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1. 发明授权

US4152325A Novel steroids and their use 失效
标题翻译：新颖的甾体及其使用
公开(公告)号：US4152325A
公开(公告)日：1979-05-01
申请号：US855177
申请日：1977-11-28
申请人： Alain Jouquey , Andre Pierdet
发明人： Alain Jouquey , Andre Pierdet
IPC分类号： A61K51/00 , C07J1/00 , C07J7/00 , C07J9/00 , C07J17/00 , G01N33/53 , G01N33/534 , C07J71/00
CPC分类号： C07J1/0081 , C07J1/0096 , C07J17/00 , C07J7/0045 , C07J9/00
摘要： Novel pregnatetraenes of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, tetrahydropyranyl, trityl and trimethylsilyl and intermediates therefore and a process for their preparation and a process for the preparation of tritium labelled steroids.

2. 发明授权

US4203981A Novel 17 .alpha.-aryl-steroids 失效
标题翻译：新型17α-芳基类固醇
公开(公告)号：US4203981A
公开(公告)日：1980-05-20
申请号：US692
申请日：1979-01-03
申请人： Andre Pierdet , Vesperto Torelli , Roger Deraedt
发明人： Andre Pierdet , Vesperto Torelli , Roger Deraedt
IPC分类号： A61K31/565 , A61K31/58 , A61P29/00 , C07J1/00 , C07J17/00 , C07J33/00 , C07J43/00 , C07J71/00 , A61K31/56
CPC分类号： C07J43/003 , C07J1/0011 , C07J1/0033 , C07J17/00 , C07J33/002 , C07J71/0015
摘要： Novel steroids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.2 is selected from the group consisting of optionally substituted aryl of 6 to 12 carbon atoms and optionally substituted heterocyclic selected from the group consisting of furyl, thienyl, pyridyl and pyrimidyl, the optional substituents being selected from the group consisting of hydroxy, alkyl and alkoxy of 1 to 4 carbon atoms, halogens and --CF.sub.3, the dotted line in the A ring indicates an optional .DELTA..sup.1(2) - double bond and A may be oxo and B is hydrogen or A is .DELTA.--OH and B is hydrogen or halogen or A and B form a .DELTA..sup.9(10) - double bond having very good anti-inflammatory activity and their preparation and novel intermediates.
摘要翻译：式（Ⅰ）的新型类固醇，其中R 1选自氢和1至18个碳原子的有机羧酸的酰基，R 2选自任选取代的6至12个碳原子的芳基和任选取代的杂环基，其选自呋喃基，噻吩基，吡啶基和嘧啶基，任选的取代基选自羟基，1至4个碳原子的烷基和烷氧基，卤素和-CF 3，环表示可选的DELTA 1（2） - 双键，A可以是氧代，B是氢或A是DELTA -OH，B是氢或卤素，或A和B形成具有非常特异的DELTA 9（10） - 双键良好的抗炎活性及其制备及新型中间体。

3. 发明授权

US4105761A Anabolisant-androgenic compounds 失效
标题翻译：合成代谢物 - 雄激素化合物
公开(公告)号：US4105761A
公开(公告)日：1978-08-08
申请号：US553249
申请日：1975-02-26
申请人： Andre Pierdet , Genevieve Azadian
发明人： Andre Pierdet , Genevieve Azadian
IPC分类号： C07J51/00 , A61K31/565 , A61P3/00 , A61P5/00 , C07J1/00 , A61K31/56
CPC分类号： C07J1/0077
摘要： Anabolisant-androgenic compositions comprising an effective amount of 17.beta.-n-amyloxy-.DELTA..sup.4,9,11 -estratriene-3-one and a pharmaceutical carrier and to a novel method of inducing androgenic and anabolisant activity in humans and other warm-blooded animals by administration of an effective amount of 17.beta.-n-amyloxy-.DELTA..sup.4,9,11 -estratriene-3-one.
摘要翻译：包含有效量的17β-n-戊氧基-TATA 4,9,11-雌三烯-3-酮和药物载体的合成代谢雄激素组合物以及诱导人和其他温血的雄激素和去代谢活性的新方法通过施用有效量的17β-正 - 戊氧基-TATA 4,9,11-雌三烯-3-酮的动物。

4. 发明授权

US5158981A Antiandrogenic compounds and methods 失效
标题翻译：抗原化合物和方法
公开(公告)号：US5158981A
公开(公告)日：1992-10-27
申请号：US502922
申请日：1990-03-30
申请人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
发明人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
IPC分类号： C07C69/013 , A61K8/00 , A61K8/11 , A61K8/35 , A61K8/37 , A61K8/49 , A61K31/045 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/44 , A61K31/4406 , A61K31/455 , A61P17/00 , A61P43/00 , A61Q5/00 , C07C45/00 , C07C45/61 , C07C45/67 , C07C49/513 , C07C49/517 , C07C49/737 , C07C49/753 , C07C67/00 , C07C69/03 , C07C69/08 , C07C313/00 , C07C323/13 , C07D213/79 , C07D213/80 , C07D317/70 , C07D317/72
CPC分类号： C07D213/80 , C07C49/513 , C07D317/70 , C07D317/72 , C07C2103/16
摘要： A antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

5. 发明授权

US4318910A Indolobenzoxazines 失效
标题翻译：吲哚溴嗪
公开(公告)号：US4318910A
公开(公告)日：1982-03-09
申请号：US246169
申请日：1981-03-23
申请人： Lucien Nedelec , Andre Pierdet , Claude Dumont
发明人： Lucien Nedelec , Andre Pierdet , Claude Dumont
IPC分类号： A61K31/535 , A61P9/12 , A61P25/00 , A61P43/00 , C07D209/90 , C07D498/06 , A01N43/84
CPC分类号： C07D209/90
摘要： Novel indolobenzoxazines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, chlorine and bromine, R.sub.2 ' is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, alkenyl and alkynyl of 3 to 7 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms and the dotted line between 5 and 5a indicates the optional presence of a double bond and their non-toxic, pharmaceutically acceptable acid addition salts having hypotensive, antihypertensive and dopaminergic agonist properties and a process for their preparation.
摘要翻译：式“IMAGE”I'的新型吲哚并恶嗪其中R选自氢，1至5个碳原子的烷基和任选取代的7至12个碳原子的芳烷基，R 1选自氢，氯和溴，R 2'选自氢，任选取代的1至5个碳原子的烷基，4至7个碳原子的环烷基烷基，3至7个碳原子的链烯基和炔基，以及7-12个碳原子的任选取代的芳烷基原子和5和5a之间的虚线表示任选存在双键及其无毒的药学上可接受的具有降压，抗高血压和多巴胺能激动剂性质的酸加成盐及其制备方法。

6. 发明授权

US4242335A Novel 17.alpha.-aryl-steroids 失效
标题翻译：新型17α-芳基类固醇
公开(公告)号：US4242335A
公开(公告)日：1980-12-30
申请号：US955403
申请日：1978-10-27
申请人： Genevieve Azadian , Daniel Philibert , Andre Pierdet
发明人： Genevieve Azadian , Daniel Philibert , Andre Pierdet
IPC分类号： A61K31/565 , C07J1/00 , C07J21/00
CPC分类号： C07J1/0088 , C07J21/006
摘要： Novel 17.alpha.-aryl-steroids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.3 is aryl of 6 to 12 carbon atoms optionally substituted with at least one substituent selected from the group consisting of --OH, halogen, alkoxy and alkyl of 1 to 4 carbon atoms and --CF.sub.3, the dotted line in the B ring indicating an optional double bond in the 9(10)-position, and A and B are hydrogen and when there is a double bond in the 9(10)-position, A and B form a double bond in the 11(12) position or B is hydrogen and A is an 11.beta.-hydroxy having progestomimetic activity activity without androgenic activity and a process for their preparation and novel intermediates produced therein.
摘要翻译：新型17α-芳基 - 类固醇，其中R 1为1至3个碳原子的烷基，R 2选自氢，1至12个碳原子的烷基和有机羧酸的酰基 1至18个碳原子，R3是任选被至少一个选自-OH，卤素，烷氧基和1至4个碳原子的烷基和-CF 3的取代基取代的6至12个碳原子的芳基，虚线在 B环表示9（10）位中任选的双键，A和B是氢，当在9（10）位具有双键时，A和B在11（10） - 位上形成双键， 12）位置或B是氢，A是具有没有雄激素活性的模拟活动活性的11β-羟基，其制备方法和其中产生的新的中间体。

7. 发明授权

US4927975A Process for preparing certain decahydro-7H-3-ol-7-ones 失效
标题翻译：制备某些十氢-7H-3-醇-7-酮的方法
公开(公告)号：US4927975A
公开(公告)日：1990-05-22
申请号：US223636
申请日：1988-07-25
申请人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
发明人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
IPC分类号： C07C69/013 , A61K8/00 , A61K8/11 , A61K8/35 , A61K8/37 , A61K8/49 , A61K31/045 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/44 , A61K31/4406 , A61K31/455 , A61P17/00 , A61P43/00 , A61Q5/00 , C07C45/00 , C07C45/61 , C07C45/67 , C07C49/513 , C07C49/517 , C07C49/737 , C07C49/753 , C07C67/00 , C07C69/03 , C07C69/08 , C07C313/00 , C07C323/13 , C07D213/79 , C07D213/80 , C07D317/70 , C07D317/72 , C07C49/403 , C07C49/497 , C07C49/603
CPC分类号： C07D213/80 , C07C49/513 , C07D317/70 , C07D317/72 , C07C2103/16
摘要： Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

8. 发明授权

US4189477A Novel .DELTA..sup.4 -pregnenes 失效
标题翻译：新型DELTA 4-孕烯
公开(公告)号：US4189477A
公开(公告)日：1980-02-19
申请号：US903600
申请日：1978-05-08
申请人： Lucien Nedelec , Andre Pierdet , Roger Deraedt
发明人： Lucien Nedelec , Andre Pierdet , Roger Deraedt
IPC分类号： C07J5/00 , A61K31/57 , A61K31/573 , A61P29/00 , A61P37/08 , C07J41/00 , A61K31/56 , C07J1/00
CPC分类号： C07J41/0016
摘要： Novel .DELTA..sup.4 -pregnenes of the formula ##STR1## wherein X.sub.1 is selected from the group consisting of .dbd.O and ##STR2## Y is selected from the group consisting of hydrogen and halogen, R.sub.1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, X.sub.2 is selected from the group consisting of hydrogen and --OH, R in the 16.alpha.- or .beta.-position is selected from the group consisting of hydrogen, --OH and methyl, Z is selected from the group consisting of (1) --OH, (2) alkoxy of 1 to 12 carbon atoms, (3) cycloalkoxy of 3 to 12 carbon atoms, (4) acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms, (5) ##STR3## wherein W is a hydrocarbon of 1 to 12 carbon atoms, (6) ##STR4## wherein R.sub.2 is hydrogen or alkyl of 1 to 12 carbon atoms, (7) ##STR5## wherein R.sub.3 is a hydrocarbon of 1 to 12 carbon atoms and (8) ##STR6## the dotted line in the A ring indicates the optional presence of a double bond in the 1(2)-position and A and B are both hydrogen or A is methyl, chlorine or fluorine while B is hydrogen or A and B may form a double bond in the 6(7)-position with the proviso that if the A ring has a 1(2) double bond, A is hydrogen or fluorine, B is hydrogen, Y is hydrogen or fluorine, X.sub.2 is hydrogen or --OH, R is methyl and Z is not --OH having a very marked antiallergic activity with a reduced anti-inflammatory activity and a process for their preparation.
摘要翻译：式（I）其中X1选自= O和Y的新型DELTA 4-孕烯选自氢和卤素，R 1选自氢和酰基的1至18个碳原子的有机羧酸，X 2选自氢和-OH，16个α-或β-位中的R选自氢，-OH和甲基，Z 选自（1）-OH，（2）1至12个碳原子的烷氧基，（3）3至12个碳原子的环烷氧基，（4）1至18个碳原子的有机羧酸的酰氧基（5）其中W是1至12个碳原子的烃，（6）其中R 2是氢或1至12个碳原子的烷基，（7）其中R 3是 1至12个碳原子和（8）A环中的虚线表示在1（2）位中任选存在双键，A和B均为氢基或A是甲基，氯或氟，而B是氢或A和B可以在6（7） - 位上形成双键，条件是如果A环具有1（2）双键，则A是氢或氟，B是氢，Y是氢或氟，X2是氢或-OH，R是甲基，Z不是-OH，具有非常显着的抗过敏活性，抗炎活性降低及其制备方法。

9. 发明授权

US3988356A Novel haptenes and antigens 失效
标题翻译：新的半抗原和抗原
公开(公告)号：US3988356A
公开(公告)日：1976-10-26
申请号：US593268
申请日：1975-07-07
申请人： Andre Pierdet , Michel Vignau
发明人： Andre Pierdet , Michel Vignau
IPC分类号： G01N33/53 , A61K38/16 , C07J7/00 , C07J41/00 , C07J9/00 , C07J5/00
CPC分类号： C07J7/002 , C07J41/0016 , Y10S436/823
摘要： Novel haptenes of the formula ##SPC1##Wherein when X is hydrogen, Y is =N-O-(CH.sub.2).sub.a --COOH and a is a whole number of 1 to 12 and when ##EQU1## X is hemiterephthaloyloxy in the .alpha.- or .beta.-position and antigens prepared therefrom by condensation with beef serum albumin.
摘要翻译：新的半抗体，当X是氢时，Y是= NO-（CH2）a-COOH，a是1到12的整数，当HY是ANGLE时，HX是α-或β-位中的对映草酰氧基和抗原通过与牛血清白蛋白缩合制备。

10. 发明授权

US4607054A Antiandrogenic compositions containing indene-7-ones 失效
标题翻译：含有茚-7-酮的抗雄激素组合物
公开(公告)号：US4607054A
公开(公告)日：1986-08-19
申请号：US543315
申请日：1983-10-19
申请人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
发明人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
IPC分类号： C07C69/013 , A61K8/00 , A61K8/11 , A61K8/35 , A61K8/37 , A61K8/49 , A61K31/045 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/44 , A61K31/4406 , A61K31/455 , A61P17/00 , A61P43/00 , A61Q5/00 , C07C45/00 , C07C45/61 , C07C45/67 , C07C49/513 , C07C49/517 , C07C49/737 , C07C49/753 , C07C67/00 , C07C69/03 , C07C69/08 , C07C313/00 , C07C323/13 , C07D213/79 , C07D213/80 , C07D317/70 , C07D317/72 , C07C69/14
CPC分类号： C07D213/80 , C07C49/513 , C07D317/70 , C07D317/72 , C07C2103/16
摘要： Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.
摘要翻译：包含抗雄激素有效量的至少一种下式化合物的新型抗雄激素组合物，其中R是1至4个碳原子的烷基，R 1是1至2个碳原子的烷基，R 2选自氢任选地被2至8个碳原子的链烯基和炔基任选地中断为具有2至18个碳原子的有机羧酸的杂原子，甲酰基和酰基的1-8个碳原子的烷基，所述烷基任选地被2至8个碳原子的烯基和炔基中断，由氢，1至4个碳原子的烷基和2至4个碳原子的烯基和炔基组成，R4选自氢和1至4个碳原子的烷基，虚线表示任选存在双键在4（5）和5a（6）碳之间，波浪线表示R4可以是α或β-位，一种无毒的药物载体或赋形剂，以及一种在温暖血液中治疗雄激素过多症状的方法有动物

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