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1. 发明授权

US07241765B2 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
标题翻译：黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物
公开(公告)号：US07241765B2
公开(公告)日：2007-07-10
申请号：US11436099
申请日：2006-05-17
申请人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
发明人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
IPC分类号： A61K31/495 , C07D295/096 , A61K31/451
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

2. 发明授权

US07081458B2 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
标题翻译：黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物
公开(公告)号：US07081458B2
公开(公告)日：2006-07-25
申请号：US11103246
申请日：2005-04-11
申请人： Alan J. Hutchison , John M. Peterson , Dario Doller , Wallace C. Pringle , Helen Yin
发明人： Alan J. Hutchison , John M. Peterson , Dario Doller , Wallace C. Pringle , Helen Yin
IPC分类号： A61K31/407 , A61K31/4439 , C07D487/04
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

3. 发明申请

US20050182068A1 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
公开(公告)号：US20050182068A1
公开(公告)日：2005-08-18
申请号：US11103246
申请日：2005-04-11
申请人： Alan Hutchison , John Peterson , Dario Doller , Wallace Pringle , Helen Yin
发明人： Alan Hutchison , John Peterson , Dario Doller , Wallace Pringle , Helen Yin
IPC分类号： G01N33/53 , A61K31/352 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/551 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07D209/86 , C07D211/44 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D223/04 , C07D239/47 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/108 , C07D295/18 , C07D311/18 , C07D311/58 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D513/04 , G01N33/566 , C07D43/02
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

4. 发明申请

US20050065162A1 MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES 失效
标题翻译：梅拉宁浓缩激素受体配体：取代的1-苄氧基-4-芳基哌嗪类似物
公开(公告)号：US20050065162A1
公开(公告)日：2005-03-24
申请号：US10152189
申请日：2002-05-21
申请人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Doller , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Yiping Shen , Cheryl Steenstra , Helen Yin , Xiao-shu He
发明人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Doller , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Yiping Shen , Cheryl Steenstra , Helen Yin , Xiao-shu He
IPC分类号： G01N33/53 , A61K31/352 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/551 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07D209/86 , C07D211/44 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D223/04 , C07D239/47 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/108 , C07D295/18 , C07D311/18 , C07D311/58 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D513/04 , G01N33/566 , C07D43/14
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

5. 发明授权

US5339472A Infant head and neck support pillow 失效
标题翻译：婴儿头颈支撑枕头
公开(公告)号：US5339472A
公开(公告)日：1994-08-23
申请号：US77746
申请日：1993-06-18
申请人： Helen Yin
发明人： Helen Yin
IPC分类号： A47C16/00 , A47D13/08
CPC分类号： A47D15/006 , A47C7/383
摘要： An infant head support pillow neck made of a filler-cushion material which is covered by a top half and bottom half which are sewn together. The top and bottom halves are identically shaped so as to give the infant pillow head support a substantially rectangular appearance. The shape of the infant head support pillow is defined by first and second latitudinal sides and first and second longitudinal sides, the longitudinal sides being longer in length than the latitudinal sides. The second longitudinal side has a first keyhole wing and a second keyhole wing which curve inward in the direction of the first longitudinal side to form an opening between them. The second longitudinal side extends from the first and second keyhole wings to form a keyhole region at the center of the pillow. The keyhole region has a diameter which is approximately one-fourth the distance between the first and second latitudinal sides. The pillow provides support while the infant is being held or carried by an individual as well as when using any commercially available baby product.
摘要翻译：一个由填充物 - 衬垫材料制成的婴儿头部支撑枕头颈部，其被缝合在一起的上半部分和下半部分覆盖。顶部和底部两半的形状相同，从而使婴儿枕头支撑件基本上呈矩形的外观。婴儿头支撑枕头的形状由第一和第二纬度侧以及第一和第二纵向侧面限定，纵向长度比纬向侧长。第二纵向侧面具有第一键孔机翼和第二键孔机翼，其在第一纵向侧面的方向上向内弯曲以在它们之间形成开口。第二纵向侧面从第一和第二锁孔延伸，以在枕头的中心形成锁眼区域。键孔区域的直径约为第一和第二纬向侧面之间的距离的四分之一。当婴儿由个人持有或携带时以及使用任何商业上可买到的婴儿用品时，该枕头提供支持。

6. 发明申请

US20060229298A1 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
公开(公告)号：US20060229298A1
公开(公告)日：2006-10-12
申请号：US11436099
申请日：2006-05-17
申请人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
发明人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
IPC分类号： A61K31/496 , A61K31/551 , A61K31/495 , C07D403/02
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

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