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    • 2. 发明授权
    • 4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof
    • 4-氨基(烷基)环己烷-1-甲酰胺化合物及其用途
    • US5478838A
    • 1995-12-26
    • US204211
    • 1994-03-07
    • Masafumi AritaTadamasa SaitoHirofumi OkudaHiroyuki SatoMasayoshi Uehata
    • Masafumi AritaTadamasa SaitoHirofumi OkudaHiroyuki SatoMasayoshi Uehata
    • C07D213/75C07D213/81C07D237/20C07D239/42C07D239/48C07D239/50C07D471/04A61K31/435
    • C07D213/75C07D213/81C07D237/20C07D239/42C07D239/48C07D239/50C07D471/04
    • 4-Amino(alkyl)cyclohexane-1-carboxamide compounds of the formula (I) ##STR1## wherein each symbol is as defined in the Specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof.The 4-amino(alkyl)cyclohexane-1-carboxamide compounds, isomers thereof and pharmaceutically acceptable acid addition salts thereof of the present invention have potent and long-lasting coronary, cerebral, renal and peripheral blood flow increasing actions and are less toxic, and thus are useful as a potent and long-lasting antihypertensive agent and an agent for the prevention and treatment of diseases in the circulatory organs such as coronary, cerebral, renal and peripheral arteries. Moreover, the compounds of the present invention exhibit inhibitory action on experimental asthma of guinea pigs, which is caused by histamine inhalation, and inhibitory action on contraction of trachea strips isolated from guinea pigs, which is caused by acetylcholine, and thus are useful as therapeutic agents for asthma.
    • PCT No.PCT / JP92 / 01139 Sec。 371日期:1994年3月7日 102(e)1994年3月7日PCT PCT 1992年9月4日PCT公布。 公开号WO93 / 05021 日期:1993年3月18日4-氨基(烷基)环己烷-1-甲酰胺化合物其中每个符号如本说明书中所定义,其异构体和其药学上可接受的酸加成盐。 本发明的4-氨基(烷基)环己烷-1-甲酰胺化合物,其异构体及其药学上可接受的酸加成盐具有强力和持久的冠状动脉,脑,肾和外周血流量增加作用,毒性较小, 因此可用作有效和持久的抗高血压剂和用于预防和治疗循环器官如冠状动脉,脑,肾和外周动脉疾病的药剂。 此外,本发明的化合物对由组胺吸入引起的豚鼠的实验性哮喘具有抑制作用,并且对由乙酰胆碱引起的豚鼠分离的气管条的收缩具有抑制作用,因此可用作治疗 哮喘药物。
    • 4. 发明授权
    • Differential
    • 微分
    • US5529547A
    • 1996-06-25
    • US493967
    • 1995-06-23
    • Hirofumi OkudaShiro IchikiHideyuki Sato
    • Hirofumi OkudaShiro IchikiHideyuki Sato
    • B60K17/16F16H48/20F16H48/38F16H48/40F16H1/38
    • F16H48/285
    • In a differential for vehicles, a pair of side gears are received in a housing and coaxial with the housing. The pair of side gears are spline-connected with end portions of a pair of coaxial output shafts. The pair of side gears are meshed with each other through paired element gears. Each side gear has a protrusion of a reduced diameter to be inserted in a receiving recess of the housing. A primary thrust washer and a coned disk spring are interposed between a shoulder of each side gear and the housing. A secondary thrust washer is interposed between the protrusion of the side gear and the housing. With a distal end face of the protrusion of the side gear contacting the housing through the secondary thrust washer, a distance between the shoulder of the side gear and the inner surface of the housing is larger than a total thickness of the primary thrust washer and the coned disk spring.
    • 在车辆的差速器中,一对侧齿轮容纳在壳体中并与壳体同轴。 一对侧齿轮与一对同轴输出轴的端部花键连接。 一对侧齿轮通过成对的齿轮啮合。 每个侧齿轮具有直径减小的突起,以插入壳体的容纳凹部中。 一个主推力垫圈和一个碟形弹簧插在每个侧齿轮的肩部和壳体之间。 二次止推垫圈设置在侧齿轮的突出部和壳体之间。 通过侧齿轮的突起的远端面通过次级止推垫圈与壳体接触,侧齿轮的肩部与壳体的内表面之间的距离大于主止推垫圈的总厚度 锥形弹簧。
    • 7. 发明申请
    • Method of forming internal gear, and internal gear
    • 形成内齿轮和内齿轮的方法
    • US20050166654A1
    • 2005-08-04
    • US10505351
    • 2003-02-10
    • Yukio WadaHirofumi OkudaYasufumi NakamuraAkinao Minegishi
    • Yukio WadaHirofumi OkudaYasufumi NakamuraAkinao Minegishi
    • B21D53/28B21H5/00B21H5/02B21D22/16
    • B21H5/025B21D53/28Y10T29/49471
    • At the time for forming an internal gear from a raw material 2 of an internal gear, first, the raw material 2 is externally inserted onto a forming die 3 and fixed to the forming die 3 through a pressing die 4. Next, a forming roll 5 is moved in a direction as indicated by an arrow B of FIG. 6 while rotating the forming die 3. By this, the inner peripheral surface of the raw material 3 is pressed against an outer gear part 3b formed on the outer peripheral surface of the forming die 3 so that an internal gear part 1c is formed on the inner peripheral surface of the raw material 2. The rotating direction of the forming die 3 is selected such that the first end part of the outer gear part 3b located on the front side in the feeding direction of the forming roll 5 is moved ahead in the rotating direction (the direction as indicated by an arrow A of FIG. 6) of the second end part located on the rear side in the feeding direction of the forming roll 5.
    • 在从内齿轮的原料2形成内齿轮的时刻,首先将原料2从外部插入到成型模具3上,并通过压模4固定在成形模具3上。 接下来,成形辊5沿图1的箭头B所示的方向移动。 同时旋转成形模具3。 由此,原料3的内周面被压在形成在成形模3的外周面上的外齿轮部3b上,从而在原料的内周面上形成有内齿轮部1c 材料2。 选择成形模3的旋转方向,使得位于成形辊5的供给方向的前侧的外齿轮部3b的第一端部沿旋转方向(所示的方向(如 位于成形辊5的进给方向后侧的第二端部的图6的箭头A.
    • 8. 发明授权
    • Method of forming internal gear, and internal gear
    • 形成内齿轮和内齿轮的方法
    • US07152446B2
    • 2006-12-26
    • US10505351
    • 2003-02-10
    • Yukio WadaYasufumi NakamuraAkinao MinegishiHirofumi Okuda
    • Yukio WadaYasufumi NakamuraAkinao MinegishiHirofumi Okuda
    • B21D22/00
    • B21H5/025B21D53/28Y10T29/49471
    • At the time for forming an internal gear from a raw material 2 of an internal gear, first, the raw material 2 is externally inserted onto a forming die 3 and fixed to the forming die 3 through a pressing die 4. Next, a forming roll 5 is moved in a direction as indicated by an arrow B of FIG. 6 while rotating the forming die 3. By this, the inner peripheral surface of the raw material 3 is pressed against an outer gear part 3b formed on the outer peripheral surface of the forming die 3 so that an internal gear part 1c is formed on the inner peripheral surface of the raw material 2. The rotating direction of the forming die 3 is selected such that the first end part of the outer gear part 3b located on the front side in the feeding direction of the forming roll 5 is moved ahead in the rotating direction (the direction as indicated by an arrow A of FIG. 6) of the second end part located on the rear side in the feeding direction of the forming roll 5.
    • 在从内齿轮的原料2形成内齿轮的时刻,首先将原料2从外部插入到成型模具3上,并通过压模4固定在成形模具3上。 接下来,成形辊5沿图1的箭头B所示的方向移动。 同时旋转成形模具3。 由此,原料3的内周面被压在形成在成形模3的外周面上的外齿轮部3b上,从而在原料的内周面上形成有内齿轮部1c 材料2。 选择成形模3的旋转方向,使得位于成形辊5的供给方向的前侧的外齿轮部3b的第一端部沿旋转方向(所示的方向(如 位于成形辊5的进给方向后侧的第二端部的图6的箭头A.