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1. 发明申请

US20120040463A1 HOLLOW, NOTABLY MULTI-MEMBRANE FIBERS, METHOD FOR PREPARATION THEREOF BY SPINNING AND DEVICE FOR APPLYING SAID METHOD 审中-公开
标题翻译：中空纤维，多孔膜纤维，其纺丝方法及用于施用方法的装置
公开(公告)号：US20120040463A1
公开(公告)日：2012-02-16
申请号：US12676560
申请日：2008-09-05
申请人： Alain Domard , Laurent David , Rocío Nohemí Rivas Araiza
发明人： Alain Domard , Laurent David , Rocío Nohemí Rivas Araiza
IPC分类号： C12N5/07 , B29C55/22 , D01D5/06
CPC分类号： D01D5/24 , B01D69/087 , B01D69/088 , D01D5/06 , D01F2/28 , D01F4/00 , D01F9/00 , D01F9/04
摘要： The present invention relates to a method for preparing fibers, notably of polysaccharide or collagen, by wet spinning under coagulation, said method notably comprising: a step for extruding a coagulable macromolecular assembly solution through a normal die; at least one partial coagulation cycle comprising a coagulation step on the one hand and a step for interrupting the coagulation on the other hand; and a step for receiving, notably by winding up, the obtained hollow fiber. The invention also relates to multi-membrane hollow fibers consisting of a same macromolecular assembly which may be spun by coagulation, notably a natural or modified natural polysaccharide in the physical hydrogel or partly dehydrated state. Said fibers including at least over their length two superposed coaxial membranes separated from each other by an inter-membrane space. The invention also relates to the spinning device for applying said method.
摘要翻译：本发明涉及通过在凝固下湿法纺丝制备纤维，特别是多糖或胶原纤维的方法，所述方法特别包括：通过正常模具挤出可凝结的大分子装配溶液的步骤; 至少一个部分凝固循环一方面包括凝固步骤和另一方面中断凝固的步骤; 以及用于接收，特别是通过卷绕所获得的中空纤维的步骤。本发明还涉及由可以通过凝结而纺出的相同的大分子组合物组成的多膜中空纤维，特别是物理水凝胶或部分脱水状态的天然或改性天然多糖。所述纤维至少在其长度上包括通过膜间间隔彼此分离的两个重叠的同轴膜。本发明还涉及用于应用所述方法的纺丝装置。

2. 发明授权

US09238880B2 Chitosan yarn having a crystal structure corresponding to the anhydrous allomorph and a tensile strength, after immersion in demineralized water for fifteen hours, of at least 150 MPA 有权
标题翻译：具有对应于无水异构体的晶体结构的壳聚糖纱线和在软化水中浸泡15小时后的拉伸强度为至少150MPA
公开(公告)号：US09238880B2
公开(公告)日：2016-01-19
申请号：US13201489
申请日：2010-02-15
申请人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
发明人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
IPC分类号： D01F2/08 , D01F9/00 , D01D5/06 , D01F2/24
CPC分类号： D01F9/00 , B29C47/0014 , B29C47/8805 , B29C47/8895 , D01D5/06 , D01F2/24
摘要： The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element. The chitosan thread has a crystalline structure corresponding to the anhydrous allomorph and a rupture stress of at least 150 MPa after being immersed in demineralized water for fifteen hours. The apparatus (1) for the wet extrusion of polysaccharide thread (10) includes an extruder (2) with at least one extrusion die (3), an evaporation enclosure (4) placed immediately after the output (3a) of the extrusion die (3) and supplied with a hot air flow, a neutralization unit (5), a washing unit (6), a drying unit (8) and a winding unit (9).
摘要翻译：本发明涉及一种用于生产细长多糖元件，特别是壳聚糖螺纹的方法，其包括通过挤出模挤出所述多糖的可渗透溶液的操作和使挤出溶液凝结的操作。可膨胀溶液是含有在大气压下不与水形成共沸物并且沸点大于150℃的醇的水醇溶液。凝结操作包括蒸发水，优选在醇上的步骤，产生主要为醇凝胶形式的凝胶化挤出细长元件，特别是通过将挤出的溶液经受热空气流。消除所述凝胶中所含的醇的至少一种操作使得可以获得细长多糖元件。壳聚糖螺纹具有对应于无水异构体的晶体结构，并且在浸入软化水中15小时后的破裂应力至少为150MPa。用于多糖螺纹（10）的湿挤压的装置（1）包括具有至少一个挤出模头（3）的挤出机（2），紧紧在挤出模头的输出（3a）之后放置的蒸发外壳（4）供给热风流，中和单元（5），清洗单元（6），干燥单元（8）和卷绕单元（9）。

3. 发明申请

US20120022242A1 METHOD FOR PRODUCING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD, AND POLYSACCCHARIDE THREAD OBTAINED 有权
标题翻译：生产优质多糖元素的方法，特别是芝士螺纹和多晶硅螺纹获得
公开(公告)号：US20120022242A1
公开(公告)日：2012-01-26
申请号：US13201489
申请日：2010-02-15
申请人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
发明人： Alain Domard , Laurent David , Alexandra Montembault , Mylène Desorme
IPC分类号： C08B37/08 , B29C47/88 , D01F2/08 , B29C47/78 , D01D5/06
CPC分类号： D01F9/00 , B29C47/0014 , B29C47/8805 , B29C47/8895 , D01D5/06 , D01F2/24
摘要： The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element. The chitosan thread has a crystalline structure corresponding to the anhydrous allomorph and a rupture stress of at least 150 MPa after being immersed in demineralised water for fifteen hours. The apparatus (1) for the wet extrusion of polysaccharide thread (10) includes an extruder (2) with at least one extrusion die (3), an evaporation enclosure (4) placed immediately after the output (3a) of the extrusion die (3) and supplied with a hot air flow, a neutralisation unit (5), a washing unit (6), a drying unit (8) and a winding unit (9).
摘要翻译：本发明涉及一种用于生产细长多糖元件，特别是壳聚糖螺纹的方法，其包括通过挤出模挤出所述多糖的可渗透溶液的操作和使挤出溶液凝结的操作。可膨胀溶液是含有在大气压下不与水形成共沸物并且沸点大于150℃的醇的水醇溶液。凝结操作包括蒸发水，优选在醇上的步骤，产生主要为醇凝胶形式的凝胶化挤出细长元件，特别是通过将挤出的溶液经受热空气流。消除所述凝胶中所含的醇的至少一种操作使得可以获得细长多糖元件。壳聚糖螺纹具有对应于无水异构体的晶体结构，并且在浸入软化水中15小时后的破裂应力至少为150MPa。用于多糖螺纹（10）的湿挤压的装置（1）包括具有至少一个挤出模头（3）的挤出机（2），紧紧在挤出模头的输出（3a）之后放置的蒸发外壳（4）供给热风流，中和单元（5），清洗单元（6），干燥单元（8）和卷绕单元（9）。

4. 发明申请

US20100310631A1 FILAMENT BASED ON HYALURONIC ACID IN THE FORM OF FREE ACID AND METHOD FOR OBTAINING IT 有权
标题翻译：基于免疫酸形式的羟丙酸纤维和获得其的方法
公开(公告)号：US20100310631A1
公开(公告)日：2010-12-09
申请号：US12680257
申请日：2008-09-26
申请人： Alain Domard , Laurent David , Florence Dupasquier
发明人： Alain Domard , Laurent David , Florence Dupasquier
IPC分类号： A61K9/70 , B29C47/00 , D02G3/22 , D02G3/36 , A61K38/22 , A61K38/18 , A61K38/20 , A61K38/21 , A61P31/04 , A61P31/10
CPC分类号： A61K9/70 , A61K47/36 , A61L27/20 , C08J7/04 , C08J7/065 , C08J2305/08 , D01D5/06 , D01F9/00 , D01F11/00 , Y10T428/2913 , Y10T428/2933 , Y10T428/298
摘要： The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
摘要翻译：本发明涉及通过以游离酸形式，特别是可溶于水的方式湿法纺丝基于透明质酸的连续长丝来制备方法。根据本发明的制备方法包括以下步骤：a）制备透明质酸或透明质酸盐，优选透明质酸钠溶液的可纺丝水溶液; b）将所述溶液挤出到挤出模头; c）通过将挤出的溶液通入乙酸浴中形成长丝，浓缩至80％以上，拉伸和干燥。本发明还涉及一种基于游离酸形式的透明质酸的长丝，所述长丝在水和生理液体中具有溶胀性质，而且在某些条件下可溶于水。

5. 发明授权

US08753671B2 Filament based on hyaluronic acid in the form of free acid and method for obtaining it 有权
标题翻译：以游离酸形式的基于透明质酸的丝和获得它的方法
公开(公告)号：US08753671B2
公开(公告)日：2014-06-17
申请号：US12680257
申请日：2008-09-26
申请人： Alain Domard , Laurent David , Florence Dupasquier
发明人： Alain Domard , Laurent David , Florence Dupasquier
IPC分类号： A61F13/00 , A61K9/70 , A61K45/00 , A61K38/21 , A61K38/18 , A61K38/22 , D02G3/00 , D02G1/20 , C07K14/475 , C07K14/575 , B29D28/00 , D02J1/22
CPC分类号： A61K9/70 , A61K47/36 , A61L27/20 , C08J7/04 , C08J7/065 , C08J2305/08 , D01D5/06 , D01F9/00 , D01F11/00 , Y10T428/2913 , Y10T428/2933 , Y10T428/298
摘要： The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
摘要翻译：本发明涉及通过以游离酸形式，特别是可溶于水的方式湿法纺丝基于透明质酸的连续长丝来制备方法。根据本发明的制备方法包括以下步骤：a）制备透明质酸或透明质酸盐，优选透明质酸钠溶液的可纺丝水溶液; b）将所述溶液挤出到挤出模头; c）通过将挤出的溶液通入乙酸浴中形成长丝，浓缩至80％以上，拉伸和干燥。本发明还涉及一种基于游离酸形式的透明质酸的长丝，所述长丝在水和生理液体中具有溶胀性质，而且在某些条件下可溶于水。

6. 发明申请

US20050074742A1 Cartilaginous neo-tissue capable of being grafted 审中-公开
标题翻译：可移植的软骨新组织
公开(公告)号：US20050074742A1
公开(公告)日：2005-04-07
申请号：US10473359
申请日：2002-03-29
申请人： Alain Domard , Marie-Therese Corvol , Francois Guillot , Xavier Chevalier , Isabelle Morfin , Dominique Vacher
发明人： Alain Domard , Marie-Therese Corvol , Francois Guillot , Xavier Chevalier , Isabelle Morfin , Dominique Vacher
IPC分类号： A61K35/12 , A61L27/20 , A61L27/38 , A61L27/52 , C12N5/00 , C12N5/02 , C12N5/077
CPC分类号： A61L27/3817 , A61K35/12 , A61L27/20 , A61L27/3633 , A61L27/3654 , A61L27/3856 , A61L27/52 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N2533/72 , C08L5/08
摘要： A cartilaginous neo-tissue that is capable of being grafted is constituted by rows of approximately parallel cells with a cell maturation gradient orientated from a predetermined zone towards its periphery. During preparation of the cartilaginous neo-tissue with a chitosan hydrogel, the predetermined zone corresponds to the junction of cells with the chitosan hydrogel in contact with which the neo-tissue develops.
摘要翻译：能够接枝的软骨新组织由具有从预定区域朝向其周边定向的细胞成熟梯度的大致平行细胞行构成。在用壳聚糖水凝胶制备软骨新组织期间，预定区域对应于与新生组织形成接触的壳聚糖水凝胶的细胞的连接处。

7. 发明申请

US20050042265A1 Composition for cutaneous repair and cicatrization comprising exclusively a true physical hydrogel of chitosan 审中-公开
标题翻译：用于皮肤修复和瘢痕形成的组合物仅包含壳聚糖的真实物理水凝胶
公开(公告)号：US20050042265A1
公开(公告)日：2005-02-24
申请号：US10915621
申请日：2004-08-10
申请人： Francois Guillot , Alain Domard
发明人： Francois Guillot , Alain Domard
IPC分类号： A61K47/36 , A61F13/02 , A61K9/06 , A61K9/70 , A61L15/28 , A61P17/02 , A61K9/14 , A61L15/00
CPC分类号： A61L15/28 , C08L5/08
摘要： A composition for repairing and cicatrization of cutaneous lesions of chronic or acute wounds including a hydrogel of chitosan, the degree of acetylation of which is no greater than about 40%.
摘要翻译：用于修复和修复包括壳聚糖的水凝胶的慢性或急性创伤的皮肤损伤的组合物，其乙酰化程度不大于约40％。

8. 发明授权

US07241498B2 Support covered with a chitosan-based coating and method for the production thereof 有权
标题翻译：覆盖有基于壳聚糖的涂层的支撑及其生产方法
公开(公告)号：US07241498B2
公开(公告)日：2007-07-10
申请号：US10508870
申请日：2003-03-12
申请人： Alain Domard , Eliane Espuche , Séverine Despond , Noël Cartier
发明人： Alain Domard , Eliane Espuche , Séverine Despond , Noël Cartier
IPC分类号： D02G3/00 , B05D3/02
CPC分类号： D21J1/08 , C09D105/08 , D06N3/02 , D06N3/183 , D21H19/18 , D21H19/34 , D21H19/72 , D21H19/824 , D21H27/10 , Y10T428/2933 , Y10T428/2965 , Y10T428/2967 , Y10T428/2991 , Y10T428/2998 , Y10T428/31971
摘要： Support based on organic and/or inorganic fibres covered at least on one of the faces thereof with a chitosan-based layer, characterized in that the layer is obtained by depositing a chitosan-based aqueous solution, the average molar mass of which has a mass less then 130 000 g/mol, the concentration of which is between 6 and 30% by weight and the viscosity of which is between 100 and 3000 cps.
摘要翻译：基于有机和/或无机纤维的基于壳聚糖层的至少一个表面覆盖的载体，其特征在于，通过沉积基于壳聚糖的水溶液获得该层，其平均摩尔质量具有质量小于130000g / mol，其浓度为6至30重量％，其粘度为100至3000cps。

9. 发明授权

US07189326B2 Use of material based on organic and/or inorganic fibres and chitosan for fixing metal ions 失效
标题翻译：使用基于有机和/或无机纤维和壳聚糖的材料固定金属离子
公开(公告)号：US07189326B2
公开(公告)日：2007-03-13
申请号：US10484319
申请日：2002-07-15
申请人： Alain Domard , Eliane Espuche , Severine Despond , Noel Cartier
发明人： Alain Domard , Eliane Espuche , Severine Despond , Noel Cartier
IPC分类号： B01D15/00 , C02F1/28
CPC分类号： C02F1/288 , B01J20/24 , B01J45/00 , C02F1/001 , C02F1/286 , C02F2101/20 , C02F2103/10 , C02F2103/16 , C02F2103/20 , C02F2201/006
摘要： The invention concerns the use of a material based on organic and/or inorganic fibres and chitosan for fixing metal ions contained in an effluent. The invention is characterised in that chitosan represents between 0.01 and 20% by dry weight of fibres and its degree of deacetylation is higher than 90%.
摘要翻译：本发明涉及使用基于有机和/或无机纤维和壳聚糖的材料来固定包含在流出物中的金属离子。本发明的特征在于壳聚糖占干纤维的0.01〜20％，脱乙酰度高于90％。

10. 发明申请

US20050084677A1 Support covered with a chitosan-based coating and method for the production thereof 有权
标题翻译：覆盖有基于壳聚糖的涂层的支撑及其生产方法
公开(公告)号：US20050084677A1
公开(公告)日：2005-04-21
申请号：US10508870
申请日：2003-03-12
申请人： Alain Domard , Eliane Espuche , Severine Despond , Noel Cartier
发明人： Alain Domard , Eliane Espuche , Severine Despond , Noel Cartier
IPC分类号： C09D5/00 , C09D105/00 , C09D105/08 , C09D191/06 , D06M13/00 , D06M15/03 , D06N3/02 , D06N3/18 , D21H19/18 , D21H19/34 , D21H19/72 , D21H19/82 , D21H27/10 , D21J1/08 , B05D3/12 , B32B5/16 , B32B15/02
CPC分类号： D21J1/08 , C09D105/08 , D06N3/02 , D06N3/183 , D21H19/18 , D21H19/34 , D21H19/72 , D21H19/824 , D21H27/10 , Y10T428/2933 , Y10T428/2965 , Y10T428/2967 , Y10T428/2991 , Y10T428/2998 , Y10T428/31971
摘要： Support based on organic and/or inorganic fibres covered at least on one of the faces thereof with a chitosan-based layer, characterised in that the layer is obtained by depositing a chitosan-based aqueous solution, the average molar mass of which has a mass less then 130 000 g/mol, the concentration of which is between 6 and 30% by weight and the viscosity of which is between 100 and 3000 cps.
摘要翻译：基于有机和/或无机纤维的基于壳聚糖层的至少一个表面覆盖的载体，其特征在于，通过沉积基于壳聚糖的水溶液获得该层，其平均摩尔质量具有质量小于130000g / mol，其浓度为6至30重量％，其粘度为100至3000cps。

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