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1. 发明申请

US20210161826A1 BIODEGRADABLE POLYMER FORMULATIONS FOR EXTENDED EFFICACY OF BOTULINUM TOXIN 有权
公开(公告)号：US20210161826A1
公开(公告)日：2021-06-03
申请号：US17170614
申请日：2021-02-08
申请人： Akina, Inc.
发明人： Kinam Park , Yeonhee Yun , Sarah Michelle Skidmore , Byung Kook Lee , John Solomon Garner
IPC分类号： A61K9/50 , A61K47/36 , A61K47/34 , A61K9/00 , A61K9/16 , A61K9/14 , A61K9/51 , A61K38/48 , C01G9/04 , C08G63/08
摘要： Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

2. 发明申请

US20170037196A1 NOVEL HYDROGEL TISSUE EXPANDERS 有权
标题翻译：新型HYDROGEL TISSUE扩展器
公开(公告)号：US20170037196A1
公开(公告)日：2017-02-09
申请号：US15304495
申请日：2015-04-13
申请人： AKINA, INC. (AN INDIANA (US) CORP) , The United States Government as Represented by the Department of Veterans Affairs
发明人： Kinam Park , Clark Tobias Barco , Haesun Park , Yourong Fu , John Solomon Garner
IPC分类号： C08J3/075 , A61F2/28 , A61B90/00 , A61C8/02 , A61K47/34 , C08F299/02
CPC分类号： C08J3/075 , A61B17/8858 , A61B90/02 , A61B2017/00004 , A61B2017/00898 , A61B2017/681 , A61C8/0006 , A61F2/2803 , A61F2310/00383 , A61K47/34 , C08F299/024 , C08G81/00 , C08J2353/00
摘要： The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.
摘要翻译：本发明提供了包含在干燥状态下是弹性的可生物降解的，化学交联的水凝胶的组织扩张器。这些生物相容的组织扩张器是自膨胀和无膜的。它们缓慢膨胀并引起最小的负面组织反应，同时允许外科医生在放置时快速和容易地操作。

3. 发明申请

US20160128941A1 DEVICE FOR LARGE-SCALE MICROPARTICLE PRODUCTION AND METHOD OF USING THE SAME 有权
标题翻译：用于大规模生产微生物的装置及其使用方法
公开(公告)号：US20160128941A1
公开(公告)日：2016-05-12
申请号：US14896276
申请日：2014-06-09
申请人： AKINA, INC.
发明人： Kinam Park , Sarah Michelle Skidmore , Larry Fultz , Yeonhee Yun , Byung Kook Lee
IPC分类号： A61K9/16 , B02C19/00
CPC分类号： A61K9/1682 , B02C19/00
摘要： A semi-automated device that provides a mechanism to produce large-scale microparticle formulations of specific sizes with no scum layer formation, and a method for using the device.
摘要翻译：提供生产具有特定尺寸的大规模微粒制剂，无浮渣层形成的机制的半自动化装置，以及使用该装置的方法。

4. 发明申请

US20150150807A1 Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof 审中-公开
标题翻译：溶胶凝胶相可逆水凝胶模板及其用途
公开(公告)号：US20150150807A1
公开(公告)日：2015-06-04
申请号：US14617804
申请日：2015-02-09
申请人： AKINA, INC.
发明人： Kinam Park , Ghanashyam Acharya , Haesun Park
IPC分类号： A61K9/16
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/5031 , A61K9/5089 , A61K31/00 , Y10S977/773 , Y10S977/887 , Y10S977/89 , Y10S977/906
摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.
摘要翻译：使用溶胶 - 凝胶相可逆水凝胶模板制备预定尺寸和形状的离散微结构。将水凝胶形成材料的水溶液覆盖在具有预定义的微特征（例如柱）的微制造硅晶片主模板上。通常通过降低温度形成水凝胶模板，并将形成的水凝胶模板从硅主模板剥离。在水凝胶模板上预定尺寸和形状的孔填充有水不溶性聚合物的溶液或糊剂，并除去溶剂以形成固体结构。通过在水中简单地熔化水凝胶模板，将形成的微结构从水凝胶模板中释放出来。通过离心收集微结构。通过该方法制造的微结构显示出与水凝胶模板的微孔完全对应的预定义的尺寸和形状。基于水凝胶模板制备微结构的方法简单，容易产生大量微结构。

5. 发明授权

US12122870B2 Synthesis of environmentally degradable alkyl polyesters 有权
公开(公告)号：US12122870B2
公开(公告)日：2024-10-22
申请号：US17304496
申请日：2021-06-22
申请人： Akina, Inc
发明人： John Solomon Garner , Kinam Park
IPC分类号： C08L67/04 , C08G63/08 , C08G63/12 , C08G63/82 , C08L67/00
CPC分类号： C08G63/12 , C08G63/08 , C08G63/82 , C08L67/04 , C08L2201/06 , C08L2203/202 , C08L2203/206 , C08L2312/00
摘要： A solid crosslinked polyester composition is disclosed wherein the crosslinked polyester is environmentally degradable in less than about 180 days. The crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester.

6. 发明申请

US20180221281A1 Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof 审中-公开
公开(公告)号：US20180221281A1
公开(公告)日：2018-08-09
申请号：US15872895
申请日：2018-01-16
申请人： AKINA, INC.
发明人： Kinam Park , Ghanashyam S. Acharya , Haesun Park
IPC分类号： A61K9/16 , A61K9/50 , A61K31/00
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/5031 , A61K9/5089 , A61K31/00 , Y10S977/773 , Y10S977/887 , Y10S977/89 , Y10S977/906
摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.

7. 发明公开

US20240199795A1 SYNTHESIS OF ENVIRONMENTALLY DEGRADABLE ALKYL POLYESTERS 审中-公开
公开(公告)号：US20240199795A1
公开(公告)日：2024-06-20
申请号：US18332724
申请日：2023-06-10
申请人： Akina Inc.
发明人： Kinam Park , John Solomon Garner
IPC分类号： C08G63/137
CPC分类号： C08G63/137 , C08G2230/00
摘要： A solid polyester wherein the polyester is environmentally degradable in less than about 5 to about 7 months. The polyester is the direct dehydration polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds without added catalysts or cyclic precursors; or the polyester is the direct dehydration polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester without requiring added catalysts or cyclic precursors.

8. 发明授权

US10925837B2 Biodegradable polymer formulations for extended efficacy of botulinum toxin 有权
公开(公告)号：US10925837B2
公开(公告)日：2021-02-23
申请号：US15684134
申请日：2017-08-23
申请人： Akina, Inc.
发明人： Kinam Park , Yeonhee Yun , Sarah Michelle Skidmore , Byung Kook Lee , John Solomon Garner
IPC分类号： A61K9/50 , A61K47/36 , A61K47/34 , A61K9/00 , A61K9/16 , A61K9/14 , A61K9/51 , A61K38/48 , C01G9/04 , C08G63/08 , A61K9/113
摘要： Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

9. 发明授权

US10011689B2 Hydrogel tissue expanders 有权
公开(公告)号：US10011689B2
公开(公告)日：2018-07-03
申请号：US15304495
申请日：2015-04-13
申请人： Akina, Inc. , The United States of America, as Represented by the Department of Veterans Affairs
发明人： Kinam Park , Clark Tobias Barco , Haesun Park , Yourong Fu , John Solomon Garner
IPC分类号： C08J3/075 , C08G81/00 , A61C8/02 , A61B90/00 , A61F2/28 , A61K47/34 , C08F299/02 , A61B17/88 , A61B17/68 , A61B17/00
CPC分类号： C08J3/075 , A61B17/8858 , A61B90/02 , A61B2017/00004 , A61B2017/00898 , A61B2017/681 , A61C8/0006 , A61F2/2803 , A61F2310/00383 , A61K47/34 , A61L31/06 , A61L31/145 , A61L31/16 , A61L33/0011 , C08F287/00 , C08F290/062 , C08F299/024 , C08G63/664 , C08G63/912 , C08G81/00 , C08J2353/00 , C08L67/04 , C08L71/02 , C08F2222/1013 , C08F222/1006
摘要： The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.

10. 发明申请

US20210403639A1 SYNTHESIS OF ENVIRONMENTALLY DEGRADABLE ALKYL POLYESTERS 有权
公开(公告)号：US20210403639A1
公开(公告)日：2021-12-30
申请号：US17304496
申请日：2021-06-22
申请人： Akina, Inc
发明人： John Solomon Garner , Kinam Park
IPC分类号： C08G63/12 , C08G63/08 , C08G63/82 , C08L67/04
摘要： A solid crosslinked polyester composition is disclosed wherein the crosslinked polyester is environmentally degradable in less than about 180 days. The crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester.

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