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1. 发明授权

US5665415A Composition and method for increasing the pH of acid foods 失效
标题翻译：增加酸性食物pH值的组成和方法
公开(公告)号：US5665415A
公开(公告)日：1997-09-09
申请号：US507095
申请日：1995-07-26
申请人： Alan E. Kligerman , Sarah Hartzell
发明人： Alan E. Kligerman , Sarah Hartzell
IPC分类号： C12G1/00 , A23F5/14 , A23F5/24 , A23F5/42 , A23L1/03 , A23L1/226 , A23L1/304 , A23L2/00 , A23L2/52 , A23L2/68 , C12C5/02 , A23F3/20 , A23F5/22
CPC分类号： A23F5/42 , A23F5/14 , A23F5/243 , A23L2/52 , A23L29/05 , A23L33/16
摘要： A method is provided for increasing the pH of acidic foods and beverages, to thereby reduce the tendency of such foodstuffs to cause heartburn and other gastrointestinal distress to the consumer. An acidic food or beverage, such as coffee, is combined with an amount of calcium glycerophosphate (CGP) effective to raise the pH of the food or beverage, preferably by at least about 0.5 pH units, and more preferably to a pH of between about 5.4 and 7.0. Edible compositions including CGP, having a pH of greater than about 5.4 are obtained. The CGP may also be added to acidic foods to remove the biting flavor that such foods have, and thus CGP serves as a flavor modulator. Packages comprising CGP inside a container, where the container may be easily opened to provide a single dose of CGP, are useful in the method and in forming the edible compositions.
摘要翻译：提供了一种提高酸性食品和饮料的pH值的方法，从而减少了这种食物对消费者的胃灼热和其他胃肠道痛苦的倾向。将酸性食品或饮料（例如咖啡）与一定量的有助于提高食物或饮料的pH的磷酸钙（CGP）组合，优选至少约0.5pH单位，更优选至约约pH 5.4和7.0。得到包含CGP的食用组合物，其pH值大于约5.4。 CGP也可以添加到酸性食物中以除去这些食物具有的咬味，因此CGP用作调味剂。在容器中包含CGP的包装，其中容器可以容易地打开以提供单剂量的CGP，在该方法和形成可食用组合物中是有用的。

2. 发明授权

US5869119A Method of reducing distress in mammals due to ingestion of acidic foods and beverages 失效
标题翻译：由于摄取酸性食物和饮料而减少哺乳动物的痛苦的方法
公开(公告)号：US5869119A
公开(公告)日：1999-02-09
申请号：US913132
申请日：1997-09-08
申请人： Alan E. Kligerman , Sarah Hartzell
发明人： Alan E. Kligerman , Sarah Hartzell
IPC分类号： C12G1/00 , A23F5/14 , A23F5/24 , A23F5/42 , A23L1/03 , A23L1/226 , A23L1/304 , A23L2/00 , A23L2/52 , A23L2/68 , C12C5/02 , A23F3/20 , A23F5/22
CPC分类号： A23F5/42 , A23F5/14 , A23F5/243 , A23L2/52 , A23L29/05 , A23L33/16
摘要： A method is provided for increasing the pH of acidic foods and beverages, to thereby reduce the tendency of such foodstuffs to cause heartburn and other esophageal and/or gastrointestinal distress to the consumer. An acidic food or beverage, such as coffee, is combined with an amount of calcium glycerophosphate (CGP) effective to raise the pH of the food or beverage, preferably by at least about 0.5 pH units, and more preferably to a pH of between about 5.4 and 7.0. Edible compositions including CGP, having a pHl of greater than about 5.4 are obtained. The CGP may also be added to acidic foods to remove the biting flavor that such foods have, and thus CGP serves as a flavor modulator, Packages comprising CGP inside a container, where the container may be easily opened to provide a single dose of CGP, are useful in the method and in forming the edible compositions.
摘要翻译： PCT No.PCT / US96 / 12105 Sec。 371日期：1997年9月8日 102（e）1997年9月8日PCT PCT 1996年7月23日PCT公布。出版物WO97 / 04661 日期1997年2月13日提供了一种提高酸性食品和饮料的pH值的方法，从而减少这种食品对消费者的胃灼热和其他食道和/或胃肠道痛苦的倾向。将酸性食品或饮料（例如咖啡）与一定量的有助于提高食物或饮料的pH的磷酸钙（CGP）组合，优选至少约0.5pH单位，更优选至约约pH 5.4和7.0。得到包含pH1大于约5.4的CGP的食用组合物。 CGP也可以加入到酸性食物中以除去这些食物具有的咬味，因此CGP用作风味调节剂，在容器内包含CGP的包装，容器可以容易地打开以提供单剂量的CGP，可用于该方法和形成可食用组合物。

3. 发明授权

US4886160A Carton for containing a plurality of items for transport, storage and display 失效
标题翻译：用于包含用于运输，存储和显示的多个物品的纸箱
公开(公告)号：US4886160A
公开(公告)日：1989-12-12
申请号：US267668
申请日：1988-11-07
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： B65D5/52 , B65D5/54 , H05H1/46
CPC分类号： H05H1/46 , H05H1/30
摘要： A carton formed from a unitary blank, wherein the carton is used for shipping and displaying purposes. When shipping, products are positioned within the carton in a manner in which the available space within the carton is utilized efficiently. When the carton is ready to be placed in a display mode, an upper portion of the carton is detached and the front panel of the carton folds forward to allow products which are positioned within the carton in a non-displayable manner to be placed thereon for display purposes.
摘要翻译：由整体坯料形成的纸箱，其中纸箱用于运输和显示目的。在运输时，产品以纸箱内可用空间有效利用的方式定位在纸箱内。当纸箱被准备好放置在显示模式中时，纸箱的上部被分离，纸箱的前面板向前折叠，以便以非可显示的方式将定位在纸箱内的产品放置在其上以供显示目的。

4. 发明申请

US20100239645A1 Methods and Compositions for Wound Healing 有权
标题翻译：伤口愈合的方法和组成
公开(公告)号：US20100239645A1
公开(公告)日：2010-09-23
申请号：US12740510
申请日：2008-11-12
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： A61K9/70 , A61K31/661 , A61K33/40 , A61K31/715 , A61P17/02
CPC分类号： A61L26/0066 , A61K31/21 , A61K31/66 , A61K31/661 , A61K45/06 , A61L15/44 , A61L26/0076 , A61L2300/112 , A61L2300/402 , A61L2300/404 , A61L2300/45 , A61K2300/00
摘要： Glycerophosphate salts have been found to hasten the healing of wounds and minimize the formation of scars, particularly when it is first applied to a wound about 0 to about 7 days after the wound is inflicted. Methods and compositions are provided for treating wounds using a composition comprising an effective amount of glycerophosphate salt. In particular, methods are provided for treating wounds using calcium glycerophosphate (CGP), for accelerating the healing process, reducing pain and scar formation, and for the cosmetic reducing, excision, erasure and/or complete repair of scars (scar revision).
摘要翻译：已经发现甘油磷酸盐可以加速伤口的愈合并使瘢痕的形成最小化，特别是在伤口发生后约0至约7天首次应用伤口时。提供了使用包含有效量的甘油磷酸盐的组合物来治疗伤口的方法和组合物。特别地，提供了使用甘油磷酸钙（CGP）治疗伤口，用于加速愈合过程，减少疼痛和瘢痕形成以及用于化妆品减少，切除，擦除和/或完全修复疤痕（瘢痕修复）的方法。

5. 发明申请

US20100029590A1 METHODS FOR TREATING OR PREVENTING HEMORRHAGIC CYSTITIS USING A GLYCEROPHOSPHATE SALT 审中-公开
标题翻译：使用甘油磷酸盐治疗或预防疟原虫的方法
公开(公告)号：US20100029590A1
公开(公告)日：2010-02-04
申请号：US12526959
申请日：2008-02-13
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： A61K31/66
CPC分类号： A61K31/683
摘要： Glycerophosphate salts have been found to mitigate the syndromes or conditions of discomfort associated with hem-orrhagic cystitis. Therefore, methods are provided for treating or preventing the syndromes or conditions of discomfort associated with hemorrhagic cystitis using a glycerophosphate salt, hi particular, methods are provided for treating or preventing the syndromes or conditions of discomfort associated with hemorrhagic cystitis using calcium glycerophosphate (CGP).
摘要翻译：已经发现甘油磷酸盐可以缓解与下疝性膀胱炎相关的综合征或不适症状。因此，提供了使用甘油磷酸盐治疗或预防与出血性膀胱炎相关的综合征或不适症状的方法。特别地，提供了使用磷酸三钙（CGP）治疗或预防与出血性膀胱炎相关的综合征或不适症状的方法，。

6. 发明申请

US20080107743A1 COMPOSITION AND METHOD FOR ENHANCING SKIN CELL GROWTH, PROLIFERATION AND REPAIR 审中-公开
标题翻译：用于增强皮肤细胞生长，增殖和修复的组合物和方法
公开(公告)号：US20080107743A1
公开(公告)日：2008-05-08
申请号：US11934305
申请日：2007-11-02
申请人： Alan E. Kligerman , Margaret Weis
发明人： Alan E. Kligerman , Margaret Weis
IPC分类号： A61K31/66 , A61K9/14 , A61P17/00
CPC分类号： A61K31/66 , A61K9/0014 , A61K9/06
摘要： A skin treatment composition is provided which contains calcium glycerophosphate and a fatty acid source derived from an animal or a vegetable. The composition enhances skin cell proliferation and growth and repair of damage to skin cells. Methods for enhancing skin cell repair, proliferation, and growth and for enhancing ceramide synthesis involve topically applying to the skin a composition containing calcium glycerophosphate and a fatty acid source derived from an animal or a vegetable.
摘要翻译：提供了含有甘油磷酸钙和源自动物或蔬菜的脂肪酸源的皮肤处理组合物。该组合物增强皮肤细胞增殖和皮肤细胞损伤的生长和修复。用于增强皮肤细胞修复，增殖和生长以及用于增强神经酰胺合成的方法涉及将含有甘油磷酸钙和源自动物或植物的脂肪酸源的组合物局部施用于皮肤。

7. 发明授权

US3980210A Measuring and dispensing device for fluent material 失效
标题翻译：流通材料的测量和分配装置
公开(公告)号：US3980210A
公开(公告)日：1976-09-14
申请号：US561610
申请日：1975-03-24
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： G01F11/26
CPC分类号： G01F11/261
摘要： A container having bottom, top and side walls for fluent contents, a tubular exit member extending internally of the container along one region of the side wall with a lower internal tubular extension along the bottom wall and an upper tubular extension through and exteriorly of the top wall, the upper tubular extension being swingable to overlie the top wall.
摘要翻译：具有用于流动内容物的底部，顶部和侧壁的容器，沿着侧壁的一个区域沿容器的内部延伸的管状出口构件，沿着底壁具有下部内部管状延伸部，以及通过顶部和外部的上部管状延伸部上部管状延伸部可摆动地覆盖在顶壁上。

8. 发明申请

US20100255070A1 COMPOSITIONS AND METHODS FOR PREVENTING, MINIMIZING AND HEALING SKIN IRRITATION AND TRAUMA 审中-公开
标题翻译：预防，最小化和治疗皮肤刺激和血栓的组合物和方法
公开(公告)号：US20100255070A1
公开(公告)日：2010-10-07
申请号：US12600031
申请日：2008-05-22
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： A61L15/20 , A61K8/55 , A61Q17/00
CPC分类号： A61K31/662 , A61K8/55 , A61K8/731 , A61K8/737 , A61Q19/00
摘要： A composition for preventing, mitigating, and alleviating irritation and skin trauma is described. The composition contains calcium glycerophosphate and at least one skin compatible, film-forming component. The composition may be applied to the skin prior to application of an adhesive tape to reduce damage to the skin which is inflicted upon removal of the tape by forming a film on the skin. Upon removal of the adhesive tape from the skin, the film, rather than skin cells, is removed with the tape. The calcium glycerophosphate component of the composition also penetrates the skin and serves to alleviate any damage which may be inflicted on the skin. The composition may also be applied to the skin to prevent subsequent irritation, such as irritation inflicted by contact with poison ivy, clothing, jewelry, insect bites, a prosthetic, etc. A medical dressing which contains the composition is also included. Finally, methods for preventing and mitigating skin irritation and trauma using the inventive composition are described.
摘要翻译：描述了用于预防，减轻和减轻刺激和皮肤创伤的组合物。该组合物含有甘油磷酸钙和至少一种皮肤相容的成膜组分。组合物可以在施加胶带之前施用于皮肤，以减少在通过在皮肤上形成膜而去除胶带时对皮肤的损伤。从皮肤上取出胶带后，用胶带除去胶片而不是皮肤细胞。组合物中的甘油磷酸钙组分还渗透皮肤并用于减轻可能对皮肤造成的任何损伤。组合物也可以施用于皮肤以防止随后的刺激，例如与毒藤，衣服，珠宝，昆虫叮咬，假体等接触引起的刺激。还包括含有该组合物的医用敷料。最后，描述了使用本发明的组合物预防和减轻皮肤刺激和创伤的方法。

9. 发明申请

US20100041630A1 Methods for Treating or Preventing Inflammation Using a Glycerophosphate Salt 审中-公开
标题翻译：使用甘油磷酸盐治疗或预防炎症的方法
公开(公告)号：US20100041630A1
公开(公告)日：2010-02-18
申请号：US12526818
申请日：2008-02-13
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： A61K31/66
CPC分类号： A61K31/70
摘要： Glycerophosphate salts have been found to mitigate the syndromes or conditions of discomfort associated with inflammation. Therefore, methods are provided for treating or preventing an inflammatory condition using a glycerophosphate salt. In particular, methods are provided for treating or preventing an inflammatory condition using calcium glycerophosphate (CGP).
摘要翻译：已经发现甘油磷酸盐缓解与炎症相关的综合征或不适症状。因此，提供了使用甘油磷酸盐治疗或预防炎性病症的方法。特别地，提供了使用甘油磷酸钙（CGP）治疗或预防炎性病症的方法。

10. 发明授权

US06344196B1 Compositions and method for reducing gastro-intestinal distress due to alpha-d-galactoside-linked/containing sugars 失效
标题翻译：用于减少由于α-D-半乳糖苷连接/含有糖引起的肠胃窘迫的组合物和方法
公开(公告)号：US06344196B1
公开(公告)日：2002-02-05
申请号：US09634088
申请日：2000-08-08
申请人： Alan E. Kligerman
发明人： Alan E. Kligerman
IPC分类号： A61K3847
CPC分类号： C12Y302/01022 , A23L29/06 , A61K38/47
摘要： A composition is provided for ingestion by mammals for in vivo conversion of alpha-D-galactoside comprising an amount of alpha-galactosidase effective to hydrolyze alpha-D-galactoside to D-galactose, and non-toxic, ingestible excipient(s) for said alpha-galactosidase. Gastric distress in mammals due to ingestion of foods containing alpha-D-galactoside may be reduced by ingesting the foregoing composition of alpha-galactosidase and non-toxic, ingestible excipient contemporaneously with the ingestion of said food in an amount effective to hydrolyze the alpha-D-galactoside to D-galactose.
摘要翻译：本发明提供一种哺乳动物摄取用于体内转化α-D-半乳糖苷的组合物，其包含一定量的有效水解α-D-半乳糖苷的D-半乳糖苷，以及无毒，可摄取的赋形剂，用于所述 α-半乳糖苷酶。通过摄入含有α-D-半乳糖苷的食物的哺乳动物的胃窘迫可以通过摄取上述组合物的α-半乳糖苷酶和无毒的可摄取的赋形剂，同时摄入所述食物以有效水解α- D-半乳糖苷与D-半乳糖。

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