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1. 发明授权

US08257974B2 Method of reaction in flow channel of microchip and analysis device 有权
标题翻译：微芯片流量通道反应方法及分析装置
公开(公告)号：US08257974B2
公开(公告)日：2012-09-04
申请号：US12803060
申请日：2010-06-18
申请人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
发明人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).
摘要翻译：在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为有效地传递到反应物中，从而促进反应的进行。在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动）。反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道（10），同时在其前缘侧提供气体。在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。

2. 发明申请

US20090155927A1 MICROREACTOR AND METHOD OF LIQUID FEEDING MAKING USE OF THE SAME 有权
标题翻译：液体进料的微生物和方法使用该方法
公开(公告)号：US20090155927A1
公开(公告)日：2009-06-18
申请号：US12092116
申请日：2006-10-18
申请人： Kusunoki Higashino , Akihisa Nakajima , Yasuhiro Sando , Youichi Aoki
发明人： Kusunoki Higashino , Akihisa Nakajima , Yasuhiro Sando , Youichi Aoki
IPC分类号： G01N1/10 , B01J19/00 , G01N35/08 , G01N37/00
CPC分类号： B01L3/502738 , B01F5/0602 , B01F5/0647 , B01F13/0059 , B01J19/0093 , B01J2219/00891 , B01L3/502723 , B01L3/502746 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0439 , B01L2400/0487 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0017 , F16K99/0034 , F16K99/0057 , F16K2099/0084 , Y10T436/2575
摘要： A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and reagents and realizes high-precision controlling of the timing of mixing of reagents and other liquids, the mixing ratio of liquids, the pressure for liquid feeding, etc. Further, there is provided a method of liquid feeding making use of the same. Accordingly, a flow path branched at the position of an inlet from a flow path through which an opening communicating with an external pump communicates with the inlet is provided with an air evacuation flow path with its terminal open outward. Further, the flow path resistance of the air evacuation flow path for a liquid is made greater than the flow path resistance, for the liquid, of a flow channel from the reagent storage chamber to a reagent feed-out flow path.
摘要翻译：能够在样品和含有多种试剂的混合物的混合试剂之间反应的微反应器，该微反应器避免在驱动溶液和试剂之间插入空气，并实现对试剂和其它液体的混合时间的高精度控制，混合液体的比例，液体供给的压力等。此外，提供了一种使用该液体的方法。因此，在与从外部泵连通的开口与流路连通的流路的入口位置分支的流路设置有使其端子向外侧开口的排气流路。此外，使液体的排气流路的流路阻力大于液体对从试剂储存室到试剂送出流路的流路的流路阻力。

3. 发明申请

US20100261290A1 Method of reaction in flow channel of microchip and analysis device 有权
标题翻译：微芯片流量通道反应方法及分析装置
公开(公告)号：US20100261290A1
公开(公告)日：2010-10-14
申请号：US12803060
申请日：2010-06-18
申请人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
发明人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
IPC分类号： G01N1/00
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).
摘要翻译：在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为有效地传递到反应物中，从而促进反应的进行。在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动）。反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道（10），同时在其前缘侧提供气体。在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。

4. 发明申请

US20090233378A1 Method of Reaction in Flow Channel of Microchip and Analysis Device 审中-公开
标题翻译： Microchip流量通道和分析装置的反应方法
公开(公告)号：US20090233378A1
公开(公告)日：2009-09-17
申请号：US12225598
申请日：2007-02-21
申请人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
发明人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki , Kohsuke Tanimoto
IPC分类号： G01N21/00 , G01N1/00
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In case of performing a reaction between reacting material and reagent by bringing the reagent in contact with the reacting material through flowing the reagent into a reaction flow channel in which the reaction material which reacts with the reagent is carried on a wall surface of the reaction flow channel of a microchip, the reaction is expedited efficiently by passing the reagent to the reacting material. The reagent 30a is flowed such that a peripheral portion of a gas-liquid interface at a front end of the reagent moves back and forth on the wall surface of the reaction flow channel 10 when the reaction is performed.
摘要翻译：通过使试剂与反应物质接触而使反应物质与试剂反应的反应流入反应流路，反应物质与反应物质反应的反应物质与试剂反应的反应物质在反应流的壁面上进行反应微芯片的通道，通过使试剂通过反应材料而有效地加速反应。试剂30a流动，使得当进行反应时，试剂前端的气 - 液界面的周边部分在反应流路10的壁表面上来回移动。

5. 发明申请

US20080118369A1 Microchip Inspection System and Microchip Inspection System Program 审中-公开
标题翻译： Microchip检测系统和Microchip检测系统程序
公开(公告)号：US20080118369A1
公开(公告)日：2008-05-22
申请号：US11940598
申请日：2007-11-15
申请人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
发明人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
IPC分类号： F04B49/00
CPC分类号： F04B43/043 , B01L3/50273 , B01L7/00 , B01L2200/14 , B01L2200/143 , B01L2300/0627 , B01L2300/0645 , B01L2300/1822 , B01L2400/0487 , G01N2035/1034 , G01P13/0006 , G05D7/0694
摘要： An objective is to provide a microchip inspection system in which an amount of driving liquid filled in a flow path between a micropump and a microchip is kept constant. Also disclosed is a microchip inspection system possessing a micropump by which driving liquid is injected into a microchip from a flow path; a driving liquid sensing device by which a sensing signal is output by sensing presence or absence of the driving liquid at a predetermined position of the flow path; and a pump driving control section by which the driving liquid is moved to a position based on the predetermined position as a reference position by driving the micropump in response to the sensing signal obtained from the driving liquid sensing device.
摘要翻译：目的是提供一种微芯片检查系统，其中填充在微型泵和微芯片之间的流动路径中的驱动液体的量保持恒定。还公开了一种具有微型泵的微芯片检查系统，通过该微泵将驱动液体从流路注入微芯片; 驱动液体检测装置，通过在所述流路的预定位置处感测驱动液体的存在或不存在来输出感测信号; 以及泵驱动控制部，通过利用从驱动液体检测装置得到的感测信号，通过驱动微型泵将驱动液体移动到基于规定位置的位置作为基准位置。

6. 发明申请

US20080101992A1 Microchip and Microchip Inspection System 审中-公开
标题翻译： Microchip和Microchip检测系统
公开(公告)号：US20080101992A1
公开(公告)日：2008-05-01
申请号：US11923234
申请日：2007-10-24
申请人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki
发明人： Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Youichi Aoki
IPC分类号： B01J19/00
CPC分类号： B01L3/502707 , B01L2200/16 , B01L2300/042 , B01L2300/049 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0439 , B01L2400/0677
摘要： An objective is to provide a microchip exhibiting no scattering of stored reagent together with reduced size, which is capable of rapidly mixing the reagent when used. Also disclosed is a microchip possessing a reaction section in which reaction with a reagent or a specimen supplied from a flow path is conducted via heat, wherein the reaction section possesses a storage section to store the reagent in advance, and the reagent previously stored in the storage section is sealed with a material which generates phase transition from a solid phase to a liquid phase between a storage temperature and a reaction temperature.
摘要翻译：目的是提供一种显示不存在的试剂的散射的微芯片以及减小的尺寸，其能够在使用时快速混合试剂。还公开了具有反应部的微芯片，其中与从流路供给的试剂或试样的反应通过加热进行反应，其中反应部具有预先存储试剂的储存部，预先存储在试剂中的试剂存储部分用在储存温度和反应温度之间产生从固相到液相的相变的材料密封。

7. 发明申请

US20100232986A1 MICRO TOTAL ANALYSIS SYSTEM EQUIPPED WITH LEAKAGE PREVENTION MECHANISM 审中-公开
标题翻译： MICRO总分析系统配备防漏机制
公开(公告)号：US20100232986A1
公开(公告)日：2010-09-16
申请号：US12304077
申请日：2007-05-08
申请人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
发明人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
IPC分类号： F04B49/00
CPC分类号： G01N35/08
摘要： A micro total analysis system, comprising: an examination chip provided with a micro flow path and a flow path opening section communicating with a micropump on the upstream side of a reagent containing section, a drive fluid tank containing drive fluid, a micropump unit provided with a plurality of the micropumps such that the upstream side of each micropump communicates with the drive fluid tank and a flow path opening communicating with the micro flow path of the examination chip is provided on the downstream side, and a system body including the micropump unit and the drive fluid tank in one storing body, wherein analysis is performed while the examination chip is attached to the system body, and a mechanism for altering the direction of pressure at the flow path opening of the micropump unit depending on attaching/detaching of the examination chip to/from the system main body is provided.
摘要翻译：一种微型总分析系统，包括：具有微流路的检查芯片和与试剂容纳部的上游侧的微型泵连通的流路开口部，容纳驱动流体的驱动流体槽，设置有多个微型泵，使得每个微型泵的上游侧与驱动流体箱连通，并且在下游侧设置有与检查芯片的微流路连通的流路开口，并且包括微泵单元和所述驱动流体箱在一个存储体中，其中在所述检查芯片附接到所述系统主体的同时进行分析，以及用于根据所述检查的附着/分离改变所述微型泵单元的流路开口处的压力方向的机构提供了与/从系统主体的芯片。

8. 发明申请

US20100028206A1 MICROCHIP AND METHOD OF MANUFACTURING MICROCHIP 审中-公开
标题翻译： MICROCHIP和MICROCHIP制造方法
公开(公告)号：US20100028206A1
公开(公告)日：2010-02-04
申请号：US12446708
申请日：2007-09-22
申请人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
发明人： Yasuhiro Sando , Akihisa Nakajima , Kusunoki Higashino , Youichi Aoki
IPC分类号： B01J19/00 , B32B37/00 , B32B38/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/565 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0487 , B29C45/372
摘要： A microchip having: two flow path substrates having flow paths in a shape of a groove formed on one side of each substrate thereof; and a communication hole substrate on which a communication hole is formed to communicate the flow paths of the two substrates each other; wherein the two substrates are bonded in a way that the surfaces, on which the flow paths in the shape of the groove formed, face each other, having the communication hole substrate therebetween.
摘要翻译：一种微芯片，其具有：两个流路基板，其具有形成在其每个基板的一侧上的凹槽的形状的流动路径; 以及连通孔基板，其上形成有连通所述两个基板的流路的连通孔; 其特征在于，所述两个基板的接合方式是，形成有所述槽的形状的流路的面彼此面对，所述两个基板之间具有连通孔基板。

9. 发明申请

US20060094004A1 Micro-reactor, biological material inspection device, and microanalysis system 审中-公开
标题翻译：微反应器，生物材料检测装置和微量分析系统
公开(公告)号：US20060094004A1
公开(公告)日：2006-05-04
申请号：US11255664
申请日：2005-10-21
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida , Youichi Aoki
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida , Youichi Aoki
IPC分类号： C12Q1/70
CPC分类号： B01L3/502738 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/141 , B01L2300/0654 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2300/1861 , B01L2400/0415 , B01L2400/0487 , B01L2400/0616 , B01L2400/0638 , B01L2400/0655 , B01L2400/082
摘要： A micro reactor for inspecting a biological material, comprising: a first substrate on which a minute flow path is formed; a second substrate laminated on the first substrate so as to cover the minute flow path; a detection section provided on the minute flow path formed between the first and second substrates so as to inspect a liquid mixture of a sample and a reagent; (4) an opening section formed at a region on the second substrate corresponding to the detection section so as to irradiate inspection light to the liquid mixture arriving the detection; and (5) a transparent member to cover the opening section.
摘要翻译：一种用于检查生物材料的微反应器，包括：形成有微小流路的第一基板; 层叠在所述第一基板上以覆盖所述微小流路的第二基板; 检测部，设置在形成在第一和第二基板之间的微小流路上，以检查样品和试剂的液体混合物; （4）形成在与所述检测部对应的所述第二基板上的区域的开口部，以将检查光照射到到达所述检测的所述液体混合物; 和（5）透明构件以覆盖开口部分。

10. 发明申请

US20110226339A1 MICROCHIP AND LIQUID SENDING METHOD FOR MICROCHIP 审中-公开
标题翻译： MICROCHIP的微型化和液体发送方法
公开(公告)号：US20110226339A1
公开(公告)日：2011-09-22
申请号：US12809137
申请日：2008-12-09
申请人： Youichi Aoki , Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Yoshikazu Kurihara
发明人： Youichi Aoki , Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Yoshikazu Kurihara
IPC分类号： F15D1/00
CPC分类号： B01L3/502746 , B01J2219/00619 , B01L3/5027 , B01L3/502723 , B01L2200/027 , B01L2200/0642 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , C12Q2565/629 , G01N2021/0346 , G01N2035/00158 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T137/0318 , Y10T137/8593 , Y10T436/25 , Y10T436/2575
摘要： A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
摘要翻译：即使在通道结构简单的情况下，也能够将微流路内的液体送到规定的位置而与压力差无关，并且将两液体质量混合物送出到规定的位置。微芯片包括设置在微流动通道中并适于临时保持通过微流动通道传送的液体的中间储存部分。微芯片的特征在于，中间储存部分具有侧通道，中间储存器部分的体积小于送入中间储存器部分的液体的总体积，侧通道用于连通微流道在中间储存部的上游侧，在其下游侧具有微流路，并且侧流路的截面积小于微流路的截面积。

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