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1. 发明授权

US06902912B2 Process for producing glutathione 有权
标题翻译：谷胱甘肽生产方法
公开(公告)号：US06902912B2
公开(公告)日：2005-06-07
申请号：US10609561
申请日：2003-07-01
申请人： Alberto Benedetti , Enrico Giuseppe Roberto Berardi , Matilde Manzoni , Marina Nichele , Hermes Pagani , Manuela Rollini
发明人： Alberto Benedetti , Enrico Giuseppe Roberto Berardi , Matilde Manzoni , Marina Nichele , Hermes Pagani , Manuela Rollini
IPC分类号： C12P21/00 , C12P21/02 , C12R1/84 , C12P21/04 , C12P21/06
CPC分类号： C12P21/02
摘要： There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione producing yeast wherein the glutathione content per biomass unit is higher than 1.2% w/w; (b) the cultivation, in aerobic conditions, of the resulting biomass pre-culture such that the resulting biomass density is higher than 50 g/l; (c) the activation of the cultured biomass; and (d) the recovery of the cultured biomass, extracting glutathione at a pH equal to or lower than 6 and purifying the resulting glutathione. The process allows to obtain glutathione with high yields and relatively low costs.
摘要翻译：公开了用于产生谷胱甘肽的发酵方法，其包括（a）通过在需氧条件下预培养产生谷胱甘肽的酵母的菌株获得生物量预培养物，其中每个生物质单位的谷胱甘肽含量高于1.2％ w / w; （b）在需氧条件下培养所得生物质预培养物，使得所得生物质密度高于50g / l; （c）培养的生物质的活化; 和（d）培养的生物质的回收，在等于或低于6的pH下提取谷胱甘肽并纯化得到的谷胱甘肽。该方法允许以高产率和相对低的成本获得谷胱甘肽。

2. 发明授权

US08679786B2 Copper-enriched biomass, method for the preparation thereof and pro-biotic, cosmetic, dietary and nutraceutic products comprising the same 有权
标题翻译：富铜生物质，其制备方法和包含其的生物，化妆品，膳食和营养制品
公开(公告)号：US08679786B2
公开(公告)日：2014-03-25
申请号：US13054299
申请日：2009-07-15
申请人： Matilde Manzoni , Manuela Silvia Rollini , Alberto Benedetti
发明人： Matilde Manzoni , Manuela Silvia Rollini , Alberto Benedetti
IPC分类号： C12P21/04 , C12N1/00
CPC分类号： C12N1/18 , A23L33/135 , A23L33/14 , A23L33/16 , C12R1/865
摘要： The invention relates to a method for the preparation of a copper-enriched biomass, comprising, in a first step, culturing Saccharomyces cerevisiae yeast cells in a liquid nutrient medium comprising a carbon source, a nitrogen source, at least one amino acid and a copper salt, so as to obtain copper-enriched yeast biomass in the form of a Cu-GSH complex, wherein the intracellular content of Cu-GSH is higher than 1% dw and, in a second step, separating the copper-enriched yeast biomass from the nutrient liquid medium. Two strains of Saccharomyces cerevisiae are described, designated as SA 221 BM and SA 586 BM, respectively (accession numbers DSM 21530 and DSM 21531, deposited with the DSMZ on Jun. 6, 2008), which have the ability to accumulate particularly high levels of intracellular copper. Moreover, the invention relates to the copper-enriched yeast biomass obtainable by the method of the invention, which has an intracellular Cu-GSH content higher than 1% dw, and its use in cosmetic and probiotic products.
摘要翻译：本发明涉及一种制备富含铜的生物质的方法，包括在第一步中，在包含碳源，氮源，至少一个氨基酸和铜的液体营养培养基中培养酿酒酵母酵母盐，以获得Cu-GSH络合物形式的富铜酵母生物质，其中Cu-GSH的细胞内含量高于1％dw，并且在第二步中，将富含铜的酵母生物质从营养液介质。描述了两种酿酒酵母菌株，分别命名为SA 221 BM和SA 586 BM（登录号DSM 21530和DSM 21531，保藏于2008年6月6日的DSMZ），其具有积累特别高水平的能力细胞内铜。此外，本发明涉及通过本发明的方法获得的富含铜的酵母生物质，其具有高于1％dw的细胞内Cu-GSH含量，以及其在化妆品和益生菌产品中的用途。

3. 发明申请

US20110117604A1 COPPER-ENRICHED BIOMASS, METHOD FOR THE PREPARATION THEREOF AND PRO-BIOTIC , COSMETIC, DIETARY AND NUTRACEUTIC PRODUCTS COMPRISING THE SAME 有权
标题翻译：富铜生物质，其制备方法和生物化学，化妆品，膳食和包含其的营养产品
公开(公告)号：US20110117604A1
公开(公告)日：2011-05-19
申请号：US13054299
申请日：2009-07-15
申请人： Matilde Manzoni , Manuela Silvia Rollini , Alberto Benedetti
发明人： Matilde Manzoni , Manuela Silvia Rollini , Alberto Benedetti
IPC分类号： C12P21/02 , C12N1/16
CPC分类号： C12N1/18 , A23L33/135 , A23L33/14 , A23L33/16 , C12R1/865
摘要： The invention relates to a method for the preparation of a copper-enriched biomass, comprising, in a first step, culturing Saccharomyces cerevisiae yeast cells in a liquid nutrient medium comprising a carbon source, a nitrogen source, at least one amino acid and a copper salt, so as to obtain copper-enriched yeast biomass in the form of a Cu-GSH complex, wherein the intracellular content of Cu-GSH is higher than 1% dw and, in a second step, separating the copper-enriched yeast biomass from the nutrient liquid medium. Two strains of Saccharomyces cerevisiae are described, designated as SA 221 BM and SA 586 BM, respectively (accession numbers DSM 21530 and DSM 21531, deposited with the DSMZ on Jun. 6, 2008), which have the ability to accumulate particularly high levels of intracellular copper. Moreover, the invention relates to the copper-enriched yeast biomass obtainable by the method of the invention, which has an intracellular Cu-GSH content higher than 1% dw, and its use in cosmetic and probiotic products.
摘要翻译：本发明涉及一种制备富含铜的生物质的方法，包括在第一步中，在包含碳源，氮源，至少一个氨基酸和铜的液体营养培养基中培养酿酒酵母酵母盐，以获得Cu-GSH络合物形式的富铜酵母生物质，其中Cu-GSH的细胞内含量高于1％dw，并且在第二步中，将富含铜的酵母生物质从营养液介质。描述了两种酿酒酵母菌株，分别命名为SA 221 BM和SA 586 BM（登录号DSM 21530和DSM 21531，保藏于2008年6月6日的DSMZ），其具有积累特别高水平的能力细胞内铜。此外，本发明涉及通过本发明的方法获得的富含铜的酵母生物质，其具有高于1％dw的细胞内Cu-GSH含量，以及其在化妆品和益生菌产品中的用途。

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