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1. 发明授权

US09650378B2 (1-azinone)-substituted pyridoindoles 有权
公开(公告)号：US09650378B2
公开(公告)日：2017-05-16
申请号：US15045652
申请日：2016-02-17
申请人： Albany Molecular Research, Inc.
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang , Mark Hadden , James Grabowski , Alexander Usyatinsky
IPC分类号： C07D471/04 , C07D521/00 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00 , C07D521/00
摘要： Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

2. 发明申请

US20160159798A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES 有权
标题翻译：（1-AZINONE）-SUBSTITUTED PYRIDOINDOLES
公开(公告)号：US20160159798A1
公开(公告)日：2016-06-09
申请号：US15045652
申请日：2016-02-17
申请人： Albany Molecular Research, Inc.
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang , Mark Hadden , James Grabowski , Alexander Usyatinsky
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00 , C07D521/00
摘要： Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.
摘要翻译：用于并入用于治疗各种疾病的药物组合物中的取代的吡啶并吲哚对应于其中R 1为H或任选取代的烷基的式（I） R 2，R 3，R 4各自独立地选自H，-O-烷基，-S-烷基，烷基，卤素，-CF 3和-CN; G为-CR12R13-NR5-或-NR5-CR12R13; R 5是H，任选取代的烷基，任选取代的杂环，-C（= O）-R 6，-C（= O）-O-R 7或-C（= O）-NR 19 R 20; R6和R7各自为任选取代的烷基或任选取代的杂环; R 8，R 9，R 10，R 11，R 12，R 13，R 19和R 20各自独立地选自H或任选取代的烷基; R 14和R 15各自独立地为H或卤素; L是-CH 2 -O-，-CH 2 CH 2 - ， - CH = CH-或键; 和B是芳基或杂芳基或环烷基; 条件是当L是直接键时，B不能是被氟单取代的未取代的杂芳基或杂芳基。

3. 发明授权

US09296743B2 (1-azinone)-substituted pyridoindoles 有权
标题翻译：（1-氮杂酮） - 取代吡啶并吲哚
公开(公告)号：US09296743B2
公开(公告)日：2016-03-29
申请号：US14223151
申请日：2014-03-24
申请人： Albany Molecular Research, Inc.
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang , Mark Hadden , James Grabowski , Alexander Usyatinsky
IPC分类号： C07D471/04 , C07D521/00
CPC分类号： C07D471/04 , C07D519/00 , C07D521/00
摘要： Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.
摘要翻译：用于并入用于治疗各种疾病的药物组合物中的取代的吡啶并吲哚对应于其中R 1为H或任选取代的烷基的式（I） R 2，R 3，R 4各自独立地选自H，-O-烷基，-S-烷基，烷基，卤素，-CF 3和-CN; G为-CR12R13-NR5-或-NR5-CR12R13; R 5是H，任选取代的烷基，任选取代的杂环，-C（= O）-R 6，-C（= O）-O-R 7或-C（= O）-NR 19 R 20; R6和R7各自为任选取代的烷基或任选取代的杂环; R 8，R 9，R 10，R 11，R 12，R 13，R 19和R 20各自独立地选自H或任选取代的烷基; R 14和R 15各自独立地为H或卤素; L是-CH 2 -O-，-CH 2 CH 2 - ， - CH = CH-或键; 和B是芳基或杂芳基或环烷基; 条件是当L是直接键时，B不能是被氟单取代的未取代的杂芳基或杂芳基。

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