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1. 发明申请

US20060148808A1 Substituted heterocycle fused gamma-carbolines 有权
标题翻译：取代的杂环稠合的γ-咔啉
公开(公告)号：US20060148808A1
公开(公告)日：2006-07-06
申请号：US11375125
申请日：2006-03-14
申请人： Albert Robichaud , Taekyu Lee , Wei Deng , Ian Mitchell , Michael Yang , Simon Haydar , Wenting Chen , Christopher McClung , Emilie Calvello , David Zawrotny
发明人： Albert Robichaud , Taekyu Lee , Wei Deng , Ian Mitchell , Michael Yang , Simon Haydar , Wenting Chen , Christopher McClung , Emilie Calvello , David Zawrotny
IPC分类号： A61K31/498 , C07D487/14
CPC分类号： C07D471/06 , C07D221/18 , C07D223/32 , C07D471/16 , C07D487/06 , C07D491/06 , C07D495/06 , C07D513/06 , C07D513/16 , C07D519/00
摘要： The present invention is directed to compounds useful for treating addictive behavior and sleep disorders represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The compounds used in the method of treatment of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including addictive behavior and sleep disorders.
摘要翻译：本发明涉及可用于治疗由结构式（I）或其药学上可接受的盐形式表示的成瘾行为和睡眠障碍的化合物，其中R 1，R 5， R 6a，R 6b，R 7，R 8，R 9， X，b，k，m和n，这里描述虚线。用于治疗本发明的方法中的化合物是血清素激动剂和拮抗剂，并且可用于控制或预防中枢神经系统疾病，包括上瘾行为和睡眠障碍。

2. 发明授权

US09214144B1 System and method for generating song transitions using measure groupings 有权
标题翻译：使用度量分组生成歌曲转换的系统和方法
公开(公告)号：US09214144B1
公开(公告)日：2015-12-15
申请号：US13950276
申请日：2013-07-24
申请人： Michael Yang
发明人： Michael Yang
IPC分类号： G10H1/36 , G10H1/08
CPC分类号： G10H1/08 , G10H1/46 , G10H7/008 , G10H2210/381 , G10H2210/385 , G10H2220/086 , G10H2250/035
摘要： A system and method are provided for mixing song data based on measure groupings. A player or program may recognize measure groupings in a song through identifying cuepoints. The player or program may use the cuepoints and/or other identifiers of measure groupings to generate a transition between the song and other songs. Parts of one or both songs may be time-stretched, or frames may be added or deleted, such that the beats in both songs are substantially aligned during the transition. The system and method may also involve altering the sequence of frames in one or both of the songs, so that the transition may have various sonic qualities as desired by a user. A choice of transition modes may be provided via a user interface that allow the user some control over when and how transitions between songs are executed.
摘要翻译：提供了一种基于测量分组来混合歌曲数据的系统和方法。播放器或程序可以通过识别曲线来识别歌曲中的测量分组。播放器或程序可以使用度量分组的点和/或其他标识符来产生歌曲和其他歌曲之间的转换。一首或两首歌曲的部分可能是时间延长的，或者可以添加或删除帧，使得两首歌曲中的节拍在转换期间基本对准。系统和方法还可以涉及改变一个或两个歌曲中的帧序列，使得转换可以具有如用户所期望的各种声音质量。转换模式的选择可以通过用户界面来提供，其允许用户对歌曲之间的转换何时以及如何进行控制。

3. 发明授权

US09111519B1 System and method for generating cuepoints for mixing song data 有权
标题翻译：用于生成用于混合歌曲数据的曲线的系统和方法
公开(公告)号：US09111519B1
公开(公告)日：2015-08-18
申请号：US13282432
申请日：2011-10-26
申请人： Michael Yang , Neel U. Sukhatme
发明人： Michael Yang , Neel U. Sukhatme
IPC分类号： G10H1/36 , G10H7/00 , G10H1/40
CPC分类号： G10H1/40 , G10H2210/385 , G10H2220/126 , G10H2240/325 , G11B27/038 , G11B27/322
摘要： A system and method are provided for generating cuepoints for mixing song data. One or more people may listen to a song and identify measure groupings within the song. The one or more people might generate markings corresponding to these measure groupings and submit the markings to a cuepoint generation system. The markings may then be reconciled into cuepoints that may be used for mixing the song with other song data. In some embodiments, the cuepoints may be adjusted based on characteristics of the particular songs that are to be mixed together.
摘要翻译：提供了一种用于产生用于混合歌曲数据的点的系统和方法。一个或多个人可以听歌曲，并在歌曲中识别测量组。一个或多个人可能产生与这些度量分组相对应的标记，并将标记提交给一个生成系统。然后可以将标记调整成可用于将歌曲与其他歌曲数据混合的连接点。在一些实施例中，可以基于要混合在一起的特定歌曲的特征来调整节点。

4. 发明授权

US09002478B1 Passive fixation for epicardial lead 有权
标题翻译：被动固定为心外膜导联
公开(公告)号：US09002478B1
公开(公告)日：2015-04-07
申请号：US13036821
申请日：2011-02-28
申请人： Michael Yang , Wenbo Hou , Sheldon Williams
发明人： Michael Yang , Wenbo Hou , Sheldon Williams
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0587
摘要： An epicardial lead is passively fixed in a pericardial space by a passive fixation member. The passive fixation member extends from a distal portion of an epicardial lead and acts against a pericardial layer and an epicardial layer to hold the lead in place. The epicardial lead may include an electrode that is connected to a conductor that extends from a distal portion of the lead. In some embodiments the epicardial lead includes a material that promotes fibrosis to fix the lead to heart tissue. The passive fixation member may include a shocking coil.
摘要翻译：心外膜由被动固定构件被动地固定在心包空间中。被动固定构件从心外膜引导件的远端部分延伸并作用于心包层和心外膜层以将引线保持在适当位置。心外膜引线可以包括连接到从引线的远端部分延伸的导体的电极。在一些实施方案中，心外膜引线包括促进纤维化以将引线固定到心脏组织的材料。被动固定构件可包括震动线圈。

5. 发明授权

US08478388B2 Cardiac coordinate system for motion analysis 有权
标题翻译：用于运动分析的心脏坐标系
公开(公告)号：US08478388B2
公开(公告)日：2013-07-02
申请号：US12755359
申请日：2010-04-06
申请人： Thao Thu Nguyen , Kjell Norén , Allen Keel , Kyungmoo Ryu , Stuart Rosenberg , Wenbo Hou , Steve Koh , Michael Yang
发明人： Thao Thu Nguyen , Kjell Norén , Allen Keel , Kyungmoo Ryu , Stuart Rosenberg , Wenbo Hou , Steve Koh , Michael Yang
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/042 , A61B5/7203 , A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36578 , A61N1/3684 , A61N1/37258 , A61N1/37264
摘要： An exemplary method includes accessing cardiac information acquired via a catheter located at various positions in a venous network of a heart of a patient wherein the cardiac information comprises position information with respect to time for one or more electrodes of the catheter; performing a principal component analysis on at least some of the position information; and selecting at least one component of the principal component analysis to represent an axis of a cardiac coordinate system. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括访问经由位于患者心脏的静脉网络中的各个位置的导管获取的心脏信息，其中所述心脏信息包括相对于导管的一个或多个电极的时间的位置信息; 对至少一些所述位置信息进行主成分分析; 以及选择所述主成分分析的至少一个分量来表示心脏坐标系的轴。还公开了各种其它方法，装置，系统等。

6. 发明授权

US08346372B2 Motion-based optimization for placement of cardiac stimulation electrodes 有权
标题翻译：基于运动的心脏刺激电极放置优化
公开(公告)号：US08346372B2
公开(公告)日：2013-01-01
申请号：US13416211
申请日：2012-03-09
申请人： Michael Yang , Euljoon Park , Kyungmoo Ryu , Stuart Rosenberg , Michael J. Coyle
发明人： Michael Yang , Euljoon Park , Kyungmoo Ryu , Stuart Rosenberg , Michael J. Coyle
IPC分类号： A61N1/00 , A61B5/02 , A61B5/05
CPC分类号： A61N1/056 , A61B5/0422 , A61B5/06 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N2001/0585
摘要： An exemplary method includes use of a multielectrode device that can help position a cardiac stimulation lead to an optimal site in the heart based at least in part on cardiac motion information acquired via the multielectrode device and one or more pairs of current delivery electrodes that establish potential fields (e.g., for use as a coordinate system). An exemplary mutlielectrode device may be a multielectrode catheter or a multifilar, electrode-bearing guidewire. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用多电极装置，其可以帮助将心脏刺激引导定位到心脏中的最佳部位，至少部分地基于通过多电极装置获取的心脏运动信息和建立潜在的一对或多对电流输送电极字段（例如，用作坐标系）。示例性的聚电极装置可以是多电极导管或多针，电极轴承导丝。还公开了各种其它示例性方法，装置，系统等。

7. 发明申请

US20120257675A1 SCALABLE VIDEO CODEC ENCODER DEVICE AND METHODS THEREOF 审中-公开
标题翻译：可扩展视频编解码器编码器及其方法
公开(公告)号：US20120257675A1
公开(公告)日：2012-10-11
申请号：US13084142
申请日：2011-04-11
申请人： Bob Wang , Michael Yang , Xiangjun Zhang , Xin Guo , Xu Gang Zhao
发明人： Bob Wang , Michael Yang , Xiangjun Zhang , Xin Guo , Xu Gang Zhao
IPC分类号： H04N7/26 , H04N7/32
CPC分类号： H04N19/33 , H04N19/42
摘要： Encoding a video signal according to a scalable video coding (SVC) technique employs two different encoding paths for the base layer and the enhancement layers respectively, whereby the two encoding paths share common hardware encoding modules. For example, a control module can route received video information associated with the base layer directly to the hardware encoder modules for encoding, while routing video information associated with the enhancement layers to an upscaler. The upscaled video information is then provided to the hardware encoder module for processing in similar fashion to the base layer information. The hardware encoder provides encoded video information to another control module, which determines whether to route the information to a hardware or software entropy encoder, based on whether the encoded video information is associated with the base layer or an enhancement layer, respectively.
摘要翻译：根据可伸缩视频编码（SVC）技术编码视频信号分别为基本层和增强层使用两种不同的编码路径，由此两个编码路径共享共同的硬件编码模块。例如，当将与增强层相关联的视频信息路由到升档器时，控制模块可以将接收到的与基本层相关联的视频信息直接路由到硬件编码器模块进行编码。然后将放大的视频信息提供给硬件编码器模块，以与基本层信息类似的方式进行处理。硬件编码器将编码视频信息提供给另一个控制模块，该控制模块基于编码视频信息是分别与基本层还是增强层相关联来确定是否将信息路由到硬件或软件熵编码器。

8. 发明授权

US08195292B2 Cardiac resynchronization therapy optimization using parameter estimation from realtime electrode motion tracking 有权
标题翻译：心脏再同步治疗优化使用实时电极运动跟踪的参数估计
公开(公告)号：US08195292B2
公开(公告)日：2012-06-05
申请号：US12398460
申请日：2009-03-05
申请人： Stuart Rosenberg , Kjell Noren , Kyungmoo Ryu , Wenbo Hou , Allen Keel , Michael Yang
发明人： Stuart Rosenberg , Kjell Noren , Kyungmoo Ryu , Wenbo Hou , Allen Keel , Michael Yang
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/0422 , A61B5/06 , A61B34/20 , A61N1/36578 , A61N1/3684 , A61N1/37235 , G06F19/00 , G06F19/3481 , G16H40/63 , G16H50/50
摘要： An exemplary method includes providing at least two-dimensional position information, for at least two points in time, for an electrode located in a cardiac space; determining a local estimator based on the position information; and, based at least in part on the determined local estimator, selecting a configuration for delivering a cardiac pacing therapy or diagnosing a cardiac condition. Exemplary methods for regional estimators and exemplary methods for global estimators are also disclosed along with devices and systems configured to perform various methods.
摘要翻译：一种示例性方法包括为至少两个时间点为位于心脏空间中的电极提供至少二维位置信息; 基于所述位置信息确定本地估计器; 并且至少部分地基于所确定的本地估计器，选择用于递送心脏起搏治疗或诊断心脏病症的配置。还公开了用于全局估计器的区域估计器和示例性方法的示例性方法以及被配置为执行各种方法的设备和系统。

9. 发明授权

US08155756B2 Motion-based optimization for placement of cardiac stimulation electrodes 有权
标题翻译：基于运动的心脏刺激电极放置优化
公开(公告)号：US08155756B2
公开(公告)日：2012-04-10
申请号：US12392964
申请日：2009-02-25
申请人： Michael Yang , Euljoon Park , Kyungmoo Ryu , Stuart Rosenberg , Michael J. Coyle
发明人： Michael Yang , Euljoon Park , Kyungmoo Ryu , Stuart Rosenberg , Michael J. Coyle
IPC分类号： A61N1/00 , A61B5/05 , A61B5/02
CPC分类号： A61N1/056 , A61B5/0422 , A61B5/06 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N2001/0585
摘要： An exemplary method includes use of a multielectrode device that can help position a cardiac stimulation lead to an optimal site in the heart based at least in part on cardiac motion information acquired via the multielectrode device and one or more pairs of current delivery electrodes that establish potential fields (e.g., for use as a coordinate system). An exemplary multielectrode device may be a multielectrode catheter or a multifilar, electrode-bearing guidewire. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用多电极装置，该多电极装置能够至少部分地基于通过多电极装置获得的心脏运动信息和建立潜在的一对或多对电流输送电极来帮助将心脏刺激引导到心脏中的最佳位置字段（例如，用作坐标系）。示例性的多电极装置可以是多电极导管或多电极，带电极的导丝。还公开了各种其它示例性方法，装置，系统等。

10. 发明授权

US08019409B2 Cardiac resynchronization therapy optimization using electromechanical delay from realtime electrode motion tracking 有权
标题翻译：使用实时电极运动跟踪的机电延迟的心脏再同步治疗优化
公开(公告)号：US08019409B2
公开(公告)日：2011-09-13
申请号：US12416771
申请日：2009-04-01
申请人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
发明人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61B5/1107 , A61B5/6876 , A61B2562/043 , A61N1/36514 , A61N1/36578 , A61N1/3684 , A61N1/37252
摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).
摘要翻译：示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械激活时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

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