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1. 发明申请

US20120022131A1 BREAST CANCER RELATED GENE RQCD1 审中-公开
标题翻译：乳腺癌相关基因RQCD1
公开(公告)号：US20120022131A1
公开(公告)日：2012-01-26
申请号：US13060671
申请日：2009-08-13
申请人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
发明人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
IPC分类号： A61K31/713 , A61P35/00 , C12Q1/68 , G01N33/574 , C12N15/113 , C12N15/63
CPC分类号： G01N33/57415 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N2333/4703 , G01N2500/04
摘要： The present invention provides methods for detecting and diagnosing cancer, such methods involving the determination of the expression level of the RQCD1, GIGYF1 or GIGYF2 genes. These genes were discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer and methods for treating cancer. Moreover, the present invention provides siRNAs targeting the RQCD1, GIGYF1 and/or GIGYF2 genes, all of which are suggested to be useful in the treatment of cancer.
摘要翻译：本发明提供了检测和诊断癌症的方法，所述方法涉及确定RQCD1，GIGYF1或GIGYF2基因的表达水平。发现这些基因可以区别癌细胞与正常细胞。此外，本发明提供筛选用于治疗癌症的治疗剂的方法和用于治疗癌症的方法。此外，本发明提供靶向RQCD1，GIGYF1和/或GIGYF2基因的siRNA，所有这些都被认为可用于治疗癌症。

2. 发明授权

US4245697A Tubular body 失效
标题翻译：管状体
公开(公告)号：US4245697A
公开(公告)日：1981-01-20
申请号：US94124
申请日：1979-11-14
申请人： Akira Togashi
发明人： Akira Togashi
IPC分类号： F16L11/12 , F28F1/08 , F28F1/42
CPC分类号： F28F1/426 , F28F1/42 , Y10S165/535
摘要： A tubular body on whose external surface are formed a series of periodically wavy recesses of specific depth and angle, said recesses becoming the corresponding series of similarly wavy projections and thereby improving the mixed state or heat conduction efficiency of a fluid flowing therein.
摘要翻译：其外表面形成一系列具有特定深度和角度的周期性波浪凹槽的管状体，所述凹槽变成相应的一系列类似的波浪形突起，从而改善流过其中的流体的混合状态或热传导效率。

3. 发明申请

US20110319280A1 ECT2 ONCOGENE AS A THERAPEUTIC TARGET AND PROGNOSTIC INDICATOR FOR LUNG AND ESOPHAGEAL CANCER 审中-公开
标题翻译： ECT2 ONCOGENE作为肺癌和食管癌的治疗目标和预防指标
公开(公告)号：US20110319280A1
公开(公告)日：2011-12-29
申请号：US13002977
申请日：2009-07-16
申请人： Yusuke Nakamura , Yataro Daigo , Akira Togashi
发明人： Yusuke Nakamura , Yataro Daigo , Akira Togashi
IPC分类号： C40B30/04 , G01N33/566 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N2800/50
摘要： The invention features methods for detecting lung cancer or esophageal cancer, by detecting over-expression of ECT2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing lung cancer or esophageal cancer, based on the over-expression of ECT2 in the lung cancer or esophageal cancer, the cell proliferation function of ECT2. Also, provided are a method for treating lung cancer or esophageal cancer by administering a double-stranded molecule against the ECT2 gene or an antibody against ECT2 protein. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
摘要翻译：本发明特征在于检测肺癌或食管癌的方法，通过检测ECT2与正常器官的过表达。还公开了基于ECT2在肺癌或食管癌中的过表达，ECT2的细胞增殖功能，鉴定用于治疗和预防肺癌或食管癌的化合物的方法。此外，提供了通过对ECT2基因施用双链分子或针对ECT2蛋白的抗体来治疗肺癌或食管癌的方法。本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

4. 发明申请

US20110251090A1 PANCREATIC CANCER RELATED GENE TTLL4 审中-公开
标题翻译：胰腺癌相关基因TTLL4
公开(公告)号：US20110251090A1
公开(公告)日：2011-10-13
申请号：US13061071
申请日：2009-08-21
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Akira Togashi
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Akira Togashi
IPC分类号： C40B30/04 , C07K16/40 , C12Q1/68 , C07H21/00 , C12Q1/25 , G01N33/53
CPC分类号： G01N33/57438 , C12N9/93 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y603/02025
摘要： The present invention relates to the roles played by TTLL4 genes in pancreatic cancer carcinogenesis and features a method for treating or preventing pancreatic cancer by administering a double-stranded molecule against one or more of the TTLL4 genes or a composition, vector or cell containing such a double stranded molecule. Also, disclosed are methods of identifying compounds for treating and preventing pancreatic cancer, using as an index their effect on the over-expression of TTLL4 in the pancreatic cancer cell.
摘要翻译：本发明涉及TTLL4基因在胰腺癌发生中的作用，其特征在于通过对一种或多种TTLL4基因施用双链分子或含有这样一种或多种的TTLL4基因的组合物，载体或细胞来治疗或预防胰腺癌的方法双链分子。此外，公开了鉴定用于治疗和预防胰腺癌的化合物的方法，其作为对胰腺癌细胞中TTLL4的过表达的影响的指标。

5. 发明申请

US20110237518A1 METHOD FOR TREATING OR PREVENTING BLADDER CANCER USING THE DEPDC1 POLYPEPTIDE 有权
标题翻译：使用DEPDC1多肽治疗或预防刮板癌的方法
公开(公告)号：US20110237518A1
公开(公告)日：2011-09-29
申请号：US13061064
申请日：2009-08-21
申请人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
发明人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
IPC分类号： A61K38/10 , C07K7/08 , C07H21/00 , A61K31/713 , A61K31/7088 , C07K7/06 , C07K14/00 , A61P35/00 , A61P13/10 , G01N33/53 , C12Q1/02 , C12Q1/68 , C12N15/63
CPC分类号： C07K14/82 , A61K38/00 , A61K48/00 , C07K2319/10 , C12N15/113 , C12N2310/14 , G01N33/5011
摘要： The present invention provides therapeutic agents and methods for treating cancer using the polypeptides posed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. Furthermore, the present invention provides methods of screening for therapeutic agents or compounds useful in inhibition of the DEPDC1/ZN-F224 complex formation or the treatment of cancer. The present invention also provides siRNAs targeting the ZNF224 gene, which are suggested to be useful in the treatment of bladder cancer.
摘要翻译：本发明提供使用包含DEPDC1的多肽片段的氨基酸序列构建的多肽来治疗癌症的治疗剂和方法。本发明的多肽可以通过用转染试剂例如聚精氨酸修饰多肽而被引入到癌细胞中。此外，本发明提供筛选用于抑制DEPDC1 / ZN-F224复合物形成或治疗癌症的治疗剂或化合物的方法。本发明还提供靶向ZNF224基因的siRNA，其被认为可用于治疗膀胱癌。

6. 发明申请

US20110160293A1 PRMT1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS 有权
标题翻译： PRMT1用于目标癌基因治疗和诊断
公开(公告)号：US20110160293A1
公开(公告)日：2011-06-30
申请号：US13060672
申请日：2009-08-25
申请人： Yusuke Nakamura , Ryuji Hamamoto , Akira Togashi
发明人： Yusuke Nakamura , Ryuji Hamamoto , Akira Togashi
IPC分类号： A61K31/7052 , C12Q1/68 , G01N33/53 , C12Q1/02 , C12Q1/48 , C07H21/00 , C12N15/63 , A61P35/00
CPC分类号： C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y201/01125 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.
摘要翻译：本文描述了用于诊断发展中的癌症，特别是膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌的易感性的客观方法。在一个实施方案中，诊断方法包括确定PRMT1基因的表达水平。本发明还提供筛选用于治疗PRMT1相关疾病例如癌症的治疗剂的方法，例如癌症。膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。本发明还提供了抑制细胞生长和治疗或减轻PRMT1相关疾病症状的方法。本发明还涉及包括双链分子和编码它们的载体以及包含它们的组合物的产品。

7. 发明申请

US20100273855A1 COMPOSITIONS AND METHODS OF TREATING CANCER 审中-公开
标题翻译：治疗癌症的组合物和方法
公开(公告)号：US20100273855A1
公开(公告)日：2010-10-28
申请号：US12666253
申请日：2008-06-26
申请人： Akira Togashi , Ryutaro Tobita , Yuka Ishizaki , Akiko Konuma
发明人： Akira Togashi , Ryutaro Tobita , Yuka Ishizaki , Akiko Konuma
IPC分类号： A61K31/713 , C07H21/00 , C12N15/63 , A61P35/00
CPC分类号： C12N15/113 , C12N2310/14
摘要： The invention features a method for treating cancer by administering a double-stranded nucleic acid molecule against a CX gene selected from the group consisting of C14orf78, MYBL2, UBE2S and UBE2T. The invention also features products, including the double-stranded nucleic acid molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods. The methods of the invention are suited for the treatment of cancers including lung cancer, breast cancer, bladder cancer, esophagus cancer, prostate cancer, cholangiocellular carcinoma and testicular seminoma.
摘要翻译：本发明的特征在于通过对选自C14orf78，MYBL2，UBE2S和UBE2T的CX基因施用双链核酸分子来治疗癌症的方法。本发明还包括产物，包括双链核酸分子和编码它们的载体，以及包含所提供方法中有用的分子或载体的组合物。本发明的方法适用于治疗包括肺癌，乳腺癌，膀胱癌，食道癌，前列腺癌，胆管细胞癌和睾丸精原细胞癌等癌症。

8. 发明授权

US4175308A Gathering the ends of heat-conducting pipes in heat exchangers 失效
标题翻译：在热交换器中收集导热管的端部
公开(公告)号：US4175308A
公开(公告)日：1979-11-27
申请号：US667108
申请日：1976-03-15
申请人： Akira Togashi
发明人： Akira Togashi
IPC分类号： F28F9/04 , F28D7/16 , F28F9/02 , F28F9/18 , B23P15/26
CPC分类号： F28F9/0221 , Y10S165/91 , Y10T29/4935 , Y10T29/49393
摘要： In a heat exchanger, ends of adjacent heat-conducting pipes are flattened to form joining faces and these faces are butt-welded together to form a parallel pipe heat exchanger without end plates.
摘要翻译：在热交换器中，相邻导热管的端部平坦化以形成接合面，并将这些面对接在一起形成不具有端板的平行管式热交换器。

9. 发明授权

US08975086B2 Method for treating or preventing bladder cancer using the DEPDC1 polypeptide 有权
标题翻译：使用DEPDC1多肽治疗或预防膀胱癌的方法
公开(公告)号：US08975086B2
公开(公告)日：2015-03-10
申请号：US13061064
申请日：2009-08-21
申请人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
发明人： Yusuke Nakamura , Toyomasa Katagiri , Akira Togashi
IPC分类号： G01N33/53 , A61K38/00 , C07K7/00 , C07K14/00 , C07K14/82 , C12N15/113 , G01N33/50 , A61K48/00
CPC分类号： C07K14/82 , A61K38/00 , A61K48/00 , C07K2319/10 , C12N15/113 , C12N2310/14 , G01N33/5011
摘要： The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. Furthermore, the present invention provides methods of screening for therapeutic agents or compounds useful in inhibition of the DEPDC1/ZN-F224 complex formation or the treatment of cancer. The present invention also provides siRNAs targeting the ZNF224 gene, which are suggested to be useful in the treatment of bladder cancer.
摘要翻译：本发明提供使用由包含DEPDC1的多肽片段的氨基酸序列组成的多肽来治疗癌症的治疗剂和方法。本发明的多肽可以通过用转染试剂例如聚精氨酸修饰多肽而被引入到癌细胞中。此外，本发明提供筛选用于抑制DEPDC1 / ZN-F224复合物形成或治疗癌症的治疗剂或化合物的方法。本发明还提供靶向ZNF224基因的siRNA，其被认为可用于治疗膀胱癌。

10. 发明授权

US08512944B2 PRMT1 for target genes of cancer therapy and diagnosis 有权
标题翻译： PRMT1用于癌症治疗和诊断的靶基因
公开(公告)号：US08512944B2
公开(公告)日：2013-08-20
申请号：US13060672
申请日：2009-08-25
申请人： Yusuke Nakamura , Ryuji Hamamoto , Akira Togashi
发明人： Yusuke Nakamura , Ryuji Hamamoto , Akira Togashi
IPC分类号： C12Q1/00
CPC分类号： C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y201/01125 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.
摘要翻译：本文描述了用于诊断发展中的癌症，特别是膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌的易感性的客观方法。在一个实施方案中，诊断方法包括确定PRMT1基因的表达水平。本发明还提供筛选用于治疗PRMT1相关疾病例如癌症的治疗剂的方法，例如癌症。膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。本发明还提供了抑制细胞生长和治疗或减轻PRMT1相关疾病症状的方法。本发明还涉及包括双链分子和编码它们的载体以及包含它们的组合物的产品。

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