会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明授权
    • Glycyl urea derivatives as anti-convulsants
    • 甘氨酰脲衍生物作为抗惊厥药
    • US5288905A
    • 1994-02-22
    • US761111
    • 1991-09-17
    • Alex A. CordiClaude L. Gillet
    • Alex A. CordiClaude L. Gillet
    • C07C275/50C07C275/48
    • C07C275/50
    • A class of glycyl urea derivatives is described having use in treatment of CNS dysfunctions such as epilepsy and convulsive disorders. Compounds of interest are those of the formula ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group independently selected from hydrido, alkyl, aralkyl, aryloxyalkyl and arylthioalkyl, any one of which groups having a substitutable position may be substituted with one or more radicals selected from halo, alkyl of one to about ten carbon atoms, alkenyl of two to about ten carbon atoms, alkynyl of two to about ten carbon atoms, haloalkyl, alkoxy, alkylthio, alkylsulfinyl and alkylsulfonyl; or a pharmaceutically-acceptable salt thereof; with the proviso that when each of R.sup.1 and R.sup.2 is ethyl, then R.sup.3 and R.sup.4 cannot be hydrido simultaneously.
    • 描述了一类甘氨酰脲衍生物用于治疗CNS功能障碍如癫痫和惊厥性疾病。 感兴趣的化合物是式(*化学结构*)的化合物,其中R 1,R 2,R 3和R 4各自独立地选自氢,烷基,芳烷基,芳氧基烷基和芳硫基烷基,其中任何一个具有可取代位置的基团 被一个或多个选自卤素,1至约10个碳原子的烷基,2至约10个碳原子的烯基,2至约10个碳原子的炔基,卤代烷基,烷氧基,烷硫基,烷基亚磺酰基和烷基磺酰基取代; 或其药学上可接受的盐; 条件是当R 1和R 2各自为乙基时,则R 3和R 4不能同时氢化。