating this organic phase in an apparatus, as a counter current against an aqueous phase A3. The extractant is an N,N-dialkylamide and the ratio between the flow rate at which the organic phase obtained at the end of step b) and the aqueous phase A3 circulate in the apparatus where step c) occurs, is greater than 1.
摘要翻译：可以纯化来自天然铀浓缩物的铀的方法，包括：a）在天然铀浓缩物在硝酸中溶解的水相A1中提取作为硝酸铀酰存在的铀，通过含有有机稀释剂中的萃取剂; b）用水相A2洗涤在步骤a）结束时获得的有机相; 和c）通过将该有机相循环在装置中，作为逆水相A3的逆流，汽提在步骤b）结束时获得的有机相的铀酰硝酸盐。萃取剂为N，N-二烷基酰胺，步骤b）结束时得到的有机相与水相A3在步骤c）的装置中循环的流动速率之比大于1。

8. 发明申请

US20120247276A1 METHOD FOR PURIFYING THE URANIUM FROM A NATURAL URANIUM CONCENTRATE 有权
标题翻译：从天然铀浓缩液中净化铀的方法
公开(公告)号：US20120247276A1
公开(公告)日：2012-10-04
申请号：US13515499
申请日：2010-12-20
申请人： Manuel Miguirditchian , Pascal Baron , Isabelle Bisel , Binh Dinh , Christian Sorel , Jean Bertin
发明人： Manuel Miguirditchian , Pascal Baron , Isabelle Bisel , Binh Dinh , Christian Sorel , Jean Bertin
IPC分类号： C22B60/02
CPC分类号： C22B3/0024 , C22B60/0239 , C22B60/026 , G21C19/46 , Y02P10/234 , Y02W30/883
摘要： A method with which uranium from a natural uranium concentrate may be purified, includinga) extracting the uranium present as uranyl nitrate in an aqueous phase A1 resulting from the dissolution of the natural uranium concentrate in nitric acid, by means of an organic phase which contains an extractant in an organic diluent;b) washing the organic phase obtained at the end of step a), with an aqueous phase A2; andc) stripping the uranyl nitrate of the organic phase obtained at the end of step b), by circulating this organic phase in an apparatus, as a counter current against an aqueous phase A3.The extractant is an N,N-dialkylamide and the ratio between the flow rate at which the organic phase obtained at the end of step b) and the aqueous phase A3 circulate in the apparatus where step c) occurs, is greater than 1.
摘要翻译：可以纯化来自天然铀浓缩物的铀的方法，包括：a）在天然铀浓缩物在硝酸中溶解的水相A1中提取作为硝酸铀酰存在的铀，通过含有有机稀释剂中的萃取剂; b）用水相A2洗涤在步骤a）结束时获得的有机相; 和c）通过将该有机相循环在装置中，作为逆水相A3的逆流，汽提在步骤b）结束时获得的有机相的铀酰硝酸盐。萃取剂为N，N-二烷基酰胺，步骤b）结束时得到的有机相与水相A3在步骤c）的装置中循环的流动速率之比大于1。

9. 发明授权

US4425351A Therapeutically useful oxygen derivatives of 3,7a-diazacyclohepta[j,k]fluorenes 失效
标题翻译： 3,7a-二氮杂环庚烯[j，k]芴的治疗有用的氧衍生物
公开(公告)号：US4425351A
公开(公告)日：1984-01-10
申请号：US446358
申请日：1982-12-02
申请人： Jean Bertin , Jonathan R. Frost
发明人： Jean Bertin , Jonathan R. Frost
IPC分类号： A61K31/55 , A61P9/00 , A61P25/28 , C07D209/16 , C07D471/16 , C07D471/14
CPC分类号： C07D209/16
摘要： Compounds of the general formula: ##STR1## wherein R.sub.1 represents hydrogen, chlorine or methoxy, R.sub.2 represents hydrogen, methyl or benzyl, and R.sub.3 and R.sub.4 represent hydrogen, or R.sub.3 represents methyl and R.sub.4 represents hydrogen, or R.sub.3 represents hydrogen and R.sub.4 represents methyl, with the exception of those compounds wherein R.sub.1, R.sub.3 and R.sub.4 each represent a hydrogen atom simultaneously, are new therapeutically useful compounds; they possess an antianoxic activity.
摘要翻译：通式为：其中R1代表氢，氯或甲氧基，R2代表氢，甲基或苄基，R3和R4代表氢，或R3代表甲基，R4代表氢，或R3代表氢，R4代表甲基除了其中R 1，R 3和R 4各自同时代表氢原子的那些化合物，是新的治疗上有用的化合物; 他们具有抗毒活性。

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