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1. 发明授权

US5945425A Method of using (H.sup.+ /K.sup.+)ATPase inhibitors as antiviral agents 失效
标题翻译：使用（H + / K +）ATP酶抑制剂作为抗病毒剂的方法
公开(公告)号：US5945425A
公开(公告)日：1999-08-31
申请号：US737251
申请日：1996-10-24
申请人： Alan E. Moormann , Daniel P. Becker , Daniel L. Flynn , Hui Li , Clara I. Villamil
发明人： Alan E. Moormann , Daniel P. Becker , Daniel L. Flynn , Hui Li , Clara I. Villamil
IPC分类号： A61K31/00 , A61K31/4164 , A61K31/4184 , A61K31/437 , A61K31/4402 , A61K31/4439 , C07D235/28 , C07D401/12 , C07D403/12 , A61K31/42 , A61K31/415 , A61K31/425
CPC分类号： C07D401/12 , A61K31/00 , A61K31/4164 , A61K31/4184 , A61K31/437 , A61K31/4402 , A61K31/4439 , C07D235/28 , C07D403/12
摘要： A class of compounds which are (H.sup.+ /K.sup.+)ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1## wherein D is N or CH; wherein R.sup.7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R.sup.8 is selected from hydrido, alkyl and cycloalkyl; wherein R.sup.9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R.sup.10 and R.sup.11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R.sup.10 and R.sup.11 together with the nitrogen atom form a heterocyclic ring.
摘要翻译： PCT No.PCT / US95 / 05021 Sec。 371日期1996年10月24日第 102（e）日期1996年10月24日PCT提交1995年5月1日PCT公布。出版物WO95 / 29897 1995年11月9日，一类（H + / K +）ATP酶抑制剂的化合物可用于治疗病毒感染。特别感兴趣的化合物由式III定义：其中D是N或CH; 其中R7是一个或多个选自氢，烷氧基，氨基，氰基，硝基，羟基，烷基，卤素，卤代烷基，羧基，烷酰基，硝基，氨基，烷基氨基，氨基羰基，氨基磺酰基，烷基氨基羰基，烷基羰基氨基，烷氧基羰基，烷基氨基磺酰基，，烷硫基，烷基亚磺酰基和烷基磺酰基; 其中R8选自氢，烷基和环烷基; 其中R9是一个或多个选自氢，烷氧基，氨基，烷基，卤素，氰基，硝基，羟基，卤代烷基，硝基，羧基，烷酰基，氨基，烷基氨基，二烷基氨基，氨基羰基，烷基氨基羰基，烷基羰基氨基，氨基磺酰基，烷基氨基磺酰基，，烷氧基羰基，烷硫基，烷基亚磺酰基和烷基磺酰基; 并且其中R 10和R 11独立地选自氢，烷基，芳基，烷基羰基和芳基羰基，其中所述芳基环可以进一步被一个或多个选自烷基，卤素，肼基羰基，氨基羰基和烷氧基的基团取代; 或其中R 10和R 11与氮原子一起形成杂环。

2. 发明授权

US06683077B2 2-Amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并恶嗪酮用于治疗病毒感染
公开(公告)号：US06683077B2
公开(公告)日：2004-01-27
申请号：US10035433
申请日：2002-01-04
申请人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
发明人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
IPC分类号： A61K31535
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式I定义，其中R-R 4如本文所定义，或其药学上可接受的盐。

3. 发明授权

US06380189B1 2-amino benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基苯并恶嗪酮用于治疗病毒感染
公开(公告)号：US06380189B1
公开(公告)日：2002-04-30
申请号：US09502038
申请日：2000-02-11
申请人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
发明人： Norman Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A. Schretzman , Clara I. Villamil
IPC分类号： A61K31536
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式I定义，其中R-R4如本文所定义，或其药学上可接受的盐。

4. 发明授权

US5985872A 2-amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并恶嗪酮用于治疗病毒感染
公开(公告)号：US5985872A
公开(公告)日：1999-11-16
申请号：US448795
申请日：1995-05-24
申请人： Norman Anthony Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A Schretzman , Clara I Villamil
发明人： Norman Anthony Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A Schretzman , Clara I Villamil
IPC分类号： C07D265/22 , A61K31/535 , A61P31/12 , A61P43/00 , C07D265/12 , C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R.sup.29 is selected from hydrido, alkyl, halo, ##STR2## wherein R.sup.30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R.sup.31 is alkyl; wherein R.sup.32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式II定义，其中R28选自（a）被一个或两个选自烷基，芳烷基，杂核烷基，杂环和芳基的基取代的氨基，和（b）氨基酸残基及其衍生物; 其中R 29选自氢，烷基，卤素，其中R 30选自烷基，烷氧基，烷基氨基，羧基烷基，烷氧基烷基，烷基氨基烷基，环烷基，杂环基，杂环烷基，杂环烷氧基，烷基氨基烷氧基，烷基氨基烷基氨基，杂环烷基氨基和N-芳烷基氨基。其中R31是烷基; 其中R32是烷基和芳基; 或其药学上可接受的盐。

5. 发明授权

US06638952B1 Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds 失效
标题翻译：芳香磺酰α-环氨基异羟肟酸化合物
公开(公告)号：US06638952B1
公开(公告)日：2003-10-28
申请号：US09254530
申请日：1999-12-23
申请人： Hui Li , Daniel P. Becker , Clara I. Villamil , Terri L. Boehm , Daniel P. Getman , Joseph J. McDonald , Gary A. DeCrescenzo
发明人： Hui Li , Daniel P. Becker , Clara I. Villamil , Terri L. Boehm , Daniel P. Getman , Joseph J. McDonald , Gary A. DeCrescenzo
IPC分类号： A61K31445
CPC分类号： C07D213/30 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/16 , C07D211/62 , C07D213/82 , C07D295/15
摘要： An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-cycloamino hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
摘要翻译：公开了芳族磺酰基α-环氨基异羟肟酸化合物，其特别是抑制基质金属蛋白酶活性，其处理方法包括将预期的具有MMP酶抑制有效量的芳族磺酰基α-环氨基异羟肟酸化合物给予具有条件与病理基质金属蛋白酶活性相关。

6. 发明授权

US06750233B2 Aromatic sulfone hydroxamic acid metalloprotease inhibitor 失效
标题翻译：芳香砜异羟肟酸金属蛋白酶抑制剂
公开(公告)号：US06750233B2
公开(公告)日：2004-06-15
申请号：US09954451
申请日：2001-09-17
申请人： Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Yvette M. Fobian , John N. Freskos , Daniel P. Getman , Joseph J. McDonald , Susan L. Hockerman , Susan C. Howard , Steve A. Kolodziej , Hui Li , Deborah A. Mischke , Joseph G. Rico , Nathan W. Stehle , Michael B. Tollefson , William F. Vernier , Clara I. Villamil
发明人： Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Yvette M. Fobian , John N. Freskos , Daniel P. Getman , Joseph J. McDonald , Susan L. Hockerman , Susan C. Howard , Steve A. Kolodziej , Hui Li , Deborah A. Mischke , Joseph G. Rico , Nathan W. Stehle , Michael B. Tollefson , William F. Vernier , Clara I. Villamil
IPC分类号： A61K31382
CPC分类号： C07D451/02 , A61K31/445 , C07D207/16 , C07D211/66 , C07D211/78 , C07D221/22 , C07D221/24 , C07D225/02 , C07D239/04 , C07D239/10 , C07D239/14 , C07D239/22 , C07D263/06 , C07D265/30 , C07D277/06 , C07D279/06 , C07D281/06 , C07D285/16 , C07D307/24 , C07D309/08 , C07D319/06 , C07D327/02 , C07D333/38 , C07D335/02 , C07D337/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , Y02A50/411
摘要： A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.
摘要翻译：公开了一种治疗方法，其包括施用有效量的一种或多种基质金属蛋白酶（MMP）酶如MMP-2，MMP-9和MMP-13的优异抑制活性的芳香族砜异羟肟酸，同时基本上至少具有MMP-1对具有与病理基质金属蛋白酶活性相关的病症的宿主的抑制作用较小。还公开了具有这些选择活性的金属蛋白酶抑制剂化合物，制备这种化合物的方法和使用抑制剂的药物组合物。

7. 发明授权

US6087359A Thioaryl sulfonamide hydroxamic acid compounds 失效
标题翻译：硫代磺酰胺异羟肟酸化合物
公开(公告)号：US6087359A
公开(公告)日：2000-07-11
申请号：US254534
申请日：1999-09-10
申请人： Daniel P. Getman , Daniel P. Becker , Thomas E. Barta , Clara I. Villamil , Susan L. Hockerman , Louis J. Bedell , Hui Li , John N. Freskos , Robert M. Heintz , Joseph J. McDonald , Gary A. DeCrescenzo
发明人： Daniel P. Getman , Daniel P. Becker , Thomas E. Barta , Clara I. Villamil , Susan L. Hockerman , Louis J. Bedell , Hui Li , John N. Freskos , Robert M. Heintz , Joseph J. McDonald , Gary A. DeCrescenzo
IPC分类号： C07D295/13 , C07D309/12 , A61K31/5375 , A61K31/5377 , C07D295/15 , C07D413/12
CPC分类号： C07D295/13 , C07D309/12
摘要： A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
摘要翻译： PCT No.PCT / US98 / 04298 Sec。 371 1999年9月10日第 102（e）1999年9月10日PCT PCT 1998年3月4日PCT公布。第WO98 / 39313号公报日本9月11日，日本公开了一种特别是抑制基质金属蛋白酶活性的硫代芳基磺酰胺异羟肟酸化合物，其处理方法包括将具有MMP酶抑制有效量的预期硫代芳基磺酰胺异羟肟酸化合物施用于具有相关病症的宿主具有病理基质金属蛋白酶活性。

8. 外观设计

USD995846S1 Vehicle light 有权
公开(公告)号：USD995846S1
公开(公告)日：2023-08-15
申请号：US29886817
申请日：2023-03-14
申请人： Hui Li
设计人： Hui Li
摘要： FIG. 1 is a front, right and top perspective view of a vehicle light, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines depict portions of the vehicle light that form no part of the claimed design.

9. 发明申请

US20220246075A2 DRIVING UNIT, GATE DRIVING CIRCUIT, ARRAY SUBSTRATE, AND DISPLAY APPARATUS 有权
公开(公告)号：US20220246075A2
公开(公告)日：2022-08-04
申请号：US17481376
申请日：2021-09-22
申请人： Jianbo Xian , Chunping Long , Hui Li , Yong Qiao
发明人： Jianbo Xian , Chunping Long , Hui Li , Yong Qiao
IPC分类号： G09G3/20
摘要： The present disclosure relates to a driving unit. The driving unit may include a first driving sub-circuit, a second driving sub-circuit, and a driving control circuit. The first driving sub-circuit may include a plurality of first switching elements, and at least some of the plurality of first switching elements may be configured to output a first signal to a first output terminal of the driving unit in response to a control signal from the driving control circuit. The second driving sub-circuit may include one or more second switching elements, and at least one of the one or more second switching elements may be configured to output a second signal to a second output terminal of the driving unit in response to the control signal from the driving control circuit. The driving control circuit may be configured to output the control signal at a control signal output terminal.

10. 发明申请

US20210057141A1 TRANSFORMER CORES AND ASSEMBLY METHODS THEREOF FOR HIGH EFFICIENCY AND HIGH ANTI-CORROSION PERFORMANCE 有权
公开(公告)号：US20210057141A1
公开(公告)日：2021-02-25
申请号：US17045932
申请日：2018-04-23
申请人： Zhongbo WANG , Martin Alsina NAVARRO , Andre Luiz MORENO , Wei CHEN , Hui LI , Siemens Aktiengesellschaft , Hainan Jinpan Smart Technology Co., Ltd. , HAINAN JINPAN ELECTRIC RESEARCH INSTITUTE CO., LTD.
发明人： Zhongbo Wang , Martin Alsina Navarro , Andre Luiz Moreno , Wei Chen , Hui Li
IPC分类号： H01F27/26 , H01F27/28 , H01F41/02
摘要： A transformer core for a dry-type transformer includes a laminated construction having several groups of stacked laminations that form a step-lap sequence of laminations. Each group in the step-lap sequence has a mean length different than an adjacent group in the step-lap sequence and has at least two identical laminations per group, wherein at least one group has at least four identical laminations. Methods of assembling a transformer core are also provided, as are other aspects.

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