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1. 发明授权

US5480956A Feline interferon and process for production thereof 失效
标题翻译：猫干扰素及其生产方法
公开(公告)号：US5480956A
公开(公告)日：1996-01-02
申请号：US200297
申请日：1994-02-23
申请人： Akira Yanai , Yoshizumi Ueda , Toru Sakurai , Masahiro Satoh
发明人： Akira Yanai , Yoshizumi Ueda , Toru Sakurai , Masahiro Satoh
IPC分类号： C12P21/02 , C07K14/00 , C07K14/52 , C07K14/555 , C07K14/56 , C12N5/10 , C12N7/00 , C12N15/02 , C12N15/20 , C12N15/866 , C12R1/91 , C12N15/00
CPC分类号： C12N15/86 , C07K14/555 , C12N2710/14143
摘要： A recombinant silkworm nuclear polyhedrosis virus containing DNA coding for a protein of feline interferon; the recombinant virus is constructed by cotransfection a recombinant plasmid having a gene coding for a protein of feline interferon and a silkworm nuclear polyhedrosis virus DNA into established silkworm cells, and cloning the desired recombinant virus. The recombinant virus is useful for a mass-production of feline interferon.
摘要翻译：含有编码猫干扰素蛋白质的DNA的重组蚕核多角体病毒; 通过将具有编码猫干扰素和蚕核多角体病毒DNA的蛋白质的基因的重组质粒共转染到建立的蚕细胞中，并克隆所需的重组病毒构建重组病毒。重组病毒可用于大量生产猫干扰素。

2. 发明授权

US5194381A Feline interferon and process for production thereof 失效
标题翻译： FELINE INTERFERON及其生产工艺
公开(公告)号：US5194381A
公开(公告)日：1993-03-16
申请号：US544504
申请日：1990-06-27
申请人： Akira Yanai , Yoshizumi Ueda , Toru Sakurai , Masahiro Satoh
发明人： Akira Yanai , Yoshizumi Ueda , Toru Sakurai , Masahiro Satoh
IPC分类号： C12P21/02 , C07K14/00 , C07K14/52 , C07K14/555 , C07K14/56 , C12N5/10 , C12N7/00 , C12N15/02 , C12N15/20 , C12N15/866 , C12R1/91
CPC分类号： C12N15/86 , C07K14/555 , C12N2710/14143
摘要： A recombinant silkworm nuclear polyhedrosis virus containing DNA coding for a protein of feline interferon; the recombinant virus is constructed by cotransfection a recombinant plasmid having a gene coding for a protein of feline interferon and a silkworm nuclear polyhedrosis virus DNA into established silkworm cells, and cloning the desired recombinant virus. The recombinant virus is useful for a mass-production of feline interferon.

3. 发明授权

US4945058A Plasmid with wide host range and process of producing L. threonine using the same 失效
标题翻译：具有广泛宿主范围的质粒和使用其生产苏氨酸的方法
公开(公告)号：US4945058A
公开(公告)日：1990-07-31
申请号：US919993
申请日：1986-10-17
申请人： Akira Yanai , Yoshizumi Ueda
发明人： Akira Yanai , Yoshizumi Ueda
IPC分类号： C12N15/52 , C12N15/74 , C12P13/08
CPC分类号： C12N15/74 , C12N15/52 , C12P13/08
摘要： This invention provides a plasmid with a wide host range, which can replicate in microorganisms belonging to the family Enterobacteriaceae. These plasmids may be used to clone the genes repsonsible for the fermentative production of various useful biochemicals. The recombinant plasmids containing these genes can be used to transform bacteria so that the fermentative production of the biochemical is enhanced.
摘要翻译：本发明提供了具有宽宿主范围的质粒，其可以在属于肠杆菌科的微生物中复制。这些质粒可用于克隆对各种有用的生物化学物质的发酵生产代表负责的基因。含有这些基因的重组质粒可用于转化细菌，从而提高生物化学的发酵生产。

4. 发明授权

US06391296B1 Method of stabilizing useful protein and useful protein compositions 有权
标题翻译：稳定有用蛋白质和有用的蛋白质组成的方法
公开(公告)号：US06391296B1
公开(公告)日：2002-05-21
申请号：US09269833
申请日：1999-04-26
申请人： Fumiyoshi Okano , Katsushige Yamada , Masatoshi Watanabe , Naomi Hara , Akira Yanai
发明人： Fumiyoshi Okano , Katsushige Yamada , Masatoshi Watanabe , Naomi Hara , Akira Yanai
IPC分类号： A61K4500
CPC分类号： C07K14/555 , A61K38/00
摘要： A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon containing a useful protein and a compound having the basic structure of arabic acid; gum arabic is preferred as a compound having the basic structure of arabic acid, and examples of a useful protein include cytokine and interferon; and a production method for canine interferon-&ggr; and stabilization thereof.
摘要翻译：通过混合有用蛋白质和具有阿拉伯酸碱性结构的化合物的水溶液和含有有用蛋白质的稳定化有用蛋白质组合物和具有阿拉伯酸碱性结构的化合物来稳定有用蛋白质的方法; 优选阿拉伯树胶作为具有阿拉伯酸碱性结构的化合物，有用的蛋白质的实例包括细胞因子和干扰素; 以及犬干扰素γ的制造方法及其稳定化。

5. 发明授权

US06365206B1 Paste-form natto and a process for producing the same 失效
标题翻译：糊状纳豆及其制造方法
公开(公告)号：US06365206B1
公开(公告)日：2002-04-02
申请号：US09638492
申请日：2000-08-15
申请人： Akira Yanai , Kumi Chikushi
发明人： Akira Yanai , Kumi Chikushi
IPC分类号： A23L1211
CPC分类号： A23L11/09
摘要： Paste-form natto which has a comfortable feeling on the tongue and has little or none of the undesired properties of viscous thread, odor and bitterness of ordinary natto, and a method of producing it in which dried soybeans are dehulled and the kernels sliced to 0.1-5 mm thickness and soaked in 1.0-2.5 times their weight in water, steamed, and lumps of steamed soybean flakes are decomposed during or before seeding with commercial [Bacillus nattol] Bacillus natto. The seeded soybean flakes are fermented aerobically, aged in a chilled room to produce paste-form natto, which had a good feeling on the tongue, does not have the viscous thread, odor and bitterness of ordinary natto. The paste-form natto is packed in plastic or edible containers of any size, chilled or frozen, and shipped to food processing plants. The packed and frozen paste-form natto is not contaminated by micro-organisms and is sanitary. Accordingly, it can be supplied to food manufacturing plants without leaking natto bacteria to the outside. The paste-form natto is useful to sandwiches, rice balls, sushi, etc.
摘要翻译：在舌头上具有舒适感觉的糊状纳豆，并且具有很少或没有普通纳豆的粘性线，气味和苦味的不期望的性质，以及其中制造干大豆脱壳的方法，并将籽粒切成0.1 -5毫米厚，浸泡在水中的重量的1.0-2.5倍，蒸，蒸的大豆薄片块在用纳豆芽孢杆菌纳豆芽孢杆菌播种期间或之前分解。种子大豆薄片有氧发酵，在冷藏室中陈化，生成糊状纳豆，舌头感好，不含普通纳豆的粘稠线，气味和苦味。糊状纳豆包装在任何尺寸，冷冻或冷冻的塑料或可食用容器中，并运送到食品加工厂。包装和冷冻的糊状纳豆不被微生物污染并且是卫生的。因此，可以将食品制造厂提供给不向外界泄漏的纳豆菌。糊状纳豆用于三明治，米饭，寿司等。

6. 发明授权

US5714382A Synthetic plasmids and transformants comprising a feline interferon cDNA 失效
标题翻译：包含猫干扰素cDNA的合成质粒和转化体
公开(公告)号：US5714382A
公开(公告)日：1998-02-03
申请号：US463242
申请日：1995-06-05
申请人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
发明人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
IPC分类号： C12N1/21 , A61K38/21 , A61P37/00 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C12N5/10 , C12N15/09 , C12N15/21 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/555
摘要： A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline viral disease and tumor.
摘要翻译：将编码猫干扰素的蛋白质的DNA整合的合成质粒，通过使用合成质粒转化宿主细胞而获得的转化体和具有由具有特定氨基酸序列的蛋白质赋予的生物活性的猫干扰素，编码猫干扰素的猫干扰素基因，由可切割肽或与猫干扰素的N末端连接的信号肽构成的猫干扰素前体，编码猫干扰素前体的猫干扰素前体基因，以及制备猫干扰素，其被用于大量生产猫干扰素，用作猫病毒性疾病和肿瘤的补救剂。

7. 发明授权

US5508291A Feline interferon 失效
标题翻译：猫干扰素
公开(公告)号：US5508291A
公开(公告)日：1996-04-16
申请号：US291597
申请日：1988-12-29
申请人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
发明人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
IPC分类号： C12N1/21 , A61K38/21 , A61P37/00 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C12N5/10 , C12N15/09 , C12N15/21 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/555
摘要： Purified feline interferon polypeptides are disclosed. A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline vital disease and tumor.
摘要翻译：公开了纯化的猫干扰素多肽。将编码猫干扰素的蛋白质的DNA整合的合成质粒，通过使用合成质粒转化宿主细胞而获得的转化体和具有由具有特定氨基酸序列的蛋白质赋予的生物活性的猫干扰素，编码猫干扰素的猫干扰素基因，由可切割肽或与猫干扰素的N末端连接的信号肽构成的猫干扰素前体，编码猫干扰素前体的猫干扰素前体基因，以及制备猫干扰素，其用于大量生产用于猫科动物疾病和肿瘤的猫干扰素的大量生产。

8. 发明授权

US06620411B1 Method for inhibiting brain tumor or colon carcinoma 失效
标题翻译：抑制脑肿瘤或结肠癌的方法
公开(公告)号：US06620411B1
公开(公告)日：2003-09-16
申请号：US09806684
申请日：2001-06-06
申请人： Akira Yanai , Saburo Sone , Akemi Kajita
发明人： Akira Yanai , Saburo Sone , Akemi Kajita
IPC分类号： A61K3821
CPC分类号： A61K38/215
摘要： A method for inhibiting cell growth is provided. The method includes the step of systemically administering a pharmaceutical preparation containing an interferon as an active ingredient two or more times a day, and is specifically useful for cancer treatment.
摘要翻译：提供了抑制细胞生长的方法。该方法包括以每日两次或多次全身剂量给药含有干扰素作为活性成分的药物制剂的步骤，特别适用于癌症治疗。

9. 发明授权

US06359616B1 Coordinate input apparatus 失效
标题翻译：坐标输入装置
公开(公告)号：US06359616B1
公开(公告)日：2002-03-19
申请号：US09336420
申请日：1999-06-17
申请人： Tsuyoshi Ogura , Harumi Takase , Shoji Suzuki , Yoshiyuki Kikuchi , Akira Yanai
发明人： Tsuyoshi Ogura , Harumi Takase , Shoji Suzuki , Yoshiyuki Kikuchi , Akira Yanai
IPC分类号： G09G500
CPC分类号： G06F3/0418 , G06F3/03547
摘要： A coordinate input apparatus for correcting the shift in an input coordinate system between different coordinate input apparatuses relative to an opening of each apparatus. A data processing block captures information from a coordinate detector PD to determine whether a tapping operation has been performed and determine whether the finger is being slid on a sensor board. A data analyzing block compares inputted absolute coordinates (X, y) with minimum coordinate values (Xmin, Ymin) and maximum coordinate values (Xmax, Ymax) indicative of a preset effective pointing area on the sensor board. A control block controls the data analyzing block to transfer replaced minimum coordinate values (Xmin, Ymin), maximum coordinate values (Xmax, Ymax) and the values of absolute coordinates (X, Y) to a data correcting block. Based on these minimum coordinate values (Xmin, Ymin) and maximum coordinate values (Xmax, Ymax), the data correcting block transforms the absolute coordinates (X, Y) into display coordinates. The control block moves a screen window or a cursor to a position indicated by absolute coordinates (X′, Y′) on a display screen.
摘要翻译：一种坐标输入装置，用于相对于每个装置的开口来校正不同坐标输入装置之间的输入坐标系的偏移。数据处理块从坐标检测器PD捕获信息，以确定是否执行了敲击操作，并且确定手指是否在传感器板上滑动。数据分析块将输入的绝对坐标（X，y）与表示传感器板上的预设有效指示区域的最小坐标值（Xmin，Ymin）和最大坐标值（Xmax，Ymax）进行比较。控制块控制数据分析块将替代的最小坐标值（Xmin，Ymin），最大坐标值（Xmax，Ymax）和绝对坐标值（X，Y）传送到数据校正块。基于这些最小坐标值（Xmin，Ymin）和最大坐标值（Xmax，Ymax），数据校正块将绝对坐标（X，Y）变换为显示坐标。控制块将屏幕窗口或光标移动到显示屏上由绝对坐标（X'，Y'）表示的位置。

10. 发明授权

US5781181A Apparatus and method for changing an operation mode of a coordinate input apparatus 失效
标题翻译：用于改变坐标输入装置的操作模式的装置和方法
公开(公告)号：US5781181A
公开(公告)日：1998-07-14
申请号：US682057
申请日：1996-07-16
申请人： Akira Yanai , Osamu Hara , Tsuyoshi Ogura
发明人： Akira Yanai , Osamu Hara , Tsuyoshi Ogura
IPC分类号： G06F3/041 , G06F3/033 , G06F3/038 , G06F3/048 , G08C21/00
CPC分类号： G06F3/04883
摘要： A coordinate detection system capable of displaying relevant coordinates when operated with only one fingertip or like coordinate designator even during a repeat operation of the latter with no complicated designator manipulations required. The system comprises a coordinate detection apparatus and a coordinate output apparatus. The coordinate detection apparatus includes a sensor substrate to be operated by the coordinate designator, scan driving output units for generating a detection signal in response to the coordinate designator operation, and signal processing units for extracting tap and slide component data from the detection signal and supplying the extracted data to the coordinate output apparatus. The coordinate output apparatus includes a state detecting unit for detecting the state of the tap and slide component data, a measuring unit for measuring the tap component data, a mode changing unit for changing operation modes depending on the result of the measurement, a control unit for controlling the apparatus and a display unit for displaying various kinds of data. Operation modes are changed only if the tap component data is supplied in a predetermined state.
摘要翻译：一种坐标检测系统，即使在后者的重复操作中也只能使用一个指尖或类似的坐标指示器来显示相关坐标，而不需要复杂的指示符操作。该系统包括坐标检测装置和坐标输出装置。坐标检测装置包括由坐标指示器操作的传感器基板，响应于坐标指示器操作产生检测信号的扫描驱动输出单元和用于从检测信号中提取抽头和滑动分量数据的信号处理单元，提取的数据到坐标输出装置。坐标输出装置包括用于检测抽头和滑动部件数据的状态的状态检测单元，用于测量分接部件数据的测量单元，用于根据测量结果改变操作模式的模式改变单元，控制单元用于控制装置和用于显示各种数据的显示单元。仅当在预定状态下提供抽头分量数据时才改变操作模式。

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