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1. 发明申请

US20080176341A1 Method for Suppressing Intermolecular Nonspecific Interaction and for Intensifying Intermolecular Specific Interaction on Metal Surface 审中-公开
标题翻译：抑制分子间非特异性相互作用和加强金属表面分子间特异性相互作用的方法
公开(公告)号：US20080176341A1
公开(公告)日：2008-07-24
申请号：US11573868
申请日：2004-08-19
申请人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
发明人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
IPC分类号： G01N33/553
CPC分类号： G01N33/54393 , G01N33/553
摘要： The present invention provides a method of searching for a target molecule for a ligand immobilized on a metal surface or analyzing the interaction between a ligand and a target molecule, characterized in that the immobilization of the ligand on the metal surface via a hydrophilic spacers, and the method eliminates or suppresses a nonspecific interaction that prevents analysis of intermolecular interaction on a metal surface, and can intensify specific intermolecular interactions.
摘要翻译：本发明提供了一种搜索用于固定在金属表面上的配体的目标分子或分析配体和靶分子之间的相互作用的方法，其特征在于通过亲水间隔物将配体固定在金属表面上，以及该方法消除或抑制非特异性相互作用，其阻止金属表面上分子间相互作用的分析，并且可以加强特定的分子间相互作用。

2. 发明申请

US20070167594A1 Affinity resin 有权
标题翻译：亲和树脂
公开(公告)号：US20070167594A1
公开(公告)日：2007-07-19
申请号：US10573165
申请日：2004-10-15
申请人： Akito Tanaka , Takaaki Shiyama , Akira Yamazaki
发明人： Akito Tanaka , Takaaki Shiyama , Akira Yamazaki
IPC分类号： C08F26/00 , C08F126/00 , C08F226/00 , C07C69/73
CPC分类号： G01N33/53 , A61K6/083 , B01D15/3804 , B01J20/267 , B01J20/289 , C08F220/36 , C08L33/10 , G01N33/543 , G01N33/545
摘要： A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.
摘要翻译：通过聚合包含亲水间隔基的单体组分和通过将配体固定在树脂上获得的配体固定的固相载体制备的树脂能够降低除了靶分子以外的物质的非特异性吸附在样品中混合的配体与树脂和/或配体结合。因此，能够实现具有较少噪声的靶分子搜索，识别等。

3. 发明授权

US08778613B2 Affinity resin 有权
标题翻译：亲和树脂
公开(公告)号：US08778613B2
公开(公告)日：2014-07-15
申请号：US10573165
申请日：2004-10-15
申请人： Akito Tanaka , Takaaki Shiyama , Akira Yamazaki
发明人： Akito Tanaka , Takaaki Shiyama , Akira Yamazaki
IPC分类号： G01N33/53 , G01N33/545 , G01N33/543 , C08F220/36 , A61K6/083 , C08L33/10 , B01J20/26
CPC分类号： G01N33/53 , A61K6/083 , B01D15/3804 , B01J20/267 , B01J20/289 , C08F220/36 , C08L33/10 , G01N33/543 , G01N33/545
摘要： A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.
摘要翻译：通过聚合包含亲水间隔基的单体组分和通过将配体固定在树脂上获得的配体固定的固相载体制备的树脂能够降低除了靶分子以外的物质的非特异性吸附在样品中混合的配体与树脂和/或配体结合。因此，能够实现具有较少噪声的靶分子搜索，识别等。

4. 发明授权

US07919653B2 Method of inhibiting nonspecific interaction between molecules on solid phase support 有权
标题翻译：抑制固相载体上分子之间非特异性相互作用的方法
公开(公告)号：US07919653B2
公开(公告)日：2011-04-05
申请号：US10522716
申请日：2003-07-30
申请人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
发明人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
IPC分类号： G01N33/53 , G01N37/00 , G01N33/543
CPC分类号： C08G65/33396 , G01N33/54393
摘要： The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
摘要翻译：本发明提供了抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定在固相载体上并分析分子与与固相分子特异性相互作用的分子之间的特异性相互作用的方法调节固相载体中固相表面的疏水性，特别是在将分子固定在固相载体上时，亲水间隔物被嵌入，该方法可以抑制分子之间的非特异性相互作用，并减少对固相的非特异性吸附。

5. 发明申请

US20060177943A1 Method of inhibiting nonspecific interaction between molecules on solid phase support 有权
标题翻译：抑制固相载体上分子之间非特异性相互作用的方法
公开(公告)号：US20060177943A1
公开(公告)日：2006-08-10
申请号：US10522716
申请日：2003-07-30
申请人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
发明人： Akito Tanaka , Tomohiro Terada , Tsuruki Tamura , Takaaki Shiyama , Akira Yamazaki , Minoru Furuya , Masayuki Haramura
IPC分类号： G01N33/543 , C07C229/64
CPC分类号： C08G65/33396 , G01N33/54393
摘要： The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
摘要翻译：本发明提供了抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定在固相载体上并分析分子与与固相分子特异性相互作用的分子之间的特异性相互作用的方法调节固相载体中固相表面的疏水性，特别是在将分子固定在固相载体上时，亲水间隔物被嵌入，该方法可以抑制分子之间的非特异性相互作用，并减少对固相的非特异性吸附。

6. 发明授权

US07923211B2 Method of calibrating ligand specificity 有权
标题翻译：校准配体特异性的方法
公开(公告)号：US07923211B2
公开(公告)日：2011-04-12
申请号：US12543801
申请日：2009-08-19
申请人： Akito Tanaka , Akira Yamazaki
发明人： Akito Tanaka , Akira Yamazaki
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54313 , G01N33/54393 , Y10S435/973 , Y10T436/10 , Y10T436/25375
摘要： A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a solid phase carrier second extract obtained by treating the pretreated sample again with a ligand-immobilized solid phase carrier in terms of the proteins contained therein, and identifying a protein whose content is remarkably decreased in the second extract compared to the first extract, in order to solve 1) the problem of the solubility of subject ligand, 2) the problem of the non-specific protein-denaturing effect of the subject ligand added, and the like, in antagonism experiments in target search using an affinity resin.
摘要翻译：确定配体结合特异性的方法包括比较通过预处理样品与固定配体的固相载体获得的固相载体第一提取物和通过用配体固定化处理再次处理预处理的样品获得的固相载体第二提取物固相载体与其中所含的蛋白质相比，并鉴定出与第一提取物相比，第二提取物中其含量显着降低的蛋白质，以解决1）本发明配体的溶解度问题，2）使用亲和树脂进行目标检测的拮抗实验中加入的受试者配体的非特异性蛋白质变性效应等。

7. 发明申请

US20090042318A1 METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE 审中-公开
标题翻译：有效搜索目标分子的方法
公开(公告)号：US20090042318A1
公开(公告)日：2009-02-12
申请号：US11814986
申请日：2006-01-26
申请人： Akito Tanaka , Akira Yamazaki , Masayuki Haramura
发明人： Akito Tanaka , Akira Yamazaki , Masayuki Haramura
IPC分类号： G01N33/545
CPC分类号： G01N33/54393 , B01J20/3227 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J20/3285 , G01N33/54306
摘要： The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides a solid phase carrier having a ligand and a capping agent immobilized thereon, with the hydrophobic property of the surface thereof adjusted to enable the binding of the target molecule to the ligand, or to increase the amount of target molecule bound to the ligand; various methods using the solid phase carrier (for example, method of concentrating, isolating, or purifying a target molecule, a method of selectively adsorbing a particular target molecule to the solid phase carrier, or a method of analyzing the interaction between ligand and target molecule therefor); a production method for the solid phase carrier; and an improvement method for a solid phase carrier having a ligand and a capping agent immobilized thereon and the like.
摘要翻译：本发明提供了能够吸附高度疏水的靶分子例如膜相关蛋白的固相载体，以及不仅对于高度疏水的靶分子而且优选任选地选择的靶分子优化的固相载体。更具体地说，本发明提供一种具有固定在其上的配体和封端剂的固相载体，其表面的疏水性被调节以使靶分子与配体结合，或增加靶分子的量与配体结合; 使用固相载体的各种方法（例如，浓缩，分离或纯化靶分子的方法，将特定靶分子选择性吸附到固相载体上的方法或分析配体与靶分子之间的相互作用的方法为此）一种固相载体的制备方法; 以及其上固定有配体和封端剂等的固相载体的改进方法。

8. 发明申请

US20070082955A1 Novel target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto 失效
标题翻译：抗癌剂的新型靶蛋白和与其对应的新型抗癌剂（spnal）
公开(公告)号：US20070082955A1
公开(公告)日：2007-04-12
申请号：US10573166
申请日：2004-11-30
申请人： Akito Tanaka , Akira Yamazaki , Takeshi Tsutsumi , Tomohiro Terada , Masayuki Haramura
发明人： Akito Tanaka , Akira Yamazaki , Takeshi Tsutsumi , Tomohiro Terada , Masayuki Haramura
IPC分类号： A61K31/192 , C07C321/24 , G01N33/53
CPC分类号： C07D231/12 , A61K45/06 , C07C317/44 , C07C323/62
摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.
摘要翻译：本发明提供含有与KSRP或其功能片段特异性结合的化合物作为活性成分的药物组合物和该化合物的筛选方法。 KSRP是抗癌剂的新型靶蛋白; 能够调节这种蛋白质的表达和活性的化合物和含有该蛋白质的药物组合物对于增殖性疾病，特别是作为抗癌剂是非常有用的。通过提供新的靶蛋白，可以阐明通常不可解释的抗癌作用背后的机制。

9. 发明申请

US20090239916A1 NOVEL DRUG DISCOVERY TARGET AND MEDICINE ACTING ON THE SAME 审中-公开
标题翻译：新药发现目标与药物相同
公开(公告)号：US20090239916A1
公开(公告)日：2009-09-24
申请号：US11569555
申请日：2005-05-26
申请人： Akito Tanaka , Akira Yamazaki , Akinobu Nakanishi , Mikio Takeuchi , Masayuki Haramura
发明人： Akito Tanaka , Akira Yamazaki , Akinobu Nakanishi , Mikio Takeuchi , Masayuki Haramura
IPC分类号： A61K31/428 , G01N33/53 , C12N9/04 , G01N33/68 , C07D311/22 , C07D277/68 , A61K31/352 , A61P29/00
CPC分类号： G01N33/6893 , A61K31/352 , A61K31/428 , C07D277/68 , C07D311/24 , G01N2500/00 , G01N2800/24
摘要： The present invention provides a pharmaceutical composition comprising as an active ingredient a compound that specifically binds to MFP-2 or a functional fragment thereof and a screening method for the compound; the compound and a pharmaceutical composition comprising the same are highly useful as anti-inflammatory agents and anti-allergic agents.
摘要翻译：本发明提供一种药物组合物，其包含与MFP-2或其功能片段特异性结合的化合物作为活性成分和该化合物的筛选方法; 该化合物和包含该化合物的药物组合物作为抗炎剂和抗过敏剂是非常有用的。

10. 发明申请

US20070122913A1 Method of calibrating ligand specificity 失效
标题翻译：校准配体特异性的方法
公开(公告)号：US20070122913A1
公开(公告)日：2007-05-31
申请号：US10573167
申请日：2004-10-15
申请人： Akito Tanaka , Akira Yamazaki
发明人： Akito Tanaka , Akira Yamazaki
IPC分类号： G01N33/558
CPC分类号： G01N33/54313 , G01N33/54393 , Y10S435/973 , Y10T436/10 , Y10T436/25375
摘要： In a method comprising comparing a solid phase carrier extract 1 obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a solid phase carrier extract 2 obtained by treating the pretreated sample again with a ligand-immobilized solid phase carrier in terms of the proteins contained therein, and identifying a protein whose content is remarkably decreased in the extract 2 compared to the extract 1, 1) the problem of the solubility of subject ligand, 2) the problem of the non-specific protein-denaturing effect of the subject ligand added, and the like, which have been problematic in antagonism experiments in target search using an affinity resin, have been solved.
摘要翻译：在包括将通过预处理样品获得的固相载体提取物1与固定配体的固相载体和固相载体提取物2进行比较的方法中，所述固相载体提取物2通过用配体固定的固相载体再次处理预处理的样品而得到的蛋白质，并且鉴定与提取物1相比，提取物2中的含量显着降低的蛋白质，1）主体配体的溶解度的问题，2）非特异性蛋白质变性效应的问题已经解决了使用亲和性树脂在靶搜索中的拮抗实验中存在问题的添加的受试者配体等。

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