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1. 发明申请

US20140206560A1 NUCLEIC ACID CONSTRUCT, NUCLEIC ACID-PROTEIN COMPLEX, AND USE THEREOF 有权
标题翻译：核酸结构，核酸 - 蛋白复合物及其用途
公开(公告)号：US20140206560A1
公开(公告)日：2014-07-24
申请号：US14119730
申请日：2012-05-23
申请人： Akira Wada , Hiroyuki Osada
发明人： Akira Wada , Hiroyuki Osada
IPC分类号： G01N33/53 , C07K17/10
CPC分类号： G01N33/5308 , C07H21/04 , C07K17/10 , C07K2319/80 , C07K2319/85 , C12N15/1034 , C12N15/1041 , C12N2800/00
摘要： Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5′-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5′-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an RNA corresponding to the above-mentioned nucleic acid construct.
摘要翻译：使用核酸构建体，进行多肽与其编码序列的结合以及与靶物质结合的多肽的筛选，所述核酸构建体包含5'-非翻译区和编码区，其中，所述编码区包含编码待显示的多肽的序列，编码第一核酸结合多肽的序列和编码第二核酸结合多肽的序列; 上述5'-非翻译区包括能够结合第一核酸结合多肽的第一序列和能够结合第二核酸结合多肽的第二序列; 并且当将上述核酸构建体引入翻译系统时，从上述核酸构建体的编码区翻译的融合蛋白与对应于上述核酸构建体的RNA形成复合物。

2. 发明授权

US09863936B2 Nucleic acid construct, nucleic acid-protein complex, and use thereof 有权
公开(公告)号：US09863936B2
公开(公告)日：2018-01-09
申请号：US14119730
申请日：2012-05-23
申请人： Akira Wada , Hiroyuki Osada
发明人： Akira Wada , Hiroyuki Osada
IPC分类号： A61K38/16 , C07H21/04 , C40B30/04 , C12N15/00 , C12P21/06 , G01N33/53 , C07K17/10 , C12N15/10
CPC分类号： G01N33/5308 , C07H21/04 , C07K17/10 , C07K2319/80 , C07K2319/85 , C12N15/1034 , C12N15/1041 , C12N2800/00
摘要： Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5′-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5′-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an RNA corresponding to the above-mentioned nucleic acid construct.

3. 发明授权

US09324889B2 Compound and photoelectric conversion device 有权
标题翻译：复合光电转换装置
公开(公告)号：US09324889B2
公开(公告)日：2016-04-26
申请号：US14003452
申请日：2012-03-07
申请人： Minoru Hanaya , Kenji Kakiage , Masafumi Unno , Yohei Aoyama , Toru Yano , Daisuke Sawamoto , Hiroyuki Osada
发明人： Minoru Hanaya , Kenji Kakiage , Masafumi Unno , Yohei Aoyama , Toru Yano , Daisuke Sawamoto , Hiroyuki Osada
IPC分类号： C07F7/18 , H01L31/0256 , H01L51/00 , C07F17/02 , H01G9/20
CPC分类号： H01G9/2059 , C07F7/1804 , C07F17/02 , C09B1/16 , C09B23/0075 , C09B23/14 , C09B23/145 , C09B23/164 , C09B29/0808 , C09B57/00 , H01G9/2031 , H01L31/0256 , H01L51/005 , H01L51/0052 , H01L51/0055 , H01L51/006 , H01L51/0061 , H01L51/0065 , H01L51/0068 , H01L51/007 , H01L51/0071 , H01L51/0072 , H01L51/0073 , H01L51/0083 , H01L51/0094 , Y02E10/542
摘要： Disclosed is a novel compound represented by formula (1) below. In the formula, A represents an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic group, B represents a group including a chain of one to four pieces of one or more groups selected from groups represented by specific formulae (B-1) to (B-13) (such as —C═C— or —N═N—, specifically see the description), R1 to R3 each represent an optionally substituted hydrocarbon or hydrocarbonoxy group, at least one of R1 to R3 represents an optionally substituted hydrocarbonoxy group, R4 and R5 each represent an optionally substituted hydrocarbon group, R4 and R5 may be linked together to form a ring, and R4 and R5 may be each independently linked with A to form a ring.
摘要翻译：公开了由下式（1）表示的新化合物。式中，A表示可以具有取代基的芳香族烃环或芳香族杂环基，B表示含有1〜4个选自特定式（B-1）〜（B- 13）（例如-C≡C-或-N = N-，具体参见描述），R 1至R 3各自表示任选取代的烃或烃氧基，R 1至R 3中的至少一个表示任选取代的烃氧基， R 4和R 5各自表示任选取代的烃基，R 4和R 5可以连接在一起形成环，并且R 4和R 5可以各自独立地与A形成环。

4. 发明申请

US20080124809A1 Method of Interaction Observation 审中-公开
标题翻译：交互观察方法
公开(公告)号：US20080124809A1
公开(公告)日：2008-05-29
申请号：US11665636
申请日：2005-10-13
申请人： Naoki Kanoh , Hiroyuki Osada , Motoki Kyo
发明人： Naoki Kanoh , Hiroyuki Osada , Motoki Kyo
IPC分类号： G01N33/00 , G01N21/00
CPC分类号： G01N33/553 , G01N33/54353
摘要： A method of label-free observing of any interaction between biomolecule and substance immobilized on a metal substrate, characterized in that the substance is immobilized on the metal substrate by a covalent bond through photoreaction.
摘要翻译：固定在金属基材上的生物分子与物质之间任何相互作用的无标记观察方法，其特征在于通过光反应通过共价键将该物质固定在金属基底上。

5. 发明授权

US06670187B2 Mutant Plk protein and gene encoding the same 失效
公开(公告)号：US06670187B2
公开(公告)日：2003-12-30
申请号：US09866590
申请日：2001-05-30
申请人： Hiroyuki Osada , Siro Simizu
发明人： Hiroyuki Osada , Siro Simizu
IPC分类号： C12N1587
CPC分类号： C12N9/12
摘要： A mutant Plk protein having a mutation in C-terminal domain thereof specified by amino acid residues of from 439 to 603 of amino acid sequence of wild-type Plk protein wherein said mutation decreases affinity with Hsp90 protein, and a gene encoding said mutant Plk protein are provided. A method for detecting an abnormal cell which comprises the step of detecting the mutant Plk protein or the gene encoding the protein is also provided.

6. 发明授权

US6094556A Intermediate transfer member and image forming apparatus 有权
标题翻译：中间转印件和成像设备
公开(公告)号：US6094556A
公开(公告)日：2000-07-25
申请号：US239021
申请日：1999-01-29
申请人： Atsushi Tanaka , Minoru Shimojo , Akira Shimada , Hiroyuki Osada , Tsunenori Ashibe , Hidekazu Matsuda
发明人： Atsushi Tanaka , Minoru Shimojo , Akira Shimada , Hiroyuki Osada , Tsunenori Ashibe , Hidekazu Matsuda
IPC分类号： G03G15/16 , G03G15/01
CPC分类号： G03G15/162 , G03G15/161 , G03G2215/0119 , G03G2215/0177
摘要： An intermediate transfer member for receiving a toner image formed on a first image-bearing member and transferring the toner image onto a second image-bearing member has a surface coated with at least one of a nitrate ion adsorbent and a compound having a layer structure, whereby a scattering of toner particles during a successive image formation is effectively suppressed for a long period.
摘要翻译：用于接收形成在第一图像承载部件上并将调色剂图像转印到第二图像承载部件上的调色剂图像的中间转印部件具有涂覆有硝酸根离子吸附剂和具有层结构的化合物中的至少一种的表面，从而在连续成像期间的调色剂颗粒的散射被长时间有效地抑制。

7. 发明授权

US09530571B2 Compound and support material supporting this novel compound 有权
标题翻译：支持这种新型化合物的化合物和载体材料
公开(公告)号：US09530571B2
公开(公告)日：2016-12-27
申请号：US14350171
申请日：2012-08-21
申请人： Yohei Aoyama , Kazuyuki Noda , Hiroyuki Osada
发明人： Yohei Aoyama , Kazuyuki Noda , Hiroyuki Osada
IPC分类号： C07F7/10 , H01G9/20 , C09B69/00 , C07F15/00 , C07F7/18 , H01L51/00
CPC分类号： H01G9/2059 , C07F7/1804 , C07F15/0053 , C09B69/008 , H01G9/2031 , H01G9/204 , H01L51/006 , H01L51/0061 , H01L51/0068 , H01L51/0069 , H01L51/0072 , H01L51/0086 , H01L51/0094 , Y02E10/542
摘要： A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).)
摘要翻译：公开了由通式（1）表示的新化合物，载有新化合物的载体材料和使用该载体材料制备的光电转换装置，其中Y为任选取代的具有1至20个碳原子的烃基且具有-CO -NR 4 - 或-SO 2 -NR 4 - ，Z是共轭基团，R 1，R 2和R 3各自表示任选取代的烃基或任选取代的烃氧基，R 1，R 2和R 3中的至少一个表示任选取代的烃氧基，R 4表示氢原子或具有1至20个碳原子的任选取代的烃基，并且R 4和Z可以连接在一起形成环，条件是Y不包括由部分结构式（ Y-11）和（Y-12）。

8. 发明授权

US08980587B2 Process for producing reveromycin A or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders 有权
标题翻译：生产瑞维霉素A或其合成中间体的方法，用于生产含有螺旋酮环的化合物的方法和新型抗肿瘤剂，杀真菌剂和骨疾病治疗剂
公开(公告)号：US08980587B2
公开(公告)日：2015-03-17
申请号：US13819959
申请日：2011-08-30
申请人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
发明人： Hiroyuki Osada , Shunji Takahashi , Makoto Kawatani , Yoshiyuki Sakaki , Atsushi Toyoda
IPC分类号： C12N1/21 , C12P17/06 , C12P17/16 , C07K14/36 , C07D493/10 , C12N15/52 , C12P17/18 , C12N1/20 , A61K31/351
CPC分类号： C07D493/10 , A61K31/351 , C07K14/36 , C12N1/20 , C12N15/52 , C12P17/06 , C12P17/181
摘要： A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
摘要翻译：属于属于链霉菌属的细菌，其具有产生还原霉素A或其合成中间体的能力，所述细菌被修饰以增加编码SEQ ID NO：36的氨基酸序列的revQ基因的表达或具有SEQ ID NO：36的氨基酸序列的表达，与亲本菌株相比，与SEQ ID NO：36不小于80％的身份，因此与亲本菌株相比上述生产能力增加。

9. 发明授权

US07713706B2 Method of fixing low-molecular compound to solid-phase support 有权
标题翻译：将低分子化合物固定在固相载体上的方法
公开(公告)号：US07713706B2
公开(公告)日：2010-05-11
申请号：US10551809
申请日：2004-03-25
申请人： Hiroyuki Osada , Naoki Kanoh
发明人： Hiroyuki Osada , Naoki Kanoh
IPC分类号： G01N33/53
CPC分类号： G03F7/165 , B05D1/185 , B05D3/06 , B82Y30/00 , B82Y40/00 , G03F7/008 , G03F7/016 , G03F7/0755
摘要： A method of fixing a low-molecular compound to a solid-phase support, by bringing a solution containing a low-molecular compound into contact with a solid-phase support having a photoreactive compound bonded to the surface, evaporating the solution containing a low-molecular compound to dryness, in the state of being in contact with the solid-phase support, and irradiating the solid-phase support with light to form a covalent bond between the photoreactive compound and the low-molecular compound. This fixing method enables a low-molecular compound to be fixed to a solid-phase support without the aid of a functional group.
摘要翻译：通过使含有低分子化合物的溶液与具有键合到表面的光反应性化合物的固相载体接触来蒸发含有低分子化合物的低分子化合物的溶液，分子化合物在与固相载体接触的状态下干燥，并用光照射固相载体以在光反应性化合物和低分子化合物之间形成共价键。这种固色方法能够使低分子化合物固定在固相载体上而无需官能团的帮助。

10. 发明授权

US07612213B2 Compound having antitumor activity and process for producing the same 失效
标题翻译：具有抗肿瘤活性的化合物及其制备方法
公开(公告)号：US07612213B2
公开(公告)日：2009-11-03
申请号：US10516743
申请日：2003-06-06
申请人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
发明人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
IPC分类号： C07D207/00 , C07D209/32 , C07D303/38 , C07D491/02
CPC分类号： C07D491/04 , A61K31/407
摘要： A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.
摘要翻译：由通式（I）表示的化合物：（I）其中R表示直链，支链或环状的烷基或芳基; 一种制备该化合物的方法; 和含有该化合物作为活性成分的抗肿瘤剂。

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