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1. 发明申请

US20100056982A1 Photodynamic therapy for the treatment of acne 审中-公开
标题翻译：光动力疗法治疗痤疮
公开(公告)号：US20100056982A1
公开(公告)日：2010-03-04
申请号：US10588571
申请日：2005-02-04
申请人： Alain H. Curaudeau , Herma C. Neyndorff , Jinj-Song Tao , Morgan Chun Lam , Patrick Mark Curry , Valery Rubinchik , David W.C. Hunt
发明人： Alain H. Curaudeau , Herma C. Neyndorff , Jinj-Song Tao , Morgan Chun Lam , Patrick Mark Curry , Valery Rubinchik , David W.C. Hunt
IPC分类号： A61K41/00 , A61M37/00 , A61N5/06
CPC分类号： A61K31/07 , A61K31/203 , A61K31/409 , A61K31/555 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/062
摘要： The present method involves the photodynamic treatment of acne vulgaris. The method involves the topical administration of a photosensitizer composition comprising hydrophobic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to acne-affected skin and subsequent exposure of that skin to energy of a wavelength of activating the photosensitizer.
摘要翻译：本方法涉及寻常痤疮的光动力治疗。该方法包括局部施用包含疏水性绿色卟啉如雷米普芬，聚乙二醇和皮肤渗透促进剂如油醇和TRANSCUTOL TM的光敏剂组合物，以治疗受痤疮影响的皮肤，并随后将该皮肤暴露于激活波长的波长的能量光敏剂

2. 发明申请

US20080096857A1 Photodynamic Therapy For The Treatment Of Hyperactive Sebaceous Gland Disorders Using Topically Applied Hydrophobic Green Porphyrins 审中-公开
标题翻译：使用局部应用疏水性绿色卟啉治疗多活动性皮脂腺疾病的光动力疗法
公开(公告)号：US20080096857A1
公开(公告)日：2008-04-24
申请号：US10588419
申请日：2005-02-08
申请人： Alain H. Curaudeau , Herma C. Neyndorff , Jing-Song Tao , Julia G. Levy , David W.C. Hunt , Morgan Chun Lam , Patrick Mark Curry , Valery Rubinchik
发明人： Alain H. Curaudeau , Herma C. Neyndorff , Jing-Song Tao , Julia G. Levy , David W.C. Hunt , Morgan Chun Lam , Patrick Mark Curry , Valery Rubinchik
IPC分类号： A61K31/555 , A61K31/5415 , A61K31/409 , A61K31/195
CPC分类号： A61K31/07 , A61K31/203 , A61K31/409 , A61K31/555 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/062
摘要： The present method involves the photodynamic treatment of hyperactive gland disorders. The method involves the topical administration of a photosensitizer composition comprising hydrophobic and/or lipophilic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to affected skin and subsequent exposure of that skin to energy of a wavelength capable of activating the photosensitizer.
摘要翻译：本方法涉及光动力学治疗多发性腺体疾病。该方法包括局部施用包含疏水性和/或亲脂性绿色卟啉如雷米他芬，聚乙二醇和皮肤渗透增强剂如油醇和TRANSCUTOL TM的光敏剂组合物，以影响皮肤并随后暴露于皮肤的能量波长能够激活光敏剂。

3. 发明授权

US07122568B1 Use of low-dose PDT to inhibit restenosis 失效
标题翻译：使用低剂量PDT来抑制再狭窄
公开(公告)号：US07122568B1
公开(公告)日：2006-10-17
申请号：US09715478
申请日：2000-11-17
申请人： Beth Anne Allison , Philippe Maria Clotaire Margaron , Valery Rubinchik , Russell G. Hodge , Michael David Leslie Stonefield
发明人： Beth Anne Allison , Philippe Maria Clotaire Margaron , Valery Rubinchik , Russell G. Hodge , Michael David Leslie Stonefield
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61N5/0601 , A61N5/062 , A61N2005/0602
摘要： The present invention relates to the use of low-dose photodynamic therapy (PDT) to prevent, treat, inhibit or reduce restenosis in blood vessels. The present invention may be used in combination with any angioplastic procedure to prevent restenosis or to decrease the intima thickness, and thus luminal narrowing.
摘要翻译：本发明涉及低剂量光动力疗法（PDT）用于预防，治疗，抑制或减少血管再狭窄的用途。本发明可以与任何血管生成过程组合使用，以防止再狭窄或降低内膜厚度，从而使腔狭窄。

4. 发明申请

US20130053794A1 SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 审中-公开
标题翻译：持续释放活性药剂以治疗玻尿酸和高血压
公开(公告)号：US20130053794A1
公开(公告)日：2013-02-28
申请号：US13598573
申请日：2012-08-29
申请人： Suzanne Cadden , Yong Hao , Deepank Utkhede , Valery Rubinchik , Charles Richard Kjellbotn
发明人： Suzanne Cadden , Yong Hao , Deepank Utkhede , Valery Rubinchik , Charles Richard Kjellbotn
IPC分类号： A61F9/00 , A61M35/00
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
摘要翻译：在有需要的患者的眼睛中减少眼内压（IOP）的方法包括将第一泪液植入物通过第一泪点植入，并进入患者眼睛的第一泪小管。该方法还可以包括将第二泪液植入物植入穿过第二泪点并进入患者眼睛的第二泪小管，并持续释放治疗有效量的眼内压降治疗剂。

5. 发明授权

US08702643B2 Lacrimal implants and related methods 有权
标题翻译：泪液植入及相关方法
公开(公告)号：US08702643B2
公开(公告)日：2014-04-22
申请号：US13598201
申请日：2012-08-29
申请人： Alan R. Rapacki , Valery Rubinchik , John B. Holds , Sylvie Sim , Danny Shen
发明人： Alan R. Rapacki , Valery Rubinchik , John B. Holds , Sylvie Sim , Danny Shen
IPC分类号： A61M5/00 , A61M13/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2210/0061 , A61F2220/0008 , A61F2250/0067 , Y10T407/19 , Y10T409/304256
摘要： Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed.
摘要翻译：公开了用于治疗疾病或病症的泪液植入物。更具体地，公开了泪液植入物，制造这种植入物的方法，以及使用这种植入物治疗眼睛，呼吸，内耳或其它疾病或病症的方法。

6. 发明申请

US20120318281A1 LACRIMAL IMPLANTS AND RELATED METHODS 有权
标题翻译： LACRIMAL植入物及相关方法
公开(公告)号：US20120318281A1
公开(公告)日：2012-12-20
申请号：US13598201
申请日：2012-08-29
申请人： Alan R. Rapacki , Valery Rubinchik , John B. Holds , Sylvie Sim , Danny Shen
发明人： Alan R. Rapacki , Valery Rubinchik , John B. Holds , Sylvie Sim , Danny Shen
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2210/0061 , A61F2220/0008 , A61F2250/0067 , Y10T407/19 , Y10T409/304256
摘要： Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed.
摘要翻译：公开了用于治疗疾病或病症的泪液植入物。更具体地，公开了泪液植入物，制造这种植入物的方法，以及使用这种植入物治疗眼睛，呼吸，内耳或其它疾病或病症的方法。

7. 发明申请

US20100274204A1 LACRIMAL IMPLANTS AND RELATED METHODS 审中-公开
标题翻译： LACRIMAL植入物及相关方法
公开(公告)号：US20100274204A1
公开(公告)日：2010-10-28
申请号：US12710855
申请日：2010-02-23
申请人： Alan R. RAPACKI , Valery Rubinchik , Charles Richard Kjellbotn
发明人： Alan R. RAPACKI , Valery Rubinchik , Charles Richard Kjellbotn
IPC分类号： A61F9/00 , A61M31/00
CPC分类号： A61F9/00772 , A61F2250/0003 , A61K9/0051
摘要： Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.
摘要翻译：公开了泪液植入物和相关方法，其提供眼泪内的泪点和相关小管内的牢固的可嵌入的保留。泪液植入物可以包括植入体，其构造成用于至少部分插入通过泪点并进入小管。植入体可以包括第一和第二部分，并且可以从限定纵向近端轴线的第一部分的近端延伸到限定纵向远侧轴线的第二部分的远端。植入物本体可以被配置成使得当使用整体式扩张器植入时，在近轴和远轴之间存在成角度的交叉。以这种方式，植入物主体的至少一部分可以抵靠位于或相对于小管曲率的远侧的泪小管的至少一部分偏置，从而使用解剖结构保留泪液植入物的植入位置。

8. 发明申请

US20080071331A1 Photodynamic Therapy For The Treatment Of Prostatic Conditions 审中-公开
标题翻译：光动力疗法治疗前列腺疾病
公开(公告)号：US20080071331A1
公开(公告)日：2008-03-20
申请号：US10589086
申请日：2004-02-13
申请人： Valery Rubinchik , Mitchell D. Visser
发明人： Valery Rubinchik , Mitchell D. Visser
IPC分类号： A61N5/067 , A61M29/02 , B65D69/00
CPC分类号： A61N5/062 , A61B2017/00274 , A61B2018/00547 , A61B2018/2261 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/0601 , A61N2005/061
摘要： The present invention relates to a photodynamic method of treating prostatic disorders such as BPH. The method comprises: administering a photosensitizer by direct injection to the prostate tissue of a subject afflicted with or suspected of being afflicted with a prostatic disorder; and irradiating the prostate tissue with energy at a wavelength appropriate to activate the photosensitizer, wherein a guidewire is utilized to position the injection device and the irradiation apparatus.
摘要翻译：本发明涉及一种治疗前列腺疾病如BPH的光动力学方法。该方法包括：通过直接注射给患有或怀疑患有前列腺障碍的受试者的前列腺组织施用光敏剂; 以及以适于激活光敏剂的波长的能量照射前列腺组织，其中使用导丝来定位注射装置和照射装置。

9. 发明授权

US10238535B2 Lacrimal implants and related methods 有权
公开(公告)号：US10238535B2
公开(公告)日：2019-03-26
申请号：US12710855
申请日：2010-02-23
申请人： Alan R. Rapacki , Valery Rubinchik , Charles Richard Kjellbotn
发明人： Alan R. Rapacki , Valery Rubinchik , Charles Richard Kjellbotn
IPC分类号： A61M31/00 , A61F9/007 , A61K9/00
摘要： Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.

10. 发明授权

US09211214B2 Photodynamic therapy laser 有权
标题翻译：光动力疗法激光
公开(公告)号：US09211214B2
公开(公告)日：2015-12-15
申请号：US13426470
申请日：2012-03-21
申请人： Valery Rubinchik , Charles Richard Kjellbotn , Greg Heacock , Louise Culham , Wes A. Williams
发明人： Valery Rubinchik , Charles Richard Kjellbotn , Greg Heacock , Louise Culham , Wes A. Williams
IPC分类号： A61N5/067 , A61F9/008
CPC分类号： A61F9/00821 , A61B2018/2035 , A61F9/00823 , A61F2009/00844 , A61F2009/00863 , A61N5/062 , A61N2005/063 , A61N2005/0643 , A61N2005/0667 , A61N2005/067
摘要： A laser system including: a laser source operable to emit a first and a second laser beam having first and second operating wavelengths, respectively; a fiber optic cable to guide and homogenize the laser beams; an expander to increase the diameter of the laser beams; a cylinder to guide the laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the laser beams, wherein the optical system is positioned after the cylinder on the optical path of the laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the laser beams; and a second optical system to focus the laser beams on a tissue of the patient.
摘要翻译：一种激光系统，包括：激光源，其可操作地分别发射具有第一和第二工作波长的第一和第二激光束; 用于引导和均匀化激光束的光纤电缆; 一个扩张器来增加激光束的直径; 引导激光束并限制第一和第二激光束的相应直径的圆柱体，其中圆柱体位于激光束的光路上的扩展器之后; 用于准直激光束的第一光学系统，其中光学系统位于激光束的光路上的圆柱体之后; 一个点尺寸选择器，包括多个孔，其中光斑尺寸选择器位于激光束的光路上的第一光学系统之后; 以及将激光束聚焦在患者的组织上的第二光学系统。

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