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1. 发明授权

US08148323B2 Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides 有权
标题翻译：通过多结构两亲螺旋肽治疗或抑制炎症的方法
公开(公告)号：US08148323B2
公开(公告)日：2012-04-03
申请号：US12766761
申请日：2010-04-23
申请人： Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
发明人： Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
IPC分类号： A61K38/00 , A61P3/06 , A61F13/00
CPC分类号： C07K14/775 , A61K38/00
摘要： Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
摘要翻译：本文公开了具有多个两亲性α-螺旋结构域的肽或肽类似物，其促进通过ABCA1依赖性途径从细胞流出的脂质。本文还提供了使用多结构域两亲性α-螺旋肽或肽类似物来治疗或抑制血脂异常的方法。用于鉴定促进细胞中ABCA1依赖性脂质流出的非细胞毒性肽的方法也在本文中公开。

2. 发明授权

US08835378B2 Multi-domain amphipathic helical peptides and methods of their use 有权
标题翻译：多结构域两亲性螺旋肽及其使用方法
公开(公告)号：US08835378B2
公开(公告)日：2014-09-16
申请号：US13407132
申请日：2012-02-28
申请人： Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
发明人： Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
IPC分类号： A61K38/00 , A61P3/06 , A61F13/00 , C07K14/775
CPC分类号： C07K14/775 , A61K38/00
摘要： Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
摘要翻译：本文公开了具有多个两亲性α-螺旋结构域的肽或肽类似物，其促进通过ABCA1依赖性途径从细胞流出的脂质。本文还提供了使用多结构域两亲性α-螺旋肽或肽类似物来治疗或抑制血脂异常的方法。用于鉴定促进细胞中ABCA1依赖性脂质流出的非细胞毒性肽的方法也在本文中公开。

3. 发明授权

US08936787B2 Peptides promoting lipid efflux 有权
标题翻译：促进脂质流出的肽
公开(公告)号：US08936787B2
公开(公告)日：2015-01-20
申请号：US12937974
申请日：2009-04-14
申请人： Alan T. Remaley , Marcelo J. A. Amar
发明人： Alan T. Remaley , Marcelo J. A. Amar
IPC分类号： A61K38/16 , C07K14/00 , C07K14/775
CPC分类号： C07K14/775
摘要： Disclosed herein are peptides and peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein.
摘要翻译：本文公开了具有多个两亲性α-螺旋结构域的肽和肽类似物，其促进脂质通过ABCA1依赖性途径从细胞流出，以及激活脂蛋白脂肪酶的肽，以及包含这些肽或其组合的组合物。本文还提供了使用多结构域两亲性α-螺旋肽或肽类似物来治疗或抑制血脂异常的方法。用于鉴定促进细胞中ABCA1依赖性脂质流出并激活细胞内的脂蛋白脂肪酶的非细胞毒性肽的方法也在本文中公开。

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