专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06436911B1 IL-12 production inhibitor 有权
标题翻译： IL-12生产抑制剂
公开(公告)号：US06436911B1
公开(公告)日：2002-08-20
申请号：US09620747
申请日：2000-07-21
申请人： Akira Asari , Hitoshi Kurihara , Heping Xu , Satoshi Miyauchi , Toshikazu Minamisawa
发明人： Akira Asari , Hitoshi Kurihara , Heping Xu , Satoshi Miyauchi , Toshikazu Minamisawa
IPC分类号： A01N4304
CPC分类号： A61K31/7024
摘要： An IL-12 production inhibitor which comprises, as an active ingredient, a keratan sulfate oligosaccharide or a derivative thereof, for example, a keratan sulfate oligosaccharide comprising at least one repeating unit of either one of the disaccharides represented by the following formulas: Gal (6s)-GlcNAc (6s) and Gal (6s)-GlcNAc wherein Gal represents a galactose residue, GlcNAc represents an N-acetylglucosamine residue, 6s indicates that 6-0-sulfate ester is formed at a Hydroxyl group at the 6-position, and - represents a glycosidic linkage.
摘要翻译：作为活性成分的含有硫酸角质素寡糖或其衍生物的IL-12产生抑制剂，例如硫酸角质素寡糖，其包含由下式表示的二糖中的至少一个重复单元：Gal（ 6s）-GlcNAc（6s）和Gal（6s）-GlcNAc，其中Gal表示半乳糖残基，GlcNAc表示N-乙酰葡糖胺残基，6s表示6位羟基上形成6-0-硫酸酯，和 - 表示糖苷键。

2. 发明授权

US5939403A Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same 失效
$Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same$
标题翻译：硫酸角质素寡糖部分和含有相同的药物
公开(公告)号：US5939403A
公开(公告)日：1999-08-17
申请号：US849925
申请日：1997-06-02
申请人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
发明人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
IPC分类号： A61K31/737 , C07H11/00 , C07H13/04 , C08B37/00 , C12P19/26 , A61K31/73 , A61K31/725 , C08B3/04 , C08B3/06
CPC分类号： A61K31/7024 , A61K31/702 , A61K31/737 , C07H11/00 , C07H13/04 , C08B37/0063 , C12P19/26 , Y10S514/885
摘要： A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.
摘要翻译： PCT No.PCT / JP95 / 02386 Sec。 371日期：1997年6月2日 102（e）日期1997年6月2日PCT提交1995年11月22日PCT公布。公开号WO96 / 16973 日期：1996年6月6日硫酸角质素寡糖，其包含2至5个糖单元并且在还原端具有硫酸化的N-乙酰葡糖胺，并且其至少两个羟基被硫酸化的分子中，优选至少含有由配方Gal（6S）-GlcNAc（6S）（在分子式中，Gal，GlcN，Ac和6S分别代表半乳糖，葡糖胺，乙酰基和6-O-硫酸酯）作为构成成分，和/或其药学上可接受的盐用作抗炎剂，抗过敏剂，免疫调节剂，细胞分化诱导剂和凋亡诱导剂的活性成分。

3. 发明授权

US6159954A Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same 有权
$Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same$
标题翻译：硫酸角质素寡糖部分和含有相同的药物
公开(公告)号：US6159954A
公开(公告)日：2000-12-12
申请号：US317380
申请日：1999-05-24
申请人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
发明人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
IPC分类号： A61K31/737 , C07H11/00 , C07H13/04 , C08B37/00 , C12P19/26 , A61K31/70
CPC分类号： A61K31/7024 , A61K31/702 , A61K31/737 , C07H11/00 , C07H13/04 , C08B37/0063 , C12P19/26 , Y10S514/885
摘要： A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.
摘要翻译：硫酸角质素寡糖，其包含2至5个糖单元，并且在还原端具有硫酸化的N-乙酰葡糖胺，并且其至少两个羟基被硫酸化的分子中，优选至少含有由式Gal（6S）表示的至少二糖）-GlcNAc（6S）（在式中，Gal，GlcN，Ac和6S分别代表半乳糖，葡糖胺，乙酰基和6-O-硫酸酯）作为构成成分，和/或药学上其可接受的盐用作抗炎剂，抗过敏剂，免疫调节剂，细胞分化诱导剂和凋亡诱导剂的活性成分。

4. 发明申请

US20120246881A1 Button Fastener and Button Structure 审中-公开
标题翻译：按钮紧固件和按钮结构
公开(公告)号：US20120246881A1
公开(公告)日：2012-10-04
申请号：US13514629
申请日：2009-12-14
申请人： Satoshi Miyauchi , Akira Morishita , Toru Miyae , Jukichi Fukushima
发明人： Satoshi Miyauchi , Akira Morishita , Toru Miyae , Jukichi Fukushima
IPC分类号： A44B1/28
CPC分类号： A44B1/44 , A44B17/0005 , Y10T24/367
摘要： The button fastener comprises a fastener body and a cover member which is attached to the fastener body. The fastener body includes a disk-like base and a hollow, cylindrical post extending upward from a center area of the base concentrically. The post has a top opening at its upper end and a bottom opening in a center area of the base. The cover member covers the lower surface of the base including the bottom opening. The base includes a base bottom adjacent to the post and a base flange rising upward relative to the base bottom radially outward from the base bottom. The cover member includes a curved outer periphery curving from the lower surface side of the base and then rising upward beyond the base flange of the base.
摘要翻译：按钮紧固件包括紧固件主体和附接到紧固件主体的盖构件。紧固件主体包括圆盘状基部和从基体的中心区域同心地向上延伸的中空圆柱形柱。该柱在其上端具有顶部开口，在底部的中心区域具有底部开口。盖构件覆盖底座的下表面，包括底部开口。基部包括邻近柱的底部底部和从底部向下相对于基部底部向上升高的底部凸缘。盖构件包括弯曲的外周，其从基座的下表面侧弯曲，然后向上升高超过基座的基部凸缘。

5. 发明申请

US20110129544A1 Bone/Cartilage Formation-Stimulation Agent 审中-公开
标题翻译：骨/软骨形成刺激剂
公开(公告)号：US20110129544A1
公开(公告)日：2011-06-02
申请号：US12528765
申请日：2008-02-22
申请人： Tatsuya Miyazaki , Satoshi Miyauchi , Satoshi Matsuzaka , Osamu Suzuki
发明人： Tatsuya Miyazaki , Satoshi Miyauchi , Satoshi Matsuzaka , Osamu Suzuki
IPC分类号： A61K33/42 , C08B37/00 , A61K31/726 , A61K38/28 , A61K38/18 , A61K38/22 , A61K38/23 , A61P19/00
CPC分类号： A61K31/726 , C08B37/0069 , C08L5/08
摘要： Disclosed is a mixture of: a bone/cartilage formation promoting agent containing sulfated galactosaminoglycan having greater than or equal to 0.6 numbers of ester sulfate groups on average per constituent monosaccharide or a salt thereof as an active ingredient; a factor having a bone/cartilage formation promoting action; or a bone filler (BMP, TGF-β, FGF, IGF, insulin, PDGF, HGF, midkine, pleiotrophin, collagen, gelatin, proteoglycan, fibronectin, osteocalcin, osteopontin, osteonectin, bone sialoprotein, hydroxyapatite, dicalcium phosphate anhydride, dicalcium phosphate dehydrate, α-tricalcium phosphate, amorphous calcium phosphate, octacalcium phosphate, β-tricalcium phosphate, PLLA, PLGA, titanium, decalcified bone, autogeneous bone, or the like).
摘要翻译：公开了以下混合物：含有硫酸化半乳糖聚糖的骨/软骨形成促进剂，其平均每组成单糖或其盐作为活性成分具有大于或等于0.6个硫酸酯基数; 具有骨/软骨形成促进作用的因子; 或骨填充剂（BMP，TGF-β，FGF，IGF，胰岛素，PDGF，HGF，midkine，多余肌营养蛋白，胶原，明胶，蛋白聚糖，纤连蛋白，骨钙素，骨桥蛋白，骨粘连蛋白，骨涎蛋白，羟基磷灰石，磷酸二钙酸酐，磷酸氢盐脱水，磷酸三钙，无定形磷酸钙，磷酸八钙，磷酸三钙，PLLA，PLGA，钛，脱钙骨，自体骨等）。

6. 发明授权

US5789462A Photocured crosslinked-hyaluronic acid contact lens 失效
标题翻译：光固化交联透明质酸隐形眼镜
公开(公告)号：US5789462A
公开(公告)日：1998-08-04
申请号：US712515
申请日：1996-09-13
申请人： Yoshihiro Motani , Satoshi Miyauchi
发明人： Yoshihiro Motani , Satoshi Miyauchi
IPC分类号： G02B1/04 , G02C7/04 , C08F290/10
CPC分类号： G02B1/043
摘要： A photocured crosslinked-hyaluronic acid contact lens which comprises a photocured crosslinked-hyaluronic acid derivative produced by the formation of a crosslinked cyclobutane ring by light irradiation from mutual photoreactive crosslinking groups of a photoreactive hyaluronic acid derivative in which the photoreactive crosslinking groups are linked to hyaluronic acid, wherein the photoreactive crosslinking groups are introduced into functional groups of hyaluronic acid via a spacer group, and the contact lens has a water content of 80 to 99% and shape compatibility and tissue affinity for the eyeball. A process for preparing a photocured crosslinked-hyaluronic acid contact lens which comprises molding the photoreactive hyaluronic acid derivative into a shape that fits to the eyeball, and subsequently irradiating the shaped product with light to effect crosslinking between the mutual photoreactive crosslinking groups.
摘要翻译：一种光固化交联透明质酸隐形眼镜，其包含通过光反应性交联基团的光反应性交联基团的光照射形成交联的环丁烷环而制备的光固化交联透明质酸衍生物，其中光反应性交联基团与透明质酸酸，其中光反应性交联基团通过间隔基团引入透明质酸的官能团，并且隐形眼镜具有80至99％的水含量和眼球的形状相容性和组织亲和力。一种制备光固化交联透明质酸隐形眼镜的方法，其包括将光反应性透明质酸衍生物模塑成适合于眼球的形状，随后用光照射成形产品以实现相互光反应性交联基团之间的交联。

7. 发明授权

US07923244B2 Artificial cartilage tissue and production method thereof 有权
标题翻译：人造软骨组织及其制备方法
公开(公告)号：US07923244B2
公开(公告)日：2011-04-12
申请号：US11699400
申请日：2007-01-30
申请人： Satoshi Miyauchi , Tatsuya Miyazaki , Satoshi Matsuzaka
发明人： Satoshi Miyauchi , Tatsuya Miyazaki , Satoshi Matsuzaka
IPC分类号： C12N5/071 , A61K38/00
CPC分类号： C12N5/0655 , A61F2/30756 , C12N2501/105 , C12N2501/115 , C12N2501/15
摘要： To obtain an artificial cartilage tissue having high strength and biocompatibility. There is provided an artificial cartilage tissue which is substantially free of heterologous protein and is substantially free of scaffold derived from non-cartilage-derived cells, but contains mammalian cartilage-derived cells and an extracellular matrix formed by the cartilage-derived cells, where: (1) the water retention per mg of tissue dry weight is 17.8 mg or less; (2) collagen of 5.57 μg or more per mg of tissue wet weight is contained; (3) proteoglycan of 9.22 μg or more per mg of tissue wet weight is contained.
摘要翻译：获得具有高强度和生物相容性的人造软骨组织。提供了基本上不含异源蛋白质的人造软骨组织，并且基本上不含源自非软骨衍生细胞的支架，但是含有由软骨衍生细胞形成的哺乳动物软骨衍生细胞和细胞外基质，其中：（1）每mg组织干重的保水量为17.8mg或更少; （2）含有每毫克组织湿重5.57μg或更多的胶原蛋白; （3）含有9.22μg或更多每毫克组织湿重的蛋白聚糖。

8. 发明授权

US06232301B1 Remedies for bladder disorders 有权
标题翻译：膀胱功能障碍
公开(公告)号：US06232301B1
公开(公告)日：2001-05-15
申请号：US09142032
申请日：1998-08-27
申请人： Katsuya Takahashi , Satoshi Miyauchi
发明人： Katsuya Takahashi , Satoshi Miyauchi
IPC分类号： A61K3170
CPC分类号： A61K31/715 , A61K9/0034
摘要： In order to provide an agent for treatment of bladder troubles that has vesical mucosa epithelium dilatation promoting action and/or vesical mucosa healing action, and exhibits excellent curative effect for bladder troubles, in particular, non-bacterial intractable bladder troubles, the agent for treatment of bladder troubles is formulated with hyaluronic acid and/or a pharmaceutically acceptable salt thereof, preferably hyaluronic acid and/or a pharmaceutically acceptable salt thereof having the following physicochemical properties: (A) endotoxin content; 0.03 EU (endotoxin unit)/10 mg or less, (B) sulfur content; 0.01% or less as determined by coulometric titration, (C) iron content; 20 ppm or less, (D) protein content; 0.1% or less, and (E) weight average molecular weight; 500,000 or more, in an amount effective for promoting vesical mucosa epithelium dilatation and/or healing vesical mucosa, preferably in an amount of 0.2-0.6% by weight based on total amount of the agent.
摘要翻译：为了提供具有膀胱粘膜上皮扩张促进作用和/或膀胱粘膜愈合作用的膀胱麻烦的治疗剂，对膀胱麻烦，特别是非细菌难治性膀胱麻烦，治疗剂膀胱麻烦的透明质酸和/或其药学上可接受的盐，优选透明质酸和/或其药学上可接受的盐，具有以下物理化学性质：（A）内毒素含量; 0.03欧盟（内毒素单位）/ 10毫克或更少，（B）硫含量; 0.01％以下，通过库仑滴定测定，（C）铁含量; 20ppm以下，（D）蛋白质含量; 0.1％以下，（E）重均分子量; 500,000或更多，其量有效促进膀胱粘膜上皮扩张和/或愈合膀胱粘膜，优选为基于试剂总量的0.2-0.6重量％。

9. 发明授权

US4705154A Coin selection apparatus 失效
标题翻译：硬币选择装置
公开(公告)号：US4705154A
公开(公告)日：1987-11-10
申请号：US779122
申请日：1985-09-23
申请人： Yukio Masho , Shigeru Kakimi , Toru Ueki , Satoshi Miyauchi , Tugio Ohigashi , Hitoshi Kurohata
发明人： Yukio Masho , Shigeru Kakimi , Toru Ueki , Satoshi Miyauchi , Tugio Ohigashi , Hitoshi Kurohata
IPC分类号： G07D5/00 , G07D5/08 , G07D11/00 , G07F3/02
CPC分类号： G07D5/08 , G07D5/02
摘要： A coin selection apparatus comprises a plurality of detection coils and an oscillation circuit which detects changes of impedances of the detection coils caused when a coin pass through the detection coils, as a change of a voltage output. The plurality of detection coils include at least two sets of detection coils each including two detection coils opposingly arranged to the coin path. One set of detection coils has its two coils connected in series and in phase and the other set of detection coil has its two coils connected in series and in phase opposition. The two sets of coils are arranged at a spacing along the coin path smaller than a minimum diameter of a coin to be selected and all of the coils are connected in series and connected as a resonance element of the oscillation circuit. Thus, material, thickness and diameter and other appearance characteristic of the coin are detected based on the voltage output of the oscillation circuit. Accordingly, the coin selection apparatus is of simple construction and has a small number of components.
摘要翻译：硬币选择装置包括多个检测线圈和振荡电路，其检测当硬币通过检测线圈时引起的检测线圈的阻抗变化，作为电压输出的变化。多个检测线圈包括至少两组检测线圈，每组检测线圈包括相对地设置在硬币路径上的两个检测线圈。一组检测线圈具有串联和相位连接的两个线圈，另一组检测线圈具有串联和相位相反的两个线圈。两组线圈沿着硬币路径以比要选择的硬币的最小直径小的间隔布置，并且所有线圈串联连接并作为振荡电路的谐振元件连接。因此，基于振荡电路的电压输出来检测硬币的材料，厚度和直径等外观特性。因此，硬币选择装置结构简单，部件数量少。

10. 发明申请

US20090242354A1 COIN DISCRIMINATING DEVICE 审中-公开
标题翻译：硬币识别装置
公开(公告)号：US20090242354A1
公开(公告)日：2009-10-01
申请号：US12303325
申请日：2007-07-10
申请人： Satoshi Miyauchi , Takehiko Nara , Tooru Ueki , Kouji Ikeda
发明人： Satoshi Miyauchi , Takehiko Nara , Tooru Ueki , Kouji Ikeda
IPC分类号： G07D5/08
CPC分类号： G07D5/08
摘要： A coin discriminating device has a detecting part, a first switching part, a storage part, and a control part. The detecting part has a first sensor including a pair of coils, and an oscillating circuit, and is supplied with voltage from a power source, and in addition, outputs a detection signal varied by a coin passing between the coils. The first switching part switches magnetic connection of the coils between an in-phase connection and a reversed-phase connection a plurality of times while the coin passes between the coils. The control part compares the detection signal from the detecting part and a reference signal stored in the storage part so as to determine authentication and a denomination of the coin.
摘要翻译：硬币鉴别装置具有检测部分，第一切换部分，存储部分和控制部分。检测部具有包括一对线圈的第一传感器和振荡电路，并且从电源提供电压，并且还输出由硬币通过线圈之间变化的检测信号。第一开关部件在硬币通过线圈之间时多次在同相连接和反相连接之间切换线圈的磁连接。控制部分比较来自检测部分的检测信号和存储在存储部分中的参考信号，以便确定硬币的认证和面额。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式