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1. 发明申请

US20180104459A1 SHUNT FLUSHERS AND RELATED METHODS 审中-公开
公开(公告)号：US20180104459A1
公开(公告)日：2018-04-19
申请号：US15782247
申请日：2017-10-12
申请人： Alcyone Lifesciences, Inc.
发明人： PJ Anand , Deep Arjun Singh , Greg Eberl , Andrew East , Morgan Brophy , Ayesha Arzumand , Stela Moura , Loredana Guseila
IPC分类号： A61M27/00 , A61M39/22
摘要： Systems and methods for flushing shunt systems are disclosed herein. In some embodiments, a flusher includes a pinch tube that extends over a flush dome such that a user can simultaneously close the pinch tube and actuate the flush dome with a single motion. Flushing and refill valves of the system can be disposed in a cartridge that is laterally-offset from the flush dome, advantageously reducing the height profile of the flusher. Flushers with integrated shunt valves are also disclosed, as are shunt systems with restricted and unrestricted modes for selectively limiting the instances in which a user can open an auxiliary flow path through the system.

2. 发明授权

US09433764B2 Systems and methods for shunting fluid 有权
标题翻译：分流器的系统和方法
公开(公告)号：US09433764B2
公开(公告)日：2016-09-06
申请号：US14740478
申请日：2015-06-16
申请人： Alcyone Lifesciences, Inc.
发明人： Andrew East , Morgan Brophy , Deep Arjun Singh , PJ Anand , Robert Degon , Timothy Fallon , Allison Waller , Matthew Attar
IPC分类号： A61M27/00 , A61M39/22 , A61M39/00
CPC分类号： A61M27/006 , A61M39/225 , A61M2027/004 , A61M2039/0018
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.
摘要翻译：本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。还提供了内置流量指示器的导管。示例性的流动指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如，在磁共振成像（MRI）下可见的部分）的突出部。可以使用MRI检测由流体流过导管引起的流动指示器的运动，从而提供导管是否部分或完全阻塞的可靠指示。本文还公开了用于冲洗分流系统的系统和方法，以及用于打开通过分流系统的辅助流体路径的各种系统和方法。

3. 发明申请

US20150367110A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 有权
标题翻译：用于流体流动的系统和方法
公开(公告)号：US20150367110A1
公开(公告)日：2015-12-24
申请号：US14740478
申请日：2015-06-16
申请人： Alcyone Lifesciences, Inc.
发明人： Andrew East , Morgan Brophy , Deep Arjun Singh , PJ Anand , Robert Degon , Timothy Fallon , Allison Waller , Matthew Attar
IPC分类号： A61M27/00 , A61M39/22
CPC分类号： A61M27/006 , A61M39/225 , A61M2027/004 , A61M2039/0018
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.
摘要翻译：本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。还提供了内置流量指示器的导管。示例性的流动指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如，在磁共振成像（MRI）下可见的部分）的突出部。可以使用MRI检测由流体流过导管引起的流动指示器的运动，从而提供导管是否部分或完全阻塞的可靠指示。本文还公开了用于冲洗分流系统的系统和方法，以及用于打开通过分流系统的辅助流体路径的各种系统和方法。

4. 发明申请

US20190314574A1 DEVICES AND METHODS FOR PERCUTANEOUS LUNG INTRATUMORAL THERAPY DELIVERY 审中-公开
公开(公告)号：US20190314574A1
公开(公告)日：2019-10-17
申请号：US16286707
申请日：2019-02-27
申请人： ALCYONE LIFESCIENCES, INC.
发明人： Katelyn Perkins-Neaton , Gregory Eberl , Morgan Brophy , Andrew East , PJ Anand , Deep Arjun Singh , Loredana Guseila , Jon Freund , Derek Peter
IPC分类号： A61M5/168 , A61M25/00
摘要： Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.

5. 发明申请

US20190160254A1 Drug Delivery Systems and Methods 审中-公开
公开(公告)号：US20190160254A1
公开(公告)日：2019-05-30
申请号：US16192500
申请日：2018-11-15
申请人： ALCYONE LIFESCIENCES, INC.
发明人： PJ Anand , Morgan Brophy , Deep Arjun Singh , Greg Eberl , Ayesha Arzumand , Stela Moura , Andrew East , Jonathan Freund
IPC分类号： A61M25/00 , A61M25/10 , A61M39/02
摘要： Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

6. 发明授权

US10828424B2 Automated drug delivery systems and methods 有权
公开(公告)号：US10828424B2
公开(公告)日：2020-11-10
申请号：US15662416
申请日：2017-07-28
申请人： Alcyone Lifesciences, Inc.
发明人： PJ Anand , Ayesha Arzumand , Morgan Brophy , Andrew East , Gregory Eberl , Deep Arjun Singh
IPC分类号： A61M5/31 , A61M5/315 , A61M5/145 , A61M5/20 , A61M5/32 , A61M5/19
摘要： Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.

7. 发明申请

US20180064919A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 审中-公开
公开(公告)号：US20180064919A1
公开(公告)日：2018-03-08
申请号：US15654749
申请日：2017-07-20
申请人： Alcyone Lifesciences, Inc.
发明人： Andrew East , Morgan Brophy , Deep Arjun Singh , PJ Anand , Robert Degon , Timothy Fallon , Allison Waller , Matthew Attar
IPC分类号： A61M27/00 , A61M39/22 , A61M39/00
CPC分类号： A61M27/006 , A61M39/225 , A61M2027/004 , A61M2039/0018
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

8. 发明申请

US20170189656A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 审中-公开
公开(公告)号：US20170189656A1
公开(公告)日：2017-07-06
申请号：US15462599
申请日：2017-03-17
申请人： Alcyone Lifesciences, Inc.
发明人： PJ Anand , Deep Arjun Singh , Morgan Brophy , Timothy Fallon , Robert Degon , Matthew Attar , Anthony Wong , Allison Waller , Andrew East , Jon T. McIntyre
IPC分类号： A61M27/00 , A61M39/22
CPC分类号： A61M27/006 , A61M25/0108 , A61M25/0127 , A61M39/225 , A61M2025/0019 , A61M2039/0018 , A61M2205/0205 , A61M2205/32 , A61M2205/3344 , A61M2230/20
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

9. 发明授权

US09629987B2 Systems and methods for shunting fluid 有权
公开(公告)号：US09629987B2
公开(公告)日：2017-04-25
申请号：US14160768
申请日：2014-01-22
申请人： Alcyone Lifesciences, Inc.
发明人： P J Anand , Deep Arjun Singh , Morgan Brophy , Timothy Fallon , Robert Degon , Matthew Attar , Anthony Wong , Allison Waller , Andrew East , Jon T. McIntyre
IPC分类号： A61M5/00 , A61M27/00 , A61M39/22 , A61M25/00 , A61M39/00
CPC分类号： A61M27/006 , A61M39/225 , A61M2025/0019 , A61M2039/0018 , A61M2205/0205 , A61M2205/32 , A61M2205/3344 , A61M2230/20
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

10. 发明申请

US20150297874A1 SYSTEMS AND METHODS FOR SHUNTING FLUID 有权
公开(公告)号：US20150297874A1
公开(公告)日：2015-10-22
申请号：US14690389
申请日：2015-04-18
申请人： ALCYONE LIFESCIENCES, INC.
发明人： Andrew East , Morgan Brophy , Deep Arjun Singh , PJ Anand , Robert Degon , Timothy Fallon , Allison Waller , Matthew Attar
IPC分类号： A61M27/00 , A61M39/22
CPC分类号： A61M27/006 , A61M39/225 , A61M2027/004 , A61M2039/0018
摘要： Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

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