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1. 发明申请

US20190209489A1 COMPOSITION FOR EYE HEALTH 审中-公开
公开(公告)号：US20190209489A1
公开(公告)日：2019-07-11
申请号：US15866450
申请日：2018-01-09
申请人： Aleksandra Niedzwiecki , Matthias W. Rath , Anna Goc , Waldemar Sumera
发明人： Aleksandra Niedzwiecki , Matthias W. Rath , Anna Goc , Waldemar Sumera
IPC分类号： A61K31/07 , A61K31/375 , A61K31/355 , A61K31/198 , A61K31/385 , A61K31/047 , A61K31/01 , A61K36/28 , A61K36/15 , A61K36/87 , A61K36/45 , A61K33/30 , A61P27/02
CPC分类号： A61K31/07 , A23K20/174 , A23L33/105 , A61K8/27 , A61K31/01 , A61K31/047 , A61K31/198 , A61K31/355 , A61K31/375 , A61K31/385 , A61K33/30 , A61K36/15 , A61K36/28 , A61K36/45 , A61K36/87 , A61K36/88 , A61P27/02
摘要： The nutrient mixture made up of vitamin, carotenoid, micronutrient, essential trace element, and plant extract was much more effective in proactively protecting the corneal cells (human) and retinal pigment endothelial cells (rat) against damaging effects of H2O2 and glycosylated proteins (AGE-BSA) compared to its individual components. A mixture is made up of vitamin A, vitamin C, vitamin E, Lycopene, lutein, marigold flower extract, a saffron extract, pine bark extract, grape seed extract, bilberry extract, lipoic acid, L-Arginine and zinc.

2. 发明申请

US20160106777A1 NOVEL COMPOSITION METHOD OF USING THE SAME FOR THE TREATMENT OF LYME DISEASE 审中-公开
标题翻译：使用它们治疗LYME疾病的新型组合物方法
公开(公告)号：US20160106777A1
公开(公告)日：2016-04-21
申请号：US14517887
申请日：2014-10-19
申请人： Matthias W. Rath , Aleksandra Niedzwiecki , Anna Goc
发明人： Matthias W. Rath , Aleksandra Niedzwiecki , Anna Goc
IPC分类号： A61K33/18 , A61K31/201 , A61K31/23 , A61K31/353 , A61K31/216 , A61K31/375 , A61K31/51 , A61K31/525 , A61K31/455 , A61K31/191 , A61K31/4415 , A61K31/4188 , A61K31/519 , A61K31/714 , A61K31/593
CPC分类号： A61K33/18 , A61K31/05 , A61K31/13 , A61K31/19 , A61K31/191 , A61K31/195 , A61K31/197 , A61K31/20 , A61K31/201 , A61K31/216 , A61K31/22 , A61K31/23 , A61K31/231 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/375 , A61K31/4188 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/593 , A61K31/675 , A61K31/7048 , A61K31/714 , A61K31/737 , A61K36/03 , A61K36/185 , A61K36/35 , A61K36/53 , A61K36/73 , A61K36/87 , A61K45/06 , A61K2300/00 , Y02A50/401
摘要： A composition for treating Lyme disease caused by Borrelia Species, comprising a vitamin, a small fatty acid signaling molecule, an essential amino acid, a flavonoid, a plant extract and a mineral.
摘要翻译：用于治疗由疏螺旋体种引起的莱姆病的组合物，其包含维生素，小脂肪酸信号分子，必需氨基酸，类黄酮，植物提取物和矿物质。

3. 发明授权

US08968004B2 Integrated multimedia tool system and method to explore and study the virtual human body 有权
标题翻译：综合多媒体工具系统和方法，探索和研究虚拟人体
公开(公告)号：US08968004B2
公开(公告)日：2015-03-03
申请号：US13209382
申请日：2011-08-13
申请人： Matthias W. Rath , Aleksandra Niedzwiecki
发明人： Matthias W. Rath , Aleksandra Niedzwiecki
IPC分类号： G09B23/28 , G09B5/06
CPC分类号： G09B23/28 , G09B5/06
摘要： Several methods, processes and system for modular tool as an integrated multimedia tool system to explore and study the virtual human body is disclosed. Content and context modules allow for scientific gaming using modular multimedia objects, social media and different configurations. The disclosure allows an individual to travel through the virtual human body in a self guided and interactive tour. It specifically enables the user to learn the structure and function of different organs, different types of cells, intercellular space as well as different cellular organelles etc. Further, the system may be used by the local authority as an electronic study tool for seamless integrated mode of delivering the educational tool suited to the local curriculum. This may also serve as a tool for patients, doctors, focus groups and student to explore and learn about the pathological and physiological conditions in a human body.
摘要翻译：披露了多种模块化工具的方法，过程和系统，作为综合多媒体工具系统，探索和研究虚拟人体。内容和上下文模块允许使用模块化多媒体对象，社交媒体和不同配置的科学游戏。该公开允许个人以自我指导和互动的方式旅行通过虚拟人体。它具体使用户能够了解不同器官，不同类型的细胞，细胞间隙以及不同的细胞器等的结构和功能。此外，该系统可被地方当局用作无缝集成模式的电子学习工具提供适合当地课程的教育工具。这也可以作为病人，医生，焦点小组和学生探索和了解人体病理和生理状况的工具。

4. 发明申请

US20130011423A1 METALLOPROTEINASE OLIGOPEPTIDES AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：金属蛋白酶寡核苷酸及其治疗用途
公开(公告)号：US20130011423A1
公开(公告)日：2013-01-10
申请号：US13549329
申请日：2012-07-13
申请人： Matthias W. Rath , Aleksandra Niedzwiecki , Waheed M. Roomi
发明人： Matthias W. Rath , Aleksandra Niedzwiecki , Waheed M. Roomi
IPC分类号： A61K38/48 , C12Q1/37 , A61P35/00
CPC分类号： G02B5/1861 , A61K38/4886 , A61K39/0011 , A61K2039/6081 , C12N9/6491 , G02B5/18 , G02B5/1857 , G02B5/3058
摘要： The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides, SEQID 5-SEQID 21. These oligopeptides are bound to antibodies to create an immune response in the subject mammal against the matrix metalloproteinases of various diseases. This is a means of therapeutic intervention against the disease spread created by the matrix metalloproteinases. Further use of these oligopeptide-antibody responses can be extended to any and all diseases that use the matrix metalloproteinases to aid in their pathogenicity.
摘要翻译：本发明公开了基质金属蛋白酶寡肽SEQ ID 5-SEQ ID 21的鉴定和治疗用途。这些寡肽与抗体结合以在受试哺乳动物中产生针对各种疾病的基质金属蛋白酶的免疫应答。这是针对由基质金属蛋白酶产生的疾病传播的治疗干预手段。这些寡肽 - 抗体应答的进一步使用可以扩展到使用基质金属蛋白酶的任何和所有疾病以帮助其致病性。

5. 发明申请

US20130040273A1 INTEGRATED MULTIMEDIA TOOL SYSTEM AND METHOD TO EXPLORE AND STUDY THE VIRTUAL HUMAN BODY 有权
标题翻译：综合多媒体工具系统和探索虚拟人体的方法
公开(公告)号：US20130040273A1
公开(公告)日：2013-02-14
申请号：US13209382
申请日：2011-08-13
申请人： Matthias W. Rath , Aleksandra Niedzwiecki
发明人： Matthias W. Rath , Aleksandra Niedzwiecki
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , G09B5/06
摘要： Several methods, processes and system for modular tool as an integrated multimedia tool system to explore and study the virtual human body is disclosed. Content and context modules allow for scientific gaming using modular multimedia objects, social media and different configurations. The disclosure allows an individual to travel through the virtual human body in a self guided and interactive tour. It specifically enables the user to learn the structure and function of different organs, different types of cells, intercellular space as well as different cellular organelles etc. Further, the system may be used by the local authority as an electronic study tool for seamless integrated mode of delivering the educational tool suited to the local curriculum. This may also serve as a tool for patients, doctors, focus groups and student to explore and learn about the pathological and physiological conditions in a human body.
摘要翻译：披露了多种模块化工具的方法，过程和系统，作为综合多媒体工具系统，探索和研究虚拟人体。内容和上下文模块允许使用模块化多媒体对象，社交媒体和不同配置的科学游戏。该公开允许个人以自我指导和互动的方式旅行通过虚拟人体。它具体使用户能够了解不同器官，不同类型的细胞，细胞间隙以及不同的细胞器等的结构和功能。此外，该系统可被地方当局用作无缝集成模式的电子学习工具提供适合当地课程的教育工具。这也可以作为病人，医生，焦点小组和学生探索和了解人体病理和生理状况的工具。

6. 发明授权

US10968441B2 Metalloproteinase-9 oligopeptides and their therapeutic use 有权
公开(公告)号：US10968441B2
公开(公告)日：2021-04-06
申请号：US13859748
申请日：2013-04-10
申请人： Matthias W. Rath
发明人： Matthias W. Rath , Aleksandra Niedzwiecki , Waheed M Roomi
IPC分类号： C12N9/50 , C12N9/64 , A61K38/48
摘要： The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides, SEQ ID NO: wherein the matrix metalloproteinase oligopeptide is at least one of SEQ ID NO: 7, 11, 12, 18 and 19 and combination thereof. These oligopeptides are bound to antibodies to create an immune response in the subject mammal against the matrix metalloproteinases of various diseases. The instance method is a means of therapeutic intervention against the disease spread created by the matrix metalloproteinases. Further use of these oligopeptide-antibody responses can be extended to any and all diseases that use the matrix metalloproteinases to aid in their pathogenicity.

7. 发明授权

US5278189A Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A) 失效
标题翻译：用抗坏血酸盐和抑制脂蛋白结合的物质预防和治疗闭塞性心血管疾病（A）
公开(公告)号：US5278189A
公开(公告)日：1994-01-11
申请号：US557516
申请日：1990-07-24
申请人： Matthias W. Rath , Linus C. Pauling
发明人： Matthias W. Rath , Linus C. Pauling
IPC分类号： A61K31/375 , A61K31/195 , A61K31/34 , A61K31/44
CPC分类号： A61K31/375 , Y10S514/824
摘要： A method is provided for prevention and treatment of cardiovascular disease, such as atherosclerosis, by administering therapeutically effective dosages of a drug comprised of ascorbate, lipoprotein(a) binding inhibitors, and antioxidants.
摘要翻译：提供了通过施用治疗有效剂量的由抗坏血酸盐，脂蛋白（a）结合抑制剂和抗氧化剂组成的药物来预防和治疗心血管疾病如动脉粥样硬化的方法。

8. 发明授权

US5230996A Use of ascorbate and tranexamic acid solution for organ and blood vessel treatment prior to transplantation 失效
标题翻译：在移植前使用抗坏血酸和凝血酸溶液进行器官和血管治疗
公开(公告)号：US5230996A
公开(公告)日：1993-07-27
申请号：US556968
申请日：1990-07-24
申请人： Matthias W. Rath , Linus C. Pauling
发明人： Matthias W. Rath , Linus C. Pauling
IPC分类号： A61K31/375
CPC分类号： A61K31/375
摘要： A method and pharmaceutical agent are provided for the prevention and treatment of cardiovascular disease, particularly cardiovascular disease in the context of diabetic angiopathy, by-pass surgery, organ transplantation, and hemodialysis, by administering ascorbate and substances that inhibit the binding of lipoprotein (a) to blood vessel walls. The use of ascorbate and lipoprotein (a) binding inhibitors such as tranexamic acid in a temporary storage solution for blood vessels and organs prior to transplantation is also demonstrated.
摘要翻译：提供了一种方法和药剂，用于通过施用抗坏血酸盐和抑制脂蛋白结合的物质来预防和治疗心血管疾病，特别是在糖尿病性血管病，旁路手术，器官移植和血液透析的情况下的心血管疾病（a ）到血管壁。还证明了在移植之前在血管和器官的临时储存溶液中使用抗坏血酸和脂蛋白（a）结合抑制剂如氨甲环酸。

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