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1. 发明授权

US07431914B2 Contrast agent 失效
标题翻译：对比剂
公开(公告)号：US07431914B2
公开(公告)日：2008-10-07
申请号：US10559880
申请日：2004-11-23
申请人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
发明人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
IPC分类号： A61K51/00
CPC分类号： A61K51/0497
摘要： A contrast agent of formula I: V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linear or branched amino acid-comprising biomodifier or linker moiety, and R is a reporter moiety detectable in in vivo imaging of a human or animal body.
摘要翻译：式I的造影剂：VLR（I）其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是包含直链或支链氨基酸的生物改性剂或连接体部分，R是可检测的报道部分人体或动物身体的体内成像。

2. 发明申请

US20090203584A1 Peptide-based Compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US20090203584A1
公开(公告)日：2009-08-13
申请号：US12423953
申请日：2009-04-15
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
IPC分类号： A61K38/12 , C07K7/64 , A61P35/00
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

3. 发明授权

US07994134B2 Peptide-based compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US07994134B2
公开(公告)日：2011-08-09
申请号：US12423953
申请日：2009-04-15
申请人： Alan Cuthbertson , Bård Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bård Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
IPC分类号： A61K38/00 , A61K38/12 , C07K14/705
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

4. 发明授权

US07521419B2 Peptide-based compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US07521419B2
公开(公告)日：2009-04-21
申请号：US10753729
申请日：2004-01-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
IPC分类号： A61K38/00 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

5. 发明授权

US08299030B2 Peptide-based compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US08299030B2
公开(公告)日：2012-10-30
申请号：US13204935
申请日：2011-08-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
IPC分类号： A61K38/00 , A61K38/12 , C07K14/705
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

6. 发明授权

US07767796B2 N4 chelator conjugates 有权
标题翻译： N4螯合剂共轭物
公开(公告)号：US07767796B2
公开(公告)日：2010-08-03
申请号：US11572161
申请日：2005-07-19
申请人： Anthony Eamonn Storey , Harry John Wadsworth , Nigel Anthony Powell , Philip Duncanson
发明人： Anthony Eamonn Storey , Harry John Wadsworth , Nigel Anthony Powell , Philip Duncanson
IPC分类号： C07F13/00
CPC分类号： A61K51/0478 , A61K51/0497
摘要： The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalized at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimize lipophilicity and steric hulk. Protected versions of the chelators are provided which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals.
摘要翻译：本发明提供四胺螯合剂与生物靶向部分，通过连接基团和其锝络合物作为放射性药物连接。接头基团使得螯合剂在桥头位置被单官能化并且提供柔性和缺乏或芳基，以使亲脂性和空间巨大的最小化。提供了螯合剂的保护形式，其允许与宽范围的靶向分子缀合，而不与四胺螯合剂的胺氮化物发生干扰反应。描述了官能化螯合剂的合成以及双官能螯合物前体。本发明描述了包含本发明的锝金属络合物的放射性药物组合物，以及用于制备这种放射性药物的非放射性试剂盒。

7. 发明申请

US20120020882A1 PEPTIDE-BASED COMPOUNDS 有权
标题翻译：基于肽的化合物
公开(公告)号：US20120020882A1
公开(公告)日：2012-01-26
申请号：US13204935
申请日：2011-08-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
IPC分类号： A61K51/08 , A61P9/00 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

8. 发明申请

US20080131368A1 N4 Chelator Conjugates 有权
标题翻译： N4切换器共轭体
公开(公告)号：US20080131368A1
公开(公告)日：2008-06-05
申请号：US11572161
申请日：2005-07-19
申请人： Anthony Eamonn Storey , Harry John Wadsworth , Nigel Anthony Powell , Philip Duncanson
发明人： Anthony Eamonn Storey , Harry John Wadsworth , Nigel Anthony Powell , Philip Duncanson
IPC分类号： A61K51/08 , C07K7/06 , C07C271/10 , C07D403/08 , C07K5/062
CPC分类号： A61K51/0478 , A61K51/0497
摘要： The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalised at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimise lipophilicity and steric hulk. Protected versions of the chelators are provided which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals.
摘要翻译：本发明提供四胺螯合剂与生物靶向部分，通过连接基团和其锝络合物作为放射性药物连接。接头基团使得螯合剂在桥头位置单官能化并提供柔性和缺乏或芳基，以使亲脂性和空间巨噬最小化。提供了螯合剂的保护形式，其允许与宽范围的靶向分子缀合，而不与四胺螯合剂的胺氮化物发生干扰反应。描述了官能化螯合剂的合成以及双官能螯合物前体。本发明描述了包含本发明的锝金属络合物的放射性药物组合物，以及用于制备这种放射性药物的非放射性试剂盒。

9. 发明授权

US07919071B2 Contrast agent 失效
标题翻译：对比剂
公开(公告)号：US07919071B2
公开(公告)日：2011-04-05
申请号：US10541949
申请日：2004-01-09
申请人： Magne Solbakken , Torgrim Engell , Harry John Wadsworth , Colin M. Archer
发明人： Magne Solbakken , Torgrim Engell , Harry John Wadsworth , Colin M. Archer
IPC分类号： A61K51/00 , A61M36/14 , A61B6/00 , C07D257/04
CPC分类号： C07K5/0819 , A61K49/0002 , A61K51/0497 , C07D403/10 , C07D493/10 , C07D495/04
摘要： The present invention relates to a contrast agent of Formula I V-L-Z Formula I where V is a non-peptidic vector having affinity for the Angiotensin II receptor, L is a bond, a spacer or a linker moiety and Z represents a moiety detectable in an in vivo imaging procedure of a human or animal body.
摘要翻译：本发明涉及式I VLZ式I的造影剂，其中V是对血管紧张素II受体具有亲和性的非肽载体，L是键，间隔基或连接体部分，Z表示可以在人体或动物体的体内成像过程。

10. 发明授权

US08158804B2 Chelating agents 失效
标题翻译：螯合剂
公开(公告)号：US08158804B2
公开(公告)日：2012-04-17
申请号：US12521195
申请日：2008-01-11
申请人： Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea
发明人： Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea
IPC分类号： C07D213/89 , C07D213/69
CPC分类号： C07D213/81 , A61K49/103
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
摘要翻译：本发明涉及螯合剂，特别涉及能够与顺磁金属离子如铁（III）和钆（III）形成络合物的螯合剂。本发明还涉及形成的复合物及其作为MRI造影剂的用途。

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