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1. 发明授权

US06692742B1 Remedies for myeloma to be used together with nitrogen mustard antitumor agents 失效
标题翻译：治疗骨髓瘤与氮芥抗肿瘤药物一起使用
公开(公告)号：US06692742B1
公开(公告)日：2004-02-17
申请号：US09202802
申请日：1998-12-22
申请人： Akito Nakamura , Kenichi Akamatsu
发明人： Akito Nakamura , Kenichi Akamatsu
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/395 , A61K39/39541 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A therapeutic agent for myeloma comprising a combined use of a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody. Thus, a therapeutic agent for myeloma comprising anti-IL-6 receptor antibody for use in combination with a nitrogen mustard anticancer agent; a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent for use in combination with anti-IL-6 receptor antibody; and a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody.
摘要翻译：骨髓瘤治疗剂，其包含氮芥抗癌剂和抗IL-6受体抗体的组合使用。因此，用于与氮芥抗癌剂组合使用的包含抗IL-6受体抗体的骨髓瘤治疗剂; 骨髓瘤治疗剂，其包含与抗IL-6受体抗体组合使用的氮芥抗癌剂; 和包含氮芥抗癌剂和抗IL-6受体抗体的骨髓瘤治疗剂。

2. 发明授权

US07771723B2 Remedies for myeloma to be used together with nitrogen mustard antitumor agents 失效
标题翻译：治疗骨髓瘤与氮芥抗肿瘤药物一起使用
公开(公告)号：US07771723B2
公开(公告)日：2010-08-10
申请号：US10749538
申请日：2003-12-30
申请人： Akito Nakamura , Kenichi Akamatsu
发明人： Akito Nakamura , Kenichi Akamatsu
IPC分类号： A61K38/00
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/395 , A61K39/39541 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A therapeutic agent for myeloma comprising a combined use of a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody. Thus, a therapeutic agent for myeloma comprising anti-IL-6 receptor antibody for use in combination with a nitrogen mustard anticancer agent; a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent for use in combination with anti-IL-6 receptor antibody; and a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody.
摘要翻译：骨髓瘤治疗剂，其包含氮芥抗癌剂和抗IL-6受体抗体的组合使用。因此，用于与氮芥抗癌剂组合使用的包含抗IL-6受体抗体的骨髓瘤治疗剂; 骨髓瘤治疗剂，其包含与抗IL-6受体抗体组合使用的氮芥抗癌剂; 和包含氮芥抗癌剂和抗IL-6受体抗体的骨髓瘤治疗剂。

3. 发明授权

US07566453B2 Methods for treating melanomas 失效
标题翻译：治疗黑色素瘤的方法
公开(公告)号：US07566453B2
公开(公告)日：2009-07-28
申请号：US10098874
申请日：2002-03-15
申请人： Akito Nakamura , Kenichi Akamatsu
发明人： Akito Nakamura , Kenichi Akamatsu
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/395 , A61K39/39541 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： A therapeutic agent for myeloma comprising a combined use of a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody. Thus, a therapeutic agent for myeloma comprising anti-IL-6 receptor antibody for use in combination with a nitrogen mustard anticancer agent; a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent for use in combination with anti-IL-6 receptor antibody; and a therapeutic agent for myeloma comprising a nitrogen mustard anticancer agent and anti-IL-6 receptor antibody.
摘要翻译：骨髓瘤治疗剂，其包含氮芥抗癌剂和抗IL-6受体抗体的组合使用。因此，用于与氮芥抗癌剂组合使用的包含抗IL-6受体抗体的骨髓瘤治疗剂; 骨髓瘤治疗剂，其包含与抗IL-6受体抗体组合使用的氮芥抗癌剂; 和包含氮芥抗癌剂和抗IL-6受体抗体的骨髓瘤治疗剂。

4. 发明授权

US06365640B2 Silicone rubber sponge composition and sponge articles therefrom 有权
标题翻译：硅橡胶海绵组合物和海绵制品
公开(公告)号：US06365640B2
公开(公告)日：2002-04-02
申请号：US09862835
申请日：2001-05-23
申请人： Katsuya Baba , Manabu Suto , Hiroshi Honma , Akito Nakamura
发明人： Katsuya Baba , Manabu Suto , Hiroshi Honma , Akito Nakamura
IPC分类号： C08J932
CPC分类号： C08J9/32 , C08G77/14 , C08G77/20 , C08G77/24 , C08G77/46 , C08J2203/22 , C08J2383/04 , C08L83/04 , C08L83/00 , C08L2666/54 , C08L2666/02
摘要： A silicone rubber sponge composition, a silicone rubber sponge, and a process for making a silicone rubber sponge. The silicone rubber sponge composition comprises (A) 100 parts by weight of an organopolysiloxane gum described by average structural unit RaSiO(4−a)/2, where R is a monovalent hydrocarbon radical or haloalkyl and a is 1.95 to 2.05, (B) 1 to 400 parts by weight of an inorganic filler, (C) 0.01 to 50 parts by weight hollow thermoplastic resin particles (D) a mixture of (a) water-soluble silicone and (b) water in an amount such that the water in the mixture is equivalent to 0.01 to 10 parts by weight per 100 parts by weight of component (A), and (E) a curing agent in an amount sufficient to cure the composition.
摘要翻译：硅橡胶海绵组合物，硅橡胶海绵和制造硅橡胶海绵的方法。硅橡胶海绵组合物包含（A）100重量份平均结构单元RaSiO（4-a）/ 2所述的有机聚硅氧烷胶，其中R为单价烃基或卤代烷基，a为1.95至2.05，（B） 1至400重量份的无机填料，（C）0.01至50重量份的中空热塑性树脂颗粒（D）（a）水溶性硅氧烷和（b）水的混合物，其量使得混合物相当于每100重量份组分（A）为0.01至10重量份，和（E）以足以固化组合物的量的固化剂。

5. 发明授权

US6090887A Silicone rubber composition for fluororesin-covered fixing rolls and fluororesin-covered fixing rolls 失效
标题翻译：用于氟树脂覆盖的定影辊和含氟树脂覆盖的定影辊的硅橡胶组合物
公开(公告)号：US6090887A
公开(公告)日：2000-07-18
申请号：US697997
申请日：1996-11-25
申请人： Akito Nakamura , Yoshito Ushio
发明人： Akito Nakamura , Yoshito Ushio
IPC分类号： B29C45/14 , B29L31/32 , B32B1/08 , B32B25/08 , B65H27/00 , C08K3/00 , C08L83/04 , C08L83/05 , C08L83/07 , G03G15/20 , C08G77/12
CPC分类号： G03G15/2057 , B29C65/485 , B29C65/4865 , B29C65/542 , B29C66/343 , B29C66/52272 , B29C66/742 , B29C66/91411 , B29C66/91445 , B29C66/919 , C08L83/04 , B29C65/4835 , C08G77/12 , C08G77/20 , C08G77/70 , Y10T29/49549 , Y10T29/49563
摘要： Silicone rubber composition comprising an alkenyl-substituted diorganopolysiloxane, an inorganic filler, an organopolysiloxane that contains at least two silicon-bonded hydrogen atoms in each molecule, in a quantity that affords a value from 0.4 to 10 for the molar ratio of silicon-bonded hydrogen in the organopolysiloxane to alkenyl groups in the alkenyl-substituted diorganopolysiloxane, an organohydrogenpolysiloxane, in a quantity that affords a value from 0.01 to 0.5 for the molar ratio of silicon-bonded hydrogen in this component to alkenyl groups in the alkenyl-substituted diorganopolysiloxane, and a platinum catalyst. A fluororesin-covered fixing roll in which a fluororesin layer is placed over the circumference of a roll shaft with a silicone rubber layer interposed between the fluororesin layer and the roll shaft, wherein said silicone rubber composition is formed by curing the silicone rubber composition described above.
摘要翻译：含有链烯基取代的二有机聚硅氧烷，无机填料，在每个分子中含有至少两个与硅键合的氢原子的有机聚硅氧烷的硅橡胶组合物的量相对于硅键合氢的摩尔比为0.4至10 在有机聚硅氧烷中烯基取代的二有机基聚硅氧烷中的烯基，有机氢聚硅氧烷，其量使得该组分中与硅键合的氢与烯基取代的二有机基聚硅氧烷中的烯基的摩尔比为0.01-0.5，以及铂催化剂。一种氟树脂覆盖的定影辊，其中氟树脂层被放置在辊轴的圆周上，其中硅橡胶层介于氟树脂层和辊轴之间，其中所述硅橡胶组合物通过固化上述硅橡胶组合物而形成。

6. 发明授权

US5994461A Liquid silicone rubber composition for application to high-voltage electrical insulators and articles 失效
标题翻译：液体硅橡胶组合物适用于高压绝缘子和制品
公开(公告)号：US5994461A
公开(公告)日：1999-11-30
申请号：US104920
申请日：1998-06-25
申请人： Akito Nakamura , Yasumichi Shigehisa , Yuichi Tsuji
发明人： Akito Nakamura , Yasumichi Shigehisa , Yuichi Tsuji
IPC分类号： C08K3/36 , C08L83/04 , C08L83/05 , C08L83/07 , H01B3/46
CPC分类号： C08L83/04 , C08G77/12 , C08G77/20 , C08G77/24 , C08G77/70
摘要： A high voltage electrical insulator formed from a curable liquid silicone rubber composition, and subsequently cured, a composition consisting essentially of(A) 100 weight parts of a fluid mixture of polyorganosiloxane comprising(a) at least 5 weight percent of a polyorganosiloxane resin comprising repeating units selected from the group consisting of SiO.sub.4/2 and RSiO.sub.3/2, where R is a monovalent hydrocarbon group, and(b) polydiorganosiloxane having a viscosity in the range from about 100 mPa.multidot.s to 100,000 mPa.multidot.s, that contains at least 2 silicon-bonded alkenyl groups in each molecule,(B) 1 to 100 weight parts microparticulate silica,(C) polyorganohydrogensiloxane that contains at least 2 silicon-bonded hydrogen atoms in each molecule, in a quantity that provides a value from 0.5:1 to 20:1 for the ratio of the number of moles of silicon-bonded hydrogen in the instant composition to the number of moles of silicon-bonded alkenyl in component (A), and(D) a catalytic quantity of a platinum catalyst.The liquid silicone rubber composition, prior to its cure, evidences a desirable fluidity and excellent moldability. Upon its cure the composition produces very mechanically strong silicone rubber moldings that have excellent high-voltage insulating properties tracking resistance, erosion resistance, arcing resistance without the use of fillers such as aluminum oxide, aluminum hydroxide or quartz.
摘要翻译：一种由可固化液体硅橡胶组合物形成并随后固化的高压电绝缘体，组合物基本上由（A）100重量份聚有机硅氧烷的流体混合物组成，其包含（a）至少5重量％的聚有机硅氧烷树脂，其包含重复选自SiO4 / 2和RSiO3 / 2的单元，其中R是一价烃基，和（b）粘度在约100mPax至100,000mPaxs的聚二有机硅氧烷，其含有至少2个硅键合（B）1〜100重量份微粒二氧化硅，（C）在各分子中含有至少2个与硅键合的氢原子的聚有机氢硅氧烷，其数量为0.5:1〜20:1 对于本发明组合物中与硅键合的氢的摩尔数与组分（A）中与硅键合的烯基的摩尔数的比率，和（D）催化量的铂 um催化剂。液体硅橡胶组合物在其固化之前证明了所需的流动性和优异的成型性。在其固化时，组合物产生非常机械强度的硅橡胶模制品，其具有优异的耐高压绝缘性能，耐侵蚀性，耐电弧性，而不使用填料如氧化铝，氢氧化铝或石英。

7. 发明授权

US5973067A Primer composition and adhesion method 失效
标题翻译：底漆组成和粘合方法
公开(公告)号：US5973067A
公开(公告)日：1999-10-26
申请号：US868134
申请日：1997-06-03
申请人： Akito Nakamura , Katsuyoshi Nakasuji , Yoshito Ushio
发明人： Akito Nakamura , Katsuyoshi Nakasuji , Yoshito Ushio
IPC分类号： C08L83/04 , C08L83/07 , C09D4/00 , C09D183/04 , C09J5/02 , C09D1/00
CPC分类号： C09J5/02 , C09D183/04 , C09D4/00 , C08L83/04 , C09J2205/306 , C09J2400/166 , C09J2483/00
摘要： A novel primer composition, which is especially adapted for promoting the adhesion of thermosetting rubbers to substrates having exceptionally inert surfaces, such a nickel, stainless steel and organic resins is disclosed. The composition comprises: (A) 100 parts, by weight, of an organosilicon compound selected from the group consisting of (1) alkenyltrialkoxysilane and (2) mild hydrolyzates of (1); (B) 0.01-200 parts, by weight, of a platinum compound; (C) 0.1-100 parts by weight of an organic titanic acid ester; and optionally (D) a solvent.
摘要翻译：公开了一种新颖的底漆组合物，其特别适用于促进热固性橡胶对具有异常惰性表面的基材的粘附，例如镍，不锈钢和有机树脂。组合物包含：（A）100重量份选自（1）烯基三烷氧基硅烷和（2）（1）的温和水解产物的有机硅化合物; （B）0.01〜200重量份的铂化合物; （C）0.1-100重量份的有机钛酸酯; 和任选的（D）溶剂。

8. 发明授权

US5153244A Curable organosiloxane composition yielding elastomers exhibiting reduced compression set values 失效
标题翻译：可固化有机硅氧烷组合物焊接弹性体展示减少压缩值
公开(公告)号：US5153244A
公开(公告)日：1992-10-06
申请号：US600564
申请日：1990-10-19
申请人： Hiroshi Akitomo , Akito Nakamura
发明人： Hiroshi Akitomo , Akito Nakamura
IPC分类号： C08K5/00 , C08K5/3467 , C08L83/04 , C08L83/05 , C08L83/07
CPC分类号： C08K5/3467 , C08K5/0091 , C08L83/04 , C08G77/12 , C08G77/20 , C08G77/24 , C08G77/70 , Y02P30/48
摘要： The compression set values of elastomers prepared from organosiloxane compositions that cure by a platinum-catalyzed hydrosilylation reaction are substantially reduced by the presence in said compositions of a phthalocyanine compound or a metal derivative of such a compound, where the metal is copper, nickel, cobalt or iron.

9. 发明授权

US5091511A Lymphokine activated killer suppressive factor (LAKSF), process for producing it and immunosuppressive agent comprising it 失效
标题翻译：淋巴因子激活的杀伤因子（LAKSF），其生产方法和包含它的免疫抑制剂
公开(公告)号：US5091511A
公开(公告)日：1992-02-25
申请号：US411846
申请日：1989-09-25
申请人： Saburo Sone , Masanobu Munekata , Akito Nakamura , Kiichi Uchida , Kazumaro Seto
发明人： Saburo Sone , Masanobu Munekata , Akito Nakamura , Kiichi Uchida , Kazumaro Seto
IPC分类号： C12P21/00 , A61K38/00 , A61P37/06 , C07K14/005 , C07K14/195 , C07K14/52 , C12R1/91
CPC分类号： C07K14/52 , A61K38/00 , Y10S530/827
摘要： Lymphokine activated killer suppressive factor (LAKSF) and a process for producing the LAKSF by cultivating human mono-cytic cells for alveolar macrophages activated by a stimulator to produce LAKSF and harvesting it. The LAKSF has a LAK induction suppressive activity and an immunosuppressive effect and thus the LAKSF is useful as a medicine.
摘要翻译：淋巴因子激活的杀伤因子（LAKSF）和LAKSF的生产过程，培养用于刺激器激活的肺泡巨噬细胞的人单细胞细胞以产生LAKSF并收获。 LAKSF具有LAK诱导抑制活性和免疫抑制作用，因此LAKSF可用作药物。

10. 发明授权

US06464923B2 Method for producing molded silicone rubber product 有权
标题翻译：硅橡胶制品的制造方法
公开(公告)号：US06464923B2
公开(公告)日：2002-10-15
申请号：US09791135
申请日：2001-02-22
申请人： Yuichi Tsuji , Akito Nakamura
发明人： Yuichi Tsuji , Akito Nakamura
IPC分类号： C08J500
CPC分类号： C08L83/04 , C08G77/06 , C08G77/12 , C08G77/20 , C08L83/00 , C08L2666/54
摘要： A method for producing a molded silicone rubber product comprising (i) forming a mixture comprising (A) a primary composition in the form of a paste comprising an inorganic filler and a diorganopolysiloxane containing at least 2 silicon atom-bonded alkenyl groups per molecule, (B) a liquid catalyst composition comprising a platinum catalyst and an organopolysiloxane containing at least 2 silicon atom-bonded alkenyl groups per molecule, and (C) a liquid curing composition comprising an organopolysiloxane having at least 2 silicon atom-bonded hydrogen atoms per molecule and an organopolysiloxane having at least 2 silicon atom-bonded alkenyl groups per molecule; (ii) feeding the mixture comprising components (A), (B), and (C) into a molding device; and (iii) curing the mixture comprising components (A), (B), and (C) by heating.
摘要翻译：一种制备模塑硅橡胶产品的方法，包括（i）形成混合物，所述混合物包含（A）包含无机填料和每分子含有至少2个硅原子键合的烯基的二有机聚硅氧烷形式的初级组合物的混合物（ B）液体催化剂组合物，其包含铂催化剂和每分子含有至少2个硅原子键合的烯基的有机聚硅氧烷，和（C）包含每分子具有至少2个硅原子键合的氢原子的有机聚硅氧烷的液体固化组合物，以及每分子具有至少2个硅原子键合的烯基的有机聚硅氧烷;（ii）将包含组分（A），（B）和（C）的混合物进料到模塑装置中; 和（iii）通过加热固化包含组分（A），（B）和（C）的混合物。

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