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    • 5. 发明授权
    • Methods and apparatus for high throughput pressure infiltration casting
    • 高通量压力渗透铸造的方法和装置
    • US06360809B1
    • 2002-03-26
    • US09687004
    • 2000-10-12
    • James A. CornieStephen S. CornieRalph P. MasonMark A. Ryals
    • James A. CornieStephen S. CornieRalph P. MasonMark A. Ryals
    • B22D1800
    • B22D27/15B22D18/04B22D19/14
    • Disclosed are economical methods and apparatus for high throughput pressure infiltration casting. Methods of the invention use a mold vessel as an evacuation chamber along with an evacuation cap to produce superior quality near-net shape finished cast parts with low porosity. Other methods of the invention use an improved heat transfer technique for directionally solidifying molten infiltrant at an increased rate to increase further the throughput of the pressure infiltration casting cycle. The invention also provides apparatus for practicing methods for high throughput pressure infiltration casting. One embodiment of an apparatus of the invention is a removable evacuation cap, often used in conjunction with a fill tube. Another apparatus embodiment is an evacuation cap coupled to a mold vessel which is used as an evacuation chamber.
    • 公开了用于高通量压力渗透铸造的经济方法和装置。 本发明的方法使用模具容器作为抽真空室以及排气帽,以产生具有低孔隙率的优质近净形状的成品铸造件。 本发明的其它方法使用改进的传热技术来以增加的速率定向凝固熔融浸润剂,以进一步增加压力渗透铸造循环的生产量。 本发明还提供了用于实施高通量压力渗透铸造方法的装置。 本发明的装置的一个实施例是可移除的抽空帽,通常与填充管一起使用。 另一个设备实施例是联接到模具容器的抽空帽,其用作抽空室。
    • 7. 发明授权
    • Use of .sup.19 F magnetic resonance to non-invasively assess pO.sub.2
and temperature in vivo
    • 使用19F磁共振来非侵入性地评估体内的pO2和体温
    • US5397562A
    • 1995-03-14
    • US092122
    • 1993-07-15
    • Ralph P. MasonPeter P. Antich
    • Ralph P. MasonPeter P. Antich
    • A61K49/00A61K49/12C07H5/06C07K14/00C07K16/00C08B37/02A61B5/055
    • A61K49/126A61K49/085A61K49/10A61K49/146Y10S436/806Y10S514/832Y10T436/24
    • Oxygen tension of tissue in a living subject may be determined non-invasively by a method which involves: administering to a living mammalian subject a biologically compatible perfluorocarbon emulsion in an amount effective to generate a measurable .sup.19 F spectrum under .sup.19 F NMR spectroscopy; allowing sufficient time to elapse for substantially all of the perfluorocarbon emulsion to be cleared from the vascular system of the subject, with a portion of the perfluorocarbon emulsion becoming sequestered in tissue of the subject; subjecting the tissue in which the perfluorocarbon emulsion has become sequestered to a .sup.19 F magnetic resonance spectroscopy procedure in which simultaneous measurements are made of spin-lattice relaxation rates for at least two separate resonances of the perfluorocarbon emulsion; and comparing the at least two spin-lattice relaxation rates measured in the .sup.19 F magnetic resonance spectroscopy procedure to a predetermined relation of spin-lattice relaxation rate to oxygen tension and temperature for the perfluorocarbon emulsion used, and thereby determining the oxygen tension and temperature of the tissue.
    • 活体受试者中组织的氧张力可通过以下方法非侵入性地确定:一种方法,其包括:向活的哺乳动物受试者施用生物相容的全氟化碳乳剂,其有效量在19F NMR光谱下产生可测量的19F光谱; 允许足够的时间经过基本上所有的全氟化碳乳液从受试者的血管系统中清除,一部分全氟化碳乳液被隔离在受试者的组织中; 将全氟化碳乳液已经被隔离的组织经受19F磁共振光谱法,其中同时测量全氟化碳乳液的至少两个分开共振的自旋晶格弛豫速率; 并将在19F磁共振光谱法中测量的至少两个自旋晶格弛豫速率与自旋晶格弛豫率的预定关系与所用全氟化碳乳液的氧气张力和温度进行比较,从而确定所述全氟碳乳液的氧气张力和温度 组织。