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    • 1. 发明申请
    • STABILIZATION OF SIGNAL GENERATION IN PARTICLES USED IN ASSAYS
    • 用于测定的颗粒中信号产生的稳定性
    • US20110091978A1
    • 2011-04-21
    • US12603364
    • 2009-10-21
    • Alan R. CraigZhu TengCarsten SchelpJason SnyderChristine Moran
    • Alan R. CraigZhu TengCarsten SchelpJason SnyderChristine Moran
    • G01N21/76G01N31/00
    • G01N21/76G01N21/6428G01N33/54393Y10S435/968Y10T436/10Y10T436/2525
    • Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support comprises a chemiluminescent composition that comprises a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles comprising other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium comprising the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
    • 公开了用于进行测定的方法和试剂。 本发明的方法和试剂的实施方案涉及固体支持物,例如颗粒。 载体包括包含金属螯合物的化学发光组合物。 本发明人观察到,当将这样的载体例如颗粒用于测定分析物时,与颗粒相关的化学发光组合物输出的信号的稳定性与包含其它化学发光组合物的颗粒的稳定性不能接受地降低 。 根据本发明的实施方案,通过在包含颗粒的介质中包含足量的一种或多种稳定剂(其可以是螯合剂和/或金属螯合物)来增加来自这些颗粒的信号输出的稳定性,例如 例如,与颗粒相关的金属螯合物。
    • 2. 发明授权
    • Stabilization of signal generation in particles used in assays
    • 在测定中使用的颗粒中信号产生的稳定性
    • US08153442B2
    • 2012-04-10
    • US12603364
    • 2009-10-21
    • Alan R. CraigZhu TengCarsten SchelpJason SnyderChristine Moran
    • Alan R. CraigZhu TengCarsten SchelpJason SnyderChristine Moran
    • G01N1/00G01N21/76G01N33/546
    • G01N21/76G01N21/6428G01N33/54393Y10S435/968Y10T436/10Y10T436/2525
    • Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support includes a chemiluminescent composition that includes a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles including other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium that contains the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
    • 公开了用于进行测定的方法和试剂。 本发明的方法和试剂的实施方案涉及固体支持物,例如颗粒。 载体包括包含金属螯合物的化学发光组合物。 本发明人观察到,当将这种载体例如颗粒用于测定分析物时,与包含其它化学发光组合物的颗粒相比,由与颗粒相关的化学发光组合物输出的信号的稳定性不可接受地降低 。 根据本发明的实施方案,通过在含有颗粒的介质中包含足量的一种或多种稳定剂(其可以是螯合剂和/或金属螯合物)来增加来自这些颗粒的信号输出的稳定性 例如与颗粒相关的金属螯合物。