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1. 发明申请

US20120150147A1 SYSTEM AND METHOD FOR TREATING ISCHEMIC STROKE 审中-公开
标题翻译：用于处理等离子体的系统和方法
公开(公告)号：US20120150147A1
公开(公告)日：2012-06-14
申请号：US13312816
申请日：2011-12-06
申请人： Aleksandr Leynov , Dave Barry , Vikas Gupta , Soe Ngwe , Arani Bose
发明人： Aleksandr Leynov , Dave Barry , Vikas Gupta , Soe Ngwe , Arani Bose
IPC分类号： A61M25/10 , B23P17/04 , A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/008 , Y10T29/49826
摘要： A system for restoring blood flow through an occluded vessel in the cerebrovasculature is disclosed. The system includes a tubular element constructed of shape memory material eccentrically mounted on the distal end of an introducer. The walls of the tubular element are defined by standards and connectors, and the standards are oriented at an angle to the longitudinal axis of the tubular element. A method of manufacture of the system includes cutting a tube of shape memory material, conferring a twist on the cut tube, and heat setting the tube. The method further includes affixing the shape set tube to an introducer. A method of treatment using the system is also described.
摘要翻译：公开了一种通过脑血管系统中的闭塞血管恢复血流的系统。该系统包括由偏心安装在导引器的远端上的形状记忆材料构成的管状元件。管状元件的壁由标准件和连接器限定，并且标准件与管状元件的纵向轴线成一定角度。一种制造该系统的方法包括切割形状记忆材料管，赋予切割管上的扭曲，并对该管进行加热。该方法还包括将形状组合件附接到导引器。还描述了使用该系统的治疗方法。

2. 发明申请

US20070239261A1 Aneurysm occlusion system and method 审中-公开
标题翻译：动脉瘤闭塞系统及方法
公开(公告)号：US20070239261A1
公开(公告)日：2007-10-11
申请号：US11784236
申请日：2007-04-06
申请人： Arani Bose , David Barry , Vikas Gupta , Aleksandr Leynov , Delilah Hui
发明人： Arani Bose , David Barry , Vikas Gupta , Aleksandr Leynov , Delilah Hui
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61B17/12 , A61B17/12036 , A61B17/12118 , A61B90/39 , A61B2017/12054 , A61F2/844 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/3008 , A61F2002/823 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91575 , A61F2230/0008 , A61F2230/0034 , A61F2230/0054 , A61F2230/0091 , A61F2230/0095 , A61F2250/0098
摘要： An aneurysm occlusion device is positionable within a cerebral blood vessel covering a neck of an aneurysm on the blood vessel. The device includes a tubular element having a lumen surrounded by an occlusive sidewall including a plurality of gaps. The gaps are sufficiently small to cause at least partial occlusion against flow of blood from the blood vessel through the side wall into the aneurysm, but are expandable in response to a fluid pressure differential between a first area inside the lumen and a second area outside the lumen to allow flow of fluid through the side wall between the blood vessel and a side branch vessel.
摘要翻译：动脉瘤闭塞装置位于覆盖血管内的动脉瘤颈部的脑血管内。该装置包括管状元件，该管状元件具有由包括多个间隙的闭塞侧壁包围的内腔。间隙足够小以至少部分阻塞血液从血管通过侧壁流入动脉瘤，但是可响应于内腔内的第一区域和外腔内的第二区域之间的流体压力差而扩张内腔以允许流体流过血管和侧分支血管之间的侧壁。

3. 发明授权

US09655633B2 System and method for treating ischemic stroke 有权
公开(公告)号：US09655633B2
公开(公告)日：2017-05-23
申请号：US13253242
申请日：2011-10-05
申请人： Aleksander Leynov , Dave Barry , Vikas Gupta , Arani Bose
发明人： Aleksander Leynov , Dave Barry , Vikas Gupta , Arani Bose
IPC分类号： A61B17/221 , A61B17/22 , A61F2/01 , A61M25/10 , A61B17/00
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/00526 , A61B2017/22034 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052 , Y10T29/49826
摘要： A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.

4. 发明申请

US20120116440A1 SYSTEM AND METHOD FOR TREATING ISCHEMIC STROKE 有权
标题翻译：用于处理等离子体的系统和方法
公开(公告)号：US20120116440A1
公开(公告)日：2012-05-10
申请号：US13253242
申请日：2011-10-05
申请人： Aleksander Leynov , Dave Barry , Vikas Gupta , Arani Bose
发明人： Aleksander Leynov , Dave Barry , Vikas Gupta , Arani Bose
IPC分类号： A61F2/01 , B23P15/00
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/00526 , A61B2017/22034 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052 , Y10T29/49826
摘要： A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.
摘要翻译：用于治疗缺血性卒中的血栓栓塞去除系统，包括引导和闭塞导管，输送和抽吸导管，抽吸泵，血栓栓塞接收器和血栓栓塞分离器。

5. 发明授权

US08460312B2 System and method for treating ischemic stroke 有权
公开(公告)号：US08460312B2
公开(公告)日：2013-06-11
申请号：US13073645
申请日：2011-03-28
申请人： Arani Bose , Vikas Gupta , Sean Donohue , Delilah Hui
发明人： Arani Bose , Vikas Gupta , Sean Donohue , Delilah Hui
IPC分类号： A61M29/00 , A61B17/22
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052
摘要： A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.

6. 发明申请

US20110253525A1 THIN FILM SHAPE MEMORY ALLOY DEVICE AND METHOD 有权
标题翻译：薄膜形状记忆合金装置及方法
公开(公告)号：US20110253525A1
公开(公告)日：2011-10-20
申请号：US13171243
申请日：2011-06-28
申请人： A. David Johnson , Valery V. Martynov , Vikas Gupta , Arani Bose
发明人： A. David Johnson , Valery V. Martynov , Vikas Gupta , Arani Bose
IPC分类号： C23C14/35
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/9155 , C22F1/006 , C23C14/0005 , C23C14/14
摘要： A thin film device, such as an intravascular stent, is disclosed. The device is formed of a seamless expanse of thin-film (i) formed of a sputtered nitinol shape memory alloy, defining, in an austenitic state, an open, interior volume, having a thickness between 0.5-50 microns, having an austenite finish temperature Af below 37° C.; and demonstrating a stress/strain recovery greater than 3% at 37° C. The expanse can be deformed into a substantially compacted configuration in a martensitic state, and assumes, in its austenitic state, a shape defining such open, interior volume. Also disclosed is a sputtering method for forming the device.
摘要翻译：公开了一种薄膜装置，例如血管内支架。该装置由无定形的薄膜形成（i）由溅射的镍钛诺形状记忆合金形成，其以奥氏体状态限定具有0.5-50微米厚度的开放内部体积，具有奥氏体光洁度温度低于37℃。并且在37℃下表现出大于3％的应力/应变恢复。该膨胀物可以以马氏体状态变形为基本上压实的构造，并且以其奥氏体状态呈现限定这种敞开的内部体积的形状。还公开了一种用于形成该器件的溅射方法。

7. 发明申请

US20060058836A1 System and method for treating ischemic stroke 有权
公开(公告)号：US20060058836A1
公开(公告)日：2006-03-16
申请号：US11210634
申请日：2005-08-24
申请人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
发明人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
IPC分类号： A61M29/00
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052
摘要： A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.

8. 发明申请

US20140180377A1 ANEURYSM OCCLUSION SYSTEM AND METHOD 审中-公开
标题翻译： ANEURYSM OCCLUSION系统和方法
公开(公告)号：US20140180377A1
公开(公告)日：2014-06-26
申请号：US13722709
申请日：2012-12-20
申请人： Arani Bose , Vikas Gupta
发明人： Arani Bose , Vikas Gupta
IPC分类号： A61F2/07
CPC分类号： A61B17/12118 , A61B17/12172
摘要： An aneurysm occlusion system includes devices positionable within a cerebral blood vessel covering a neck of an aneurysm in the blood vessel. A component device includes an expandable tubular body, an expandable anchor, and a link connecting the body to the anchor. One or more devices deployed using a method according to the invention includes a novel feature that guarantees that the distal high coverage segment aligns with the neck of the aneurysm. A single device or multiple devices, used in conjunction with an embolic material or coil, may be combined to form a system according to the invention. When positioned and deployed strategically either alone or with a second device utilizing a method according to the invention, the system has a high coverage region covering a neck of an aneurysm, and a gap between the system and healthy vessel. The system and method prevent blood flow into an aneurysm while permitting blood flow through healthy vessel.
摘要翻译：动脉瘤闭塞系统包括可覆盖在血管内的动脉瘤颈部的脑血管内的装置。部件装置包括可膨胀管状体，可膨胀锚，以及将主体连接到锚固件的连杆。使用根据本发明的方法部署的一个或多个装置包括保证远端高覆盖段与动脉瘤颈部对准的新颖特征。与栓塞材料或线圈结合使用的单个装置或多个装置可以组合以形成根据本发明的系统。当采用根据本发明的方法单独或利用第二装置进行定位和部署时，系统具有覆盖动脉瘤颈部的高覆盖区域以及系统与健康血管之间的间隙。该系统和方法防止血液流入动脉瘤，同时允许血液流经健康血管。

9. 发明申请

US20140155931A1 SYSTEM AND METHOD FOR TREATING ISCHEMIC STROKE 有权
标题翻译：用于处理等离子体的系统和方法
公开(公告)号：US20140155931A1
公开(公告)日：2014-06-05
申请号：US13889201
申请日：2013-05-07
申请人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
发明人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052
摘要： A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.
摘要翻译：用于治疗缺血性卒中的血栓栓塞去除系统，包括引导和闭塞导管，输送和抽吸导管，抽吸泵，血栓栓塞接收器和血栓栓塞分离器。

10. 发明授权

US08366735B2 System and method for treating ischemic stroke 有权
标题翻译：缺血性脑卒中治疗系统及方法
公开(公告)号：US08366735B2
公开(公告)日：2013-02-05
申请号：US11210634
申请日：2005-08-24
申请人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
发明人： Arani Bose , Vikas Gupta , Sean Donahue , Delilah Hui
IPC分类号： A61M29/00 , A61B17/22
CPC分类号： A61B17/221 , A61B17/22 , A61B2017/22044 , A61B2017/2215 , A61B2217/005 , A61F2/013 , A61M2025/1052
摘要： A thromboembolic removal system for treating ischemic stroke includes an aspiration catheter and an elongate member having a separator on a distal portion of the elongate member. During use of the thromboembolic removal system, the aspiration catheter and elongate member are positioned in a blood vessel, with the elongate member extending through the lumen of the aspiration catheter. Vacuum is applied through the aspiration catheter and the separator is deployed distal to the aspiration catheter into contact with thromboembolic material within a blood vessel. Manipulation of the separator during aspiration can facilitate aspiration by loosening, separating, or softening pieces of thromboembolic material, by removing any clogs or flow restrictions within the lumen of the aspiration catheter, and/or by pushing or plunging loosened material towards and/or into the distal end of the aspiration catheter for subsequent aspiration out of the body.
摘要翻译：用于治疗缺血性中风的血栓栓塞去除系统包括抽吸导管和在细长构件的远端部分上具有隔离物的细长构件。在血栓栓塞去除系统的使用期间，吸引导管和细长构件定位在血管中，细长构件延伸穿过抽吸导管的内腔。通过抽吸导管施加真空，并且将分离器部署在吸引导管远端与血管内的血栓栓塞材料接触。抽吸期间分离器的操纵可以通过松开，分离或软化血栓栓塞材料片来促进抽吸，通过去除吸引导管的内腔内的任何堵塞物或流动限制，和/或通过将松动的材料推向或插入到/ 吸引导管的远端用于随后抽出身体。

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