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1. 发明申请

US20110257036A1 Methods and Compositions for the Diagnosis of Cancer Susceptibilities and Defective DNA Repair Mechanisms and Treatment Thereof 审中-公开
标题翻译：用于诊断癌症易感性和缺陷DNA修复机制及其治疗的方法和组合
公开(公告)号：US20110257036A1
公开(公告)日：2011-10-20
申请号：US12749419
申请日：2010-03-29
申请人： Alan D. D'Andrea , Toshiyasu Taniguchi , Cynthia Timmers , Markus Grompe , Edward A. Fox
发明人： Alan D. D'Andrea , Toshiyasu Taniguchi , Cynthia Timmers , Markus Grompe , Edward A. Fox
IPC分类号： C40B30/06 , G01N33/566 , C12N5/071 , C07K14/47 , C12Q1/02
CPC分类号： G01N33/5011 , A01K2217/05 , A01K2217/075 , C07K14/47 , C07K16/18 , C12Q1/025 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/5091 , G01N33/574 , G01N33/57484 , G01N33/6893 , G01N2333/47 , G01N2500/00 , G01N2800/52
摘要： Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing Fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monoubiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway.
摘要翻译：提供了用于诊断癌症易感性，缺陷DNA修复机制及其治疗的方法和组合物。在这里提供的序列中，已经鉴定了FANCD2基因，并提供了探针和引物，用于筛选基因型测试中的患者和诊断范康尼贫血和癌症。可以在体内靶向FANCD2基因，以制备用于筛选用于治疗涉及有缺陷的DNA修复的病症的新治疗剂的实验小鼠模型。 FANCD2多肽已被测序，已被证明存在于被鉴定为FANCD2-S的两种同种型和单配FANCD-L形式中。已经制备了包括多克隆和单克隆抗体的抗体，其区分两种同种型并且已经用于诊断测试以确定受试者是否具有完整的范可尼贫血/ BRCA途径。

2. 发明授权

US09497928B2 System for automating animal testing protocols 有权
标题翻译：用于自动化动物试验协议的系统
公开(公告)号：US09497928B2
公开(公告)日：2016-11-22
申请号：US13376671
申请日：2010-06-08
申请人： Joseph P. Garner , Michelle Murphy Niedziela , Edward A. Fox
发明人： Joseph P. Garner , Michelle Murphy Niedziela , Edward A. Fox
IPC分类号： A01K1/03 , A01K29/00
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimenter-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个设备，其有助于完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

3. 发明授权

US4749117A Tube sheet welding 失效
标题翻译：管板焊接
公开(公告)号：US4749117A
公开(公告)日：1988-06-07
申请号：US846966
申请日：1986-04-01
申请人： Renato R. Noe , Edward A. Fox
发明人： Renato R. Noe , Edward A. Fox
IPC分类号： B21D39/06 , B23K20/08
CPC分类号： B21D39/066 , Y10T29/49375 , Y10T29/49806
摘要： An improved method for the explosive expansion and welding of tubes to tube sheet includes trepanning the rear face of the tube sheet to form integral collars around each tube-receiving bore in the tube sheet. The collars prevent accumulation of corrosive material in a gap between the tube and tube sheet bore, and provide support to the tube wall when the tube is explosively expanded beyond the region of the tube surrounded by the collar.
摘要翻译：用于管到管板的爆炸膨胀和焊接的改进方法包括切割管板的后表面以在管板中的每个管接收孔周围形成一体的环。套环防止腐蚀性材料在管和管板孔之间的间隙中积聚，并且当管爆炸性地膨胀超过由套环包围的管的区域时，向管壁提供支撑。

4. 发明授权

US07346621B2 Method and system for ranking objects based on intra-type and inter-type relationships 失效
标题翻译：基于内部类型和类型间关系对对象进行排序的方法和系统
公开(公告)号：US07346621B2
公开(公告)日：2008-03-18
申请号：US10846835
申请日：2004-05-14
申请人： Benyu Zhang , Hua-Jun Zeng , Wei-Ying Ma , Wensi Xi , Zheng Chen , Edward A. Fox
发明人： Benyu Zhang , Hua-Jun Zeng , Wei-Ying Ma , Wensi Xi , Zheng Chen , Edward A. Fox
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30882 , Y10S707/954 , Y10S707/955 , Y10S707/962 , Y10S707/99942 , Y10S707/99943
摘要： A method and system for ranking objects based on relationships with objects of a different object type is provided. The ranking system defines an equation for each attribute of each type of object. The equations define the attribute values and are based on relationships between the attribute and the attributes associated with the same type of object and different types of objects. The ranking system iteratively calculates the attribute values for the objects using the equations until the attribute values converge on a solution. The ranking system then ranks objects based on attribute values.
摘要翻译：提供了一种用于基于与不同对象类型的对象的关系对对象进行排序的方法和系统。排名系统定义每种类型对象的每个属性的方程。方程式定义属性值，并且基于属性和与相同类型的对象和不同类型对象相关联的属性之间的关系。排序系统使用等式迭代地计算对象的属性值，直到属性值收敛于解。然后，排名系统根据属性值排列对象。

5. 发明申请

US20120180731A1 SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS 有权
标题翻译：自动化动物试验方案系统
公开(公告)号：US20120180731A1
公开(公告)日：2012-07-19
申请号：US13376671
申请日：2010-06-08
申请人： Joseph P. Garner , Michelle Murphy Niedziela , Edward A. Fox
发明人： Joseph P. Garner , Michelle Murphy Niedziela , Edward A. Fox
IPC分类号： A01K1/03
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimentor-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个装置，促进完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

6. 发明授权

US06672478B1 Method for dispensing viscous liquids from deformable flexible tubes 失效
标题翻译：从可变形柔性管分配粘性液体的方法
公开(公告)号：US06672478B1
公开(公告)日：2004-01-06
申请号：US09473834
申请日：2000-01-03
申请人： Edward A. Fox
发明人： Edward A. Fox
IPC分类号： B65D3532
CPC分类号： B65D35/28
摘要： Disclosed herein is a method for dispensing neat and measured quantities of the viscous liquid contents of deformable flexible tubes. The disclosed method entails dispensing a small quantity of the contents until a depleted portion near the crimped end of the tube is created, and then folding the depleted portion toward the open end of the tube and securing the fold with an elastic band stretched to encircle and fit snugly around the folded portion. Dispensing, folding and securing are continued until the entire tube is secured in folds and the tube is nearly devoid of contents.
摘要翻译：本文公开了一种用于分配整洁和测量量的可变形柔性管的粘性液体内容物的方法。所公开的方法需要分配少量的内容物，直到产生管子的压接端附近的耗尽部分，然后将耗尽部分朝向管的开口端折叠，并将弹性带固定在一起，以使其环绕和紧贴在折叠部分周围。持续进行点胶，折叠和固定，直到整个管固定成折叠，并且管几乎没有内容物。

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