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1. 发明授权

US6110905A Long-acting oxytetracycline composition 有权
标题翻译：长效土霉素组成
公开(公告)号：US6110905A
公开(公告)日：2000-08-29
申请号：US159680
申请日：1998-09-24
申请人： Alan Patterson , Drew Holmes
发明人： Alan Patterson , Drew Holmes
IPC分类号： A61K9/08 , A61K31/65 , A61K47/02 , A61K47/10 , A61K47/22
CPC分类号： A61K9/08 , A61K31/65 , A61K47/02 , A61K47/10 , A61K47/22 , A61K9/0019
摘要： An injectable composition of higher residual effect with reduced detrimental effects such as pain at injection site, swelling, tissue irritancy or necrosis and containing as active principle a tetracycline compound, either as the free base or a salt thereof with a physiologically acceptable acid, complexed with a substantially equimolar amount of a magnesium compound, is solubilized in a water miscible solvent system comprising, either (i) a) glycerol formal in an amount of from about 10 to 50% v/v; with b) polyethylene glycol in an amount of from about 1 to 15% v/v; or (ii) from about 25 to about 75% v/v of N-methylpyrrolidone, the composition optionally containing a pH modifier in an amount sufficient to maintain a physiochemically acceptable pH, the balance being made up with water q.s.
摘要翻译：具有较高残留效应的可注射组合物，其具有降低的有害作用，例如注射部位疼痛，肿胀，组织刺激或坏死，并且作为活性成分含有四环素类化合物，作为游离碱或其与生理学上可接受的酸的盐，与基本上等摩尔量的镁化合物溶解在水混溶性体系中，其包含（i）a）约10至50％v / v的量的甘油缩甲醛; 其中b）约1至15％v / v的量的聚乙二醇; 或（ii）约25至约75％v / v的N-甲基吡咯烷酮，所述组合物任选地含有一定量的pH调节剂，其量足以保持生理学上可接受的pH，余量由水补足。

2. 发明授权

US06310053B1 Long-acting oxytetracycline composition 有权
标题翻译：长效土霉素组成
公开(公告)号：US06310053B1
公开(公告)日：2001-10-30
申请号：US09617795
申请日：2000-07-17
申请人： Alan Patterson , Drew Holmes
发明人： Alan Patterson , Drew Holmes
IPC分类号： A61K3165
CPC分类号： A61K47/02 , A61K9/0019 , A61K9/08 , A61K31/65 , A61K47/10 , A61K47/22
摘要： An injectable composition is described having a higher residual effect with reduced detrimental effects such as pain at injection site, swelling, tissue irritancy or necrosis. The composition contains as active principle a tetracycline compound, either as the free base or a salt thereof with a physiologically acceptable acid, complexed with a substantially equimolar amount of a magnesium compound, and is solubilized in a water miscible solvent system comprising glycerol formal in a an amount of about 40 (v/v); with from about 1% to about 20% (v/v) polyethylene glycol and optionally containing a pH modifier in an amount sufficient to maintain a physiologically acceptable pH. In addition, the composition may further comprise a thickener, such as polyvinyl in an amount of about 10% (w/v). The balance of the composition comprises water.
摘要翻译：描述了具有较高残留效应并具有降低的有害作用如注射部位疼痛，肿胀，组织刺激或坏死的可注射组合物。该组合物作为活性成分含有四环素化合物，其作为游离碱或其与生理上可接受的酸的盐，与基本上等摩尔量的镁化合物络合，并且溶解在包含甘油缩合物的水混溶性溶剂体系中约为40（v / v）; 与约1％至约20％（v / v）的聚乙二醇，并且任选地含有足以维持生理上可接受的pH的量的pH调节剂。此外，组合物还可以包含约10％（w / v）的增稠剂，例如聚乙烯。组合物的余量包括水。

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