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1. 发明授权

US07202041B2 Immunoreaction measurement method 有权
标题翻译：免疫反应测定法
公开(公告)号：US07202041B2
公开(公告)日：2007-04-10
申请号：US10516067
申请日：2003-12-09
申请人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
发明人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
IPC分类号： G01N33/53 , G01N33/536 , G01N21/00 , C07K16/00
CPC分类号： G01N33/5306 , Y10S435/961 , Y10S436/805
摘要： The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids having a hydroxyl group, dicarboxylic acids having a double bond, straight-chain dicarboxylic acids expressed by the chemical formula (1): HOOC(CH2)nCOOH (n is an integer), and the salts of these dicarboxylic acids, and an antibody or antigen as a specifically binding substance capable of specifically binding to the subject substance, to obtain an acidic reaction solution, and then an antigen-antibody complex, generated by an antigen-antibody reaction of the subject substance with the specifically binding substance in the reaction solution was detected. This makes it possible to improve a measurement value and to relax a limitation of a measurement range due to a zone phenomenon that occurs in an antigen-excess region.
摘要翻译：本发明涉及一种用于测量样品中作为主体物质的抗原或抗体的免疫反应测定方法，其中将样品与选自由具有羟基的二羧酸组成的组中选择的至少一种化合物混合，双键，由化学式（1）表示的直链二羧酸：HOOC（CH 2 CH 2）n COOH（n为整数），其盐这些二羧酸和作为特异性结合物质的能够与本发明物质特异性结合的抗体或抗原，获得酸性反应溶液，然后将抗原 - 抗体复合物通过本发明物质的抗原 - 抗体反应与检测反应溶液中特异性结合物质。这使得可以改善测量值并且放松由于在抗原过量区域中发生的区域现象引起的测量范围的限制。

2. 发明申请

US20050009102A1 Turbidimetric immunoassay and an apparatus therefor 失效
标题翻译：浊度免疫测定及其设备
公开(公告)号：US20050009102A1
公开(公告)日：2005-01-13
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
IPC分类号： G01N21/82 , G01N33/52 , G01N33/53 , G01N33/536 , G01N33/557
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译：根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。水平。

3. 发明授权

US07241578B2 Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit 失效
标题翻译：免疫测定法/设备，生物成分可测量马桶，抗白蛋白单克隆抗体，产生相同的细胞株和白蛋白检测试剂盒
公开(公告)号：US07241578B2
公开(公告)日：2007-07-10
申请号：US10441192
申请日：2003-05-20
申请人： Keiko Yugawa , Nobuyuki Shigetoh , Akihito Kamei , Tatsurou Kawamura
发明人： Keiko Yugawa , Nobuyuki Shigetoh , Akihito Kamei , Tatsurou Kawamura
IPC分类号： G01K33/53 , G01K33/536 , G01K33/557 , G01K33/577 , C07K16/18 , C12N5/20 , C12P21/08
CPC分类号： A61B5/415 , A61B5/20 , A61B10/0038 , A61B10/007 , C07K16/18 , G01N33/577 , G01N33/68
摘要： The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monoclonal antibody capable of specifically binding to the subject substance; and (b) measuring an optical property of the mixed solution. The first monoclonal antibody is capable of binding to a first epitope of the subject substance, and the second monoclonal antibody is capable of binding to a second epitope of the subject substance different from the first epitope. Each of the first and second epitopes exists singly in the subject substance.
摘要翻译：本发明的免疫测定方法测定样品中目标物质的含量。该方法包括以下步骤：（a）通过混合样品和包含第一单克隆抗体和能够特异性结合本发明物质的第二单克隆抗体的抗体溶液来制备混合溶液; 和（b）测量混合溶液的光学性质。第一单克隆抗体能够结合受试物质的第一表位，第二单克隆抗体能够结合不同于第一表位的受试物质的第二表位。第一和第二表位中的每一个单独存在于主题物质中。

4. 发明授权

US07226777B2 Turbidimetric immunoassay and an apparatus therefor 失效
标题翻译：浊度免疫测定及其设备
公开(公告)号：US07226777B2
公开(公告)日：2007-06-05
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译：根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。水平。

5. 发明申请

US20050176063A1 Immunoreaction measurement method 有权
标题翻译：免疫反应测定法
公开(公告)号：US20050176063A1
公开(公告)日：2005-08-11
申请号：US10516067
申请日：2003-12-09
申请人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
发明人： Akihito Kamei , Tatsurou Kawamura , Keiko Yugawa
IPC分类号： G01N33/53 , G01N33/531
CPC分类号： G01N33/5306 , Y10S435/961 , Y10S436/805
摘要： The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids having a hydroxyl group, dicarboxylic acids having a double bond, straight-chain dicarboxylic acids expressed by the chemical formula (1): HOOC(CH2)nCOOH (n is an integer), and the salts of these dicarboxylic acids, and an antibody or antigen as a specifically binding substance capable of specifically binding to the subject substance, to obtain an acidic reaction solution, and then an antigen-antibody complex, generated by an antigen-antibody reaction of the subject substance with the specifically binding substance in the reaction solution was detected. This makes it possible to improve a measurement value and to relax a limitation of a measurement range due to a zone phenomenon that occurs in an antigen-excess region.
摘要翻译：本发明涉及一种用于测量样品中作为主体物质的抗原或抗体的免疫反应测定方法，其中将样品与选自由具有羟基的二羧酸组成的组中选择的至少一种化合物混合，双键，由化学式（1）表示的直链二羧酸：HOOC（CH 2 CH 2）n COOH（n为整数），其盐这些二羧酸和作为特异性结合物质的能够与本发明物质特异性结合的抗体或抗原，获得酸性反应溶液，然后将抗原 - 抗体复合物通过本发明物质的抗原 - 抗体反应与检测反应溶液中特异性结合物质。这使得可以改善测量值并且放松由于在抗原过量区域中发生的区域现象引起的测量范围的限制。

6. 发明授权

US07790470B2 Stirring method, cell, and measuring apparatus using the same 有权
标题翻译：搅拌方法，电池和使用其的测量装置
公开(公告)号：US07790470B2
公开(公告)日：2010-09-07
申请号：US10588546
申请日：2005-03-23
申请人： Akihito Kamei , Fumihisa Kitawaki , Tatsurou Kawamura , Hiroshi Nakayama , Nobuyuki Shigetou
发明人： Akihito Kamei , Fumihisa Kitawaki , Tatsurou Kawamura , Hiroshi Nakayama , Nobuyuki Shigetou
IPC分类号： G01N1/00 , G01N33/00 , G01N21/00 , G01N15/06 , G01N33/53
CPC分类号： B01F5/0057 , B01F1/0022 , B01F5/0206 , B01F2215/0037 , G01N21/03 , G01N21/76 , G01N2035/00544 , Y10T436/25
摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.
摘要翻译：能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至获得液体混合物。至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。

7. 发明申请

US20060288253A1 Biological information utilization system, biological information utilization method, program and recording medium 审中-公开
标题翻译：生物信息利用系统，生物信息利用方法，程序和记录介质
公开(公告)号：US20060288253A1
公开(公告)日：2006-12-21
申请号：US10559872
申请日：2004-06-10
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
IPC分类号： G06F11/00
CPC分类号： G06F19/3418 , G06Q50/24 , G16H10/20 , G16H10/60
摘要： In a vital data utilization system, measurement systems include a measurement unit for measuring the vital data of subjects, a clock unit for detecting each measurement time at which vital data is measured and a communication unit for sending the vital data including measurement time to a server, a server includes a communication unit for receiving sets of vital data from measurement systems, a vital data storage unit in which vital data are stored, a value-added information making unit for making the value-added information indicating the changes over time of average values of subjects' vital data in a predetermined geographical area based on the vital data stored in the vital data storage unit and a communication unit for providing the made value-added information to the measurement systems and the PCs of service destinations, and PCs output the provided value-added information.
摘要翻译：在重要的数据利用系统中，测量系统包括用于测量被摄体的重要数据的测量单元，用于检测测量重要数据的每个测量时间的时钟单元和用于将包括测量时间的重要数据发送到服务器的通信单元服务器包括用于从测量系统接收重要数据集的通信单元，其中存储重要数据的重要数据存储单元，增值信息制造单元，用于使增值信息指示随时间变化的增长信息基于存储在重要数据存储单元中的重要数据的预定地理区域中的受试者的重要数据的值以及用于将所提供的增值信息提供给测量系统和服务目的地的PC的通信单元，并且PC输出提供增值信息。

8. 发明申请

US20060281195A1 Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same 有权
公开(公告)号：US20060281195A1
公开(公告)日：2006-12-14
申请号：US11507011
申请日：2006-08-21
申请人： Akihito Kamei , Nobuyuki Shigetoh , Tatsurou Kawamura
发明人： Akihito Kamei , Nobuyuki Shigetoh , Tatsurou Kawamura
IPC分类号： C12M1/34 , G01N33/551
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.

9. 发明授权

US6046804A Sample cell for polarimetry, polarimeter, and polarimetry 失效
标题翻译：用于测光，旋光仪和偏光镜的样品池
公开(公告)号：US6046804A
公开(公告)日：2000-04-04
申请号：US149084
申请日：1998-09-08
申请人： Tatsurou Kawamura , Jinsei Miyazaki , Akihito Kamei
发明人： Tatsurou Kawamura , Jinsei Miyazaki , Akihito Kamei
IPC分类号： G01N21/21 , G01N21/01
CPC分类号： G01N21/21
摘要： A sample cell for polarimetry is disclosed. It comprises: a base member having a tubular cavity for holding a specimen and for permitting a light to transmit therethrough, and a pair of light-transmitting windows for sealing a pair of open ends of the cavity; and a coil arranged around the base member for generating a magnetic field inside the cavity along an axial direction of the cavity. The specimen is supplied to the cavity through a channel for communicating the cavity with the outside.
摘要翻译：公开了一种用于极化法的样品池。它包括：具有用于保持样本并允许光透过其的管状空腔的基座构件和用于密封空腔的一对开口端的一对透光窗口; 以及围绕所述基座构件设置的线圈，用于沿着所述空腔的轴向方向在所述空腔内产生磁场。样品通过用于将空腔与外部连通的通道供应到空腔。

10. 发明授权

US07476544B2 Method of judging homogenization/reaction completion and method of measuring solution concentration using the same 失效
标题翻译：判断均质/反应完成的方法及使用该方法测定溶液浓度的方法
公开(公告)号：US07476544B2
公开(公告)日：2009-01-13
申请号：US10507313
申请日：2003-03-12
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
IPC分类号： G01N21/75 , G01N21/47
CPC分类号： G01N21/272 , B01F5/0206 , G01N21/51 , G01N21/532 , G01N21/59 , G01N21/82 , G01N2021/0325 , G01N2021/513 , G01N2021/755 , G01N2021/7783 , G01N2201/1222
摘要： It is intended to provide a method for determining homogenization and/or reaction completion, capable of making the measurement time necessary and sufficient and enhancing the measurement speed, and a method for measuring solution concentration using the same. According to the method for determining homogenization and/or reaction completion and the method for measuring solution concentration using the same, homogenization and reaction completion are determined based on the optical property of the liquid mixture of a test liquid and a reagent liquid.
摘要翻译：旨在提供一种能够确定均匀化和/或反应完成的方法，其能够使测量时间需要和充分并且提高测量速度，以及使用该方法测量溶液浓度的方法。根据用于确定均质化和/或反应完成的方法以及使用其测定溶液浓度的方法，基于测试液体和试剂液体的液体混合物的光学性质来确定均化和反应完成。

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