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1. 发明授权

US08278479B2 Method for producing optically active fluorine-containing carbonyl-ene product 有权
标题翻译：光学活性含氟羰基产物的制备方法
公开(公告)号：US08278479B2
公开(公告)日：2012-10-02
申请号：US12519959
申请日：2007-12-18
申请人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
发明人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
IPC分类号： C07C69/732
CPC分类号： C07C67/347 , C07B53/00 , C07B2200/07 , C07C67/343 , C07C69/732
摘要： An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost.
摘要翻译：通过在具有光学活性配体的过渡金属络合物的存在下使含氟α-酮酯与烯烃反应来制备光学活性的含氟羰基产物。在没有反应溶剂的情况下进行该反应的方式1，在相对介电常数低的溶剂中进行该反应的方式2，以及在卤代烃系溶剂中进行该反应的方式3。在这三种模式中的每一种中，可以以低成本制造光学活性的含氟羰基产物。

2. 发明申请

US20110306781A1 Method for Producing Optically Active Fluorinated Oxetane 有权
标题翻译：生产光学活性氟化氧杂环丁烷的方法
公开(公告)号：US20110306781A1
公开(公告)日：2011-12-15
申请号：US13201171
申请日：2010-02-22
申请人： Koichi Mikami , Kohsuke Aikawa , Junpei Aida , Akihiro Ishii , Misugi Kato , Takashi Masuda
发明人： Koichi Mikami , Kohsuke Aikawa , Junpei Aida , Akihiro Ishii , Misugi Kato , Takashi Masuda
IPC分类号： C07D305/08
CPC分类号： C07D305/04 , B01J31/223 , B01J31/2409 , B01J2231/32 , B01J2531/0266 , B01J2531/46 , B01J2531/824 , C07B53/00 , C07D305/08
摘要： Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity.
摘要翻译：公开了通过在过渡金属络合物与光学活性配体的存在下，通过氟化α-酮酯与酰基烯基醚的反应，制备可以是重要的药物或农业中间体的光学活性氟化氧杂环丁烷的方法。该方法利用催化不对称合成方法，不需要化学计量的手性源。因此，可以显着地减少不对称催化剂的使用量，特别是当在高浓度的底物（使用少量的反应溶剂）下进行反应时，或者在没有反应溶剂的情况下条件）。此外，可以高产率和非常高的光学纯度获得目标光学活性氟化氧杂环丁烷。该产品几乎没有难以分离的杂质，显示出高的化学纯度。

3. 发明申请

US20090312574A1 Method for Producing Optically Active Fluorine-Containing Carbonyl-ene Product 有权
标题翻译：生产含活性氟的羰基产物的方法
公开(公告)号：US20090312574A1
公开(公告)日：2009-12-17
申请号：US12519959
申请日：2007-12-18
申请人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
发明人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
IPC分类号： C07C51/04
CPC分类号： C07C67/347 , C07B53/00 , C07B2200/07 , C07C67/343 , C07C69/732
摘要： An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost.
摘要翻译：在具有光学活性配体的过渡金属络合物的存在下，通过使含氟α-酮酯与烯烃反应制备光学活性的含氟羰基产物。在没有反应溶剂的情况下进行该反应的方式1，在相对介电常数低的溶剂中进行该反应的方式2，以及在卤代烃系溶剂中进行该反应的方式3。在这三种模式中的每一种中，可以以低成本制造光学活性的含氟羰基产物。

4. 发明授权

US08809557B2 Method for producing optically active fluorinated oxetane 有权
标题翻译：光学活性氟代氧杂环丁烷的制造方法
公开(公告)号：US08809557B2
公开(公告)日：2014-08-19
申请号：US13201171
申请日：2010-02-22
申请人： Koichi Mikami , Kohsuke Aikawa , Junpei Aida , Akihiro Ishii , Misugi Kato , Takashi Masuda
发明人： Koichi Mikami , Kohsuke Aikawa , Junpei Aida , Akihiro Ishii , Misugi Kato , Takashi Masuda
IPC分类号： C07D305/04
CPC分类号： C07D305/04 , B01J31/223 , B01J31/2409 , B01J2231/32 , B01J2531/0266 , B01J2531/46 , B01J2531/824 , C07B53/00 , C07D305/08
摘要： Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity.
摘要翻译：公开了通过氟化α-酮酯与酰基烯基醚在过渡金属配合物与光学活性配体的存在下反应，制备可以是重要的药用或农业中间体的光学活性氟化氧杂环丁烷的方法。该方法利用催化不对称合成方法，不需要化学计量的手性源。因此，可以显着地减少不对称催化剂的使用量，特别是当在高浓度的底物（使用少量的反应溶剂）下进行反应时，或者在没有反应溶剂的情况下条件）。此外，可以高产率和非常高的光学纯度获得目标光学活性氟化氧杂环丁烷。该产品几乎没有难以分离的杂质，显示出高的化学纯度。

5. 发明授权

US06326520B1 Optically active compound and method for producing same 失效
标题翻译：光学活性化合物及其制备方法
公开(公告)号：US06326520B1
公开(公告)日：2001-12-04
申请号：US09377688
申请日：1999-08-20
申请人： Akihiro Ishii , Koichi Mikami
发明人： Akihiro Ishii , Koichi Mikami
IPC分类号： C07C49213
CPC分类号： C07F7/1892 , B01J31/223 , B01J2231/341 , B01J2531/0266 , B01J2531/46 , C07C43/1787 , C07C45/30 , C07C49/82
摘要： The invention relates to a method for producing a novel optically active compound represented by the general formula [IV]. This method includes the step of reacting a vinyl ether with a halogenated acetaldehyde in the presence of an optically active binaphthol-titanium complex. With this, the novel optically active compound can be produced very easily. Furthermore, the novel optically active compound can easily be oxidized to a novel optically active &agr;,&bgr;-dihydrexyketone represented by the general formula [V]. These novel optically active compounds can each be used as useful intermediates. where R is a lower alkyl group or —Si(R3)3, where R3 is a lower alkyl group and three of R3 may be the same or different groups, R1 is a lower alkyl group or a substituted or unsubstituted phenyl group, R2 is hydrogen atom or a lower alkyl group or a substituted or unsubstituted phenyl group, or R1 and R2 are combined to form an alkylene group, and X is hydrogen, fluorine, chlorine or bromine with a proviso that three of said X may be the same or different atoms, but are not hydrogen at the same time.
摘要翻译：本发明涉及一种由通式[Ⅳ]表示的新的光学活性化合物的制备方法。该方法包括在光学活性联萘酚钛络合物存在下使乙烯基醚与卤代乙醛反应的步骤。由此，可以非常容易地制造新颖的光学活性化合物。此外，新的光学活性化合物可以容易地被氧化成由通式[V]表示的新的光学活性α，β-二羟基酮。这些新的光学活性化合物各自可用作有用的中间体。其中R是低级烷基或-Si（R3）3，其中R3是低级烷基，R3中的三个可以是相同或不同的基团，R1是低级烷基或取代或未取代的苯基，R 2为氢原子或低级烷基或取代或未取代的苯基，或R 1和R 2结合形成亚烷基，X为氢，氟，氯或溴条件是所述X中的三个可以是相同或不同的原子，但不是同时是氢。

6. 发明授权

US08999463B2 Glare-proofing optical laminate 有权
标题翻译：防眩光学层压板
公开(公告)号：US08999463B2
公开(公告)日：2015-04-07
申请号：US11817818
申请日：2006-03-29
申请人： Koichi Mikami , Yukimitsu Iwata , Yoshihiro Nishimura , Takashi Kodama
发明人： Koichi Mikami , Yukimitsu Iwata , Yoshihiro Nishimura , Takashi Kodama
IPC分类号： C09K19/00 , G02B5/02 , G02B5/30
CPC分类号： G02B1/111 , G02B5/02 , G02B5/3033 , Y10T428/1036 , Y10T428/24372 , Y10T428/24537 , Y10T428/2457 , Y10T428/25 , Y10T428/26
摘要： An anti-dazzling laminate made of an optical laminate including a light transparent base material and an anti-dazzling layer having a concavoconvex shape provided on the material. The laminate simultaneously satisfies formulae: 0≦G100≦15 (I), 0.1≦Hs≦5.0 (II), 0.3≦Rz≦1.8 (III) wherein G100 represents a scintillation value which is a standard deviation of a variation in brightness distribution at a resolution of 100 ppi measured on the surface of the laminate; Hs represents the surface haze value of the laminate; and Rz represents the average roughness of the concavoconvex shape of the anti-dazzling layer.
摘要翻译：由光学层压制品制成的防光泽层压材料，该层压材料包括透明基材和具有凹凸形状的抗眩光层。层压板同时满足公式：0＆nlE; G100＆nlE; 15（I），0.1＆nlE; Hs＆nlE; 5.0（II），0.3＆nlE; Rz＆nlE; 1.8（III）其中G100表示闪烁值，其是亮度变化的标准偏差在层压板的表面上测量的分辨率为100ppi的分布; Hs表示层压板的表面雾度值; Rz表示防炫目层的凹凸形状的平均粗糙度。

7. 发明授权

US08741499B2 Solid oxide fuel cell 失效
标题翻译：固体氧化物燃料电池
公开(公告)号：US08741499B2
公开(公告)日：2014-06-03
申请号：US12926400
申请日：2010-11-16
申请人： Kuniaki Yoshikata , Koichi Mikami , Hirotoshi Sakamoto
发明人： Kuniaki Yoshikata , Koichi Mikami , Hirotoshi Sakamoto
IPC分类号： H01M8/24
CPC分类号： H01M8/1246 , H01M8/0247 , H01M8/0297 , H01M8/1213 , H01M8/1286 , H01M8/24 , H01M8/2425 , H01M8/2428 , Y02E60/525 , Y02P70/56
摘要： The solid oxide fuel cell of the present invention has a substrate (1); an electrolyte (3) that is disposed on one surface of the substrate (1); and at least one electrode element E having an anode (5) and a cathode (7) disposed on the same surface of the electrolyte (3) with a predetermined space therebetween.
摘要翻译：本发明的固体氧化物型燃料电池具有基板（1）。设置在所述基板（1）的一个表面上的电解质（3）; 以及至少一个具有阳极（5）和阴极（7）的电极元件E，其间以预定的间隔设置在电解质（3）的同一表面上。

8. 发明申请

US20130310580A1 Method For Producing Optically Active Fluorine-Containing Oxeten 有权
标题翻译：生产含活性氟的Oxeten的方法
公开(公告)号：US20130310580A1
公开(公告)日：2013-11-21
申请号：US13989662
申请日：2011-11-16
申请人： Koichi Mikami , Kohsuke Aikawa , Yuta Hioki
发明人： Koichi Mikami , Kohsuke Aikawa , Yuta Hioki
IPC分类号： C07D305/10
CPC分类号： C07D305/10 , C07D407/04 , C07D409/04
摘要： A method for producing an optically active fluorine-containing oxeten, the method being provided to include the steps of causing a fluorine-containing α-ketoester and an internal alkyne to react with each other in the presence of a transition metal complex that has an optically active ligand.
摘要翻译：一种制备光学活性的含氟氧杂环丁酮的方法，该方法包括以下步骤：使含氟α-酮酯和内炔在具有光学性活性配体。

9. 发明授权

US08493660B2 Optical layered body comprising a light-transmitting substrate and antiglare layer, polarizer and image display device 有权
标题翻译：光学层叠体，包括透光基板和防眩光层，偏振片和图像显示装置
公开(公告)号：US08493660B2
公开(公告)日：2013-07-23
申请号：US12377782
申请日：2007-08-16
申请人： Gen Furui , Yukimitsu Iwata , Takashi Kodama , Yoshihiro Nishimura , Koichi Mikami
发明人： Gen Furui , Yukimitsu Iwata , Takashi Kodama , Yoshihiro Nishimura , Koichi Mikami
IPC分类号： G02B1/10
CPC分类号： G02B1/11 , G02B5/0221 , G02B5/0278 , G02B5/30
摘要： An optical layered body including a light-transmitting substrate and an antiglare layer provided on the light-transmitting substrate. The antiglare layer has a surface roughness on the outermost surface. In the optical layered body, a mean spacing of tops of local peak of profile S is 0.045 mm or more and 0.10 mm or less determined by the procedure disclosed in the specification. The optical layered body can attain properties such as an antiglare property, scintillation prevention and black color reproducibility such as gloss blackness simultaneously.
摘要翻译：一种光学层叠体，包括设置在透光性基板上的透光性基板和防眩光层。防眩层在最外表面具有表面粗糙度。在光学层叠体中，轮廓S的局部峰的顶部的平均间距通过说明书中公开的程序确定为0.045mm以上且0.10mm以下。光学层叠体可以同时获得诸如防眩光性质，防闪烁性和黑色再现性等光泽度的性质。

10. 发明申请

US20120002397A1 OPTICAL MULTILAYER BODY, POLARIZATION PLATE USING SAME, AND IMAGE DISPLAY 有权
标题翻译：光学多层体，使用相同的偏光板和图像显示
公开(公告)号：US20120002397A1
公开(公告)日：2012-01-05
申请号：US13230961
申请日：2011-09-13
申请人： Yukimitsu IWATA , Koichi Mikami , Yoshihiro Nishimura , Takashi Kodama
发明人： Yukimitsu IWATA , Koichi Mikami , Yoshihiro Nishimura , Takashi Kodama
IPC分类号： G09F13/04 , G02B5/02 , G02B5/30
CPC分类号： G02F1/133502 , G02B1/111 , G02F1/133528
摘要： An optical laminate is provided which has anti-dazzling properties and can realize excellent glare preventive properties and black reproducibility (gradation rendering of black at low brightness). The optical laminate includes a light transparent base material and an anti-dazzling layer or a light diffusion layer provided on the light transparent base material, wherein the outermost surface of the anti-dazzling layer or light diffusion layer has a concavoconvex surface. The anti-dazzling layer satisfies the requirements that Sm is not less than 100 μm and not more than 600 μm, θa is not less than 0.1 degree and not more than 1.2 degrees, and Rz is more than 0.2 μm and not more than 1 μm, wherein Sm represents the average spacing of concavoconvexes in the anti-dazzling layer, θa represents the average inclination angle of the concavoconvexes, and Rz represents the average roughness of the concavoconvexes.
摘要翻译：提供具有防炫目性能并且可以实现优异的防眩性和黑色再现性（低亮度下的黑色的渐变渲染）的光学层叠体。光学层叠体包括透光基材和防透光层或设置在透光基材上的光漫射层，其中抗炫目层或光扩散层的最外表面具有凹凸表面。抗眩光层满足Sm为100μm以上且600μm以下的要求，a为0.1度以上1.2以下，Rz为0.2μm以上， 1μm，其中Sm表示抗眩光层中的凹凸的平均间距，a表示凹凸的平均倾斜角，Rz表示凹凸的平均粗糙度。

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