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1. 发明授权

US5922612A Optical sensor system for determining pH values and ionic strengths 失效
标题翻译：用于测定pH值和离子强度的光学传感器系统
公开(公告)号：US5922612A
公开(公告)日：1999-07-13
申请号：US737034
申请日：1997-01-02
申请人： Alex Alder , Steven Barnard , Joseph Berger , Nils Blom , Marizel Rouilly
发明人： Alex Alder , Steven Barnard , Joseph Berger , Nils Blom , Marizel Rouilly
IPC分类号： G01N31/00 , C07D311/78 , C07D311/90 , C08F220/54 , C08F291/00 , C09D4/06 , G01N21/78 , G01N31/22 , G01N31/16
CPC分类号： G01N31/221 , C07D311/78 , C07D311/90 , C08F220/54 , C08F291/00 , C09D4/06
摘要： A method for the independent, reversible, optical determination of the pH value and the ionic strength of an aqueous sample with the aid of two different sensors in accordance with the fluorescence method, in which method two optical sensors, which are each composed of polymers of different structure but each contain the same fluorescent dye and which each consist of a coated material composed ofa) a carrier material, to which there is appliedb) at least one water-insoluble layer of a polymer comprising at least one hydrophilic monomer (A) from the group of substituted olefins, andc) a proton-sensitive fluorescent dye which is bonded directly or via a bridge group to the spine of polymer b) or which is incorporated in polymer b),are brought into contact with an aqueous test sample, irradiated with exciting light, the fluorescence is measured and the pH values and the ionic strengths are calculated from the measured fluorescence intensities with reference to calibration curves.
摘要翻译： PCT No.PCT / IB95 / 00302 Sec。 371日期1997年1月2日 102（e）日期1997年1月2日PCT提交1995年4月27日PCT公布。公开号WO95 / 30148 日期：1995年11月9日根据荧光法，借助于两种不同传感器，独立，可逆，光学测定水样品的pH值和离子强度的方法，其中两种光学传感器是每个由不同结构的聚合物组成，但每个都含有相同的荧光染料，并且每个由包含a）载体材料的涂层材料组成，其中施加有b）至少一种至少包含一种聚合物的水不溶性层一个亲水性单体（A），以及c）质子敏感的荧光染料，其直接或通过桥接基团与聚合物b）的骨架结合或掺入聚合物b）中，被引入与水性测试样品接触，用激发光照射，测量荧光，并根据测量的荧光强度参照校准计算pH值和离子强度曲线。

2. 发明授权

US6143570A Optical sensor for the determination of ions 有权
标题翻译：光学传感器用于测定离子
公开(公告)号：US6143570A
公开(公告)日：2000-11-07
申请号：US307914
申请日：1999-05-10
申请人： Alex Alder , Steven Barnard , Joseph Berger
发明人： Alex Alder , Steven Barnard , Joseph Berger
IPC分类号： C09B11/22 , C09B11/28 , C09B15/00 , C09K11/06 , G01N21/78 , G01N31/22 , G01N21/64
CPC分类号： C09B11/22 , C09B15/00 , G01N31/221 , G01N2410/10
摘要： A composition comprising(a) a transparent support(b) which is coated on at least one side with a transparent coating which comprises(b1) a plasticizer-free, hydrophobic polymer having a glass transition temperature Tg of from -150 to 50.degree. C.,(b2) counterions in the form of lipophilic salts,(b3) an ionophore which forms a complex with the ion to be determined, and(b4) a compound of the formula I or II as fluorophore ##STR1## in which R.sub.1 and R.sub.3, and R.sub.4 and R.sub.6 are C.sub.1 -C.sub.30 alkyl or C.sub.1 -C.sub.30 alkyl-CO--, and R.sub.2 and R.sub.5 are H or C.sub.1 -C.sub.30 alkyl, with the proviso that the total number of carbon atoms in the alkyl groups is at least 5, or a salt thereof with an inorganic or organic acid. The composition is highly suitable for the qualitative or quantitative optical determination of ions by fluorescence detection.
摘要翻译：一种组合物，其包含（a）透明载体（b），其在至少一侧涂覆有透明涂层，其包含（b1）玻璃化转变温度Tg为-150至50℃的不含增塑剂的疏水性聚合物（b2）亲脂性盐形式的抗衡离子，（b3）与待测离子形成络合物的离子载体，和（b4）作为荧光团的式I或II的化合物，其中R1和R3以及 R 4和R 6是C 1 -C 30烷基或C 1 -C 30烷基-CO-，R 2和R 5是H或C 1 -C 30烷基，条件是烷基中的总碳原子数至少为5，或其盐与无机或有机酸。该组合物非常适用于通过荧光检测进行离子的定性或定量光学测定。

3. 发明授权

US4990232A Process for the preparation of carbodiimides 失效
标题翻译：碳二亚胺的制备方法
公开(公告)号：US4990232A
公开(公告)日：1991-02-05
申请号：US240166
申请日：1988-09-02
申请人： Alex Alder
发明人： Alex Alder
IPC分类号： B01J19/12 , C07B31/00 , C07B43/00 , C07C67/00 , C07C241/00 , C07C255/61 , C07C267/00 , C07D213/64 , C07D213/643 , C07D213/74 , C07D265/28 , C07D295/13
CPC分类号： C07D213/643 , C07D213/74 , C07D295/13
摘要： The photooxidation of N,N'-substituted thioureas with oxygen in the presence of an acid-trapping agent gives N,N'-substituted carbodiimides. The carbodiimides can be converted into cyanoguanidines, which are suitable as latent curing agents for epoxy resins.
摘要翻译：在酸捕获剂存在下，N，N'-取代的硫脲与氧的光氧化得到N，N'-取代的碳二亚胺。碳二亚胺可以转化成氰胍，它们适用于环氧树脂的潜在固化剂。

4. 发明授权

US4883877A Azabicycloheptanes and process for their preparation 失效
标题翻译：氮杂双环庚烷及其制备方法
公开(公告)号：US4883877A
公开(公告)日：1989-11-28
申请号：US264584
申请日：1988-10-31
申请人： Alex Alder
发明人： Alex Alder
IPC分类号： C07D221/22 , C07F9/576
CPC分类号： C07D221/22
摘要： Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, for example, H, alkyl, cycloalkyl, aryl or alkaryl are suitable as an ammonium salt-forming component for acid pharmaceutical active ingredients, and in particular for the preparation of azabicyclo[3.1.1.]heptane-substituted alkanediphosphonic acids for the treatment of diseases which can be attributed to disturbances in calcium metabolism.
摘要翻译：其中R 1，R 2，R 3和R 4是例如H，烷基，环烷基，芳基或烷芳基的式I化合物（I）适合作为酸性药物活性成分的形成铵盐的组分，以及特别是制备氮杂二环[3.1.1]庚烷取代的烷二膦酸用于治疗可归因于钙代谢紊乱的疾病。

5. 发明授权

US4859761A Cyanoguanidines as hardeners for epoxy resins 失效
标题翻译：氰基胍作为环氧树脂的硬化剂
公开(公告)号：US4859761A
公开(公告)日：1989-08-22
申请号：US238638
申请日：1988-08-30
申请人： Peter Flury , Alex Alder
发明人： Peter Flury , Alex Alder
IPC分类号： C07C279/28 , C08G59/40
CPC分类号： C07C279/28 , C08G59/4021
摘要： Curable epoxy resin compositions containing cyanoguanidines of formula I ##STR1## wherein, for example, R.sup.1 and R.sup.2 are phenyl, as latent hardeners, have good properties and are especially suitable for use as laminating resins.
摘要翻译：含有式I的氰胍的可固化环氧树脂组合物（I）其中例如R1和R2为苯基作为潜在硬化剂，具有良好的性能，特别适用于层压树脂。

6. 发明授权

US4764640A Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds 失效
标题翻译：取代的氮杂双环庚烷，其用途，含有这些化合物的药物制剂，以及这些化合物的制造方法
公开(公告)号：US4764640A
公开(公告)日：1988-08-16
申请号：US32656
申请日：1987-04-01
申请人： Alex Alder , Jaroslaw Stanek , Daniel Bellus
发明人： Alex Alder , Jaroslaw Stanek , Daniel Bellus
IPC分类号： A61K31/435 , A61P35/00 , A61P43/00 , C07D211/88 , C07D221/22 , C07D311/00 , C12N9/99 , C07C101/447
CPC分类号： C07D221/22 , C07D311/00
摘要： 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
摘要翻译：式（Ⅰ）的1-苯基-3-氮杂双环[3.1.1] - 庚烷-2,4-二酮其中R 1表示氢或饱和或不饱和的脂族，脂环族，脂环族 - 脂族，脂族，芳族或具有至多并包括18个，优选至多且包含12个碳原子的芳族 - 脂族烃基，R 2表示氢，低级烷基，磺基或酰基，R 3表示氢或低级烷基，R 4表示氢，低级烷基，苯基或苯基被-N（R2）（R3）取代，并且这些化合物的盐具有有价值的药理学性质，作为芳香酶抑制剂是有效的，因此可用于治疗激素依赖性疾病，特别是乳腺癌。

7. 发明授权

US5206388A Process for the preparation of 5,6,11,12-tetrathiotetracene 失效
标题翻译：制备5,6,11,12-四氯乙烯的方法
公开(公告)号：US5206388A
公开(公告)日：1993-04-27
申请号：US872735
申请日：1992-04-22
申请人： Alex Alder
发明人： Alex Alder
IPC分类号： C07D495/06 , H01B1/12
CPC分类号： C07D495/06 , H01B1/121
摘要： The reaction of 5,6,11,12-tetrachlorotetracene with thiourea and sulfur in a polar aprotic solvent yields 5,6,11,12-tetrathiotetracene in high yield and purity. This compound is an electron donor for forming electrically conductive radical cation salts with electron donors.
摘要翻译： 5,6,11,12-四氯并苯与硫脲和硫在极性非质子溶剂中的反应产生高产率和纯度的5,6,11,12-四硫四丁烯。该化合物是用于与电子给体形成导电自由基阳离子盐的电子给体。

8. 发明授权

US4857660A Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compounds 失效
标题翻译：某些1-苯基 - 环丁烷-1,3-二羧酸类化合物
公开(公告)号：US4857660A
公开(公告)日：1989-08-15
申请号：US185205
申请日：1988-04-22
申请人： Alex Alder , Jaroslav Stanek , Daniel Bellus
发明人： Alex Alder , Jaroslav Stanek , Daniel Bellus
IPC分类号： A61K31/435 , A61P35/00 , A61P43/00 , C07D211/88 , C07D221/22 , C07D311/00 , C12N9/99
CPC分类号： C07D221/22 , C07D311/00
摘要： 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
摘要翻译：式（I）的1-苯基-3-氮杂双环[3.1.1] - 庚烷-2,4-二酮其中R 1表示氢或饱和或不饱和的脂族，脂环族，脂环族 - 脂族，芳族或芳族具有至多并包括18个，优选至多且包含12个碳原子的芳族 - 脂族烃基，R 2表示氢，低级烷基，磺基或酰基，R 3表示氢或低级烷基，R 4表示氢，低级烷基，苯基或苯基被-N（R2）（R3）取代，并且这些化合物的盐具有有价值的药理学性质，作为芳香酶抑制剂是有效的，因此可用于治疗激素依赖性疾病，特别是乳腺癌。

9. 发明授权

US4677129A Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for treating hormone-dependent diseases 失效
标题翻译：可用于治疗激素依赖性疾病的取代的3-氮杂双环[3.1.1]庚烷-2,4-二硫杂
公开(公告)号：US4677129A
公开(公告)日：1987-06-30
申请号：US746814
申请日：1985-06-20
申请人： Alex Alder , Jaroslav Stanek , Daniel Bellus
发明人： Alex Alder , Jaroslav Stanek , Daniel Bellus
IPC分类号： A61K31/435 , A61P35/00 , A61P43/00 , C07D211/88 , C07D221/22 , C07D311/00 , C12N9/99
CPC分类号： C07D221/22 , C07D311/00
摘要： 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
摘要翻译：式（Ⅰ）的1-苯基-3-氮杂双环[3.1.1] - 庚烷-2,4-二酮其中R 1表示氢或饱和或不饱和的脂族，脂环族，脂环族 - 脂族，脂族，芳族或具有至多并包括18个，优选至多且包含12个碳原子的芳族 - 脂族烃基，R 2表示氢，低级烷基，磺基或酰基，R 3表示氢或低级烷基，R 4表示氢，低级烷基，苯基或苯基被-N（R2）（R3）取代，并且这些化合物的盐具有有价值的药理学性质，作为芳香酶抑制剂是有效的，因此可用于治疗激素依赖性疾病，特别是乳腺癌。

10. 发明授权

US6165800A Chemiluminescent energy transfer conjugates and their uses as labels in binding assays 失效
标题翻译：化学发光能量转移共轭物及其用作结合测定中的标记物
公开(公告)号：US6165800A
公开(公告)日：2000-12-26
申请号：US86003
申请日：1998-05-27
申请人： Qingping Jiang , Jun Xi , Anand Natrajan , David Sharpe , Marcus Baumann , Rolf Hilfiker , Erika Schmidt , Paul Senn , Fritz Thommen , Adrian Waldner , Alex Alder , Say-Jong Law
发明人： Qingping Jiang , Jun Xi , Anand Natrajan , David Sharpe , Marcus Baumann , Rolf Hilfiker , Erika Schmidt , Paul Senn , Fritz Thommen , Adrian Waldner , Alex Alder , Say-Jong Law
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58 , C07D227/00 , G01N33/553
CPC分类号： C09B15/00 , C09B11/04 , G01N33/533 , G01N33/542 , G01N33/582 , Y10S436/80 , Y10S436/816 , Y10S436/817
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.
摘要翻译：通过在吖啶鎓或苯并吖啶鎓化合物和发光体之间形成分子内能量转移缀合物（ETC），公开了一类新的化学发光吖啶鎓或苯并吖啶鎓化合物。公开了延长吖啶鎓或苯并吖啶酯的发射波长以进一步减少或消除母体多取代芳基吖啶酯（DMAE）和苯并吖啶酯（LEAE）之间的发射光谱重叠的方法。 ETC保留吖啶鎓或苯并吖啶鎓化合物独特的所需性质，包括在很短的时间内完全发光，单相发射光谱，触发机制简单，标记生物分子的能力，形成示踪剂，以及良好的稳定性。此外，吖啶鎓或苯并吖啶鎓化合物的发射光谱的范围现在可以随意移动，并且通过选择发光体作为ETC分子的组成部分而更长的跨越。公开了化学发光标记的缀合物，其包含通过间隔基共价连接到发光体的吖啶鎓或苯并吖啶鎓部分，所述部分还与感兴趣的生物分子缀合，其中所述间隔物具有适当长度以允许从所述部分产生的激发物质转移能量有效地发送到所述发光体，导致发光在所述发光体的光谱区域。还公开了使用所述缀合物的结合测定法，包含所述缀合物的测试试剂盒和制备缀合物的方法。

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