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1. 发明申请

US20100099683A1 COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER 有权
标题翻译：禁止人类DNA细胞的化合物和治疗癌症的方法
公开(公告)号：US20100099683A1
公开(公告)日：2010-04-22
申请号：US12576410
申请日：2009-10-09
申请人： Alan E. TOMKINSON , Xi CHEN , Barbara DZIEGIELEWSKA , Alexander D. MACKERELL , Shijun ZHONG , Gerald M. Wilson
发明人： Alan E. TOMKINSON , Xi CHEN , Barbara DZIEGIELEWSKA , Alexander D. MACKERELL , Shijun ZHONG , Gerald M. Wilson
IPC分类号： A61K31/519 , C12Q1/68 , C12N5/00 , A61K31/50 , A61K31/506 , A61K31/505 , A61K31/44 , A61K31/437 , A61K31/4245 , A61K31/428 , A61K31/4196 , A61K31/404 , A61K31/381 , A61K31/341 , A61K31/165 , A61P35/00
CPC分类号： A61K31/505 , A61K31/165 , A61K31/166 , A61K31/175 , A61K31/255 , A61K31/341 , A61K31/397 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/436 , A61K31/4439 , A61K31/495 , A61K31/553 , A61K45/06 , A61N5/10 , C07D209/30 , C07D235/28 , C07D257/04 , C07D263/58 , C07D267/18 , C07D271/12 , C07D277/74 , C07D285/14 , C07D307/68 , C07D401/12 , C07D407/12 , C40B30/02 , G01N21/64 , G06F19/16 , G06F19/706
摘要： Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.
摘要翻译：使用抑制人DNA连接酶的化合物治疗癌症的方法。使用抑制人DNA连接酶的化合物提供人DNA连接酶的反应机制的见解的方法，例如鉴定参与不同DNA修复途径的人DNA连接酶。抑制人类DNA连接酶的化合物的筛选方法。

2. 发明申请

US20120256817A1 SHIFTING REGISTER AND APPARATUS FOR DRIVING GATE LINES 有权
标题翻译：移位寄存器和驱动门线的装置
公开(公告)号：US20120256817A1
公开(公告)日：2012-10-11
申请号：US13439380
申请日：2012-04-04
申请人： Xi CHEN , Wenhai Cui
发明人： Xi CHEN , Wenhai Cui
IPC分类号： G09G3/36
CPC分类号： G11C19/28 , G09G3/3674 , G09G2310/0286
摘要： The present invention discloses a shifting register and an apparatus for driving gate lines, and it relates to Liquid Crystal Display technical field, for reducing the noise of a shifting register during non-working period. The shifting register comprises: a first thin film transistor, a second thin film transistor, a third thin film transistor, a fourth thin film transistor, a capacitor and a pull-down module, and the pull-down module is connected among a clock signal port, a first node and a signal output terminal, and further is connected to a low level signal terminal, for maintaining the first node and the signal output terminal to be at low level during the non-working period of the shifting register. The apparatus for driving gate lines comprises a plurality of above shifting registers connected in serial. The present invention is applicable to driving gate lines.
摘要翻译：本发明公开了一种用于驱动栅极线的移位寄存器和装置，涉及液晶显示技术领域，用于在非工作期间减少移位寄存器的噪声。移位寄存器包括：第一薄膜晶体管，第二薄膜晶体管，第三薄膜晶体管，第四薄膜晶体管，电容器和下拉模块，并且下拉模块连接在时钟信号端口，第一节点和信号输出端子，并且还连接到低电平信号端子，用于在移位寄存器的非工作周期期间将第一节点和信号输出端子保持在低电平。用于驱动栅极线的装置包括多个串联连接的上述移位寄存器。本发明适用于驱动栅极线。

3. 发明申请

US20120201819A1 TREATMENT OF DRUG-RELATED SIDE EFFECT AND TISSUE DAMAGE BY TARGETING THE CD-24-HMGB1-SIGLEC10 AXIS 有权
标题翻译：通过瞄准CD-24-HMGB1-SIGLEC10轴治疗药物相关的副作用和组织损伤
公开(公告)号：US20120201819A1
公开(公告)日：2012-08-09
申请号：US13426392
申请日：2012-03-21
申请人： Yang LIU , Pan ZHENG , Guo-Yun CHEN , Xi CHEN , Steve KUNKEL , Xincheng ZHENG
发明人： Yang LIU , Pan ZHENG , Guo-Yun CHEN , Xi CHEN , Steve KUNKEL , Xincheng ZHENG
IPC分类号： A61K39/395 , A61K31/7008 , A61P29/00 , A61K31/715
CPC分类号： C07K16/18 , A61K31/351 , A61K38/177 , A61K45/06 , A61K2039/505 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/30 , A61K2300/00
摘要： The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.
摘要翻译：本技术提供了通过施用包含一种或多种CD24的组合物来治疗组织损伤相关免疫失调调节的方法和组合物; CD24片段，变体和衍生物，CD24Fc融合蛋白; HMBG1结合蛋白，HMBG1盒B结合蛋白; HMGB1的多肽，单克隆，重组，嵌合，人源化scFv抗体和HMGB1抗体片段或HMGB1片段的抗体以及结合并抑制HMGB1盒B活性的抗体的拮抗剂; Siglec 10激动剂如抗Siglec 10抗体; 及其组合。

4. 发明申请

US20080019368A1 APPARATUS AND METHOD FOR LAYER-2 TO LAYER-7 SEARCH ENGINE FOR HIGH SPEED NETWORK APPLICATION 有权
标题翻译：用于高速网络应用的第2层至第7层搜索引擎的装置和方法
公开(公告)号：US20080019368A1
公开(公告)日：2008-01-24
申请号：US11775833
申请日：2007-07-10
申请人： Yung-Chung LIU , Xi CHEN , Yu Chih TSAO , Chien Hsiung CHANG , Chien-Chih CHEN , Xiaochong CAO , Chih-Hsien Hsu
发明人： Yung-Chung LIU , Xi CHEN , Yu Chih TSAO , Chien Hsiung CHANG , Chien-Chih CHEN , Xiaochong CAO , Chih-Hsien Hsu
IPC分类号： H04L12/28 , G06F17/00
CPC分类号： H04L12/4641
摘要： High-speed networking application equipments with a layer-2 to layer-7 hardware search engine and method are with flexibility and performance improvement. The multi-layer switches/routers, network address translation (NAT) gateway, firewall/VPN router and network attached storage (NAS) may use the search engine for fast and efficient search requirement.
摘要翻译：具有二层到七层硬件搜索引擎和方法的高速网络应用设备具有灵活性和性能提升。多层交换机/路由器，网络地址转换（NAT）网关，防火墙/ VPN路由器和网络连接存储（NAS）可以使用搜索引擎进行快速有效的搜索需求。

5. 发明申请

US20100311712A1 MODULATORS OF CXCR7 有权
标题翻译： CXCR7的调节剂
公开(公告)号：US20100311712A1
公开(公告)日：2010-12-09
申请号：US12778913
申请日：2010-05-12
申请人： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Mark M. GLEASON , Juan C. JAEN , Lianfa LI , Jeffrey P. MCMAHON , Jay POWERS , Yibin ZENG , Penglie ZHANG , Junfa FAN
发明人： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Mark M. GLEASON , Juan C. JAEN , Lianfa LI , Jeffrey P. MCMAHON , Jay POWERS , Yibin ZENG , Penglie ZHANG , Junfa FAN
IPC分类号： A61K31/551 , C07D417/06 , C07D417/14 , A61P29/00 , A61P35/00 , A61P17/02 , C12N5/02
CPC分类号： C07D401/14 , C07D403/14 , C07D417/14
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
摘要翻译：提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。

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